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2. Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation

Author

Vasmel, Jeanine E., Groot Koerkamp, Maureen L., Mandija, Stefano, Veldhuis, Wouter B., Moman, Maaike R., Froeling, Martijn, van der Velden, Bas H.M., Charaghvandi, Ramona K., Vreuls, Celien P.H., van Diest, Paul J., van Leeuwen, A.M. Gijs, van Gorp, Joost, Philippens, Marielle E.P., van Asselen, Bram, Lagendijk, Jan J.W., Verkooijen, Helena M., van den Bongard, H.J.G. Desirée, and Houweling, Antonetta C.

Published
2022
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4. Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials

Author

Vasmel, Jeanine E., Groot Koerkamp, Maureen L., Kirby, Anna M., Russell, Nicola S., Shaitelman, Simona F., Vesprini, Danny, Anandadas, Carmel N., Currey, Adam, Keller, Brian M., Braunstein, Lior Z., Han, Kathy, Kotte, Alexis N.T.J., de Waard, Stephanie N., Philippens, Marielle E.P., Houweling, Antonetta C., Verkooijen, Helena M., and van den Bongard, H.J.G. Desiree

Published
2020
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11. Intrafraction motion during radiotherapy of breast tumor, breast tumor bed, and individual axillary lymph nodes on cine magnetic resonance imaging

Author

Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Computational Imaging, Groot Koerkamp, Maureen L, van den Bongard, H J G Desirée, Philippens, Marielle E P, van der Leij, Femke, Mandija, Stefano, Houweling, Antonetta C, Experimentele klinische fysica, Cancer, Klinische Fysica RT, MS Radiotherapie, Computational Imaging, Groot Koerkamp, Maureen L, van den Bongard, H J G Desirée, Philippens, Marielle E P, van der Leij, Femke, Mandija, Stefano, and Houweling, Antonetta C

Published
2022

12. Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation

Author

UMC Utrecht Academie, Trialbureau Beeld, Experimentele klinische fysica, Cancer, Computational Imaging, MS Radiologie, Circulatory Health, Highfield Research Group, Brain, Beeldverwerking ISI, Onderzoek Radiotherapie, Pathologie Pathologen staf, Pathologie, Klinische Fysica RT, Onderzoek Beeld, Laboranten Echo Radiologie, MS Radiotherapie, Vasmel, Jeanine E., Groot Koerkamp, Maureen L., Mandija, Stefano, Veldhuis, Wouter B., Moman, Maaike R., Froeling, Martijn, van der Velden, Bas H.M., Charaghvandi, Ramona K., Vreuls, Celien P.H., van Diest, Paul J., van Leeuwen, A. M.Gijs, van Gorp, Joost, Philippens, Marielle E.P., van Asselen, Bram, Lagendijk, Jan J.W., Verkooijen, Helena M., van den Bongard, H. J.G.Desirée, Houweling, Antonetta C., UMC Utrecht Academie, Trialbureau Beeld, Experimentele klinische fysica, Cancer, Computational Imaging, MS Radiologie, Circulatory Health, Highfield Research Group, Brain, Beeldverwerking ISI, Onderzoek Radiotherapie, Pathologie Pathologen staf, Pathologie, Klinische Fysica RT, Onderzoek Beeld, Laboranten Echo Radiologie, MS Radiotherapie, Vasmel, Jeanine E., Groot Koerkamp, Maureen L., Mandija, Stefano, Veldhuis, Wouter B., Moman, Maaike R., Froeling, Martijn, van der Velden, Bas H.M., Charaghvandi, Ramona K., Vreuls, Celien P.H., van Diest, Paul J., van Leeuwen, A. M.Gijs, van Gorp, Joost, Philippens, Marielle E.P., van Asselen, Bram, Lagendijk, Jan J.W., Verkooijen, Helena M., van den Bongard, H. J.G.Desirée, and Houweling, Antonetta C.

