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1. Beneath HMGA2 alterations in pleomorphic adenomas: Pathological, immunohistochemical, and molecular insights

Author

Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A.Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F.R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A.Lasne, Le Tourneau, C., Lefebvre, G., Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A., Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., J.-M.Prades, Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Siegfried, A., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., J.Thariat, David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., Wong, S., Alsugair, Ziyad, Lépine, Charles, Descotes, Françoise, Lanic, Marie-Delphine, Pissaloux, Daniel, Tirode, Franck, Lopez, Jonathan, Céruse, Philippe, Philouze, Pierre, Fieux, Maxime, Wassef, Michel, Baglin, Anne-Catherine, Mihaela, Onea, Castain, Claire, Sudaka, Anne, Uro-Coste, Emmanuelle, Champagnac, Anne, Costes-Martineau, Valérie, Laé, Marick, and Benzerdjeb, Nazim

Published
2024
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2. Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1: PLAG1 Gene Fusion

Author

Alsugair, Ziyad, Perrot, Jimmy, Descotes, Françoise, Lopez, Jonathan, Champagnac, Anne, Pissaloux, Daniel, Castain, Claire, Onea, Mihaela, Céruse, Philippe, Philouze, Pierre, Lépine, Charles, Lanic, Marie-Delphine, Laé, Marick, Costes-Martineau, Valérie, Benzerdjeb, Nazim, Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A. Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F. R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A. Lasne, Le Tourneau, C., Lefebvre, G, Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A, Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., Prades, J.-M., Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., Thariat, J., David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., and Wong, S.

Published
2024
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3. Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: A multicentric propensity score-based analysis

Author

Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Bettoni, J., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Bozorg Grayeli, A., Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Classe, M., Clatot, F., Colin, E., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Espitalier, F., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F.R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Lacau Saint Guily, J., Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Lasne Cardon, A., Le Tourneau, C., Lefebvre, G., Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A., Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Pham Dang, N., Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., Prades, J.-M., Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., Thariat, J., Timar David, M., Timochenko, A., Toussaint, B., Uro Coste, E., Valette, G., Van den Abbeele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., Wong, S., Chatelet, Florian, Chevret, Sylvie, Fakhry, Nicolas, Even, Caroline, Malard, Olivier, de Monès, Erwan, Saroul, Nicolas, Mouawad, François, de Boutray, Marie, Mauvais, Olivier, Vergez, Sébastien, Evrard, Diane, Righini, Christian, Schultz, Philippe, Baudouin, Robin, Poissonnet, Gilles, Atallah, Sarah, Haroun, Fabienne, Morinière, Sylvain, Evrard, Camille, Philouze, Pierre, Paasche, Agnès, Lesnik, Maria, Lelonge, Yann, Herman, Philippe, and Verillaud, Benjamin

Published
2024
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4. Characterization of a Molecularly Distinct Subset of Oncocytic Pleomorphic Adenomas/Myoepitheliomas Harboring Recurrent ZBTB47-AS1::PLAG1Gene Fusion

Author

Alsugair, Ziyad, Perrot, Jimmy, Descotes, Françoise, Lopez, Jonathan, Champagnac, Anne, Pissaloux, Daniel, Castain, Claire, Onea, Mihaela, Céruse, Philippe, Philouze, Pierre, Lépine, Charles, Lanic, Marie-Delphine, Laé, Marick, Costes-Martineau, Valérie, Benzerdjeb, Nazim, Ala-Eddine, C., Aubry, K., Babin, E., Bach, C., Badoual, C., Baglin, A.C., Barry, B., Bastit, V., Baujat, B., Benezery, K., Bensadoun, R.J., Benzerdjeb, N., Bernadach, M., Bertolus, C., Biet, A., Bodmer, D., Boisselier, P., Boulagnon-Rombi, C., Bozec, L., Grayeli, A. Bozorg, Brenet, E., Brugel, L., Calais, G., Calugaru, V., Camby, S., Casiraghi, O., Cassagnau, E., Castain, C., Castelli, J., Ceruse, P., Chabolle, F., Chevalier, D., Choussy, O., Clatot, F., Constans, J.M., Coste, A., Coste, F., Costes, V., Cottier, J.P., Coutte, A., Cristofari, J.P., Cupissol, D., Delgrande, J., Delord, J.P., Devauchelle, B., Digue, L., Dolivet, G., Doré, M., Duflo, S., Dufour, X., Dupin, C., Eker, E., Even, C., Evrard, C., Fabiano, E., Faivre, S., Fakhry, N., Ferrand, F. R., Frandon, J., Franetti, D., de Gabory, L., Galy, C., Garcier, M., Garrel, R., Gauthier, H., Gilain, L., Guihard, S., Guillerm, S., Halimi, C., Hans, S., Herman, P., Houessinon, A., Hourseau, M., Huguet, F., Jadaud, E., Jankowski, R., Jeanne, C., Jegoux, F., Juliéron, M., Kaci, R., Kaminsky, M.-C., de Kermadec, H., Kolb, F., Kreps, S., Laadhari, M., Saint Guily, J. Lacau, Laccoureye, L., Lae, M., Lagarde, F., Lagrange, A., Lallemant, B., Lamuraglia, M., Lang, P., Lapeyre, M., Lapierre, A., Cardon, A. Lasne, Le Tourneau, C., Lefebvre, G, Lefevre, M., Lelonge, Y., Leroy, X., Lesnik, M., Liem, X., Linassier, C., Maingon, P., Majoufre, C., Malard, O., Malouf, G., Marchand, C., Marie, J.-P., Maurina, T., Mauvais, O., Merol, J.-C., Michel, J., Mineur, G., Mirafzal, S., Mirghani, H., Modesto, A., Molinier-Blossier, S., de Monès, E., Morinière, S., Mouawad, F., Moya-Plana, A, Muller, L., Musat, E., Nguyen, F., Noel, G., Obongo-Anga, F.R., Onea, M., Orliac, H., Page, C., Patron, V., Pestre, J., Dang, N. Pham, Philouze, P., Poissonnet, G., Pons, C., Pouliquen, C., Prades, J.-M., Prevost, A., Queiros, C., Rahmani, A., Rambeau, A., Ramin, L., Renard, S., Righini, C.A., Rolland, F., Saada, E., Sacino, F., Salas, S., Saroul, N., Schultz, P., Simonaggio, A., Sterkers, O., Strunski, V., Sudaka, A., Xu-Shan, S., Taouachi, R., Tassart, M., Testelin, S., Thariat, J., David, M. Timar, Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbele, T., Varoquaux, A., Vauleon, E., Vergez, S., Verillaud, B., Villa, J., Villepelet, A., Volondat, M., Vulquin, N., Wagner, I., Wassef, M., Webert, L., and Wong, S.

