Search

Your search keyword '"Howard, Jane"' showing total 772 results
Start Over Author "Howard, Jane"
772 results on '"Howard, Jane"'

34. microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance

Author

Anandagoda, Nelomi, Willis, Joanna C.D., Hertweck, Arnulf, Roberts, Luke B., Jackson, Ian, Gokmen, M. Refik, Jenner, Richard G., Howard, Jane K., and Lord, Graham M.

Subjects
MicroRNA -- Research, Gene expression -- Research, Phosphodiesterases -- Research, Enzymes, Autoimmunity, Cyclic adenosine monophosphate, T cells, Health care industry
Abstract

Tregs play a fundamental role in immune tolerance via control of self-reactive effector T cells (Teffs). This function is dependent on maintenance of a high intracellular cAMP concentration. A number of microRNAs are implicated in the maintenance of Tregs. In this study, we demonstrate that peripheral immune tolerance is critically dependent on posttranscriptional repression of the cAMP-hydrolyzing enzyme phosphodiesterase- 3b (Pde3b) by microRNA-142-5p (miR-142-5p). In this manner, miR-142-5p acts as an immunometabolic regulator of intracellular cAMP, controlling Treg suppressive function. Mir142 was associated with a super enhancer bound by the Treg lineage-determining transcription factor forkhead box P3 (FOXP3), and Treg-specific deletion of miR-142 in mice ([Treg.sup.[DELTA]142]) resulted in spontaneous, lethal, multisystem autoimmunity, despite preserved numbers of phenotypically normal Tregs. Pharmacological inhibition and genetic ablation of PDE3B prevented autoimmune disease and reversed the impaired suppressive function of Tregs in [Treg.sup.[DELTA]142] animals. These findings reveal a critical molecular switch, specifying Treg function through the modulation of a highly conserved, cell-intrinsic metabolic pathway. Modulation of this pathway has direct relevance to the pathogenesis and treatment of autoimmunity and cancer., Introduction miRNAs are a class of small (~21-25 nucleotides), highly conserved, endogenous noncoding RNAs that regulate gene expression post-transcriptionally. This function is mediated through binding of the miRNA-containing RNA-induced silencing [...]

Published
2019
Full Text
View/download PDF

39. The Big Five Quickstart: An Introduction to the Five-Factor Model of Personality for Human Resource Professionals.

Author

Center for Applied Cognitive Studies, Charlotte, NC., Howard, Pierce J., and Howard, Jane M.

Abstract

The first section of this monograph shows how, by analyzing the language of personality descriptors, researchers have identified five correlated groups of behaviors. It finds that the most popular formulation of the Five-Factor Model (FFM) is that of Costa and McCrae (1992) and that their nomenclature can be adapted to come up with a version for professional development. These five factors are described: Negative Emotionality, Extraversion, Openness, Agreeableness, and Conscientiousness. Six facets identified for each of these five factors are described. Section 2 presents how the FFM may be used in fostering individual development. It covers guidelines for use of FFM test scores in professional development, including the following: awareness of small interaction effects between all five personality dimensions and aging; the social context of the Big Five; when to use factors and when to use facets; and common themes among the various facets and factors. It also addresses using the FFM in individual coaching and counseling, in a classroom setting, and in personnel selection. Section 3 presents ways in which the Big Five model can be used in working with teams. It looks at how various kinds of relationships--from two-person teams to larger work teams--can benefit from taking time to study the effects of similarities and differences in personality traits among the people in relationships. Contains 21 references. (YLB)

Published
1995

50. 1196 Circulating extracellular vesicles of patients with melanoma differ in concentration and composition compared to healthy controls

Author

Bollard, Stephanie M., primary, Casalou, Cristina, additional, Howard, Jane, additional, O'Donnell, Kelsey, additional, Wynne, Kieran, additional, Yin, Xiaofei, additional, Brennan, Lorraine, additional, Tobin, Desmond, additional, Kelly, Pamela, additional, McCann, Amanda, additional, and Potter, Shirley, additional

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results