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2. Taenia martis Neurocysticercosis--Like Lesion in Child, Associated with Local Source, the Netherlands

Author

Eggink, Hendriekje, Maas, Miriam, van den Brand, Judith M.A., Dekker, Jasja, Franssen, Frits, Hoving, Eelco W., Kortbeek, Laetitia M., Kranendonk, Mariette E.G., Meiners, Linda C., Rittscher, Anne E., Roelfsema, Jeroen, and Scholvinck, Elisabeth H.

Subjects
Cysticercosis -- Case studies -- Causes of, Communicable diseases in children -- Case studies -- Causes of, Taeniasis -- Case studies -- Causes of, Health
Abstract

The zoonotic Taenia martis tapeworm lives in mustelid intestines and has been reported across Europe (1). Human infection is thought to occur by accidental ingestion of eggs in mustelid feces [...]

Published
2024
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4. Generation of immunocompetent syngeneic allograft mouse models for pediatric diffuse midline glioma

Author

du Chatinier, Aimée, Meel, Michaël H, Das, Arvid I, Metselaar, Dennis S, Waranecki, Piotr, Bugiani, Marianna, Breur, Marjolein, Simonds, Erin F, Lu, Edbert D, Weiss, William A, Vallejo, Juan J Garcia, Hoving, Eelco W, Phoenix, Timothy N, and Hulleman, Esther

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Rare Diseases, Genetics, Pediatric, Neurosciences, Brain Cancer, Cancer, Brain Disorders, Pediatric Cancer, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, Aetiology, DMG, DIPG, immunotherapy | syngeneic allograft, tumor microenvironment
Abstract

BackgroundDiffuse midline gliomas (DMG) are highly malignant incurable pediatric brain tumors. A lack of effective treatment options highlights the need to investigate novel therapeutic strategies. This includes the use of immunotherapy, which has shown promise in other hard-to-treat tumors. To facilitate preclinical immunotherapeutic research, immunocompetent mouse models that accurately reflect the unique genetic, anatomical, and histological features of DMG patients are warranted.MethodsWe established cell cultures from primary DMG mouse models (C57BL/6) that were generated by brainstem targeted intra-uterine electroporation (IUE). We subsequently created allograft DMG mouse models by orthotopically implanting these tumor cells into syngeneic mice. Immunohistochemistry and -fluorescence, mass cytometry, and cell-viability assays were then used to verify that these murine tumors recapitulated human DMG.ResultsWe generated three genetically distinct allograft models representing histone 3 wildtype (H3WT) and K27M-mutant DMG (H3.3K27M and H3.1K27M). These allograft models recapitulated the histopathologic phenotype of their human counterparts, including their diffuse infiltrative growth and expression of DMG-associated antigens. These murine pontine tumors also exhibited an immune microenvironment similar to human DMG, characterized by considerable myeloid cell infiltration and a paucity of T-lymphocytes and NK cells. Finally, we show that these murine DMG cells display similar sensitivity to histone deacetylase (HDAC) inhibition as patient-derived DMG cells.ConclusionsWe created and validated an accessible method to generate immunocompetent allograft models reflecting different subtypes of DMG. These models adequately recapitulated the histopathology, immune microenvironment, and therapeutic response of human DMG, providing useful tools for future preclinical studies.

Published
2022

9. Protocol for investigating data quality and reporting outcomes of pediatric gliomas in population-based cancer registry research

Author

Hoogendijk, Raoull, primary, van der Lugt, Jasper, additional, Kranendonk, Mariëtte E.G., additional, Gatta, Gemma, additional, Capocaccia, Riccardo, additional, Hoving, Eelco W., additional, Wesseling, Pieter, additional, Visser, Otto, additional, van Vuurden, Dannis G., additional, and Karim-Kos, Henrike, additional

Published
2024
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11. Robotic alignment system Cirq (Brainlab) for navigated brain tumor biopsies in children

Author

Neurochirurgie, Neurochirurgen, Brain, Cancer, van Baarsen, Kirsten M., Woodley, Darwin E.A., Slot, K. Mariam, Woerdeman, Peter A., Han, Kuo S., Hoving, Eelco W., Neurochirurgie, Neurochirurgen, Brain, Cancer, van Baarsen, Kirsten M., Woodley, Darwin E.A., Slot, K. Mariam, Woerdeman, Peter A., Han, Kuo S., and Hoving, Eelco W.