Abstract

Recurrent gene fusions are common in salivary gland tumors including benign tumors, such as pleomorphic adenoma (PA) and myoepithelioma (ME). In cases where chromosomal rearrangement is identified in the pleomorphic adenoma gene 1 (PLAG1)gene, different gene partners are found. Oncocytic metaplasia, characterized by oncocytes with abundant eosinophilic granular cytoplasm and hyperchromatic nuclei, is a well-known phenomenon in salivary gland neoplasms. However, the pure oncocytic variant of PA/ME showed PLAG1gene rearrangements involving various gene partners at the molecular level, without any recurrent fusion being found. Our study includes 20 cases of PA/ME, with 11 females and 9 males. The age of patients ranged from 37 to 96 years, with a median age of 62.8 years. Most tumors originate from the parotid gland. The median size of the tumor was 26.5 mm (range: 13 to 60 mm). Among the 20 cases, 14 were a pure oncocytic variant of PA/ME, whereas 6 cases showed focal oncocytic or oncocytic-like aspects. Molecular studies on 20 cases of PA/ME were conducted. A novel recurrent ZBTB47-AS1::PLAG1fusion was identified in 6 of 12 cases with pure oncocytic metaplasia, whereas the other cases had PLAG1gene fusion with different gene partners. The transcriptomic analysis of the cases harboring ZBTB47-AS1::PLAG1fusion demonstrated that these tumors have a distinct molecular profile from conventional PA/ME. This study reveals a unique subset in the oncocytic PA/ME spectrum characterized by pure oncocytic morphology with larger oncocytic cells and recurrent ZBTB47-AS1::PLAG1fusion. It also highlights the transcriptomic distinctness of salivary gland adenomas with pure oncocytic metaplasia in the spectrum of salivary gland neoplasms. Further studies are needed to better understand the oncocytic variant of PA/ME and to determine the true nature of oncocytic cells in PA/ME.

Published
2024
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5. High levels of HPV16-L1 antibody but not HPV16 DNA load or integration predict oropharyngeal patient outcome: The Papillophar study

Author

Prétet, Jean-Luc, Dalstein, Véronique, Touzé, Antoine, Beby-Defaux, Agnès, Soussan, Patrick, Jacquin, Élise, Birembaut, Philippe, Clavel, Christine, Mougin, Christiane, Rousseau, Alexandra, Lacau Saint Guily, Jean, Agius, G., Albert, S., Babin, E., Badet, J., Badoual, C., Baglin, A., Blanc-Fournier, K., Cassagneau, E., Debry, C., de Raucourt, D., Diebold, M., Dufour, X., Hourseau, M., Lacave, R., Zalcman, E. Lechapt, Lefevre, M., Levillain, P., Malard, O., Mauvais, O., Mechine, A., Merol, J., Mirghani, H., Morinière, S., Périé, S., Rousselot, C., Simon, T., Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Reims (CHU Reims), Infectiologie et Santé Publique (UMR ISP), Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC), Université de Poitiers, Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Service de virologie [Hôpital Tenon], CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (RIGHT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Université de Franche-Comté (UFC), Unité de Recherche Clinique de l’Est Parisien [CHU Saint-Antoine] (URC-EST), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO)-CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Direction de la Recherche Clinique et de l'Innovation [AP-HP] (DRCI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Oto-Rhino-Laryngologie Chirurgie cervico-faciale [CHU Tenon], Fondation Ophtalmologique Adolphe de Rothschild [Paris], and This work was funded by the Programme Hospitalier de Recherche Clinique, French Ministry of Health (Grant Numbers AOM 08104, AOM 11 293).

Subjects
stomatognathic diseases, Oropharyngeal cancer, viruses, [SDV]Life Sciences [q-bio], virus diseases, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biomarker, General Medicine, Papillomavirus, Prognosis, neoplasms, female genital diseases and pregnancy complications, General Biochemistry, Genetics and Molecular Biology
Abstract

International audience; The incidence of oropharyngeal cancers (OPC) is increasing in the world. Among OPC, those induced by human papillomaviruses have a better prognosis than non-HPV-associated OPC. The objective of this study was to highlight the relevance of HPV16 load, HPV16 DNA integration and HPV16-L1 serology on progression-free survival and overall survival of OPC patients. The PAPILLOPHAR cohort consists of 362 patients with oropharyngeal squamous cell carcinomas prospectively followed up for 5 years after treatment. Tumor biopsies and sera were collected at inclusion to investigate tumor HPV DNA/RNA characteristics and HPV16 L1 serology, respectively. Twenty-seven percent of tumor biopsies were HPV DNA- and RNA-positive and HPV16 represented 93% of HPV-positive cases. Among them, neither HPV16 viral load nor HPV16 DNA integration was associated with overall survival (OS) or progression-free survival (PFS). In contrast, high anti-HPV16 L1 antibody titers were significantly associated with a better OS and PFS. This study reveals that HPV16 load and integration are not relevant prognosis biomarkers in OPC patients. Clinical Relevance: High levels of HPV16 L1 antibodies may be useful to predict OPC patient outcome following treatment. ClinicalTrials.gov Identifier: NCT00918710, May 2017.

Published
2021
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11. CO-41: Après bypass gastrique, l'anse alimentaire devient hyperplasique et « glucophage » et contribuerait à l'amélioration précoce de l'homéostasie glucidique

Author

Cavin, J., primary, Couvelard, A., additional, Lebtahi, R., additional, Ducroc, R., additional, Arapis, K., additional, Voitellier, E., additional, Cluzeaud, F., additional, Gillard, L., additional, Hourseau, M., additional, Mikail, N., additional, Ribeiro-Parenti, L., additional, Kapel, N., additional, Marmuse, J., additional, Bado, A., additional, and Le Gall, M., additional

Published
2016
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21. Dupilumab-induced rhinitis in severe asthma patients: A case series.

Author

Fenech G, Hourseau M, Cristofari JP, Dupin C, and Taillé C

Subjects
Humans, Female, Male, Middle Aged, Adult, Rhinitis chemically induced, Rhinitis drug therapy, Severity of Illness Index, Anti-Asthmatic Agents adverse effects, Anti-Asthmatic Agents therapeutic use, Aged, Antibodies, Monoclonal, Humanized adverse effects, Antibodies, Monoclonal, Humanized therapeutic use, Asthma drug therapy, Asthma chemically induced
Abstract

Competing Interests: Declaration of Competing Interest Camille Taillé reports grants from GSK, Sanofi, AstraZeneca; consulting fees from GSK, AstraZeneca, Sanofi, Novartis, Chiesi, outside the present manuscript. The rest of the authors declare that they have no relevant conflicts of interest.

Published
2024
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23. [Fusion genes in salivary gland tumors].

Author

Laé M, Lanic MD, Lépine C, Hourseau M, Benzerdjeb N, Uro-Coste E, and Costes-Martineau V

Abstract

Salivary gland tumors represent a diagnostic challenge for pathologists due to their rarity, their very wide histopathological and immuno-phenotypic spectrum, and the recent identification of new entities. This article presents the main molecular characteristics of these tumors in order to allow any pathologist to perceive the diagnostic tracks of these ENT tumors and to better guide the molecular approach to establish the diagnosis and guide therapy., (Copyright © 2024. Published by Elsevier Masson SAS.)

Published
2024
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24. Paraneoplastic pemphigus uncovers distinct clinical and biological phenotypes of western unicentric Castleman disease.

