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631 results on '"Hovestadt, Volker"'

1. A prognostic neural epigenetic signature in high-grade glioma

Author

Drexler, Richard, Khatri, Robin, Sauvigny, Thomas, Mohme, Malte, Maire, Cecile L., Ryba, Alice, Zghaibeh, Yahya, Dührsen, Lasse, Salviano-Silva, Amanda, Lamszus, Katrin, Westphal, Manfred, Gempt, Jens, Wefers, Annika K., Neumann, Julia E., Bode, Helena, Hausmann, Fabian, Huber, Tobias B., Bonn, Stefan, Jütten, Kerstin, Delev, Daniel, Weber, Katharina J., Harter, Patrick N., Onken, Julia, Vajkoczy, Peter, Capper, David, Wiestler, Benedikt, Weller, Michael, Snijder, Berend, Buck, Alicia, Weiss, Tobias, Göller, Pauline C., Sahm, Felix, Menstel, Joelle Aline, Zimmer, David Niklas, Keough, Michael B., Ni, Lijun, Monje, Michelle, Silverbush, Dana, Hovestadt, Volker, Suvà, Mario L., Krishna, Saritha, Hervey-Jumper, Shawn L., Schüller, Ulrich, Heiland, Dieter H., Hänzelmann, Sonja, and Ricklefs, Franz L.

Published
2024
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3. Temporal change of DNA methylation subclasses between matched newly diagnosed and recurrent glioblastoma

Author

Drexler, Richard, Khatri, Robin, Schüller, Ulrich, Eckhardt, Alicia, Ryba, Alice, Sauvigny, Thomas, Dührsen, Lasse, Mohme, Malte, Ricklefs, Tammo, Bode, Helena, Hausmann, Fabian, Huber, Tobias B., Bonn, Stefan, Voß, Hannah, Neumann, Julia E., Silverbush, Dana, Hovestadt, Volker, Suvà, Mario L., Lamszus, Katrin, Gempt, Jens, Westphal, Manfred, Heiland, Dieter H., Hänzelmann, Sonja, and Ricklefs, Franz L.

Published
2024
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5. Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2023
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6. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

Author

Nuñez, James K, Chen, Jin, Pommier, Greg C, Cogan, J Zachery, Replogle, Joseph M, Adriaens, Carmen, Ramadoss, Gokul N, Shi, Quanming, Hung, King L, Samelson, Avi J, Pogson, Angela N, Kim, James YS, Chung, Amanda, Leonetti, Manuel D, Chang, Howard Y, Kampmann, Martin, Bernstein, Bradley E, Hovestadt, Volker, Gilbert, Luke A, and Weissman, Jonathan S

Subjects
Biological Sciences, Genetics, Biotechnology, Stem Cell Research, Human Genome, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors, Cancer, Generic health relevance, CRISPR-Cas Systems, Cell Differentiation, Cellular Reprogramming, CpG Islands, DNA Methylation, Epigenesis, Genetic, Epigenome, Gene Editing, Gene Silencing, Histone Code, Humans, Induced Pluripotent Stem Cells, Neurons, Protein Processing, Post-Translational, CRISPR, DNA methylation, cell therapy, dCas9, epigenetics, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

A general approach for heritably altering gene expression has the potential to enable many discovery and therapeutic efforts. Here, we present CRISPRoff-a programmable epigenetic memory writer consisting of a single dead Cas9 fusion protein that establishes DNA methylation and repressive histone modifications. Transient CRISPRoff expression initiates highly specific DNA methylation and gene repression that is maintained through cell division and differentiation of stem cells to neurons. Pairing CRISPRoff with genome-wide screens and analysis of chromatin marks establishes rules for heritable gene silencing. We identify single guide RNAs (sgRNAs) capable of silencing the large majority of genes including those lacking canonical CpG islands (CGIs) and reveal a wide targeting window extending beyond annotated CGIs. The broad ability of CRISPRoff to initiate heritable gene silencing even outside of CGIs expands the canonical model of methylation-based silencing and enables diverse applications including genome-wide screens, multiplexed cell engineering, enhancer silencing, and mechanistic exploration of epigenetic inheritance.

Published
2021

7. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2024
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9. Unified rhombic lip origins of group 3 and group 4 medulloblastoma

Author

Smith, Kyle S., Bihannic, Laure, Gudenas, Brian L., Haldipur, Parthiv, Tao, Ran, Gao, Qingsong, Li, Yiran, Aldinger, Kimberly A., Iskusnykh, Igor Y., Chizhikov, Victor V., Scoggins, Matthew, Zhang, Silu, Edwards, Angela, Deng, Mei, Glass, Ian A., Overman, Lynne M., Millman, Jake, Sjoboen, Alexandria H., Hadley, Jennifer, Golser, Joseph, Mankad, Kshitij, Sheppard, Heather, Onar-Thomas, Arzu, Gajjar, Amar, Robinson, Giles W., Hovestadt, Volker, Orr, Brent A., Patay, Zoltán, Millen, Kathleen J., and Northcott, Paul A.

Published
2022
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10. DNA methylation-based classification of central nervous system tumours.

Author

Capper, David, Jones, David TW, Sill, Martin, Hovestadt, Volker, Schrimpf, Daniel, Sturm, Dominik, Koelsche, Christian, Sahm, Felix, Chavez, Lukas, Reuss, David E, Kratz, Annekathrin, Wefers, Annika K, Huang, Kristin, Pajtler, Kristian W, Schweizer, Leonille, Stichel, Damian, Olar, Adriana, Engel, Nils W, Lindenberg, Kerstin, Harter, Patrick N, Braczynski, Anne K, Plate, Karl H, Dohmen, Hildegard, Garvalov, Boyan K, Coras, Roland, Hölsken, Annett, Hewer, Ekkehard, Bewerunge-Hudler, Melanie, Schick, Matthias, Fischer, Roger, Beschorner, Rudi, Schittenhelm, Jens, Staszewski, Ori, Wani, Khalida, Varlet, Pascale, Pages, Melanie, Temming, Petra, Lohmann, Dietmar, Selt, Florian, Witt, Hendrik, Milde, Till, Witt, Olaf, Aronica, Eleonora, Giangaspero, Felice, Rushing, Elisabeth, Scheurlen, Wolfram, Geisenberger, Christoph, Rodriguez, Fausto J, Becker, Albert, Preusser, Matthias, Haberler, Christine, Bjerkvig, Rolf, Cryan, Jane, Farrell, Michael, Deckert, Martina, Hench, Jürgen, Frank, Stephan, Serrano, Jonathan, Kannan, Kasthuri, Tsirigos, Aristotelis, Brück, Wolfgang, Hofer, Silvia, Brehmer, Stefanie, Seiz-Rosenhagen, Marcel, Hänggi, Daniel, Hans, Volkmar, Rozsnoki, Stephanie, Hansford, Jordan R, Kohlhof, Patricia, Kristensen, Bjarne W, Lechner, Matt, Lopes, Beatriz, Mawrin, Christian, Ketter, Ralf, Kulozik, Andreas, Khatib, Ziad, Heppner, Frank, Koch, Arend, Jouvet, Anne, Keohane, Catherine, Mühleisen, Helmut, Mueller, Wolf, Pohl, Ute, Prinz, Marco, Benner, Axel, Zapatka, Marc, Gottardo, Nicholas G, Driever, Pablo Hernáiz, Kramm, Christof M, Müller, Hermann L, Rutkowski, Stefan, von Hoff, Katja, Frühwald, Michael C, Gnekow, Astrid, Fleischhack, Gudrun, Tippelt, Stephan, Calaminus, Gabriele, Monoranu, Camelia-Maria, Perry, Arie, and Jones, Chris