Published
2024

12. Protocol for investigating data quality and reporting outcomes of pediatric gliomas in population-based cancer registry research

Author

Neurochirurgen, Brain, Cancer, Hoogendijk, Raoull, van der Lugt, Jasper, Kranendonk, Mariëtte E.G., Gatta, Gemma, Capocaccia, Riccardo, Hoving, Eelco W., Wesseling, Pieter, Visser, Otto, van Vuurden, Dannis G., Karim-Kos, Henrike, Neurochirurgen, Brain, Cancer, Hoogendijk, Raoull, van der Lugt, Jasper, Kranendonk, Mariëtte E.G., Gatta, Gemma, Capocaccia, Riccardo, Hoving, Eelco W., Wesseling, Pieter, Visser, Otto, van Vuurden, Dannis G., and Karim-Kos, Henrike

Published
2024

13. Taenia martis Neurocysticercosis-Like Lesion in Child, Associated with Local Source, the Netherlands

Author

VPDC pathologie, IRAS OH Epidemiology Microbial Agents, Pathology, IRAS – One Health Microbial, Eggink, Hendriekje, Maas, Miriam, van den Brand, Judith M A, Dekker, Jasja, Franssen, Frits, Hoving, Eelco W, Kortbeek, Laetitia M, Kranendonk, Mariëtte E G, Meiners, Linda C, Rittscher, Anne E, Roelfsema, Jeroen, Schölvinck, Elisabeth H, VPDC pathologie, IRAS OH Epidemiology Microbial Agents, Pathology, IRAS – One Health Microbial, Eggink, Hendriekje, Maas, Miriam, van den Brand, Judith M A, Dekker, Jasja, Franssen, Frits, Hoving, Eelco W, Kortbeek, Laetitia M, Kranendonk, Mariëtte E G, Meiners, Linda C, Rittscher, Anne E, Roelfsema, Jeroen, and Schölvinck, Elisabeth H

Published
2024

14. Improving advanced intraoperative MRI methods during pediatric neurosurgery

Author

Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Beeldverwerking ISI, Brain, Neurochirurgen, Neurochirurgie, MS Radiologie, Precision Imaging Group, Child Health, Infection & Immunity, Jellema, Pien E.J., Mannsdörfer, Lilli M., Visser, Fredy, De Luca, Alberto, Smit, Cynthia L.E., Hoving, Eelco W., van Baarsen, Kirsten M., Lindner, Thomas, Mutsaerts, Henk Jan M.M., Dankbaar, Jan Willem, Lequin, Maarten H., Wijnen, Jannie P., Highfield Research Group, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Beeldverwerking ISI, Brain, Neurochirurgen, Neurochirurgie, MS Radiologie, Precision Imaging Group, Child Health, Infection & Immunity, Jellema, Pien E.J., Mannsdörfer, Lilli M., Visser, Fredy, De Luca, Alberto, Smit, Cynthia L.E., Hoving, Eelco W., van Baarsen, Kirsten M., Lindner, Thomas, Mutsaerts, Henk Jan M.M., Dankbaar, Jan Willem, Lequin, Maarten H., and Wijnen, Jannie P.

Published
2024

16. Improving advanced intraoperative MRI methods during pediatric neurosurgery.

Author

Jellema, Pien E. J., Mannsdörfer, Lilli M., Visser, Fredy, De Luca, Alberto, Smit, Cynthia L. E., Hoving, Eelco W., van Baarsen, Kirsten M., Lindner, Thomas, Mutsaerts, Henk‐Jan M. M., Dankbaar, Jan Willem, Lequin, Maarten H., and Wijnen, Jannie P.

Subjects
DIFFUSION magnetic resonance imaging, PATIENT positioning, NEUROSURGERY, CEREBRAL circulation, SUPINE position
Abstract