Author

Dieudonné Y, Silvestrini MA, Dossier A, Meignin V, Jouenne F, Mahévas T, Bouaziz JD, Jackson MA, Mordant P, Poirot J, Onodi F, Calvani J, Hourseau M, Evrard D, Berisha M, Perrin F, Danel C, Borie R, Galicier L, Mourah S, Bengoufa D, Oksenhendler E, Grootenboer-Mignot S, and Boutboul D

Subjects
Humans, Autoantibodies, Pemphigus diagnosis, Pemphigus etiology, Castleman Disease pathology, Myasthenia Gravis diagnosis, Paraneoplastic Syndromes etiology, Paraneoplastic Syndromes diagnosis
Abstract

Unicentric Castleman disease (UCD) is a lymphoproliferative disease of unknown cause. Paraneoplastic pemphigus (PNP) is a major complication shown to be associated with a poor prognosis, with particular severity in patients with bronchiolitis obliterans (BO). This study describes the clinical and biological characteristics of UCD-PNP patients in a large Western cohort. A total of 148 patients diagnosed with UCD were identified, including 14 patients with a defined PNP. PNP was significantly associated with myasthenia gravis (MG) and FDC sarcoma during follow-up (FDCS). PNP was also significantly associated with reduced survival. These data, together with a multivariate analysis by principal components, led to the identification of UCD-PNP as a group at risk of MG, FDCS and death. PDGFRB sequencing performed on UCD lesions from six patients found the gain-of-function p.N666S variant in two. Interestingly, both patients had hyaline-vascular UCD subtype, were in the UCD-PNP subgroup and had FDCS. Sera from 25 UCD-PNP patients and 6 PNP patients without UCD were tested for PNP-associated autoantibodies. Sera from UCD-PNP patients had a strong reactivity against the N-terminal domain of recombinant periplakin (rPPL, 82%) and showed reactivity against at least two domains of rPPL. These features were not found in patients with UCD alone or in the PNP group without UCD. These data indicate that UCD-PNP patients belong to a subgroup sharing strong clinical and biological identity that might help to decipher the different dynamics of UCD natural history., (© 2023 British Society for Haematology and John Wiley & Sons Ltd.)

Published
2023
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25. No Long-Term Mucosal Lesions in the Esophagus but More Gastric Mucosal Lesions after Sleeve Gastrectomy in Obese Rats.

Author

Coupaye M, Ribeiro-Parenti L, Baratte C, Hourseau M, Willemetz A, Duboc H, Ledoux S, Bado A, Couvelard A, and Le Gall M

Abstract

Sleeve gastrectomy (SG) often induces gastroesophageal reflux, with few and discordant long-term data on the risk of Barrett's esophagus (BE) in operated patients. The aim of this study was to analyze the impact of SG on esogastric mucosa in a rat model at 24 weeks postoperatively, which corresponds to approximately 18 years in humans. After 3 months of a high-fat diet, obese male Wistar rats were subjected to SG (n = 7) or sham surgery (n = 9). Esophageal and gastric bile acid (BA) concentrations were measured at sacrifice, at 24 weeks postoperatively. Esophageal and gastric tissues were analyzed by routine histology. The esophageal mucosa of the SG rats (n = 6) was not significantly different in comparison to that of the sham rats (n = 8), with no esophagitis or BE. However, there was more antral and fundic foveolar hyperplasia in the mucosa of the residual stomach 24 weeks after SG than in the sham group ( p < 0.001). Luminal esogastric BA concentrations did not differ between the two groups. In our study, SG induced gastric foveolar hyperplasia but no esophageal lesions at 24 weeks postoperatively in obese rats. Therefore, long-term endoscopic esophageal follow-up that is recommended in humans after SG to detect BE may also be useful for detecting gastric lesions.

Published
2023
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27. [Histiocytosis of Rosai-Dorfman-Destombes extranodal of the jawbone: Report of a case and review of the literature].

Author

Vaquier L, Abitbol C, Emile JF, Dossier A, Guyard A, and Hourseau M

Subjects
Histiocytes pathology, Humans, Lymph Nodes pathology, Skin pathology, Histiocytosis pathology, Histiocytosis, Sinus diagnosis, Histiocytosis, Sinus pathology
Abstract

Rosai-Dorfman-Destombes histiocytosis is a rare histiocytosis characterized by an accumulation of histiocytes within the tissues. It is a heterogeneous entity with various clinical phenotypes: isolated lymph nodes, in association with extranodal involvement, autoimmune disease or neoplasm. These extra nodal lesions mainly affect the skin, the nasal cavity, orofacial sinuses, or are lytic bone lesions or even damage to the central nervous system. The diagnosis is histopathological. We present here the case of a histiocytosis of Rosai-Dorfman-Destombes in a 46-year-old patient with a lesion of the left palate. Our observation discuss the diagnostic hypotheses in front of a lytic lesion of the ENT sphere predominantly histiocytic., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

Published
2022
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28. A 29-Year-Old Man With an Osteolytic Rib Lesion.

Author

Berleur M, Chapuis E, Debray MP, Pellenc Q, Hourseau M, Papo T, and Sacré K

Subjects
Adult, Diagnosis, Differential, Drug Therapy, Combination, Humans, Male, Antitubercular Agents therapeutic use, Ribs, Tuberculosis, Osteoarticular diagnosis, Tuberculosis, Osteoarticular drug therapy
Abstract

Case Presentation: A 29-year-old man with no significant medical history presented to the ED with a 4-week history of chest pain. The pain was insidious, located on the right side of the chest, increased by deep breathing, and incompletely alleviated by acetaminophen. The patient had never smoked tobacco. He denied any recent fevers, chills, dyspnea, cough, night sweats, hemoptysis, or history of trauma but had lost at least 8 kg in the past 6 months. The patient was from Morocco and had lived in France for 1 year., (Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)

Published
2021
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29. Bariatric surgery induces a new gastric mucosa phenotype with increased functional glucagon-like peptide-1 expressing cells.

Author

Ribeiro-Parenti L, Jarry AC, Cavin JB, Willemetz A, Le Beyec J, Sannier A, Benadda S, Pelletier AL, Hourseau M, Léger T, Morlet B, Couvelard A, Anini Y, Msika S, Marmuse JP, Ledoux S, Le Gall M, and Bado A

Subjects
1-Methyl-3-isobutylxanthine pharmacology, Adult, Amino Acid Sequence, Animals, Diet, High-Fat, Female, Glucagon-Like Peptide 1 chemistry, Glucose metabolism, Humans, Male, Middle Aged, Obesity pathology, Phenotype, Rats, Wistar, Rats, Bariatric Surgery, Gastric Mucosa metabolism, Gastric Mucosa pathology, Glucagon-Like Peptide 1 metabolism
Abstract

Glucagon-Like Peptide-1 (GLP-1) undergoes rapid inactivation by dipeptidyl peptidase-4 (DPP4) suggesting that target receptors may be activated by locally produced GLP-1. Here we describe GLP-1 positive cells in the rat and human stomach and found these cells co-expressing ghrelin or somatostatin and able to secrete active GLP-1 in the rats. In lean rats, a gastric load of glucose induces a rapid and parallel rise in GLP-1 levels in both the gastric and the portal veins. This rise in portal GLP-1 levels was abrogated in HFD obese rats but restored after vertical sleeve gastrectomy (VSG) surgery. Finally, obese rats and individuals operated on Roux-en-Y gastric bypass and SG display a new gastric mucosa phenotype with hyperplasia of the mucus neck cells concomitant with increased density of GLP-1 positive cells. This report brings to light the contribution of gastric GLP-1 expressing cells that undergo plasticity changes after bariatric surgeries, to circulating GLP-1 levels.

Published
2021
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30. A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors.