Subjects
Humans, Central Nervous System Neoplasms, Cohort Studies, Reproducibility of Results, DNA Methylation, Adolescent, Adult, Aged, Aged, 80 and over, Middle Aged, Child, Child, Preschool, Infant, Female, Male, Young Adult, Unsupervised Machine Learning, and over, Preschool, General Science & Technology
Abstract

Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.

Published
2018

13. The whole-genome landscape of medulloblastoma subtypes

Author

Northcott, Paul A, Buchhalter, Ivo, Morrissy, A Sorana, Hovestadt, Volker, Weischenfeldt, Joachim, Ehrenberger, Tobias, Gröbner, Susanne, Segura-Wang, Maia, Zichner, Thomas, Rudneva, Vasilisa A, Warnatz, Hans-Jörg, Sidiropoulos, Nikos, Phillips, Aaron H, Schumacher, Steven, Kleinheinz, Kortine, Waszak, Sebastian M, Erkek, Serap, Jones, David TW, Worst, Barbara C, Kool, Marcel, Zapatka, Marc, Jäger, Natalie, Chavez, Lukas, Hutter, Barbara, Bieg, Matthias, Paramasivam, Nagarajan, Heinold, Michael, Gu, Zuguang, Ishaque, Naveed, Jäger-Schmidt, Christina, Imbusch, Charles D, Jugold, Alke, Hübschmann, Daniel, Risch, Thomas, Amstislavskiy, Vyacheslav, Gonzalez, Francisco German Rodriguez, Weber, Ursula D, Wolf, Stephan, Robinson, Giles W, Zhou, Xin, Wu, Gang, Finkelstein, David, Liu, Yanling, Cavalli, Florence MG, Luu, Betty, Ramaswamy, Vijay, Wu, Xiaochong, Koster, Jan, Ryzhova, Marina, Cho, Yoon-Jae, Pomeroy, Scott L, Herold-Mende, Christel, Schuhmann, Martin, Ebinger, Martin, Liau, Linda M, Mora, Jaume, McLendon, Roger E, Jabado, Nada, Kumabe, Toshihiro, Chuah, Eric, Ma, Yussanne, Moore, Richard A, Mungall, Andrew J, Mungall, Karen L, Thiessen, Nina, Tse, Kane, Wong, Tina, Jones, Steven JM, Witt, Olaf, Milde, Till, Von Deimling, Andreas, Capper, David, Korshunov, Andrey, Yaspo, Marie-Laure, Kriwacki, Richard, Gajjar, Amar, Zhang, Jinghui, Beroukhim, Rameen, Fraenkel, Ernest, Korbel, Jan O, Brors, Benedikt, Schlesner, Matthias, Eils, Roland, Marra, Marco A, Pfister, Stefan M, Taylor, Michael D, and Lichter, Peter

Subjects
Cancer, Human Genome, Brain Disorders, Pediatric Cancer, Brain Cancer, Genetics, Biotechnology, Rare Diseases, Neurosciences, Pediatric, Aetiology, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Good Health and Well Being, Carcinogenesis, Carrier Proteins, Cohort Studies, DNA Methylation, DNA Mutational Analysis, Datasets as Topic, Epistasis, Genetic, Genome, Human, Genomics, Humans, Medulloblastoma, Molecular Targeted Therapy, Muscle Proteins, Mutation, Oncogenes, Transcription Factors, Whole Genome Sequencing, Wnt Proteins, General Science & Technology
Abstract

Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose debilitating effects on the developing child, and highlight the need for molecularly targeted treatments with reduced toxicity. Previous studies have been unable to identify the full spectrum of driver genes and molecular processes that operate in medulloblastoma subgroups. Here we analyse the somatic landscape across 491 sequenced medulloblastoma samples and the molecular heterogeneity among 1,256 epigenetically analysed cases, and identify subgroup-specific driver alterations that include previously undiscovered actionable targets. Driver mutations were confidently assigned to most patients belonging to Group 3 and Group 4 medulloblastoma subgroups, greatly enhancing previous knowledge. New molecular subtypes were differentially enriched for specific driver events, including hotspot in-frame insertions that target KBTBD4 and 'enhancer hijacking' events that activate PRDM6. Thus, the application of integrative genomics to an extensive cohort of clinical samples derived from a single childhood cancer entity revealed a series of cancer genes and biologically relevant subtype diversity that represent attractive therapeutic targets for the treatment of patients with medulloblastoma.

Published
2017

14. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

Author

Hübschmann, Daniel, Kleinheinz, Kortine, Wagener, Rabea, Bernhart, Stephan H., López, Cristina, Toprak, Umut H., Sungalee, Stephanie, Ishaque, Naveed, Kretzmer, Helene, Kreuz, Markus, Waszak, Sebastian M., Paramasivam, Nagarajan, Ammerpohl, Ole, Aukema, Sietse M., Beekman, Renée, Bergmann, Anke K., Bieg, Matthias, Binder, Hans, Borkhardt, Arndt, Borst, Christoph, Brors, Benedikt, Bruns, Philipp, Carrillo de Santa Pau, Enrique, Claviez, Alexander, Doose, Gero, Haake, Andrea, Karsch, Dennis, Haas, Siegfried, Hansmann, Martin-Leo, Hoell, Jessica I., Hovestadt, Volker, Huang, Bingding, Hummel, Michael, Jäger-Schmidt, Christina, Kerssemakers, Jules N. A., Korbel, Jan O., Kube, Dieter, Lawerenz, Chris, Lenze, Dido, Martens, Joost H. A., Ott, German, Radlwimmer, Bernhard, Reisinger, Eva, Richter, Julia, Rico, Daniel, Rosenstiel, Philip, Rosenwald, Andreas, Schillhabel, Markus, Stilgenbauer, Stephan, Stadler, Peter F., Martín-Subero, José I., Szczepanowski, Monika, Warsow, Gregor, Weniger, Marc A., Zapatka, Marc, Valencia, Alfonso, Stunnenberg, Hendrik G., Lichter, Peter, Möller, Peter, Loeffler, Markus, Eils, Roland, Klapper, Wolfram, Hoffmann, Steve, Trümper, Lorenz, Küppers, Ralf, Schlesner, Matthias, and Siebert, Reiner