Advanced intraoperative MR images (ioMRI) acquired during the resection of pediatric brain tumors could offer additional physiological information to preserve healthy tissue. With this work, we aimed to develop a protocol for ioMRI with increased sensitivity for arterial spin labeling (ASL) and diffusion MRI (dMRI), optimized for patient positioning regularly used in the pediatric neurosurgery setting. For ethical reasons, ASL images were acquired in healthy adult subjects that were imaged in the prone and supine position. After this, the ASL cerebral blood flow (CBF) was quantified and compared between both positions. To evaluate the impact of the RF coils setups on image quality, we compared different setups (two vs. four RF coils) by looking at T1‐weighted (T1w) signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR), as well as undertaking a qualitative evaluation of T1w, T2w, ASL, and dMR images. Mean ASL CBF did not differ between the surgical prone and supine positions in any of the investigated regions of interest or the whole brain. T1w SNR (gray matter: p = 0.016, 34% increase; white matter: p = 0.016, 32% increase) and CNR were higher (p = 0.016) in the four versus two RF coils setups (18.0 ± 1.8 vs. 13.9 ± 1.8). Qualitative evaluation of T1w, T2w, ASL, and dMR images resulted in acceptable to good image quality and did not differ statistically significantly between setups. Only the nonweighted diffusion image maps and corticospinal tract reconstructions yielded higher image quality and reduced susceptibility artifacts with four RF coils. Advanced ioMRI metrics were more precise with four RF coils as the standard deviation decreased. Taken together, we have investigated the practical use of advanced ioMRI during pediatric neurosurgery. We conclude that ASL CBF quantification in the surgical prone position is valid and that ASL and dMRI acquisition with two RF coils can be performed adequately for clinical use. With four versus two RF coils, the SNR of the images increases, and the sensitivity to artifacts reduces. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

Author

Custers, Lars, Khabirova, Eleonora, Coorens, Tim H. H., Oliver, Thomas R. W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, and Drost, Jarno

Published
2021
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22. Treatment and outcome of the Dutch Childhood Craniopharyngioma Cohort study: First results after centralization of care

Author

Van Schaik, Jiska, primary, Schouten-van Meeteren, Antoinette Y N, additional, Vos-Kerkhof, Evelien, additional, Janssens, Geert O, additional, Porro, Giorgio L, additional, Fiocco, Marta, additional, Bakker, Boudewijn, additional, Tissing, Wim J E, additional, Hoving, Eelco W, additional, and Santen, Hanneke M. van, additional

Published
2023
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23. LGG-15. SINGLE-NUCLEUS AND BULK RNA SEQUENCING OF PEDIATRIC PILOCYTIC ASTROCYTOMAS REVEALS CNS LOCATION-ASSOCIATED TUMOR CELL AND MICROENVIRONMENTAL HETEROGENEITY

Author

Lammers, Julie A S, primary, Rozowsky, Jacob S, additional, Kranendonk, Mariëtte E G, additional, Schouten-van Meeteren, Antoinette Y N, additional, Meijer, Lisethe, additional, Calkoen, Friso G, additional, Hoving, Eelco W, additional, Wesseling, Pieter, additional, van der Lugt, Jasper, additional, and Kester, Lennart A, additional

Published
2023
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24. Implementation of paediatric precision oncology into clinical practice: The Individualized Therapies for Children with cancer program ‘iTHER’

Author

Langenberg, Karin P.S., Meister, Michael T., Bakhuizen, Jette J., Boer, Judith M., van Eijkelenburg, Natasha K.A., Hulleman, Esther, Ilan, Uri, Looze, Eleonora J., Dierselhuis, Miranda P., van der Lugt, Jasper, Breunis, Willemijn, Schild, Linda G., Ober, Kimberley, van Hooff, Sander R., Scheijde-Vermeulen, Marijn A., Hiemcke-Jiwa, Laura S., Flucke, Uta E., Kranendonk, Mariette E.G., Wesseling, Pieter, Sonneveld, Edwin, Punt, Simone, Boltjes, Arjan, van Dijk, Freerk, Verwiel, Eugene T.P., Volckmann, Richard, Hehir-Kwa, Jayne Y., Kester, Lennart A., Koudijs, Marco M.J., Waanders, Esme, Holstege, Frank C.P., Vormoor, H. Josef, Hoving, Eelco W., van Noesel, Max M., Pieters, Rob, Kool, Marcel, Stumpf, Miriam, Blattner-Johnson, Mirjam, Balasubramanian, Gnana P., Van Tilburg, Cornelis M., Jones, Barbara C., Jones, David T.W., Witt, Olaf, Pfister, Stefan M., Jongmans, Marjolijn C.J., Kuiper, Roland P., de Krijger, Ronald R., Wijnen, Marc H.W., den Boer, Monique L., Zwaan, C. Michel, Kemmeren, Patrick, Koster, Jan, Tops, Bastiaan B.J., Goemans, Bianca F., Molenaar, Jan J., Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Dep Scheikunde, Afd Pharmaceutics, Pharmaceutics, Center of Experimental and Molecular Medicine, Oncogenomics, and CCA - Cancer Treatment and Quality of Life

