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3. Proximal colon–derived O-glycosylated mucus encapsulates and modulates the microbiota

Author

Bergstrom, Kirk, Shan, Xindi, Casero, David, Batushansky, Albert, Lagishetty, Venu, Jacobs, Jonathan P, Hoover, Christopher, Kondo, Yuji, Shao, Bojing, Gao, Liang, Zandberg, Wesley, Noyovitz, Benjamin, McDaniel, J Michael, Gibson, Deanna L, Pakpour, Sepideh, Kazemian, Negin, McGee, Samuel, Houchen, Courtney W, Rao, Chinthalapally V, Griffin, Timothy M, Sonnenburg, Justin L, McEver, Rodger P, Braun, Jonathan, and Xia, Lijun

Subjects
Digestive Diseases, Cancer, Colo-Rectal Cancer, Animals, Colon, Feces, Gastrointestinal Microbiome, Glycosylation, Mice, Mice, Knockout, Mucin-2, Mucus, Transcription, Genetic, General Science & Technology
Abstract

Colon mucus segregates the intestinal microbiota from host tissues, but how it organizes to function throughout the colon is unclear. In mice, we found that colon mucus consists of two distinct O-glycosylated entities of Muc2: a major form produced by the proximal colon, which encapsulates the fecal material including the microbiota, and a minor form derived from the distal colon, which adheres to the major form. The microbiota directs its own encapsulation by inducing Muc2 production from proximal colon goblet cells. In turn, O-glycans on proximal colon-derived Muc2 modulate the structure and function of the microbiota as well as transcription in the colon mucosa. Our work shows how proximal colon control of mucin production is an important element in the regulation of host-microbiota symbiosis.

Published
2020

4. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity

Author

Yan, Kelley S, Gevaert, Olivier, Zheng, Grace XY, Anchang, Benedict, Probert, Christopher S, Larkin, Kathryn A, Davies, Paige S, Cheng, Zhuan-fen, Kaddis, John S, Han, Arnold, Roelf, Kelly, Calderon, Ruben I, Cynn, Esther, Hu, Xiaoyi, Mandleywala, Komal, Wilhelmy, Julie, Grimes, Sue M, Corney, David C, Boutet, Stéphane C, Terry, Jessica M, Belgrader, Phillip, Ziraldo, Solongo B, Mikkelsen, Tarjei S, Wang, Fengchao, von Furstenberg, Richard J, Smith, Nicholas R, Chandrakesan, Parthasarathy, May, Randal, Chrissy, Mary Ann S, Jain, Rajan, Cartwright, Christine A, Niland, Joyce C, Hong, Young-Kwon, Carrington, Jill, Breault, David T, Epstein, Jonathan, Houchen, Courtney W, Lynch, John P, Martin, Martin G, Plevritis, Sylvia K, Curtis, Christina, Ji, Hanlee P, Li, Linheng, Henning, Susan J, Wong, Melissa H, and Kuo, Calvin J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Regenerative Medicine, Digestive Diseases, 1.1 Normal biological development and functioning, Underpinning research, Animals, Antigens, Differentiation, Enteroendocrine Cells, Gene Expression Regulation, Intestinal Mucosa, Jejunum, Mice, Mice, Transgenic, Stem Cells, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations closely resembled Lgr5+ ISCs, the most well-defined ISC pool, but Bmi1-GFP+ cells were distinct and enriched for enteroendocrine (EE) markers, including Prox1. Prox1-GFP+ cells exhibited sustained clonogenic growth in vitro, and lineage-tracing of Prox1+ cells revealed long-lived clones during homeostasis and after radiation-induced injury in vivo. Single-cell mRNA-seq revealed two subsets of Prox1-GFP+ cells, one of which resembled mature EE cells while the other displayed low-level EE gene expression but co-expressed tuft cell markers, Lgr5 and Ascl2, reminiscent of label-retaining secretory progenitors. Our data suggest that the EE lineage, including mature EE cells, comprises a reservoir of homeostatic and injury-inducible ISCs, extending our understanding of cellular plasticity and stemness.

Published
2017

5. From Inflammation to Oncogenesis: Tracing Serum DCLK1 and miRNA Signatures in Chronic Liver Diseases.

Author

Moore, Landon L., Qu, Dongfeng, Sureban, Sripathi, Mitchell, Stephanie, Pitts, Kamille, Cooper, Nasya, Fazili, Javid, Harty, Richard, Oseini, Abdul, Ding, Kai, Bronze, Michael, and Houchen, Courtney W.