Published
2021
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15. Loss over 5% of chromosome 1p is a clinically relevant and applicable cut-off for increased risk of recurrence in meningioma

Author

Maas, Sybren L.N., Hielscher, Thomas, Sievers, Philipp, Hovestadt, Volker, Suwala, Abigail K., Acker, Till, Weller, Michael, Preusser, Matthias, Herold-Mende, Christel, Wick, Wolfgang, von Deimling, Andreas, Berghaus, Natalie, Sahm, Felix, Maas, Sybren L.N., Hielscher, Thomas, Sievers, Philipp, Hovestadt, Volker, Suwala, Abigail K., Acker, Till, Weller, Michael, Preusser, Matthias, Herold-Mende, Christel, Wick, Wolfgang, von Deimling, Andreas, Berghaus, Natalie, and Sahm, Felix

Published
2024

16. Gene regulatory network landscape of Group 3/4 medulloblastoma

Author

Joshi, Piyush, primary, Stelzer, Tamina, additional, Okonechnikov, Konstantin, additional, Sarropoulos, Ioannis, additional, Sepp, Mari, additional, Pour-Jamnani, Mischan V., additional, Rademacher, Anne, additional, Yamada-Saito, Tetsuya, additional, Schneider, Céline, additional, Schmidt, Julia, additional, Schäfer, Philipp, additional, Leiss, Kevin, additional, Bortolomeazzi, Michele, additional, Mallm, Jan-Philipp, additional, da Silva, Patricia B.G., additional, Statz, Britta, additional, Wittmann, Andrea, additional, Schramm, Kathrin, additional, Blattner-Johnson, Mirjam, additional, Fiesel, Petra, additional, Jones, Barbara, additional, Milde, Till, additional, Pajtler, Kristian, additional, van Tilburg, Cornelis M., additional, Witt, Olaf, additional, Rippe, Karsten, additional, Korshunov, Andrey, additional, Jones, David T.W., additional, Hovestadt, Volker, additional, Northcott, Paul A., additional, Thongjuea, Supat, additional, Jäger, Natalie, additional, Kaessmann, Henrik, additional, Pfister, Stefan M., additional, and Kutscher, Lena M., additional

Published
2024
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18. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

Author

Oh, Sekyung, Flynn, Ryan A, Floor, Stephen N, Purzner, James, Martin, Lance, T., Brian, Schubert, Simone, Vaka, Dedeepya, Morrissy, Sorana, Li, Yisu, Kool, Marcel, Hovestadt, Volker, Jones, David TW, Northcott, Paul A, Risch, Thomas, Warnatz, Hans-Jörg, Yaspo, Marie-Laure, Adams, Christopher M, Leib, Ryan D, Breese, Marcus, Marra, Marco A, Malkin, David, Lichter, Peter, Doudna, Jennifer A, Pfister, Stefan M, Taylor, Michael D, Chang, Howard Y, and Cho, Yoon-Jae

Subjects
Pediatric, Genetics, Brain Disorders, Cancer, Rare Diseases, Brain Cancer, Cerebellar Neoplasms, DEAD-box RNA Helicases, Gene Expression Regulation, Neoplastic, HEK293 Cells, Humans, Medulloblastoma, Protein Biosynthesis, Stress, Physiological, Transcriptome, medulloblastoma, DDX3X, DDX3, RNA helicase, CLIP-seq, Oncology and Carcinogenesis
Abstract

DDX3X encodes a DEAD-box family RNA helicase (DDX3) commonly mutated in medulloblastoma, a highly aggressive cerebellar tumor affecting both children and adults. Despite being implicated in several facets of RNA metabolism, the nature and scope of DDX3's interactions with RNA remain unclear. Here, we show DDX3 collaborates extensively with the translation initiation machinery through direct binding to 5'UTRs of nearly all coding RNAs, specific sites on the 18S rRNA, and multiple components of the translation initiation complex. Impairment of translation initiation is also evident in primary medulloblastomas harboring mutations in DDX3X, further highlighting DDX3's role in this process. Arsenite-induced stress shifts DDX3 binding from the 5'UTR into the coding region of mRNAs concomitant with a general reduction of translation, and both the shift of DDX3 on mRNA and decreased translation are blunted by expression of a catalytically-impaired, medulloblastoma-associated DDX3R534H variant. Furthermore, despite the global repression of translation induced by arsenite, translation is preserved on select genes involved in chromatin organization in DDX3R534H-expressing cells. Thus, DDX3 interacts extensively with RNA and ribosomal machinery to help remodel the translation landscape in response to stress, while cancer-related DDX3 variants adapt this response to selectively preserve translation.

Published
2016

19. New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.

Author

Sturm, Dominik, Orr, Brent A, Toprak, Umut H, Hovestadt, Volker, Jones, David TW, Capper, David, Sill, Martin, Buchhalter, Ivo, Northcott, Paul A, Leis, Irina, Ryzhova, Marina, Koelsche, Christian, Pfaff, Elke, Allen, Sariah J, Balasubramanian, Gnanaprakash, Worst, Barbara C, Pajtler, Kristian W, Brabetz, Sebastian, Johann, Pascal D, Sahm, Felix, Reimand, Jüri, Mackay, Alan, Carvalho, Diana M, Remke, Marc, Phillips, Joanna J, Perry, Arie, Cowdrey, Cynthia, Drissi, Rachid, Fouladi, Maryam, Giangaspero, Felice, Łastowska, Maria, Grajkowska, Wiesława, Scheurlen, Wolfram, Pietsch, Torsten, Hagel, Christian, Gojo, Johannes, Lötsch, Daniela, Berger, Walter, Slavc, Irene, Haberler, Christine, Jouvet, Anne, Holm, Stefan, Hofer, Silvia, Prinz, Marco, Keohane, Catherine, Fried, Iris, Mawrin, Christian, Scheie, David, Mobley, Bret C, Schniederjan, Matthew J, Santi, Mariarita, Buccoliero, Anna M, Dahiya, Sonika, Kramm, Christof M, von Bueren, André O, von Hoff, Katja, Rutkowski, Stefan, Herold-Mende, Christel, Frühwald, Michael C, Milde, Till, Hasselblatt, Martin, Wesseling, Pieter, Rößler, Jochen, Schüller, Ulrich, Ebinger, Martin, Schittenhelm, Jens, Frank, Stephan, Grobholz, Rainer, Vajtai, Istvan, Hans, Volkmar, Schneppenheim, Reinhard, Zitterbart, Karel, Collins, V Peter, Aronica, Eleonora, Varlet, Pascale, Puget, Stephanie, Dufour, Christelle, Grill, Jacques, Figarella-Branger, Dominique, Wolter, Marietta, Schuhmann, Martin U, Shalaby, Tarek, Grotzer, Michael, van Meter, Timothy, Monoranu, Camelia-Maria, Felsberg, Jörg, Reifenberger, Guido, Snuderl, Matija, Forrester, Lynn Ann, Koster, Jan, Versteeg, Rogier, Volckmann, Richard, van Sluis, Peter, Wolf, Stephan, Mikkelsen, Tom, Gajjar, Amar, Aldape, Kenneth, Moore, Andrew S, Taylor, Michael D, and Jones, Chris