Subjects
Cancer Research, Adolescent, Molecular biology, Precision medicine, High-Throughput Nucleotide Sequencing, Medical Oncology, Hereditary, Oncology, Neoplasms, Mutation, Exome Sequencing, Next-generation sequencing, Humans, Molecular targeted therapy, Prospective Studies, Child, Cancer
Abstract

iTHER is a Dutch prospective national precision oncology program aiming to define tumour molecular profiles in children and adolescents with primary very high-risk, relapsed, or refractory paediatric tumours. Between April 2017 and April 2021, 302 samples from 253 patients were included. Comprehensive molecular profiling including low-coverage whole genome sequencing (lcWGS), whole exome sequencing (WES), RNA sequencing (RNA-seq), Affymetrix, and/or 850k methylation profiling was successfully performed for 226 samples with at least 20% tumour content. Germline pathogenic variants were identified in 16% of patients (35/219), of which 22 variants were judged causative for a cancer predisposition syndrome. At least one somatic alteration was detected in 204 (90.3%), and 185 (81.9%) were considered druggable, with clinical priority very high (6.1%), high (21.3%), moderate (26.0%), intermediate (36.1%), and borderline (10.5%) priority. iTHER led to revision or refinement of diagnosis in 8 patients (3.5%). Temporal heterogeneity was observed in paired samples of 15 patients, indicating the value of sequential analyses. Of 137 patients with follow-up beyond twelve months, 21 molecularly matched treatments were applied in 19 patients (13.9%), with clinical benefit in few. Most relevant barriers to not applying targeted therapies included poor performance status, as well as limited access to drugs within clinical trial. iTHER demonstrates the feasibility of comprehensive molecular profiling across all ages, tumour types and stages in paediatric cancers, informing of diagnostic, prognostic, and targetable alterations as well as reportable germline variants. Therefore, WES and RNA-seq is nowadays standard clinical care at the Princess Máxima Center for all children with cancer, including patients at primary diagnosis. Improved access to innovative treatments within biology-driven combination trials is required to ultimately improve survival.

Published
2022

28. Supplementary Table 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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30. Supplementary Table 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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31. Supplementary Figure 3 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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32. Supplementary Figure 2 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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33. Supplementary Figure 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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34. Supplementary Table 1 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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35. Supplementary Table 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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36. Supplementary Figure 4 from Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery

Author

Sikkema, Arend H., primary, Diks, Sander H., primary, den Dunnen, Wilfred F.A., primary, ter Elst, Arja, primary, Scherpen, Frank J.G., primary, Hoving, Eelco W., primary, Ruijtenbeek, Rob, primary, Boender, Piet J., primary, de Wijn, Rik, primary, Kamps, Willem A., primary, Peppelenbosch, Maikel P., primary, and de Bont, Eveline S.J.M., primary

Published
2023
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37. Incisional CSF leakage after intradural cranial surgery in children: incidence, risk factors, and complications

Author

Onderzoek NCH, Neurochirurgen, Cancer, Circulatory Health, Neurochirurgie, Slot, Emma M.H., van Doormaal, Tristan P.C., van Baarsen, Kirsten M., Krayenbühl, Niklaus, Regli, Luca, Germans, Menno R., Hoving, Eelco W., Onderzoek NCH, Neurochirurgen, Cancer, Circulatory Health, Neurochirurgie, Slot, Emma M.H., van Doormaal, Tristan P.C., van Baarsen, Kirsten M., Krayenbühl, Niklaus, Regli, Luca, Germans, Menno R., and Hoving, Eelco W.

Published
2023

38. Cerebrospinal fluid leakage after intradural spinal surgery in children

Author

Onderzoek NCH, Neurochirurgen, Cancer, Circulatory Health, Neurochirurgie, Slot, Emma M.H., van Doormaal, Tristan P.C., van Baarsen, Kirsten M., Krayenbühl, Niklaus, Regli, Luca, Germans, Menno R., Hoving, Eelco W., Onderzoek NCH, Neurochirurgen, Cancer, Circulatory Health, Neurochirurgie, Slot, Emma M.H., van Doormaal, Tristan P.C., van Baarsen, Kirsten M., Krayenbühl, Niklaus, Regli, Luca, Germans, Menno R., and Hoving, Eelco W.