Published
2022

16. Prone vs. supine accelerated partial breast irradiation on an MR-Linac: A planning study

Author

Radiotherapie, Research UMC Utrecht, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Computational Imaging, Groot Koerkamp, Maureen L., van der Leij, Femke, van 't Westeinde, Tanja, Bol, Gijsbert H., Scholten, Vincent, Bouwmans, Roel, Mandija, Stefano, Philippens, Marielle E.P., van den Bongard, H. J.G.Desirée, Houweling, Antonetta C., Radiotherapie, Research UMC Utrecht, Experimentele klinische fysica, Cancer, MS Radiotherapie, Klinische Fysica RT, Computational Imaging, Groot Koerkamp, Maureen L., van der Leij, Femke, van 't Westeinde, Tanja, Bol, Gijsbert H., Scholten, Vincent, Bouwmans, Roel, Mandija, Stefano, Philippens, Marielle E.P., van den Bongard, H. J.G.Desirée, and Houweling, Antonetta C.

Published
2021

17. Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

Author

Groot Koerkamp, Maureen L., primary, Vasmel, Jeanine E., additional, Russell, Nicola S., additional, Shaitelman, Simona F., additional, Anandadas, Carmel N., additional, Currey, Adam, additional, Vesprini, Danny, additional, Keller, Brian M., additional, De-Colle, Chiara, additional, Han, Kathy, additional, Braunstein, Lior Z., additional, Mahmood, Faisal, additional, Lorenzen, Ebbe L., additional, Philippens, Marielle E. P., additional, Verkooijen, Helena M., additional, Lagendijk, Jan J. W., additional, Houweling, Antonetta C., additional, van den Bongard, H. J. G. Desiree, additional, and Kirby, Anna M., additional

Published
2020
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18. Tumor Response After Neoadjuvant Magnetic Resonance Guided Single Ablative Dose Partial Breast Irradiation

Author

Vasmel, Jeanine E., primary, Charaghvandi, Ramona K., additional, Houweling, Antonetta C., additional, Philippens, Marielle E.P., additional, van Asselen, Bram, additional, Vreuls, Celien P.H., additional, van Diest, Paul J., additional, van Leeuwen, A.M. Gijs, additional, van Gorp, Joost, additional, Witkamp, Arjen J., additional, Koelemij, Ron, additional, Doeksen, Annemiek, additional, Sier, Maartje F., additional, van Dalen, Thijs, additional, van der Wall, Elsken, additional, van Dam, Iris, additional, Veldhuis, Wouter B., additional, Kirby, Anna M., additional, Verkooijen, Helena M., additional, and van den Bongard, H.J.G.Desiree, additional

Published
2020
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19. Tumor Response After Neoadjuvant Magnetic Resonance Guided Single Ablative Dose Partial Breast Irradiation

Author

Vasmel, Jeanine E, Charaghvandi, Ramona K, Houweling, Antonetta C, Philippens, Marielle EP, van Asselen, Bram, Vreuls, Celien PH, van Diest, Paul J, van Leeuwen, Am Gijs, van Gorp, Joost, Witkamp, Arjen J, Koelemij, Ron, Doeksen, Annemiek, Sier, Maartje F, van Dalen, Thijs, van der Wall, Elsken, van Dam, Iris, Veldhuis, Wouter B, Kirby, Anna M, Verkooijen, Helena M, van den Bongard, HJG Desiree, Vasmel, Jeanine E, Charaghvandi, Ramona K, Houweling, Antonetta C, Philippens, Marielle EP, van Asselen, Bram, Vreuls, Celien PH, van Diest, Paul J, van Leeuwen, Am Gijs, van Gorp, Joost, Witkamp, Arjen J, Koelemij, Ron, Doeksen, Annemiek, Sier, Maartje F, van Dalen, Thijs, van der Wall, Elsken, van Dam, Iris, Veldhuis, Wouter B, Kirby, Anna M, Verkooijen, Helena M, and van den Bongard, HJG Desiree