Subjects
Humans, Neuroectodermal Tumors, Central Nervous System Neoplasms, Trans-Activators, Proto-Oncogene Proteins, Tumor Suppressor Proteins, Repressor Proteins, Gene Expression Profiling, Signal Transduction, DNA Methylation, Gene Expression Regulation, Neoplastic, Amino Acid Sequence, Molecular Sequence Data, Child, Forkhead Transcription Factors, Neuroblastoma, Cancer, Pediatric, Neurosciences, Brain Disorders, Rare Diseases, Orphan Drug, Brain Cancer, Pediatric Research Initiative, Pediatric Cancer, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly aggressive, poorly differentiated embryonal tumors occurring predominantly in young children but also affecting adolescents and adults. Herein, we demonstrate that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors. From the remaining fraction of CNS-PNETs, we identify four new CNS tumor entities, each associated with a recurrent genetic alteration and distinct histopathological and clinical features. These new molecular entities, designated "CNS neuroblastoma with FOXR2 activation (CNS NB-FOXR2)," "CNS Ewing sarcoma family tumor with CIC alteration (CNS EFT-CIC)," "CNS high-grade neuroepithelial tumor with MN1 alteration (CNS HGNET-MN1)," and "CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR)," will enable meaningful clinical trials and the development of therapeutic strategies for patients affected by poorly differentiated CNS tumors.

Published
2016

20. Sarcoma classification by DNA methylation profiling

Author

Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sill, Martin, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Heilig, Christoph E., Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Ecker, Jonas, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Sievers, Philipp, Ebrahimi, Azadeh, Suwala, Abigail, Fernández-Klett, Francisco, Casalini, Belén, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Pérez, Laura, Grünewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Abdollahi, Amir, Debus, Jürgen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Jürgen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Mentzel, Thomas, Griewank, Klaus, de Álava, Enrique, Martín, Juan Díaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Büttner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjær, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Heining, Christoph, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, Alonso, Javier, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Vokuhl, Christian, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Capper, David, Jones, David T. W., Fröhling, Stefan, Pfister, Stefan M., and von Deimling, Andreas

Published
2021
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23. Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Author

Pajtler, Kristian W, Witt, Hendrik, Sill, Martin, Jones, David TW, Hovestadt, Volker, Kratochwil, Fabian, Wani, Khalida, Tatevossian, Ruth, Punchihewa, Chandanamali, Johann, Pascal, Reimand, Jüri, Warnatz, Hans-Jörg, Ryzhova, Marina, Mack, Steve, Ramaswamy, Vijay, Capper, David, Schweizer, Leonille, Sieber, Laura, Wittmann, Andrea, Huang, Zhiqin, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Fults, Daniel, Toledano, Helen, Avigad, Smadar, Hoffman, Lindsey M, Donson, Andrew M, Foreman, Nicholas, Hewer, Ekkehard, Zitterbart, Karel, Gilbert, Mark, Armstrong, Terri S, Gupta, Nalin, Allen, Jeffrey C, Karajannis, Matthias A, Zagzag, David, Hasselblatt, Martin, Kulozik, Andreas E, Witt, Olaf, Collins, V Peter, von Hoff, Katja, Rutkowski, Stefan, Pietsch, Torsten, Bader, Gary, Yaspo, Marie-Laure, von Deimling, Andreas, Lichter, Peter, Taylor, Michael D, Gilbertson, Richard, Ellison, David W, Aldape, Kenneth, Korshunov, Andrey, Kool, Marcel, and Pfister, Stefan M

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Cancer, Adaptor Proteins, Signal Transducing, Adolescent, Adult, Age Factors, Aged, Central Nervous System Neoplasms, Child, Child, Preschool, DNA Methylation, Ependymoma, Female, Gene Dosage, Gene Expression Profiling, Gene Fusion, Humans, Infant, Male, Middle Aged, Phosphoproteins, Transcription Factors, Transcription, Genetic, YAP-Signaling Proteins, Young Adult, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Ependymal tumors across age groups are currently classified and graded solely by histopathology. It is, however, commonly accepted that this classification scheme has limited clinical utility based on its lack of reproducibility in predicting patients' outcome. We aimed at establishing a uniform molecular classification using DNA methylation profiling. Nine molecular subgroups were identified in a large cohort of 500 tumors, 3 in each anatomical compartment of the CNS, spine, posterior fossa, supratentorial. Two supratentorial subgroups are characterized by prototypic fusion genes involving RELA and YAP1, respectively. Regarding clinical associations, the molecular classification proposed herein outperforms the current histopathological classification and thus might serve as a basis for the next World Health Organization classification of CNS tumors.

Published
2015

24. The molecular landscape of ETMR at diagnosis and relapse

Author

Lambo, Sander, Gröbner, Susanne N., Rausch, Tobias, Waszak, Sebastian M., Schmidt, Christin, Gorthi, Aparna, Romero, July Carolina, Mauermann, Monika, Brabetz, Sebastian, Krausert, Sonja, Buchhalter, Ivo, Koster, Jan, Zwijnenburg, Danny A., Sill, Martin, Hübner, Jens-Martin, Mack, Norman, Schwalm, Benjamin, Ryzhova, Marina, Hovestadt, Volker, Papillon-Cavanagh, Simon, Chan, Jennifer A., Landgraf, Pablo, Ho, Ben, Milde, Till, Witt, Olaf, Ecker, Jonas, Sahm, Felix, Sumerauer, David, Ellison, David W., Orr, Brent A., Darabi, Anna, Haberler, Christine, Figarella-Branger, Dominique, Wesseling, Pieter, Schittenhelm, Jens, Remke, Marc, Taylor, Michael D., Gil-da-Costa, Maria J., Łastowska, Maria, Grajkowska, Wiesława, Hasselblatt, Martin, Hauser, Peter, Pietsch, Torsten, Uro-Coste, Emmanuelle, Bourdeaut, Franck, Masliah-Planchon, Julien, Rigau, Valérie, Alexandrescu, Sanda, Wolf, Stephan, Li, Xiao-Nan, Schüller, Ulrich, Snuderl, Matija, Karajannis, Matthias A., Giangaspero, Felice, Jabado, Nada, von Deimling, Andreas, Jones, David T. W., Korbel, Jan O., von Hoff, Katja, Lichter, Peter, Huang, Annie, Bishop, Alexander J. R., Pfister, Stefan M., Korshunov, Andrey, and Kool, Marcel

Published
2019
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25. Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity.