Subjects
LIVER diseases, HEPATIC fibrosis, CHRONIC diseases, CARCINOGENESIS, MICRORNA, ASCITIC fluids, FETAL monitoring
Abstract

Chronic liver diseases, fibrosis, cirrhosis, and HCC are often a consequence of persistent inflammation. However, the transition mechanisms from a normal liver to fibrosis, then cirrhosis, and further to HCC are not well understood. This study focused on the role of the tumor stem cell protein doublecortin-like kinase 1 (DCLK1) in the modulation of molecular factors in fibrosis, cirrhosis, or HCC. Serum samples from patients with hepatic fibrosis, cirrhosis, and HCC were analyzed via ELISA or NextGen sequencing and were compared with control samples. Differentially expressed (DE) microRNAs (miRNA) identified from these patient sera were correlated with DCLK1 expression. We observed elevated serum DCLK1 levels in fibrosis, cirrhosis, and HCC patients; however, TGF-β levels were only elevated in fibrosis and cirrhosis. While DE miRNAs were identified for all three disease states, miR-12136 was elevated in fibrosis but was significantly increased further in cirrhosis. Additionally, miR-1246 and miR-184 were upregulated when DCLK1 was high, while miR-206 was downregulated. This work distinguishes DCLK1 and miRNAs' potential role in different axes promoting inflammation to tumor progression and may serve to identify biomarkers for tracking the progression from pre-neoplastic states to HCC in chronic liver disease patients as well as provide targets for treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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9. ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

Author

Yang, Jingxuan, Zhang, Zicheng, Zhang, Yuqing, Ni, Xiaoling, Zhang, Guohua, Cui, Xiaobo, Liu, Mingyang, Xu, Can, Zhang, Qiang, Zhu, Huiyun, Yan, Jie, Zhu, Vivian F., Luo, Yusheng, Hagan, John P., Li, Zhaoshen, Fang, Jing, Jatoi, Aminah, Fernandez-Zapico, Martin E., Zheng, Lei, Edil, Barish H., Bronze, Michael S., Houchen, Courtney W., Li, Yi-Ping, and Li, Min

Published
2019
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16. Supplementary Figure 1 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Author

Chandrakesan, Parthasarathy, primary, Panneerselvam, Janani, primary, May, Randal, primary, Weygant, Nathaniel, primary, Qu, Dongfeng, primary, Berry, William R., primary, Pitts, Kamille, primary, Stanger, Ben Z., primary, Rao, Chinthalapally V., primary, Bronze, Michael S., primary, and Houchen, Courtney W., primary

Published
2023
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18. Supplementary Figure 5 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Author

Chandrakesan, Parthasarathy, primary, Panneerselvam, Janani, primary, May, Randal, primary, Weygant, Nathaniel, primary, Qu, Dongfeng, primary, Berry, William R., primary, Pitts, Kamille, primary, Stanger, Ben Z., primary, Rao, Chinthalapally V., primary, Bronze, Michael S., primary, and Houchen, Courtney W., primary

Published
2023
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20. Supplementary Figure 3 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Author

Chandrakesan, Parthasarathy, primary, Panneerselvam, Janani, primary, May, Randal, primary, Weygant, Nathaniel, primary, Qu, Dongfeng, primary, Berry, William R., primary, Pitts, Kamille, primary, Stanger, Ben Z., primary, Rao, Chinthalapally V., primary, Bronze, Michael S., primary, and Houchen, Courtney W., primary

Published
2023
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21. Supplementary Figure 4 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Author

Chandrakesan, Parthasarathy, primary, Panneerselvam, Janani, primary, May, Randal, primary, Weygant, Nathaniel, primary, Qu, Dongfeng, primary, Berry, William R., primary, Pitts, Kamille, primary, Stanger, Ben Z., primary, Rao, Chinthalapally V., primary, Bronze, Michael S., primary, and Houchen, Courtney W., primary

Published
2023
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22. Supplementrary Figure 2 from DCLK1-Isoform2 Alternative Splice Variant Promotes Pancreatic Tumor Immunosuppressive M2-Macrophage Polarization

Author

Chandrakesan, Parthasarathy, primary, Panneerselvam, Janani, primary, May, Randal, primary, Weygant, Nathaniel, primary, Qu, Dongfeng, primary, Berry, William R., primary, Pitts, Kamille, primary, Stanger, Ben Z., primary, Rao, Chinthalapally V., primary, Bronze, Michael S., primary, and Houchen, Courtney W., primary