Published
2020

20. Tumor Response After Neoadjuvant Magnetic Resonance Guided Single Ablative Dose Partial Breast Irradiation

Author

Trialbureau Beeld, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, Pathologie Pathologen staf, Pathologie, MS CGO, Speerpunt Cancer, MS Radiotherapie, MS Radiologie, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E, Charaghvandi, Ramona K, Houweling, Antonetta C, Philippens, Marielle EP, van Asselen, Bram, Vreuls, Celien PH, van Diest, Paul J, van Leeuwen, Am Gijs, van Gorp, Joost, Witkamp, Arjen J, Koelemij, Ron, Doeksen, Annemiek, Sier, Maartje F, van Dalen, Thijs, van der Wall, Elsken, van Dam, Iris, Veldhuis, Wouter B, Kirby, Anna M, Verkooijen, Helena M, van den Bongard, HJG Desiree, Trialbureau Beeld, Onderzoek Radiotherapie, Cancer, Klinische Fysica RT, Pathologie Pathologen staf, Pathologie, MS CGO, Speerpunt Cancer, MS Radiotherapie, MS Radiologie, Circulatory Health, Epi Kanker Team A, JC onderzoeksprogramma Kanker, Vasmel, Jeanine E, Charaghvandi, Ramona K, Houweling, Antonetta C, Philippens, Marielle EP, van Asselen, Bram, Vreuls, Celien PH, van Diest, Paul J, van Leeuwen, Am Gijs, van Gorp, Joost, Witkamp, Arjen J, Koelemij, Ron, Doeksen, Annemiek, Sier, Maartje F, van Dalen, Thijs, van der Wall, Elsken, van Dam, Iris, Veldhuis, Wouter B, Kirby, Anna M, Verkooijen, Helena M, and van den Bongard, HJG Desiree

Published
2020

21. Consensus on Contouring Primary Breast Tumors on MRI in the Setting of Neoadjuvant Partial Breast Irradiation in Trials

Author

Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, van den Bongard, H J G Desiree, Trialbureau Beeld, Fysica Radiotherapie Research, Cancer, Klinische Fysica RT, MS Radiologie, JC onderzoeksprogramma Kanker, Epi Kanker Team A, Vasmel, Jeanine E, Groot Koerkamp, Maureen L, Kirby, Anna M, Russell, Nicola S, Shaitelman, Simona F, Vesprini, Danny, Anandadas, Carmel N, Currey, Adam, Keller, Brian M, Braunstein, Lior Z, Han, Kathy, Kotte, Alexis N T J, de Waard, Stephanie N, Philippens, Marielle E P, Houweling, Antonetta C, Verkooijen, Helena M, and van den Bongard, H J G Desiree

Published
2020

22. Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

Author

Cancer, Fysica Radiotherapie Research, Trialbureau Beeld, Klinische Fysica RT, JC onderzoeksprogramma Cancer, Epi Kanker Team A, MS Radiotherapie, Koerkamp, Maureen L. Groot, Vasmel, Jeanine E., Russell, Nicola S., Shaitelman, Simona F., Anandadas, Carmel N., Currey, Adam, Vesprini, Danny, Keller, Brian M., De-Colle, Chiara, Han, Kathy, Braunstein, Lior Z., Mahmood, Faisal, Lorenzen, Ebbe L., Philippens, Marielle E. P., Verkooijen, Helena M., Lagendijk, Jan J. W., Houweling, Antonetta C., van den Bongard, H. J. G. Desiree, Kirby, Anna M., Cancer, Fysica Radiotherapie Research, Trialbureau Beeld, Klinische Fysica RT, JC onderzoeksprogramma Cancer, Epi Kanker Team A, MS Radiotherapie, Koerkamp, Maureen L. Groot, Vasmel, Jeanine E., Russell, Nicola S., Shaitelman, Simona F., Anandadas, Carmel N., Currey, Adam, Vesprini, Danny, Keller, Brian M., De-Colle, Chiara, Han, Kathy, Braunstein, Lior Z., Mahmood, Faisal, Lorenzen, Ebbe L., Philippens, Marielle E. P., Verkooijen, Helena M., Lagendijk, Jan J. W., Houweling, Antonetta C., van den Bongard, H. J. G. Desiree, and Kirby, Anna M.