Author

Atallah S, Casiraghi O, Fakhry N, Wassef M, Uro-Coste E, Espitalier F, Sudaka A, Kaminsky MC, Dakpe S, Digue L, Bouchain O, Morinière S, Hourseau M, Bertolus C, Jegoux F, Thariat J, Calugaru V, Schultz P, Philouze P, Mauvais O, Righini CA, Badoual C, Saroul N, Goujon JM, Marie JP, Taouachi R, Brenet E, Aupérin A, and Baujat B

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Adenoid Cystic pathology, Carcinoma, Adenoid Cystic therapy, Cohort Studies, Disease Progression, Female, France epidemiology, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Humans, Male, Middle Aged, Prognosis, Progression-Free Survival, Prospective Studies, Risk Factors, Salivary Gland Neoplasms diagnosis, Salivary Gland Neoplasms epidemiology, Salivary Gland Neoplasms pathology, Salivary Gland Neoplasms therapy, Survival Analysis, Young Adult, Carcinoma, Adenoid Cystic diagnosis, Carcinoma, Adenoid Cystic epidemiology, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms epidemiology
Abstract

Background: Adenoid cystic carcinoma (ACC) accounts for 1% of malignant head and neck tumours [1] and 10% of salivary glands malignant tumours. The main objective of our study is to investigate the prognostic factors influencing the event-free survival (EFS) of patients with ACC., Patients and Methods: A multicentre prospective study was conducted from 2009 to 2018. All 470 patients with ACC whose survival data appear in the REFCOR database were included in the study. The main judgement criterion was EFS. Both a bivariate survival analysis using log-rank test and a multivariate using Cox model were performed using the R software., Results: Average age was 55 years. Females accounted for 59.4% of the cohort. The body mass index (BMI) was normal in 86% of cases. Tumours were located in minor salivary glands in 60% of cases. T3/T4 stages represented 58%; 89% of patients were cN0. histological grade III was observed on 21% of patients. The EFS and overall 5-year survival rates were 50% and 85%, respectively. After adjustment, the most significant pejorative prognostic factors were age ≥65 years (hazard ratio [HR] = 1.67), BMI<16.5 (HR = 2.62), and lymph node invasion cN (HR = 2.08)., Conclusion: Age, BMI and N stage are the three main clinical prognostic factors determining EFS identified in this prospective series of patients with ACC. Such findings open new research perspectives on the influence of these components on initial patient care., (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Published
2020
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31. Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model.

Author

Siebert M, Ribeiro-Parenti L, Nguyen ND, Hourseau M, Duchêne B, Humbert L, Jonckheere N, Nuel G, Chevallier JM, Duboc H, Rainteau D, Msika S, Kapel N, Couvelard A, Bado A, and Le Gall M

Subjects
Animals, Chronic Disease, Hyperplasia etiology, Hyperplasia metabolism, Hyperplasia pathology, Hyperplasia physiopathology, Rats, Rats, Wistar, Bile Reflux etiology, Bile Reflux metabolism, Bile Reflux pathology, Bile Reflux physiopathology, Esophageal Mucosa metabolism, Esophageal Mucosa pathology, Esophageal Mucosa physiopathology, Esophagitis etiology, Esophagitis metabolism, Esophagitis pathology, Esophagitis physiopathology, Gastric Bypass adverse effects, Gastric Mucosa metabolism, Gastric Mucosa pathology, Gastric Mucosa physiopathology, Models, Biological, Obesity, Morbid metabolism, Obesity, Morbid pathology, Obesity, Morbid physiopathology, Obesity, Morbid surgery, Postoperative Complications metabolism, Postoperative Complications pathology, Postoperative Complications physiopathology
Abstract

Although bariatric surgery is proven to sustain weight loss in morbidly obese patients, long-term adverse effects have yet to be fully characterized. This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. We evaluated the influence of biliopancreatic limb (BPL) length, malabsorption, and bile acid (BA) reflux on esogastric mucosa. After 30 weeks of follow-up, Wistar rats operated on RYGB, OAGB with a short BPL (15 cm, OAGB-15), or a long BPL (35 cm, OAGB-35), and unoperated rats exhibit no cases of esogastric cancer, metaplasia, dysplasia, or Barrett's esophagus. Compared to RYGB, OAGB-35 rats presented higher rate of esophagitis, fundic gastritis and perianastomotic foveolar hyperplasia. OAGB-35 rats also revealed the greatest weight loss and malabsorption. On the contrary, BA concentrations were the highest in the residual gastric pouch of OAGB-15 rats. Yet, no association could be established between the esogastric lesions and malabsorption, weight loss, or gastric bile acid concentrations. In conclusion, RYGB results in a better long-term outcome than OAGB, as chronic signs of biliary reflux or reactional gastritis were reported post-OAGB even after reducing the BPL length in a preclinical rat model.

Published
2020
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32. [Acinic cell carcinoma: an unsuspected malignancy of the nasal cavity].

Author

Nassereddine H, Cristofari JP, Halimi C, Couvelard A, Guyard A, and Hourseau M

Subjects
Adult, Biopsy, Female, Humans, Magnetic Resonance Imaging, Carcinoma, Acinar Cell diagnostic imaging, Carcinoma, Acinar Cell pathology, Nasal Cavity diagnostic imaging, Nasal Cavity pathology, Nasal Septum diagnostic imaging, Nasal Septum pathology, Nose Neoplasms diagnostic imaging, Nose Neoplasms pathology, Salivary Gland Neoplasms diagnostic imaging, Salivary Gland Neoplasms pathology
Abstract

Acinic cell carcinoma (ACC) is a low grade malignant tumor of the salivary glands. Primary ACC affects most frequently the parotid gland and can rarely arise in the minor salivary glands of the oral cavity, pharynx and larynx. It is extremely rare in the nasal cavity; to our knowledge only 18 cases of primary ACC of the nasal cavity are reported in the English-written literature. Herein we report a case of acinic cell carcinoma of the nasal cavity, describe the clinical, radiological and microscopic features of this uncommon presentation and finally provide a discussion in the light of relevant literature., (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)

Published
2020
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33. A 22-Year-Old Woman With Fever, Palpitations, and a Cardiac Mass.

Author

Richebé P, Roriz M, Langlais J, Sinigaglia M, Mahdjoub E, Hourseau M, Papo T, and Sacré K

Subjects
Arrhythmias, Cardiac diagnostic imaging, Female, Fever diagnostic imaging, France, Humans, Magnetic Resonance Imaging, Pericarditis, Tuberculous complications, Positron Emission Tomography Computed Tomography, Tuberculoma complications, Young Adult, Arrhythmias, Cardiac etiology, Fever etiology, Pericarditis, Tuberculous diagnosis, Tuberculoma diagnosis
Abstract

Case Presentation: A 22-year-old woman was admitted to our department for fever of unknown origin. The patient reported intermittent fever and nonspecific abdominal pain for several years. Six months before admission she started complaining of palpitations and exertional dyspnea. She had no weight loss, chest pain, headache, or joint complaints. Medical history was unremarkable. She did not consume tobacco, alcohol, or illicit drugs. The patient was from Malia. She had lived in France for 4 years and did not report recent travel., (Copyright © 2019 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)

Published
2019
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34. [Diagnostic and treatment pitfalls and guidelines for variants of squamous cell carcinomas of the head and neck: on behalf of the REFCOR].