Author

Picard, Daniel, Rosenblum, Marc, Antonelli, Manila, Aronica, Eleonora, Schüller, Ulrich, Hasselblatt, Martin, Woehrer, Adelheid, Zheludkova, Olga, Kumirova, Ella, Puget, Stephanie, Taylor, Michael, Giangaspero, Felice, Peter Collins, V, von Deimling, Andreas, Lichter, Peter, Huang, Annie, Pietsch, Torsten, Pfister, Stefan, Kool, Marcel, Korshunov, Andrey, Sturm, Dominik, Ryzhova, Marina, Hovestadt, Volker, Gessi, Marco, Jones, David, Remke, Marc, Northcott, Paul, and Perry, Arie

Subjects
Brain Neoplasms, Child, Child, Preschool, Chromosomes, Human, Pair 19, DNA Copy Number Variations, DNA Methylation, Diagnosis, Differential, Female, Genetic Loci, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Infant, Male, Neoplasm Recurrence, Local, Neoplasms, Germ Cell and Embryonal, Neuroectodermal Tumors, Primitive, Survival Analysis
Abstract

Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), and medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, and molecular analysis of 97 cases of these rare brain neoplasms, including genome-wide DNA methylation and copy number profiling of 41 tumors. We identified uniform molecular signatures in all tumors irrespective of histological patterns, indicating that ETANTR, EBL, and MEPL comprise a single biological entity. As such, future WHO classification schemes should consider lumping these variants into a single diagnostic category, such as embryonal tumor with multilayered rosettes (ETMR). We recommend combined LIN28A immunohistochemistry and FISH analysis of the 19q13.42 locus for molecular diagnosis of this tumor category. Recognition of this distinct pediatric brain tumor entity based on the fact that the three histological variants are molecularly and clinically uniform will help to distinguish ETMR from other embryonal CNS tumors and to better understand the biology of these highly aggressive and therapy-resistant pediatric CNS malignancies, possibly leading to alternate treatment strategies.

Published
2014

26. Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

Author

Kool, Marcel, Jones, David TW, Jäger, Natalie, Northcott, Paul A, Pugh, Trevor J, Hovestadt, Volker, Piro, Rosario M, Esparza, L Adriana, Markant, Shirley L, Remke, Marc, Milde, Till, Bourdeaut, Franck, Ryzhova, Marina, Sturm, Dominik, Pfaff, Elke, Stark, Sebastian, Hutter, Sonja, Şeker-Cin, Huriye, Johann, Pascal, Bender, Sebastian, Schmidt, Christin, Rausch, Tobias, Shih, David, Reimand, Jüri, Sieber, Laura, Wittmann, Andrea, Linke, Linda, Witt, Hendrik, Weber, Ursula D, Zapatka, Marc, König, Rainer, Beroukhim, Rameen, Bergthold, Guillaume, van Sluis, Peter, Volckmann, Richard, Koster, Jan, Versteeg, Rogier, Schmidt, Sabine, Wolf, Stephan, Lawerenz, Chris, Bartholomae, Cynthia C, von Kalle, Christof, Unterberg, Andreas, Herold-Mende, Christel, Hofer, Silvia, Kulozik, Andreas E, von Deimling, Andreas, Scheurlen, Wolfram, Felsberg, Jörg, Reifenberger, Guido, Hasselblatt, Martin, Crawford, John R, Grant, Gerald A, Jabado, Nada, Perry, Arie, Cowdrey, Cynthia, Croul, Sydney, Zadeh, Gelareh, Korbel, Jan O, Doz, Francois, Delattre, Olivier, Bader, Gary D, McCabe, Martin G, Collins, V Peter, Kieran, Mark W, Cho, Yoon-Jae, Pomeroy, Scott L, Witt, Olaf, Brors, Benedikt, Taylor, Michael D, Schüller, Ulrich, Korshunov, Andrey, Eils, Roland, Wechsler-Reya, Robert J, Lichter, Peter, Pfister, Stefan M, and Project, on behalf of the ICGC PedBrain Tumor

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Pediatric Research Initiative, Genetics, Rare Diseases, Cancer, Pediatric, Brain Cancer, Pediatric Cancer, Brain Disorders, Adolescent, Adult, Animals, Base Sequence, Biphenyl Compounds, Cerebellar Neoplasms, Child, Child, Preschool, DEAD-box RNA Helicases, DNA Copy Number Variations, Drug Resistance, Neoplasm, Female, Gene Expression Profiling, Hedgehog Proteins, High-Throughput Nucleotide Sequencing, Humans, Infant, Kruppel-Like Transcription Factors, Male, Medulloblastoma, Mice, Mice, Inbred NOD, Mice, SCID, Molecular Sequence Data, N-Myc Proto-Oncogene Protein, Neoplasm Transplantation, Nuclear Proteins, Oncogene Proteins, Patched Receptors, Patched-1 Receptor, Phosphatidylinositol 3-Kinases, Promoter Regions, Genetic, Proto-Oncogene Proteins c-akt, Pyridines, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Repressor Proteins, Signal Transduction, Smoothened Receptor, Telomerase, Tumor Suppressor Protein p53, Young Adult, Zinc Finger Protein Gli2, ICGC PedBrain Tumor Project, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(s) of primary resistance and identify pathways cooperating with aberrant SHH signaling, we sequenced and profiled a large cohort of SHH-MBs (n = 133). SHH pathway mutations involved PTCH1 (across all age groups), SUFU (infants, including germline), and SMO (adults). Children >3 years old harbored an excess of downstream MYCN and GLI2 amplifications and frequent TP53 mutations, often in the germline, all of which were rare in infants and adults. Functional assays in different SHH-MB xenograft models demonstrated that SHH-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant.