Published
2020

23. A single neural network for cone-beam computed tomography-based radiotherapy of head-and-neck, lung and breast cancer

Author

Computational Imaging, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Maspero, Matteo, Houweling, Antonetta C., Savenije, Mark H.F., van Heijst, Tristan C.F., Verhoeff, Joost J.C., Kotte, Alexis N.T.J., van den Berg, Cornelis A.T., Computational Imaging, Cancer, Klinische Fysica RT, Fysica Radiotherapie Research, MS Radiotherapie, Maspero, Matteo, Houweling, Antonetta C., Savenije, Mark H.F., van Heijst, Tristan C.F., Verhoeff, Joost J.C., Kotte, Alexis N.T.J., and van den Berg, Cornelis A.T.

Published
2020

27. Visibility and artifacts of gold fiducial markers used for image guided radiation therapy of pancreatic cancer on MRI

Author

Gurney-Champion, Oliver J., Lens, Eelco, van der Horst, Astrid, Houweling, Antonetta C., Klaassen, Remy, van Hooft, Jeanin E., Stoker, Jaap, van Tienhoven, Geertjan, Nederveen, Aart J., Bel, Arjan, Graduate School, Radiotherapy, Amsterdam Gastroenterology Endocrinology Metabolism, Cancer Center Amsterdam, General Internal Medicine, Gastroenterology and Hepatology, Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, and Amsterdam Neuroscience

Subjects
equipment and supplies
Abstract

In radiation therapy of pancreatic cancer, tumor alignment prior to each treatment fraction is improved when intratumoral gold fiducial markers (from here onwards: markers), which are visible on computed tomography (CT) and cone beam CT, are used. Visibility of these markers on magnetic resonance imaging (MRI) might improve image registration between CT and magnetic resonance (MR) images for tumor delineation purposes. However, concomitant image artifacts induced by markers are undesirable. The extent of visibility and artifact size depend on MRI-sequence parameters. The authors' goal was to determine for various markers their potential to be visible and to generate artifacts, using measures that are independent of the MRI-sequence parameters. The authors selected ten different markers suitable for endoscopic placement in the pancreas and placed them into a phantom. The markers varied in diameter (0.28-0.6 mm), shape, and iron content (0%-0.5%). For each marker, the authors calculated T2 (∗)-maps and ΔB0-maps using MRI measurements. A decrease in relaxation time T2 (∗) can cause signal voids, associated with visibility, while a change in the magnetic field B0 can cause signal shifts, which are associated with artifacts. These shifts inhibit accurate tumor delineation. As a measure for potential visibility, the authors used the volume of low T2 (∗), i.e., the volume for which T2 (∗) differed from the background by >15 ms. As a measure for potential artifacts, the authors used the volume for which |ΔB0| > 9.4 × 10(-8) T (4 Hz). To test whether there is a correlation between visibility and artifact size, the authors calculated the Spearman's correlation coefficient (Rs) between the volume of low T2 (∗) and the volume of high |ΔB0|. The authors compared the maps with images obtained using a clinical MR-sequence. Finally, for the best visible marker as well as the marker that showed the smallest artifact, the authors compared the phantom data with in vivo MR-images in four pancreatic cancer patients. The authors found a strong correlation (Rs = 1.00, p < 0.01) between the volume of low T2 (∗) and the volume with high |ΔB0|. Visibility in clinical MR-images increased with lower T2 (∗). Signal shift artifacts became worse for markers with high |ΔB0|. The marker that was best visible in the phantom, a folded marker with 0.5% iron content, was also visible in vivo, but showed artifacts on diffusion weighted images. The marker with the smallest artifact in the phantom, a small, stretched, ironless marker, was indiscernible on in vivo MR-images. Changes in T2 (∗) and ΔB0 are sequence-independent measures for potential visibility and artifact size, respectively. Improved visibility of markers correlates strongly to signal shift artifacts; therefore, marker choice will depend on the clinical purpose. When visibility of the markers is most important, markers that contain iron are optimal, preferably in a folded configuration. For artifact sensitive imaging, small ironless markers are best, preferably in a stretched configuration

Published
2015

28. Dosimetric effects of anatomical changes during fractionated photon radiation therapy in pancreatic cancer patients.

Author

Horst, Astrid, Houweling, Antonetta C., Tienhoven, Geertjan, Visser, Jorrit, and Bel, Arjan