Published
2023
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23. Data from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase

Author

Weygant, Nathaniel, primary, Ge, Yang, primary, Qu, Dongfeng, primary, Kaddis, John S., primary, Berry, William L., primary, May, Randal, primary, Chandrakesan, Parthasarathy, primary, Bannerman-Menson, Edwin, primary, Vega, Kenneth J., primary, Tomasek, James J., primary, Bronze, Michael S., primary, An, Guangyu, primary, and Houchen, Courtney W., primary

Published
2023
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24. Supplementary table 1 from ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism

Author

Liu, Mingyang, primary, Yang, Jingxuan, primary, Zhang, Yuqing, primary, Zhou, Zhijun, primary, Cui, Xiaobo, primary, Zhang, Liyang, primary, Fung, Kar-Ming, primary, Zheng, Wei, primary, Allard, Felicia D., primary, Yee, Eric U., primary, Ding, Kai, primary, Wu, Huanwen, primary, Liang, Zhiyong, primary, Zheng, Lei, primary, Fernandez-Zapico, Martin E., primary, Li, Yi-Ping, primary, Bronze, Michael S., primary, Morris, Katherine T., primary, Postier, Russell G., primary, Houchen, Courtney W., primary, Yang, Jing, primary, and Li, Min, primary

Published
2023
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25. Supplemental Figures and Table from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase

Author

Weygant, Nathaniel, primary, Ge, Yang, primary, Qu, Dongfeng, primary, Kaddis, John S., primary, Berry, William L., primary, May, Randal, primary, Chandrakesan, Parthasarathy, primary, Bannerman-Menson, Edwin, primary, Vega, Kenneth J., primary, Tomasek, James J., primary, Bronze, Michael S., primary, An, Guangyu, primary, and Houchen, Courtney W., primary

Published
2023
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26. Supplementary figures from ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and Claudin-1 through a ZEB1-Dependent Transcriptional Mechanism

Author

Liu, Mingyang, primary, Yang, Jingxuan, primary, Zhang, Yuqing, primary, Zhou, Zhijun, primary, Cui, Xiaobo, primary, Zhang, Liyang, primary, Fung, Kar-Ming, primary, Zheng, Wei, primary, Allard, Felicia D., primary, Yee, Eric U., primary, Ding, Kai, primary, Wu, Huanwen, primary, Liang, Zhiyong, primary, Zheng, Lei, primary, Fernandez-Zapico, Martin E., primary, Li, Yi-Ping, primary, Bronze, Michael S., primary, Morris, Katherine T., primary, Postier, Russell G., primary, Houchen, Courtney W., primary, Yang, Jing, primary, and Li, Min, primary

Published
2023
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27. Supplemental Figure Legends from Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem–like Cells Marked by DCLK1 Kinase

Author

Weygant, Nathaniel, primary, Ge, Yang, primary, Qu, Dongfeng, primary, Kaddis, John S., primary, Berry, William L., primary, May, Randal, primary, Chandrakesan, Parthasarathy, primary, Bannerman-Menson, Edwin, primary, Vega, Kenneth J., primary, Tomasek, James J., primary, Bronze, Michael S., primary, An, Guangyu, primary, and Houchen, Courtney W., primary

Published
2023
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28. Data from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a–Dependent Mechanism

Author

Sureban, Sripathi M., primary, May, Randal, primary, Lightfoot, Stan A., primary, Hoskins, Aimee B., primary, Lerner, Megan, primary, Brackett, Daniel J., primary, Postier, Russell G., primary, Ramanujam, Rama, primary, Mohammed, Altaf, primary, Rao, Chinthalapally V., primary, Wyche, James H., primary, Anant, Shrikant, primary, and Houchen, Courtney W., primary

Published
2023
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30. Supplementary Figure 3 from Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos

Author

Subramaniam, Dharmalingam, primary, Giridharan, Periyasamy, primary, Murmu, Nabendu, primary, Shankaranarayanan, Nallakandy P., primary, May, Randal, primary, Houchen, Courtney W., primary, Ramanujam, Rama P., primary, Balakrishnan, Arun, primary, Vishwakarma, Ram A., primary, and Anant, Shrikant, primary

Published
2023
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31. Supplementary Figure 4 from Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos

Author

Subramaniam, Dharmalingam, primary, Giridharan, Periyasamy, primary, Murmu, Nabendu, primary, Shankaranarayanan, Nallakandy P., primary, May, Randal, primary, Houchen, Courtney W., primary, Ramanujam, Rama P., primary, Balakrishnan, Arun, primary, Vishwakarma, Ram A., primary, and Anant, Shrikant, primary

Published
2023
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33. Supplementary Figure 2 from Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos

Author

Subramaniam, Dharmalingam, primary, Giridharan, Periyasamy, primary, Murmu, Nabendu, primary, Shankaranarayanan, Nallakandy P., primary, May, Randal, primary, Houchen, Courtney W., primary, Ramanujam, Rama P., primary, Balakrishnan, Arun, primary, Vishwakarma, Ram A., primary, and Anant, Shrikant, primary

Published
2023
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34. Supplementary Legends 1-4 and Materials from Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos

Author

Subramaniam, Dharmalingam, primary, Giridharan, Periyasamy, primary, Murmu, Nabendu, primary, Shankaranarayanan, Nallakandy P., primary, May, Randal, primary, Houchen, Courtney W., primary, Ramanujam, Rama P., primary, Balakrishnan, Arun, primary, Vishwakarma, Ram A., primary, and Anant, Shrikant, primary

Published
2023
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36. Supplementary Figure 1 from Activation of Apoptosis by 1-Hydroxy-5,7-Dimethoxy-2-Naphthalene-Carboxaldehyde, a Novel Compound from Aegle marmelos

Author

Subramaniam, Dharmalingam, primary, Giridharan, Periyasamy, primary, Murmu, Nabendu, primary, Shankaranarayanan, Nallakandy P., primary, May, Randal, primary, Houchen, Courtney W., primary, Ramanujam, Rama P., primary, Balakrishnan, Arun, primary, Vishwakarma, Ram A., primary, and Anant, Shrikant, primary

Published
2023
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37. Supplementary Materials and Methods from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a–Dependent Mechanism

Author

Sureban, Sripathi M., primary, May, Randal, primary, Lightfoot, Stan A., primary, Hoskins, Aimee B., primary, Lerner, Megan, primary, Brackett, Daniel J., primary, Postier, Russell G., primary, Ramanujam, Rama, primary, Mohammed, Altaf, primary, Rao, Chinthalapally V., primary, Wyche, James H., primary, Anant, Shrikant, primary, and Houchen, Courtney W., primary

Published
2023
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38. Supplementary Figure Legends 1-4, Table Legend from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a–Dependent Mechanism

Author

Sureban, Sripathi M., primary, May, Randal, primary, Lightfoot, Stan A., primary, Hoskins, Aimee B., primary, Lerner, Megan, primary, Brackett, Daniel J., primary, Postier, Russell G., primary, Ramanujam, Rama, primary, Mohammed, Altaf, primary, Rao, Chinthalapally V., primary, Wyche, James H., primary, Anant, Shrikant, primary, and Houchen, Courtney W., primary

Published
2023
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39. Supplementary Figures 1-4 from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a–Dependent Mechanism

Author

Sureban, Sripathi M., primary, May, Randal, primary, Lightfoot, Stan A., primary, Hoskins, Aimee B., primary, Lerner, Megan, primary, Brackett, Daniel J., primary, Postier, Russell G., primary, Ramanujam, Rama, primary, Mohammed, Altaf, primary, Rao, Chinthalapally V., primary, Wyche, James H., primary, Anant, Shrikant, primary, and Houchen, Courtney W., primary

Published
2023
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43. Supplementary Table 1 from DCAMKL-1 Regulates Epithelial–Mesenchymal Transition in Human Pancreatic Cells through a miR-200a–Dependent Mechanism

Author

Sureban, Sripathi M., primary, May, Randal, primary, Lightfoot, Stan A., primary, Hoskins, Aimee B., primary, Lerner, Megan, primary, Brackett, Daniel J., primary, Postier, Russell G., primary, Ramanujam, Rama, primary, Mohammed, Altaf, primary, Rao, Chinthalapally V., primary, Wyche, James H., primary, Anant, Shrikant, primary, and Houchen, Courtney W., primary

Published
2023
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49. Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer

Author

Zhou, Zhijun, primary, Ren, Yu, additional, Yang, Jingxuan, additional, Liu, Mingyang, additional, Shi, Xiuhui, additional, Luo, Wenyi, additional, Fung, Kar-Ming, additional, Xu, Chao, additional, Bronze, Michael S., additional, Zhang, Yuqing, additional, Houchen, Courtney W., additional, and Li, Min, additional

Published
2022
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