Published
2014

27. EPCO-45. CELLULAR HIERARCHIES OF ETMR ARE SHAPED BY ONCOGENIC MICRORNAS AND RECEPTOR-LIGAND INTERACTIONS

Author

Gabler, Lisa, primary, Beck, Alexander, additional, Cruzeiro, Gustavo, additional, Lambo, Sander, additional, Englinger, Bernhard, additional, Shaw, McKenzie L, additional, Hack, Olivia, additional, Chi, Susan, additional, Alexandrescu, Sanda, additional, Gojo, Johannes, additional, Kool, Marcel, additional, Hovestadt, Volker, additional, and Filbin, Mariella, additional

Published
2023
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28. CNSC-25. NEURAL SIGNATURE OF GBM EXHIBITS SYNAPTOGENIC AND OPC-LIKE FEATURES AND INDEPENDENTLY PREDICTS PATIENT SURVIVAL

Author

Drexler, Richard, primary, Khatri, Robin, additional, Sauvigny, Thomas, additional, Mohme, Malte, additional, Ryba, Alice, additional, Dührsen, Lasse, additional, Maire, Cecile, additional, Salviano-Silva, Amanda, additional, Lamszus, Katrin, additional, Westphal, Manfred, additional, Gempt, Jens, additional, Wefers, Annika, additional, Neumann, Julia, additional, Bode, Helena, additional, Hausmann, Fabian, additional, Huber, Tobias, additional, Bonn, Stefan, additional, Delev, Daniel, additional, Weber, Katharina, additional, Harter, Patrick, additional, Onken, Julia, additional, Vajkoczy, Peter, additional, Capper, David, additional, Wiestler, Benedikt, additional, Monje, Michelle, additional, Silverbush, Dana, additional, Hovestadt, Volker, additional, Suva, Mario, additional, Krishna, Saritha, additional, Hervey-Jumper, Shawn, additional, Schüller, Ulrich, additional, Heiland, Dieter Henrik, additional, Hänzelmann, Sonja, additional, and Ricklefs, Franz L, additional

Published
2023
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29. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, primary, Capper, David, additional, Andreiuolo, Felipe, additional, Gessi, Marco, additional, Kölsche, Christian, additional, Reinhardt, Annekathrin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Suwala, Abigail K., additional, Gielen, Gerrit H., additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Hovestadt, Volker, additional, Daenekas, Bjarne, additional, Rode, Agata, additional, Hamelmann, Stefan, additional, Previti, Christopher, additional, Jäger, Natalie, additional, Buchhalter, Ivo, additional, Blattner-Johnson, Mirjam, additional, Jones, Barbara C., additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Grund, Kerstin, additional, Sutter, Christian, additional, Hirsch, Steffen, additional, Dikow, Nicola, additional, Hasselblatt, Martin, additional, Schüller, Ulrich, additional, Koch, Arend, additional, Gerber, Nicolas U., additional, White, Christine L., additional, Buntine, Molly K., additional, Kinross, Kathryn, additional, Algar, Elizabeth M., additional, Hansford, Jordan R., additional, Gottardo, Nicholas G., additional, Schuhmann, Martin U., additional, Thomale, Ulrich W., additional, Hernáiz Driever, Pablo, additional, Gnekow, Astrid, additional, Witt, Olaf, additional, Müller, Hermann L., additional, Calaminus, Gabriele, additional, Fleischhack, Gudrun, additional, Kordes, Uwe, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Frühwald, Michael C., additional, Kramm, Christof M., additional, von Deimling, Andreas, additional, Pietsch, Torsten, additional, Sahm, Felix, additional, Pfister, Stefan M., additional, and Jones, David. T. W., additional

Published
2023
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30. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq

Author

Filbin, Mariella G., Tirosh, Itay, Hovestadt, Volker, Shaw, McKenzie L., Escalante, Leah E., Mathewson, Nathan D., Neftel, Cyril, Frank, Nelli, Pelton, Kristine, Hebert, Christine M., Haberler, Christine, Yizhak, Keren, Gojo, Johannes, Egervari, Kristof, Mount, Christopher, van Galen, Peter, Bonal, Dennis M., Nguyen, Quang-De, Beck, Alexander, Sinai, Claire, Czech, Thomas, Dorfer, Christian, Goumnerova, Liliana, Lavarino, Cinzia, Carcaboso, Angel M., Mora, Jaume, Mylvaganam, Ravindra, Luo, Christina C., Peyr, Andreas, Popović, Mara, Azizi, Amedeo, Batchelor, Tracy. T., Frosch, Matthew P., Martinez-Lage, Maria, Kieran, Mark W., Bandopadhayay, Pratiti, Beroukhim, Rameen, Fritsch, Gerhard, Getz, Gad, Rozenblatt-Rosen, Orit, Wucherpfennig, Kai W., Louis, David N., Monje, Michelle, Slavc, Irene, Ligon, Keith L., Golub, Todd R., Regev, Aviv, Bernstein, Bradley E., and Suvà, Mario L.

Published
2018

31. Resolving medulloblastoma cellular architecture by single-cell genomics

Author

Hovestadt, Volker, Smith, Kyle S., Bihannic, Laure, Filbin, Mariella G., Shaw, McKenzie L., Baumgartner, Alicia, and DeWitt, John C.

Subjects
Genomics -- Usage, Medulloblastoma -- Genetic aspects -- Structure -- Development and progression, Tissues -- Identification and classification, Phenotype -- Observations, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well defined, the extent to which cellular diversity underlies their divergent biology and clinical behaviour remains largely unexplored. Here we used single-cell transcriptomics to investigate intra- and intertumoral heterogeneity in 25 medulloblastomas spanning all molecular subgroups. WNT, SHH and Group 3 tumours comprised subgroup-specific undifferentiated and differentiated neuronal-like malignant populations, whereas Group 4 tumours consisted exclusively of differentiated neuronal-like neoplastic cells. SHH tumours closely resembled granule neurons of varying differentiation states that correlated with patient age. Group 3 and Group 4 tumours exhibited a developmental trajectory from primitive progenitor-like to more mature neuronal-like cells, the relative proportions of which distinguished these subgroups. Cross-species transcriptomics defined distinct glutamatergic populations as putative cells-of-origin for SHH and Group 4 subtypes. Collectively, these data provide insights into the cellular and developmental states underlying subtype-specific medulloblastoma biology. Characterization of medulloblastoma tissues using single-cell transcriptomics shows that the different molecular subtypes consist of distinct developmental phenotypes., Author(s): Volker Hovestadt [sup.1] [sup.2] , Kyle S. Smith [sup.3] , Laure Bihannic [sup.3] , Mariella G. Filbin [sup.1] [sup.2] [sup.4] , McKenzie L. Shaw [sup.1] [sup.2] [sup.4] , Alicia [...]

Published
2019
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32. Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes

Author

Sharma, Tanvi, Schwalbe, Edward C., Williamson, Daniel, Sill, Martin, Hovestadt, Volker, Mynarek, Martin, Rutkowski, Stefan, Robinson, Giles W., Gajjar, Amar, Cavalli, Florence, Ramaswamy, Vijay, Taylor, Michael D., Lindsey, Janet C., Hill, Rebecca M., Jäger, Natalie, Korshunov, Andrey, Hicks, Debbie, Bailey, Simon, Kool, Marcel, Chavez, Lukas, Northcott, Paul A., Pfister, Stefan M., and Clifford, Steven C.