Published
2023

39. Advanced intraoperative MRI in pediatric brain tumor surgery

Author

Highfield Research Group, Brain, Cancer, Child Health, Infection & Immunity, Beeldverwerking ISI, Neurochirurgie, MS Radiologie, Circulatory Health, Neurochirurgen, Jellema, Pien E J, Wijnen, Jannie P, De Luca, Alberto, Mutsaerts, Henk J M M, Obdeijn, Iris V, van Baarsen, Kirsten M, Lequin, Maarten H, Hoving, Eelco W, Highfield Research Group, Brain, Cancer, Child Health, Infection & Immunity, Beeldverwerking ISI, Neurochirurgie, MS Radiologie, Circulatory Health, Neurochirurgen, Jellema, Pien E J, Wijnen, Jannie P, De Luca, Alberto, Mutsaerts, Henk J M M, Obdeijn, Iris V, van Baarsen, Kirsten M, Lequin, Maarten H, and Hoving, Eelco W

Published
2023

40. Safety of growth hormone replacement therapy in childhood-onset craniopharyngioma: a systematic review and cohort study

Author

Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, van Santen, H M, Endocrinologie onderzoek, Endocrinologie patientenzorg, Neurochirurgen, Cancer, PMC Medisch specialisten, Brain, Child Health, van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y N, de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W, Tissing, Wim J E, and van Santen, H M

Published
2023

41. Could deep brain stimulation be a possible solution for acquired hypothalamic obesity?

Author

Neurochirurgen, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Dassen, Amber R, van Schaik, Jiska, van den Munckhof, Pepijn, Schuurman, P R, Hoving, Eelco W, van Santen, Hanneke M, Neurochirurgen, Cancer, Endocrinologie patientenzorg, Brain, Child Health, Dassen, Amber R, van Schaik, Jiska, van den Munckhof, Pepijn, Schuurman, P R, Hoving, Eelco W, and van Santen, Hanneke M

Published
2023

42. Towards Standardisation of a Diffuse Midline Glioma Patient-Derived Xenograft Mouse Model Based on Suspension Matrices for Preclinical Research

Author

Researchgr. Beeldg. Moleculaire Interv., Cancer, 't Hart, Elvin, Bianco, John, Besse, Helena C, Chin Joe Kie, Lois A, Cornet, Lesley, Eikelenboom, Kimberly L, van den Broek, Thijs J M, Derieppe, Marc, Su, Yan, Hoving, Eelco W, Ries, Mario G, van Vuurden, Dannis G, Researchgr. Beeldg. Moleculaire Interv., Cancer, 't Hart, Elvin, Bianco, John, Besse, Helena C, Chin Joe Kie, Lois A, Cornet, Lesley, Eikelenboom, Kimberly L, van den Broek, Thijs J M, Derieppe, Marc, Su, Yan, Hoving, Eelco W, Ries, Mario G, and van Vuurden, Dannis G

Published
2023

43. Cerebrospinal fluid leakage after intradural spinal surgery in children

Author

Slot, Emma M H; https://orcid.org/0000-0002-4296-1331, van Doormaal, Tristan P C; https://orcid.org/0000-0002-6299-3859, van Baarsen, Kirsten M, Krayenbühl, Niklaus; https://orcid.org/0000-0003-1089-221X, Regli, Luca; https://orcid.org/0000-0003-4639-4474, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, Hoving, Eelco W, Slot, Emma M H; https://orcid.org/0000-0002-4296-1331, van Doormaal, Tristan P C; https://orcid.org/0000-0002-6299-3859, van Baarsen, Kirsten M, Krayenbühl, Niklaus; https://orcid.org/0000-0003-1089-221X, Regli, Luca; https://orcid.org/0000-0003-4639-4474, Germans, Menno R; https://orcid.org/0000-0003-2185-4526, and Hoving, Eelco W