Subjects
MEDICAL dosimetry, ALTERNATIVE medicine, PHOTON emission, QUANTUM optics, PANCREATIC cancer
Abstract

Pancreatic tumors show large interfractional position variation. In addition, changes in gastrointestinal gas volumes and body contour take place over the course of radiation therapy. We aimed to quantify the effect of these anatomical changes on target dose coverage, for the clinically used fiducial marker-based patient position verification and, for comparison, also for simulated bony anatomy-based position verification. Nine consecutive patients were included in this retrospective study. To enable fraction dose calculations on cone-beam CT ( CBCT), the planning CT was deformably registered to each CBCT (13-15 per patient); gas volumes visible on CBCT were copied to the deformed CT. Fraction doses were calculated for the clinically used 10 MV VMAT treatment plan (with for the planning target volume ( PTV): D98% = 95%), according to fiducial marker-based and bony anatomy-based image registrations. Dose distributions were rigidly summed to yield the accumulated dose. To evaluate target dose coverage, we defined an iCTV+5 mm volume, i.e., the internal clinical target volume ( iCTV) expanded with a 5 mm margin to account for remaining uncertainties including delineation uncertainties. We analyzed D98%, Dmean, and D2% for iCTV+5 mm and PTV (i.e., iCTV plus 10 mm margin). We found that for fiducial marker-based registration, differences between fraction doses and planned dose were minimal. For bony anatomy-based registration, fraction doses differed considerably, resulting in large differences between planned and accumulated dose for some patients, up to a decrease in D98% of the iCTV+5 mm from 95.9% to 85.8%. Our study shows that fractionated photon irradiation of pancreatic tumors is robust against variations in body contour and gastrointestinal gas, with dose coverage only mildly affected. However, as a result of interfractional tumor position variations, target dose coverage can severely decline when using bony anatomy for patient position verification. Therefore, the use of intratumoral fiducial marker-based daily position verification is essential in pancreatic cancer patients. [ABSTRACT FROM AUTHOR]

Published
2017
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30. Functional MRI for radiotherapy dose painting

Author

van der Heide, Uulke A., van der Heide, Uulke A., Houweling, Antonetta C., Groenendaal, Greetje, Beets-Tan, Regina G. H., Lambin, Philippe, van der Heide, Uulke A., van der Heide, Uulke A., Houweling, Antonetta C., Groenendaal, Greetje, Beets-Tan, Regina G. H., and Lambin, Philippe

Abstract

Modem radiation therapy techniques are exceptionally flexible in the deposition of radiation dose in a target volume. Complex distributions of dose can be delivered reliably, so that the tumor is exposed to a high dose, whereas nearby healthy structures can be avoided. As a result, an increase in curative dose is no longer invariably associated with an increased level of toxicity. This modem technology can be exploited further by modulating the required dose in space so as to match the variation in radiation sensitivity in the tumor. This approach is called dose painting. For dose painting to be effective, functional imaging techniques are essential to identify regions in a tumor that require a higher dose. Several techniques are available in nuclear medicine and radiology. In recent years, there has been a considerable research effort concerning the integration of magnetic resonance imaging (MM) into the external radiotherapy workflow motivated by the superior soft tissue contrast as compared to computed tomography. In MRI, diffusion-weighted MRI reflects the cell density of tissue and thus may indicate regions with a higher tumor load. Dynamic contrast-enhanced MM reflects permeability of the microvasculature and blood flow, correlated to the oxygenation of the tumor. These properties have impact on its radiation sensitivity. New questions must be addressed when these techniques are applied in radiation therapy: scanning in treatment position requires alternative solutions to the standard patient setup in the choice of receive coils compared to a diagnostic department. This standard positioning also facilitates repeated imaging. The geometrical accuracy of MR images is critical for high-precision radiotherapy. In particular, when multiparametric functional data are used for dose painting, quantification of functional parameters at a high spatial resolution becomes important. In this review, we will address these issues and describe clinical developments in MRI-gui

Published
2012

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