Published
2019
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34. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Author

Venteicher, Andrew S., Tirosh, Itay, Hebert, Christine, Yizhak, Keren, Neftel, Cyril, Filbin, Mariella G., Hovestadt, Volker, Escalante, Leah E., Shaw, McKenzie L., Rodman, Christopher, Gillespie, Shawn M., Dionne, Danielle, Luo, Christina C., Ravichandran, Hiranmayi, Mylvaganam, Ravindra, Mount, Christopher, Onozato, Maristela L., Nahed, Brian V., Wakimoto, Hiroaki, Curry, William T., Iafrate, A. John, Rivera, Miguel N., Frosch, Matthew P., Golub, Todd R., Brastianos, Priscilla K., Getz, Gad, Patel, Anoop P., Monje, Michelle, Cahill, Daniel P., Rozenblatt-Rosen, Orit, Louis, David N., Bernstein, Bradley E., Regev, Aviv, and Suvà, Mario L.

Published
2017

35. Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

Author

Drexler, Richard, primary, Khatri, Robin, additional, Sauvigny, Thomas, additional, Mohme, Malte, additional, Maire, Cecile L., additional, Ryba, Alice, additional, Zghaibeh, Yahya, additional, Dührsen, Lasse, additional, Salviano-Silva, Amanda, additional, Lamszus, Katrin, additional, Westphal, Manfred, additional, Gempt, Jens, additional, Wefers, Annika K., additional, Neumann, Julia, additional, Bode, Helena, additional, Hausmann, Fabian, additional, Huber, Tobias B., additional, Bonn, Stefan, additional, Jütten, Kerstin, additional, Delev, Daniel, additional, Weber, Katharina J., additional, Harter, Patrick N., additional, Onken, Julia, additional, Vajkoczy, Peter, additional, Capper, David, additional, Wiestler, Benedikt, additional, Weller, Michael, additional, Snijder, Berend, additional, Buck, Alicia, additional, Weiss, Tobias, additional, Keough, Michael B., additional, Ni, Lijun, additional, Monje, Michelle, additional, Silverbush, Dana, additional, Hovestadt, Volker, additional, Suvà, Mario L., additional, Krishna, Saritha, additional, Hervey-Jumper, Shawn L., additional, Schüller, Ulrich, additional, Heiland, Dieter H., additional, Hänzelmann, Sonja, additional, and Ricklefs, Franz L., additional

Published
2023
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36. Mapping pediatric brain tumors to their origins in the developing cerebellum

Author

Okonechnikov, Konstantin, primary, Joshi, Piyush, additional, Sepp, Mari, additional, Leiss, Kevin, additional, Sarropoulos, Ioannis, additional, Murat, Florent, additional, Sill, Martin, additional, Beck, Pengbo, additional, Chan, Kenneth Chun-Ho, additional, Korshunov, Andrey, additional, Sah, Felix, additional, Deng, Maximilian Y, additional, Sturm, Dominik, additional, DeSisto, John, additional, Donson, Andrew M, additional, Foreman, Nicholas K, additional, Green, Adam L, additional, Robinson, Giles, additional, Orr, Brent A, additional, Gao, Qingsong, additional, Darrow, Emily, additional, Hadley, Jennifer L, additional, Northcott, Paul A, additional, Gojo, Johannes, additional, Kawauchi, Daisuke, additional, Hovestadt, Volker, additional, Filbin, Mariella G, additional, von Deimling, Andreas, additional, Zuckermann, Marc, additional, Pajtler, Kristian W, additional, Kool, Marcel, additional, Jones, David T W, additional, Jäger, Natalie, additional, Kutscher, Lena M, additional, Kaessmann, Henrik, additional, and Pfister, Stefan M, additional

Published
2023
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38. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

Author

Sahm, Felix, Schrimpf, Daniel, Stichel, Damian, Jones, David T W, Hielscher, Thomas, Schefzyk, Sebastian, Okonechnikov, Konstantin, Koelsche, Christian, Reuss, David E, Capper, David, Sturm, Dominik, Wirsching, Hans-Georg, Berghoff, Anna Sophie, Baumgarten, Peter, Kratz, Annekathrin, Huang, Kristin, Wefers, Annika K, Hovestadt, Volker, Sill, Martin, Ellis, Hayley P, Kurian, Kathreena M, Okuducu, Ali Fuat, Jungk, Christine, Drueschler, Katharina, Schick, Matthias, Bewerunge-Hudler, Melanie, Mawrin, Christian, Seiz-Rosenhagen, Marcel, Ketter, Ralf, Simon, Matthias, Westphal, Manfred, Lamszus, Katrin, Becker, Albert, Koch, Arend, Schittenhelm, Jens, Rushing, Elisabeth J, Collins, V Peter, Brehmer, Stefanie, Chavez, Lukas, Platten, Michael, Hänggi, Daniel, Unterberg, Andreas, Paulus, Werner, Wick, Wolfgang, Pfister, Stefan M, Mittelbronn, Michel, Preusser, Matthias, Herold-Mende, Christel, Weller, Michael, and von Deimling, Andreas

Published
2017
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39. A biobank of patient-derived pediatric brain tumor models

Author

Brabetz, Sebastian, Leary, Sarah E. S., Gröbner, Susanne N., Nakamoto, Madison W., Şeker-Cin, Huriye, Girard, Emily J., Cole, Bonnie, Strand, Andrew D., Bloom, Karina L., Hovestadt, Volker, Mack, Norman L., Pakiam, Fiona, Schwalm, Benjamin, Korshunov, Andrey, Balasubramanian, Gnana Prakash, Northcott, Paul A., Pedro, Kyle D., Dey, Joyoti, Hansen, Stacey, Ditzler, Sally, Lichter, Peter, Chavez, Lukas, Jones, David T. W., Koster, Jan, Pfister, Stefan M., Kool, Marcel, and Olson, James M.