Author

Thariat J, Hourseau M, Baglin AC, Digue L, Vulquin N, Badoual C, Baujat B, Janot F, Ferrand FR, and Barry B

Subjects
Carcinoma, Adenosquamous diagnosis, Carcinoma, Adenosquamous pathology, Carcinoma, Adenosquamous therapy, Carcinoma, Papillary diagnosis, Carcinoma, Papillary pathology, Carcinoma, Papillary therapy, Carcinoma, Verrucous diagnosis, Carcinoma, Verrucous pathology, Carcinoma, Verrucous therapy, Diagnosis, Differential, Diagnostic Errors, Humans, Oropharyngeal Neoplasms diagnosis, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms therapy, Carcinoma, Squamous Cell diagnosis, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell therapy, Head and Neck Neoplasms diagnosis, Head and Neck Neoplasms pathology, Head and Neck Neoplasms therapy, Rare Diseases diagnosis, Rare Diseases pathology, Rare Diseases therapy
Abstract

Among the 20,000 new cases of head and neck neoplasms in France each year, squamous cell carcinomas (HNSCC) represent about 90 % of the cases. Among these, variants of conventional squamous cell carcinomas represent between 5% and 10% of cases. Patient history and risk factors are often similar from those of conventional HSNCC. Variants may, however, be misdiagnosed, which can lead to therapeutic mismanagement due to confusion with sarcomas, glandular tumors or even benign tumors. Diagnostic workup needs to be more cautionary or to include additional exams not to omit their most aggressive component in the case of composite tumors or to under stage the tumor. Immunohistochemistry and specific molecular analyses may be required for proper diagnosis. Central pathological review may also be essential for some of these variants. In addition, some variants are radioresistant and, conversely, others are radiosensitive. An update of the REFCOR 2008 standards was carried out in the light of the international literature and the 2017 WHO/IARC classification for the seven main variants of HNSCC, verrucous, acantholytic (to be named adenoid carcinomas), basaloid, papillary, spindle cell (incorrectly named sarcomatoid), adenosquamous and lymphoepithelial carcinomas., (Copyright © 2019 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Published
2019
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35. Astonishing Evolution in Oropharyngeal Cancer with Immunotherapy: A Case Report.

Author

Rossillon A, Benhamou J, Baccar LS, Hourseau M, Beatrix B, Faivre S, Culine S, Maingon P, and Lamuraglia M

Subjects
Antineoplastic Agents therapeutic use, Drug Resistance, Neoplasm drug effects, Drug Resistance, Neoplasm immunology, Humans, Immunotherapy methods, Male, Middle Aged, Oropharyngeal Neoplasms metabolism, Programmed Cell Death 1 Receptor metabolism, Oropharyngeal Neoplasms immunology, Oropharyngeal Neoplasms therapy
Abstract

Background: Head and neck cancer is particular due to its infiltrative nature and lymphatic extension, with multidisciplinary treatment. Immunotherapy may be a brand-new therapeutic approach. Case Presentation: We report a case of patient with advanced head and neck cancer resistant to cytotoxic treatment, with astonishing response to antibodies anti Programmed Death 1 (PD1). Conclusion: Further studies are needed in order to obtained predictive index of immunotherapy responding, aiming to select appropriately patients for this treatment.

Published
2019
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36. [A paratesticular nodule].

Author

Guyard A, Sannier A, Grassano Y, Choudat L, Couvelard A, and Hourseau M

Subjects
Adult, Fibrosis, Genital Diseases, Male diagnostic imaging, Granuloma, Plasma Cell diagnostic imaging, Humans, Immunoglobulin G analysis, Immunoglobulin G4-Related Disease diagnostic imaging, Male, Plasma Cells chemistry, Plasma Cells pathology, Scrotum pathology, Genital Diseases, Male pathology, Granuloma, Plasma Cell pathology, Immunoglobulin G4-Related Disease pathology
Published
2017
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37. Uterine intravascular lymphoma as a cause of fever of unknown origin.

Author

Hadjadj J, Nielly H, Piekarski E, Cuccuini W, Deau-Fischer B, Hourseau M, Benali K, Fieschi C, Aletti M, Papo T, Oksenhendler E, Galicier L, and Boutboul D

Subjects
Aged, Female, Fever of Unknown Origin etiology, Fluorodeoxyglucose F18, Humans, Lymphoma, Large B-Cell, Diffuse complications, Middle Aged, Positron Emission Tomography Computed Tomography methods, Retrospective Studies, Uterine Neoplasms complications, Vascular Neoplasms complications, Fever of Unknown Origin diagnostic imaging, Lymphoma, Large B-Cell, Diffuse diagnostic imaging, Uterine Neoplasms diagnostic imaging, Vascular Neoplasms diagnostic imaging
Abstract

Primary intravascular large B cell lymphoma (IVL) remains a diagnostic challenge because of non-specific clinical, laboratory and imaging findings. The aim of the study was to analyse the major characteristics of IVL with uterine involvement. We retrospectively collected features of IVL with uterine involvement that was proven histologically or demonstrated by significant 18 FDG uptake on 18 FDG-PET/CT. Findings were compared to a comprehensive literature review. Five patients were identified. All of them were admitted for fever of unknown origin (FUO), with haemophagocytic lymphohistiocytosis in three cases. None had gynaecological symptom, contrasting with the literature data. Structural imaging (including whole-body CT scan and pelvic RMI) failed to yield any diagnosis. 18 FDG-PET/CT showed intense uterine uptake in all cases. Endometrial biopsy was performed in three cases and was positive in one. Diagnosis was obtained from coelioscopic iliac adenopathy biopsy in one case and from total hysterectomy in another. Punch biopsy of skin lesions led to diagnosis in the two remaining cases. Bone marrow biopsy was normal in all cases. Clinicians should be aware of potential isolated uterine involvement in IVL, especially in elderly women with FUO. Normal structural imaging does not rule out the diagnosis and 18 FDG-TEP/CT should be performed to guide high-yielding biopsy.

Published
2017
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38. [A rare endolaryngeal tumor].

Author

Ngo C, Albert S, Barry B, Copie-Bergman C, Couvelard A, and Hourseau M

Subjects
Aged, Antigens, CD analysis, Antigens, Neoplasm analysis, Biomarkers, Tumor, Biopsy, Dysphonia etiology, Epstein-Barr Virus Infections diagnostic imaging, Epstein-Barr Virus Infections pathology, Female, Herpesvirus 4, Human isolation & purification, Humans, Immunophenotyping, Laryngeal Neoplasms complications, Laryngeal Neoplasms pathology, Laryngoscopy, Lymphoma, Extranodal NK-T-Cell complications, Lymphoma, Extranodal NK-T-Cell pathology, Laryngeal Neoplasms diagnosis, Lymphoma, Extranodal NK-T-Cell diagnosis
Abstract

We report the case of a 65-year-old woman who presented with a dysphonia. ENT tomography and laryngoscopy showed an endolaryngeal tumoral lesion extended to the right supraglottis. Biopsy of the lesion revealed dense lymphoid infiltrate in the lamina propria, without necrosis or ulceration of the mucosa. The infiltrate showed many CD3+, CD5+, CD4+, CD8+ lymphocytes and plasmocytes. Larger lymphoid cells with cytologic atypia expressed CD56 and cytotoxicity markers such as TIA1 and granzyme B. In situ hybridization for EBV revealed numerous positive cells. The diagnosis of extranodal NK/T cell lymphoma was proposed. The primary laryngeal localization of this disease is exceptionally rare. Heavy admixture of inflammatory cells may mimic inflammatory process and delay the diagnosis., (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)

Published
2017
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39. Cystic lung disease in Sjögren's syndrome: An observational study.

