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19 results on '"Houtgraaf, Jaco H."'

4. Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model

Author

Larsen, Katarína, Cheng, Caroline, Tempel, Dennie, Parker, Sherry, Yazdani, Saami, den Dekker, Wijnand K., Houtgraaf, Jaco H., de Jong, Renate, Swager-ten Hoor, Stijn, Ligtenberg, Erik, Hanson, Stephen R., Rowland, Steve, Kolodgie, Frank, Serruys, Patrick W., Virmani, Renu, and Duckers, Henricus J.

Published
2012
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6. Cardiac function in a long-term follow-up study of moderate and severe porcine model of chronic myocardial infarction

Author

Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Staf Research, Aios en Stafsecr. Cardiologie, De Jong, Renate, van Hout, Gerardus P J, Houtgraaf, Jaco H., Takashima, S., Pasterkamp, Gerard, Höfer, Imo E., Duckers, Henricus J., Experimentele Afd. Cardiologie 1, Onderzoek Vrouw Hart & Vaatziekten, Circulatory Health, CDL Staf Research, Aios en Stafsecr. Cardiologie, De Jong, Renate, van Hout, Gerardus P J, Houtgraaf, Jaco H., Takashima, S., Pasterkamp, Gerard, Höfer, Imo E., and Duckers, Henricus J.

Published
2015

8. Efficiency of Statin Treatment on EPC Recruitment Depends on Baseline EPC Titer and Does Not Improve Angiographic Outcome in Coronary Artery Disease Patients Treated with the Genous™ Stent

Author

Den Dekker, Wijnand K., primary, Houtgraaf, Jaco H., additional, Rowland, Stephen M., additional, Ligtenberg, Erik, additional, De Boer, Sanneke P. M., additional, De Jong, Renate, additional, De Winter, Robbert J., additional, Den Heijer, Peter, additional, Zijlstra, Felix, additional, Serruys, Patrick W., additional, Cheng, Caroline, additional, and Duckers, Henricus J., additional

Published
2014
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9. Intracoronary Infusion of Encapsulated Glucagon-Like Peptide-1–Eluting Mesenchymal Stem Cells Preserves Left Ventricular Function in a Porcine Model of Acute Myocardial Infarction

Author

de Jong, Renate, primary, van Hout, Gerardus P.J., additional, Houtgraaf, Jaco H., additional, Kazemi, Kushan, additional, Wallrapp, Christine, additional, Lewis, Andrew, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, and Duckers, Henricus J., additional

Published
2014
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11. Intracoronary Infusion of Allogeneic Mesenchymal Precursor Cells Directly After Experimental Acute Myocardial Infarction Reduces Infarct Size, Abrogates Adverse Remodeling, and Improves Cardiac Function

Author

Houtgraaf, Jaco H., primary, de Jong, Renate, additional, Kazemi, Kushan, additional, de Groot, Daphne, additional, van der Spoel, Tycho I.G., additional, Arslan, Fatih, additional, Hoefer, Imo, additional, Pasterkamp, Gerard, additional, Itescu, Silviu, additional, Zijlstra, Felix, additional, Geleijnse, Marcel L., additional, Serruys, Patrick W., additional, and Duckers, Henricus J., additional

Published
2013
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12. Feasibility of Intracoronary GLP-1 Eluting CellBead™ Infusion in Acute Myocardial Infarction

Author

Houtgraaf, Jaco H., primary, De Jong, Renate, additional, Monkhorst, Kim, additional, Tempel, Dennie, additional, Van De Kamp, Esther, additional, Den Dekker, Wijnand K., additional, Kazemi, Kushan, additional, Hoefer, Imo, additional, Pasterkamp, Gerard, additional, Lewis, Andrew L., additional, Stratford, Peter W., additional, Wallrapp, Christine, additional, Zijlstra, Felix, additional, and Duckers, Henricus J., additional

Published
2013
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13. Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs

Author

Arslan, Fatih, primary, Houtgraaf, Jaco H., additional, Keogh, Brian, additional, Kazemi, Kushan, additional, de Jong, Renate, additional, McCormack, William J., additional, O'Neill, Luke A.J., additional, McGuirk, Peter, additional, Timmers, Leo, additional, Smeets, Mirjam B., additional, Akeroyd, Lars, additional, Reilly, Mary, additional, Pasterkamp, Gerard, additional, and de Kleijn, Dominique P.V., additional

Published
2012
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14. First Experience in Humans Using Adipose Tissue–Derived Regenerative Cells in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction

Author

Houtgraaf, Jaco H., primary, den Dekker, Wijnand K., additional, van Dalen, Bas M., additional, Springeling, Tirza, additional, de Jong, Renate, additional, van Geuns, Robert J., additional, Geleijnse, Marcel L., additional, Fernandez-Aviles, Francisco, additional, Zijlsta, Felix, additional, Serruys, Patrick W., additional, and Duckers, Henricus J., additional

Published
2012
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15. Final results of the HEALING IIB trial to evaluate a bio-engineered CD34 antibody coated stent (Genous™Stent) designed to promote vascular healing by capture of circulating endothelial progenitor cells in CAD patients