Published
2018
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40. Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Author

Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., and von Deimling, Andreas

Published
2018
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42. Abstract 3562: Dissecting mechanisms underlying FOXR2-mediated gliomagenesis in diffuse midline gliomas

Author

Tsai, Jessica W., primary, Cejas, Paloma, additional, Coppola, Marissa, additional, Wang, Dayle K., additional, Patel, Smruti, additional, Wu, David W., additional, Arounleut, Phonepasong, additional, Wei, Xin, additional, Zhou, Ningxuan, additional, Syamala, Sudeepa, additional, Dubois, Frank P., additional, Pelton, Kristine, additional, Vogelzang, Jayne, additional, Sousa, Cecilia, additional, Baguette, Audrey, additional, Chen, Xiaolong, additional, Condurat, Alexandra L., additional, Dixon-Clarke, Sarah E., additional, Charles, Annarah, additional, Zhou, Kevin N., additional, Lu, Sophie D., additional, Gonzalez, Elizabeth M., additional, Chacon, Madison S., additional, Digiacomo, Jeromy J., additional, Kumbhani, Rushil, additional, Novikov, Dana, additional, Tsoli, Maria, additional, Ziegler, David S., additional, Dirksen, Uta, additional, Jager, Natalie, additional, Balasubramanian, Gnana Prakash, additional, Kramm, Christof M., additional, Nathrath, Michaela, additional, Bielack, Stefan, additional, Baker, Suzanne J., additional, Zhang, Jinghui, additional, McFarland, James M., additional, Getz, Gad, additional, Aguet, Francois, additional, Jabado, Nada, additional, Witt, Olaf, additional, Pfister, Stefan M., additional, Ligon, Keith L., additional, Hovestadt, Volker, additional, Kleinman, Claudia, additional, Long, Henry, additional, Jones, David T., additional, Bandopadhayay, Pratiti, additional, and Phoenix, Timothy N., additional

Published
2023
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43. Data from Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Author

Malone, Clare F., primary, Dharia, Neekesh V., primary, Kugener, Guillaume, primary, Forman, Alexandra B., primary, Rothberg, Michael V., primary, Abdusamad, Mai, primary, Gonzalez, Alfredo, primary, Kuljanin, Miljan, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Dempster, Joshua M., primary, Paolella, Brenton R., primary, Dumont, Nancy, primary, Hovestadt, Volker, primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Root, David E., primary, Golub, Todd R., primary, Vazquez, Francisca, primary, and Stegmaier, Kimberly, primary

Published
2023
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44. Supplementary Figure S3 from Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Author

Malone, Clare F., primary, Dharia, Neekesh V., primary, Kugener, Guillaume, primary, Forman, Alexandra B., primary, Rothberg, Michael V., primary, Abdusamad, Mai, primary, Gonzalez, Alfredo, primary, Kuljanin, Miljan, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Dempster, Joshua M., primary, Paolella, Brenton R., primary, Dumont, Nancy, primary, Hovestadt, Volker, primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Root, David E., primary, Golub, Todd R., primary, Vazquez, Francisca, primary, and Stegmaier, Kimberly, primary

Published
2023
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45. Supplementary Table S1 from Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer

Author

Malone, Clare F., primary, Dharia, Neekesh V., primary, Kugener, Guillaume, primary, Forman, Alexandra B., primary, Rothberg, Michael V., primary, Abdusamad, Mai, primary, Gonzalez, Alfredo, primary, Kuljanin, Miljan, primary, Robichaud, Amanda L., primary, Conway, Amy Saur, primary, Dempster, Joshua M., primary, Paolella, Brenton R., primary, Dumont, Nancy, primary, Hovestadt, Volker, primary, Mancias, Joseph D., primary, Younger, Scott T., primary, Root, David E., primary, Golub, Todd R., primary, Vazquez, Francisca, primary, and Stegmaier, Kimberly, primary

Published
2023
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46. Supplementary Table from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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47. Data from A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, primary, Garcia-Gerique, Laura, primary, Lemos, Isadora, primary, Suñol, Mariona, primary, de Torres, Carmen, primary, Kulis, Marta, primary, Pérez-Jaume, Sara, primary, Carcaboso, Ángel M., primary, Luu, Betty, primary, Kieran, Mark W., primary, Jabado, Nada, primary, Kozlenkov, Alexey, primary, Dracheva, Stella, primary, Ramaswamy, Vijay, primary, Hovestadt, Volker, primary, Johann, Pascal, primary, Jones, David T.W., primary, Pfister, Stefan M., primary, Morales La Madrid, Andrés, primary, Cruz, Ofelia, primary, Taylor, Michael D., primary, Martin-Subero, Jose-Ignacio, primary, Mora, Jaume, primary, and Lavarino, Cinzia, primary

Published
2023
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48. Supplementary Appendix from A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Author

Gómez, Soledad, primary, Garrido-Garcia, Alícia, primary, Garcia-Gerique, Laura, primary, Lemos, Isadora, primary, Suñol, Mariona, primary, de Torres, Carmen, primary, Kulis, Marta, primary, Pérez-Jaume, Sara, primary, Carcaboso, Ángel M., primary, Luu, Betty, primary, Kieran, Mark W., primary, Jabado, Nada, primary, Kozlenkov, Alexey, primary, Dracheva, Stella, primary, Ramaswamy, Vijay, primary, Hovestadt, Volker, primary, Johann, Pascal, primary, Jones, David T.W., primary, Pfister, Stefan M., primary, Morales La Madrid, Andrés, primary, Cruz, Ofelia, primary, Taylor, Michael D., primary, Martin-Subero, Jose-Ignacio, primary, Mora, Jaume, primary, and Lavarino, Cinzia, primary

Published
2023
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49. Supplementary Figure from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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50. Data from FOXR2 Is an Epigenetically Regulated Pan-Cancer Oncogene That Activates ETS Transcriptional Circuits

Author

Tsai, Jessica W., primary, Cejas, Paloma, primary, Wang, Dayle K., primary, Patel, Smruti, primary, Wu, David W., primary, Arounleut, Phonepasong, primary, Wei, Xin, primary, Zhou, Ningxuan, primary, Syamala, Sudeepa, primary, Dubois, Frank P.B., primary, Crane, Alexander, primary, Pelton, Kristine, primary, Vogelzang, Jayne, primary, Sousa, Cecilia, primary, Baguette, Audrey, primary, Chen, Xiaolong, primary, Condurat, Alexandra L., primary, Dixon-Clarke, Sarah E., primary, Zhou, Kevin N., primary, Lu, Sophie D., primary, Gonzalez, Elizabeth M., primary, Chacon, Madison S., primary, Digiacomo, Jeromy J., primary, Kumbhani, Rushil, primary, Novikov, Dana, primary, Hunter, J'Ya, primary, Tsoli, Maria, primary, Ziegler, David S., primary, Dirksen, Uta, primary, Jager, Natalie, primary, Balasubramanian, Gnana Prakash, primary, Kramm, Christof M., primary, Nathrath, Michaela, primary, Bielack, Stefan, primary, Baker, Suzanne J., primary, Zhang, Jinghui, primary, McFarland, James M., primary, Getz, Gad, primary, Aguet, François, primary, Jabado, Nada, primary, Witt, Olaf, primary, Pfister, Stefan M., primary, Ligon, Keith L., primary, Hovestadt, Volker, primary, Kleinman, Claudia L., primary, Long, Henry, primary, Jones, David T.W., primary, Bandopadhayay, Pratiti, primary, and Phoenix, Timothy N., primary

Published
2023
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