Author

Lechtman S, Debray MP, Crestani B, Bancal C, Hourseau M, Dossier A, Alexandra JF, Chauveheid MP, Papo T, and Sacre K

Subjects
Aged, Female, Humans, Lung Diseases etiology, Male, Middle Aged, Tomography, X-Ray Computed, Lung Diseases diagnostic imaging, Sjogren's Syndrome complications
Abstract

Objectives: To analyze the prevalence, characteristics and outcome of cystic lung disease associated with Sjögren's syndrome (SS)., Methods: From June 2010 to February 2015, 90 consecutive SS patients [60.1±14.8years; 88 (97.8%) female, 75 (83.3%) primary SS] had a systematic chest CT-scan. The presence of thin-walled cysts was analyzed by one experienced radiologist. Demographic data, clinical history, laboratory findings, and pulmonary function tests were extracted retrospectively from medical records., Results: Twenty-one (23.3%) patients had cysts on CT scan performed 40.5±54.5months after SS diagnosis. Cysts number ranged from 1 to 25 were often bilateral (52.4%) and mostly located in the middle lung zone (76.2%). Cysts were isolated (n=6, 28.6%) or associated with other lesions, including bronchiectasis (n=5, 23.8%), micronodules (n=5, 23.8%), ground-glass opacity (n=4, 19%) and/or air trapping (n=3, 14.3%). Most patients with cysts (57.1%) had no respiratory symptoms. When comparing SS patients with and without cysts, patients with cysts tended to be older (65.3±15.3 versus 58.5±14.4years, P=0.06). Smoking habits were similar in both groups. Anti-SSB antibodies were more frequently detected in patients with cysts (57.1% vs. 26.1%, P=0.02). Pulmonary function tests were normal or displayed only mild small airways obstruction and reduced diffusion capacity to carbon monoxide. Four (19%) patients with cysts had a past history of associated pulmonary disease, including interstitial lung disease. During follow-up (25.1±17.7months), no patient developed specific lung disease or lymphoproliferative disorders., Conclusions: Cystic lung disease is frequent, benign, associated with anti-SSB/La antibodies and has no impact on outcome in SS., (Copyright © 2016 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.)

Published
2017
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40. HPV 16 in squamous cell carcinoma of 19th century tonsils.

Author

Benmoussa N, Charpentier C, Mariaggi AA, Collin G, Descamps D, Hourseau M, Barry B, Albert S, Picard A, Conan P, and Charlier P

Subjects
Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell virology, Head and Neck Neoplasms pathology, Head and Neck Neoplasms virology, History, 19th Century, Human Papillomavirus DNA Tests, Humans, Papillomavirus Infections pathology, Papillomavirus Infections virology, Squamous Cell Carcinoma of Head and Neck, Tonsillar Neoplasms pathology, Tonsillar Neoplasms virology, Carcinoma, Squamous Cell history, DNA, Viral genetics, DNA, Viral isolation & purification, Head and Neck Neoplasms history, Human papillomavirus 16 genetics, Human papillomavirus 16 isolation & purification, Museums, Palatine Tonsil pathology, Palatine Tonsil virology, Papillomavirus Infections history, Tonsillar Neoplasms history
Published
2016
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41. Human papilloma virus prevalence in HIV patients with head and neck squamous cell carcinoma.

Author

Picard A, Badoual C, Hourseau M, Halimi C, Pere H, Dib F, Barry B, and Albert S

Subjects
Female, Humans, Immunohistochemistry, In Situ Hybridization, Male, Middle Aged, Polymerase Chain Reaction, Retrospective Studies, Survival Analysis, Carcinoma, Squamous Cell epidemiology, HIV Infections complications, Head and Neck Neoplasms epidemiology, Papillomavirus Infections complications, Papillomavirus Infections epidemiology
Abstract

Objective: The implication of human papilloma virus (HPV) in head and neck squamous cell carcinoma (HNSCC) is well established, especially in oropharyngeal SCC. HIV patients have a higher risk of persistent HPV infection. We investigated the role of HPV in HNSCC carcinogenesis in HIV population., Design: Retrospective monocentric study., Methods: We studied HIV patients who presented with HNSCC between 1994 and 2014. For each patient, tumor characteristics, HIV disease, and survival information were collected. Tumor HPV testing was performed using p16 immunohistochemistry (IHC), in-situ hybridization and PCR. We assessed the percentage of HPV in this population of HIV patients with HNSCC and compared HIV disease characteristics based on HPV status., Results: Forty-seven patients were included: 11 women/36 men, the median age was 50 years. Tumor HPV testing was performed in 40 patients. Tumors were located in oropharynx (32%), oral cavity (32%), larynx (21%), and hypopharynx (11%). At the time of diagnosis, median CD4 level was 385 cells/μl, 31% of the patients were stage (Centers for Disease Control, stage C). The percentage of HPV linked to HNSCC for all locations in HIV patients was 30% (n = 12). HPV16 accounted for 50% of all HPV genotypes. HPV positive status was associated with a CD4 nadir of less than 200 (P = 0.026), but not with CD4 level at time of diagnosis (P = 0.414). HPV-negative tumors tend to be associated with poorer 5-year overall survival (hazard ratio = 2.9, P = 0.0711)., Conclusion: HPV plays a critical role in HNSCC development in HIV population. HIV immunodeficiency may increase HPV persistence and progression of HNSCC.

Published
2016
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42. Differences in Alimentary Glucose Absorption and Intestinal Disposal of Blood Glucose After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy.

Author

Cavin JB, Couvelard A, Lebtahi R, Ducroc R, Arapis K, Voitellier E, Cluzeaud F, Gillard L, Hourseau M, Mikail N, Ribeiro-Parenti L, Kapel N, Marmuse JP, Bado A, and Le Gall M

Subjects
Adaptation, Physiological, Adult, Animals, Disease Models, Animal, Glucagon-Like Peptide 1 metabolism, Glucose Transport Proteins, Facilitative genetics, Glucose Transport Proteins, Facilitative metabolism, Humans, Hyperplasia, Intestinal Mucosa pathology, Jejunum pathology, Male, Middle Aged, Positron-Emission Tomography, RNA, Messenger metabolism, Rats, Retrospective Studies, Time Factors, Tomography, X-Ray Computed, Blood Glucose metabolism, Gastrectomy methods, Gastric Bypass, Intestinal Absorption, Intestinal Mucosa metabolism, Jejunum metabolism, Obesity surgery
Abstract

Background & Aims: Bariatric procedures, such as Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), are the most effective approaches to resolve type 2 diabetes in obese individuals. Alimentary glucose absorption and intestinal disposal of blood glucose have not been directly compared between individuals or animals that underwent RYGB vs VSG. We evaluated in rats and humans how the gut epithelium adapts after surgery and the consequences on alimentary glucose absorption and intestinal disposal of blood glucose., Methods: Obese male rats underwent RYGB, VSG, or sham (control) operations. We collected intestine segments from all rats; we performed histologic analyses and measured levels of messenger RNAs encoding the sugar transporters SGLT1, GLUT1, GLUT2, GLUT3, GLUT4, and GLUT5. Glucose transport and consumption were assayed using ex vivo jejunal loops. Histologic analyses were also performed on Roux limb sections from patients who underwent RYGB 1-5 years after surgery. Roux limb glucose consumption was assayed after surgery by positron emission and computed tomography imaging., Results: In rats and humans that underwent RYGB, the Roux limb became hyperplasic, with an increased number of incretin-producing cells compared with the corresponding jejunal segment of controls. Furthermore, expression of sugar transporters and hypoxia-related genes increased and the nonintestinal glucose transporter GLUT1 appeared at the basolateral membrane of enterocytes. Ingested and circulating glucose was trapped within the intestinal epithelial cells of rats and humans that underwent RYGB. By contrast, there was no hyperplasia of the intestine after VSG, but the intestinal absorption of alimentary glucose was reduced and density of endocrine cells secreting glucagon-like peptide-1 increased., Conclusions: The intestine adapts differently to RYGB vs VSG. RYGB increases intestinal glucose disposal and VSG delays glucose absorption; both contribute to observed improvements in glycemia., (Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.)