Author

den Dekker, Wijnand K., primary, Houtgraaf, Jaco H., additional, Onuma, Yoshinobu, additional, Benit, Edouard, additional, de Winter, Robbert J., additional, Wijns, William, additional, Grisold, Manfred, additional, Verheye, Stephan, additional, Silber, Sigmund, additional, Teiger, Emmanuel, additional, Rowland, Stephen M., additional, Ligtenberg, Erik, additional, Hill, Jonathan, additional, Wiemer, Marcus, additional, den Heijer, Peter, additional, Rensing, Benno J., additional, Channon, Keith M., additional, Serruys, Patrick W.J.C., additional, and Duckers, Henricus J., additional

Published
2011
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16. Capture of circulatory endothelial progenitor cells and accelerated re-endothelialization of a bio-engineered stent in human ex vivo shunt and rabbit denudation model

Author

Larsen, Katarína, primary, Cheng, Caroline, additional, Tempel, Dennie, additional, Parker, Sherry, additional, Yazdani, Saami, additional, den Dekker, Wijnand K., additional, Houtgraaf, Jaco H., additional, de Jong, Renate, additional, Swager-ten Hoor, Stijn, additional, Ligtenberg, Erik, additional, Hanson, Stephen R., additional, Rowland, Steve, additional, Kolodgie, Frank, additional, Serruys, Patrick W., additional, Virmani, Renu, additional, and Duckers, Henricus J., additional

Published
2011
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17. Advancement of Mesenchymal Stem Cell Therapy in Solid Organ Transplantation (MISOT)

Author

Hoogduijn, Martin J., primary, Popp, Felix C., additional, Grohnert, Anja, additional, Crop, Meindert J., additional, van Rhijn, Marieke, additional, Rowshani, Ajda T., additional, Eggenhofer, Elke, additional, Renner, Philipp, additional, Reinders, Marlies E., additional, Rabelink, Ton J., additional, van der Laan, Luc J. W., additional, Dor, Frank J. M. F., additional, IJzermans, Jan N. M., additional, Genever, Paul G., additional, Lange, Claudia, additional, Durrbach, Antoine, additional, Houtgraaf, Jaco H., additional, Christ, Bruno, additional, Seifert, Martina, additional, Shagidulin, Murat, additional, Donckier, Vincent, additional, Deans, Robert, additional, Ringden, Olle, additional, Perico, Norberto, additional, Remuzzi, Giuseppe, additional, Bartholomew, Amelia, additional, Schlitt, Hans J., additional, Weimar, Willem, additional, Baan, Carla C., additional, and Dahlke, Marc H., additional

Published
2010
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18. Feasibility of Intracoronary GLP-1 Eluting CellBead™Infusion in Acute Myocardial Infarction

Author

Houtgraaf, Jaco H., De Jong, Renate, Monkhorst, Kim, Tempel, Dennie, Van De Kamp, Esther, Den Dekker, Wijnand K., Kazemi, Kushan, Hoefer, Imo, Pasterkamp, Gerard, Lewis, Andrew L., Stratford, Peter W., Wallrapp, Christine, Zijlstra, Felix, and Duckers, Henricus J.

Abstract

Cell therapy is a field of growing interest in the prevention of post acute myocardial infarction (AMI) heart failure. Stem cell retention upon local delivery to the heart, however, is still unsatisfactory. CellBeads were recently developed as a potential solution to this problem. CellBeads are 170-μm alginate microspheres that contain mesenchymal stem cells (MSCs) genetically modified to express glucagon-like peptide-1 (GLP-1) supplementary to inherent paracrine factors. GLP-1 is an incretin hormone that has both antiapoptotic and cardioprotective effects. Transplanting CellBeads in the post-AMI heart might induce cardiomyocyte salvage and ultimately abrogate adverse cardiac remodeling. We aimed to investigate the feasibility of intracoronary infusion of CellBeads in a large animal model of AMI. Four pigs were used in a pilot study to assess the maximal safe dose of CellBeads. In the remaining 21 animals, an AMI was induced by balloon occlusion of the left circumflex coronary artery for 90 min. During reperfusion, 60,000 CellBeads (n= 11), control beads (n= 4), or lactated Ringers' (n= 6) were infused. Animals were sacrificed after 2 or 7 days, and the hearts were excised for histological analyses. Intracoronary infusion did not permanently affect coronary flow in any of the groups. Histological analysis revealed CellBeads containing viable MSCs up to 7 days. Viability and activity of the MSCs was confirmed by qPCR analysis that showed expression of recombinant GLP-1 and human genes after 2 and 7 days. CellBeads reduced inflammatory infiltration by 29% (p= 0.001). In addition, they decreased the extent of apoptosis by 25% (p= 0.001) after 2 days. We show that intracoronary infusion of 5 million encapsulated MSCs is safe and feasible. Also, several parameters indicate that the cells have paracrine effects, suggesting a potential therapeutic benefit of this new approach.

Published
2013
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19. Endothelial progenitor cell (EPC) capture to aid vascular repair following coronary stenting: a new frontier in stent technology?

Author

Houtgraaf JH and Duckers HJ

Subjects
Anti-Inflammatory Agents administration & dosage, Anti-Inflammatory Agents therapeutic use, Coronary Disease prevention & control, Coronary Disease surgery, Coronary Vessels pathology, Coronary Vessels surgery, Drug-Eluting Stents adverse effects, Endothelium, Vascular cytology, Equipment Design, Humans, Immunosuppressive Agents administration & dosage, Immunosuppressive Agents therapeutic use, Regeneration drug effects, Regeneration physiology, Stem Cells cytology, Wound Healing drug effects, Wound Healing physiology, Drug-Eluting Stents trends
Published
2008

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