Abstract

PURPOSE This study aimed to establish the incidence of CSF leakage in children and associated complications after intradural spinal surgery in three tertiary neurosurgical referral centers and to describe the treatment strategies applied. METHODS Patients of 18 years or younger who underwent intradural spinal surgery between 2015 and 2021 in three tertiary neurosurgical referral centers were included. Patients who died or were lost to follow-up within six weeks after surgery were excluded. The primary outcome measure was CSF leakage within six weeks after surgery, defined as leakage of CSF through the skin. Secondary outcome measures included the presence of pseudomeningocele (PMC), meningitis, and surgical site infection (SSI). RESULTS We included a total of 75 procedures, representing 66 individual patients. The median age in this cohort was 5 (IQR = 0-13 years. CSF leakage occurred in 2.7% (2/75) of procedures. It occurred on days 3 and 21 after the index procedure, respectively. One patient was treated with a pressure bandage and an external lumbar drain on day 4 after diagnosis of the leak, and the other was treated with wound revision surgery on day 1 after the leak occurred. In total, 1 patient developed a PMC without a CSF leak which was treated with wound revision surgery. SSI occurred in 10.7%, which included both cases of CSF leak. CONCLUSIONS CSF leakage after intradural spinal surgery in the pediatric population is relatively rare (2.7%). Nevertheless, the clinical consequences with respect to secondary complications such as infection and the necessity for invasive treatment are serious.

Published
2023

45. Safety of Growth Hormone Replacement Therapy in Childhood-Onset Craniopharyngioma: A Systematic Review and Cohort Study.

Author

van Schaik, Jiska, Kormelink, Eline, Kabak, Eda, van Dalen, Elvira C, Schouten-van Meeteren, Antoinette Y.N., de Vos-Kerkhof, Evelien, Bakker, Boudewijn, Fiocco, Marta, Hoving, Eelco W., Tissing, Wim J.E., and van Santen, Hanneke M.

Subjects
SOMATOTROPIN, HORMONE therapy, CRANIOPHARYNGIOMA, COHORT analysis, INTRACRANIAL tumors, CANCER invasiveness
Abstract

Introduction: Survival of childhood-onset craniopharyngioma (cCP) is excellent; however, many survivors suffer from hypothalamic-pituitary dysfunction. Growth hormone replacement therapy (GHRT) is of high importance for linear growth and metabolic outcome. Optimal timing for initiation of GHRT in cCP is on debate because of concerns regarding tumor progression or recurrence. Methods: A systematic review and cohort studys were performed for the effect and timing of GHRT on overall mortality, tumor progression/recurrence, and secondary tumors in cCP. Within the cohort, cCP receiving GHRT ≤1 year after diagnosis were compared to those receiving GHRT >1 year after diagnosis. Results: Evidence of 18 included studies, reporting on 6,603 cCP with GHRT, suggests that GHRT does not increase the risk for overall mortality, progression, or recurrent disease. One study evaluated timing of GHRT and progression/recurrence-free survival and found no increased risk with earlier initiation. One study reported a higher than expected prevalence of secondary intracranial tumors compared to a healthy population, possibly confounded by radiotherapy. In our cohort, 75 of 87 cCP (86.2%) received GHRT for median of 4.9 years [0.0–17.1]. No effect of timing of GHRT was found on mortality, progression/recurrence-free survival, or secondary tumors. Conclusion: Although the quality of the evidence is low, the available evidence suggests no effect of GHRT or its timing on mortality, tumor progression/recurrence, or secondary neoplasms in cCP. These results support early initiation of GHRT in cCP aiming to optimize linear growth and metabolic outcome. Prospective studies are needed to increase the level of evidence upon the optimal timing to start GHRT in cCP patients. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Towards Standardisation of a Diffuse Midline Glioma Patient-Derived Xenograft Mouse Model Based on Suspension Matrices for Preclinical Research

Author

’t Hart, Elvin, primary, Bianco, John, additional, Besse, Helena C., additional, Chin Joe Kie, Lois A., additional, Cornet, Lesley, additional, Eikelenboom, Kimberly L., additional, van den Broek, Thijs J.M., additional, Derieppe, Marc, additional, Su, Yan, additional, Hoving, Eelco W., additional, Ries, Mario G., additional, and van Vuurden, Dannis G., additional

Published
2023
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49. Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor

Author

Nuijts, Myrthe A., primary, Stegeman, Inge, additional, van Seeters, Tom, additional, Borst, Marloes D., additional, Bennebroek, Carlien A. M., additional, Buis, Dennis R., additional, Naus, Nicole C., additional, Porro, Giorgio L., additional, van Egmond-Ebbeling, Michelle B., additional, Voskuil-Kerkhof, Elisabeth S. M., additional, Pott, JanWillem R., additional, Franke, Niels E., additional, de Vos-Kerkhof, Evelien, additional, Hoving, Eelco W., additional, Schouten-van Meeteren, Antoinette Y. N., additional, and Imhof, Saskia M., additional

Published
2022
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