Published
2016
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43. Remodeling of the residual gastric mucosa after roux-en-y gastric bypass or vertical sleeve gastrectomy in diet-induced obese rats.

Author

Arapis K, Cavin JB, Gillard L, Cluzeaud F, Lettéron P, Ducroc R, Le Beyec J, Hourseau M, Couvelard A, Marmuse JP, Le Gall M, and Bado A

Subjects
Animals, Blood Glucose physiology, Body Weight physiology, Diet methods, Eating physiology, Gastrectomy methods, Gastric Bypass methods, Gastric Mucosa metabolism, Ghrelin metabolism, Glucose Tolerance Test methods, H(+)-K(+)-Exchanging ATPase metabolism, Insulin metabolism, Male, Obesity blood, Obesity metabolism, Obesity surgery, RNA, Messenger metabolism, Rats, Rats, Wistar, Weight Loss physiology, Gastric Mucosa physiopathology, Obesity physiopathology
Abstract

Whereas the remodeling of intestinal mucosa after bariatric surgeries has been the matter of numerous studies to our knowledge, very few reported on the remodeling of the residual gastric mucosa. In this study, we analyzed remodeling of gastric mucosa after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) in rats. Diet-induced obese rats were subjected to RYGB, VSG or sham surgical procedures. All animals were assessed for food intake, body-weight, fasting blood, metabolites and hormones profiling, as well as insulin and glucose tolerance tests before and up to 5 weeks post-surgery. Remodeling of gastric tissues was analyzed by routine histology and immunohistochemistry studies, and qRT-PCR analyses of ghrelin and gastrin mRNA levels. In obese rats with impaired glucose tolerance, VSG and RYGB caused substantial weight loss and rats greatly improved their oral glucose tolerance. The remaining gastric mucosa after VSG and gastric pouch (GP) after RYGB revealed a hyperplasia of the mucous neck cells that displayed a strong immunoreactivity for parietal cell H+/K+-ATPase. Ghrelin mRNA levels were reduced by 2-fold in remaining fundic mucosa after VSG and 10-fold in GP after RYGB. In the antrum, gastrin mRNA levels were reduced after VSG in line with the reduced number of gastrin positive cells. This study reports novel and important observations dealing with the remaining gastric mucosa after RYGB and VSG. The data demonstrate, for the first time, a hyperplasia of the mucous neck cells, a transit cell population of the stomach bearing differentiating capacities into zymogenic and peptic cells.

Published
2015
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44. Is lymphocytic sialadenitis IgG4-related?

Author

Chavarot N, Hourseau M, Papo T, and Sacre K

Subjects
Adult, Aged, Aged, 80 and over, Autoimmune Diseases diagnosis, Autoimmune Diseases epidemiology, Biomarkers analysis, Biopsy, Female, Hospitals, University, Humans, Immunohistochemistry, Lip, Male, Middle Aged, Paris epidemiology, Predictive Value of Tests, Prevalence, Retrospective Studies, Risk Factors, Salivary Glands pathology, Sialadenitis diagnosis, Sialadenitis epidemiology, Young Adult, Autoimmune Diseases immunology, Immunoglobulin G analysis, Lymphocytes immunology, Salivary Glands immunology, Sialadenitis immunology
Published
2015

45. Focus on the role of the CXCL12/CXCR4 chemokine axis in head and neck squamous cell carcinoma.

Author

Albert S, Riveiro ME, Halimi C, Hourseau M, Couvelard A, Serova M, Barry B, Raymond E, and Faivre S

Subjects
Animals, Antineoplastic Agents pharmacology, Carcinogenesis metabolism, Carcinoma, Squamous Cell pathology, Cell Adhesion, Cell Movement, Drug Evaluation, Preclinical, Head and Neck Neoplasms pathology, Humans, Neoplasm Invasiveness, Neoplasm Metastasis prevention & control, Neovascularization, Pathologic metabolism, Prognosis, Receptors, CXCR4 antagonists & inhibitors, Carcinoma, Squamous Cell metabolism, Chemokine CXCL12 metabolism, Head and Neck Neoplasms metabolism, Receptors, CXCR4 metabolism
Abstract

The human chemokine system includes approximately 48 chemokines and 19 chemokine receptors. The CXCL12/CXCR4 system is one of the most frequently studied that is also found overexpressed in a large variety of tumors. The CXCL12/CXCR4 axis has been increasingly identified as an important target in cancer growth, metastasis, relapse, and resistance to therapy. In this review, we highlight current knowledge of the molecular mechanisms involving chemokines CXCL12/CXCR4 and their consequences in head and neck squamous cell carcinoma (HNSCC). Overexpression of CXCL12/CXCR4 in HNSCC appears to activate cellular functions, including motility, invasion, and metastatic processes. Current findings suggest that CXCR4 and epithelial-mesenchymal transition markers are associated with tumor aggressiveness and a poor prognosis, and may be suitable biomarkers for head and neck tumors with high metastatic potential. Furthermore, knowledge of the role of CXCR4 in HNSCC could influence the development of new targeted therapies for treatment, aimed at improving the prognosis of this disease., (Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company.)

Published
2013
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46. Production and significance of CCAAT enhancer binding proteins alpha and beta in sinonasal inverted papilloma.

Author

Shabana EH, Depondt J, Hourseau M, Walker F, and Berdal A

Subjects
Adolescent, Adult, Aged, Female, Humans, Immunohistochemistry, Male, Middle Aged, Neoplasm Recurrence, Local metabolism, Papilloma, Inverted pathology, Paranasal Sinus Neoplasms pathology, Reverse Transcriptase Polymerase Chain Reaction, Young Adult, Biomarkers, Tumor analysis, CCAAT-Enhancer-Binding Protein-alpha analysis, CCAAT-Enhancer-Binding Protein-beta analysis, Papilloma, Inverted metabolism, Paranasal Sinus Neoplasms metabolism
Abstract

Sinonasal inverted papilloma (SIP) is a rare benign tumor featuring increased cell proliferation, a tendency toward squamous differentiation, recurrence and malignant transformation. The CCAAT enhancer binding proteins, C/EBPs, are transcription factors regulating the proliferation and differentiation of various types of cells, including epithelial cells. We prospectively investigated the production of these transcription factors and the related proliferation and differentiation targets, keratin-10, keratin-15 and cyclin-D1, in 26 SIP patients and 8 sinonasal polyposis cases suspected for SIP. Ten of these patients had one or more recurrences over follow-up periods of one to eight years. C/EBP-alpha and C/EBP-beta proteins were not found in normal-looking sinonasal epithelial cells. The proteins and RNAs were detected in SIP and, occasionally, in polyposis tissues. The production of these factors was not significantly correlated with age, sex, site, tumor size or medical history. By contrast, correlations were found between the levels of C/EBP-alpha and keratin-10 levels and between those of C/EBP-beta and keratin-15. C/EBP-alpha levels were also significantly correlated with cyclin-D1 levels. These data suggested that the C/EBPs are implicated in the regulation of cell proliferation and differentiation in SIP. Finally, recurrent SIP produced significantly larger amounts of C/EBP-alpha than non- recurrent tumors. These results implicate CCAAT enhancer binding proteins in the pathogenesis of SIP and highlight the role of C/EBP-alpha as a candidate marker for tumor recurrence.

Published
2013
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47. Prognostic value of the chemokine receptor CXCR4 and epithelial-to-mesenchymal transition in patients with squamous cell carcinoma of the mobile tongue.

Author

Albert S, Hourseau M, Halimi C, Serova M, Descatoire V, Barry B, Couvelard A, Riveiro ME, Tijeras-Raballand A, de Gramont A, Raymond E, and Faivre S

Subjects
Carcinoma, Squamous Cell pathology, Humans, Immunohistochemistry, Prognosis, Retrospective Studies, Tongue Neoplasms pathology, Carcinoma, Squamous Cell metabolism, Epithelial-Mesenchymal Transition, Receptors, CXCR4 metabolism, Tongue Neoplasms metabolism
Abstract

Objective: The aim of this study was to evaluate the expression and the prognostic value of chemokine receptor 4 (CXCR4), its cognate ligand the CXCL12, and markers of epithelial-to-mesenchymal transition (EMT) in squamous cell carcinoma (SCC) of the mobile tongue., Patients and Methods: Patients with primary SCC of the mobile tongue who underwent surgery in our center were screened retrospectively. Patients without prior treatment, who had pre-surgery TNM staging and available tumor samples, were eligible. Protein expression of CXCL12, CXCR4, CA9, E-cadherin, and vimentin was determined by immunohistochemical staining, scored, and correlated with clinical and pathological parameters and overall survival. Multivariate and Cox proportional hazards analyses were performed., Results: Among 160 patients treated and screened, 47 were analyzed. CXCR4 and CXCL12 expression was high in tumor cells. CXCR4 expression in primary tumor samples was significantly higher in patients with high-grade tumors, lymph node metastases, and microscopic nerve invasion (p ≤ 0.05). There was a non-significant trend towards a correlation between high CXCL12 expression and pathologic tumor stage (p=0.07). Tumors with high CXCR4 expression correlated with poor overall survival (hazard ratio=3.6, 95% confidence interval 1.3-9.7; p=0.011), notably in the CXCR4(high)/vimentin-positive subgroup. Vimentin-positive tumors, characterizing EMT, were associated with lower survival (hazard ratio=4.5, 95% confidence interval 1.6-12.3; p=0.0086). Multivariate analysis confirmed vimentin (but not CXCR4) expression as an independent prognostic factor of poor overall survival (p=0.016)., Conclusion: Our results suggest that CXCR4 is a marker of tumor aggressiveness and vimentin is an important and independent prognostic factor in patients with SCC of the mobile tongue., (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Published
2012
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48. [Head and neck IgG4 related disease].

Author

Hourseau M

Subjects
Aged, Autoimmune Diseases epidemiology, Autoimmune Diseases pathology, Diagnosis, Differential, Fibrosis, Humans, Hypergammaglobulinemia diagnosis, Hypergammaglobulinemia epidemiology, Hypergammaglobulinemia pathology, Hyperplasia, Hypertrophy, Lymphocytes pathology, Mikulicz' Disease pathology, Salivary Gland Neoplasms diagnosis, Salivary Glands pathology, Sclerosis, Sialadenitis diagnosis, Sialadenitis epidemiology, Sialadenitis pathology, Sjogren's Syndrome diagnosis, Autoimmune Diseases immunology, Hypergammaglobulinemia immunology, Immunoglobulin G blood, Mikulicz' Disease immunology, Plasma Cells pathology, Sialadenitis immunology
Published
2012
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49. [Pharyngeal fibrovascular polyp].

Author

Dali H, Barry B, Wassef M, Mansouri D, Hourseau M, Hénin D, and Soufan R

Subjects
Deglutition Disorders etiology, Humans, Hypopharyngeal Neoplasms complications, Hypopharyngeal Neoplasms diagnosis, Hypopharyngeal Neoplasms surgery, Laser Therapy, Male, Middle Aged, Polyps complications, Polyps diagnosis, Polyps surgery, Pyriform Sinus pathology, Hypopharyngeal Neoplasms pathology, Polyps pathology
Abstract

The giant fibrovascular polyp of the hypopharynx is a rare and benign tumor. We report one case in a 46-year-old man. This lesion, usually unique, affects predominantly men with an average age of 53 years. These polyps are located predominantly in the upper esophagus and rarely in the hypopharynx. They are usually asymptomatic and small, detected by endoscopy. They can grow to considerable length and cause digestive or respiratory symptoms. Histologically, fibrovascular polyps consist of a various mixture of fibrous and lipomatous elements with abundant vascularisation and they are covered by normal squamous epithelium. The lack of muscular support and the pressure difference in the peristaltic wave contribute to polyp formation., (Copyright © 2011 Elsevier Masson SAS. All rights reserved.)

Published
2011
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50. [Nodular amyloidoma associated with primary pulmonary Malt lymphoma].

Author

Hourseau M, Virally J, Habib E, Juberthie B, and Bienvenu L

Subjects
Aged, Amyloidosis surgery, Female, Humans, Lung Neoplasms surgery, Lymphoma, B-Cell, Marginal Zone surgery, Amyloidosis pathology, Lung Neoplasms pathology, Lymphoma, B-Cell, Marginal Zone pathology
Abstract

Introduction: Pulmonary amyloïdoma is a nodular formation containing amyloid deposits, which can mimick a pulmonary carcinoma. Its etiologic diagnosis require the search of an underlying infectious disease, a connective tissue disorder or a lymphoma., Case Report: We report the case of a 73 year old woman, asymptomatic, presenting an incidental pulmonary opacity in the left upper lobe, associated with hilar lymphadenopathies, positive on PET scan. The patient underwent a left superior lobectomy with mediastinal lymphadenectomy. Histologically, the nodule was composed of amylodosis deposits. It was surrounded by a dense lymphoïd infiltrate. The phenotype (CD20+, CD5-, CD3-, CD23-) of the lymphoïd cells, like the demonstration of a lambda light chain restriction permited to pose the diagnostic of pulmonary Malt lymphoma and to characterize the AL lambda type of the amyloïdosis, Conclusion: Association of amyloïdoma and Malt lymphoma is a rare condition. The histologic diagnosis of lymphoma may be difficult in this case, the lymphomatous process being concealed by the volume of the amyloïd mass. Therefore it is necessary in case of amyloïdoma to search histological signs of Malt lymphoma and to confirm diagnosis by demonstrating a B clonality and a immunoglobulin light chains restriction.

Published
2008
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