Search

Your search keyword '"Hou, Yu-Chi"' showing total 300 results
Start Over Author "Hou, Yu-Chi"
300 results on '"Hou, Yu-Chi"'

1. Asymptotic of Bergman Kernel (Master Thesis)

Author

Hou, Yu-Chi

Subjects
Mathematics - Complex Variables, Mathematics - Differential Geometry, 32L10
Abstract

In this master thesis, we give a new proof on the pointwise asymptotic expansion for Bergman kernel of a hermitian holomorphic line bundle on the points where the curvature of the line bundle is positive and satisfy local spectral gap condition. The main point is to introduce a suitable semi-classical symbol space and related symbolic calculus inspired from recent work of Hsiao and Savale. Particularly, we establish the existence of pointwise asymptotic expansion on the positive part for certain semi-positive line bundles., Comment: 52 pages, Master thesis at National Taiwan University

Published
2022
Full Text
View/download PDF

31. Ginger significantly decreased the oral bioavailability of cyclosporine in rats

Author

Chiang, Hsiu-Mei, Chao, Pei-Dawn Lee, Hsiu, Su-Lan, Wen, Kuo-Ching, Tsai, Shang-Yuan, and Hou, Yu-Chi

Subjects
Rats -- Research, Rats -- Health aspects, Rattus -- Research, Rattus -- Health aspects, Ginger -- Usage, Ginger -- Health aspects, Ginger -- Research, Cyclosporine -- Analysis, Health
Published
2006

48. Effects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin.

Author

Luo, Shu-Shang, Yu, Chung-Ping, Hsieh, Yow-Wen, Chao, Pei-Dawn Lee, Sweet, Douglas H., Hou, Yu-Chi, and Lin, Shiuan-Pey

Subjects
CEFAZOLIN, ANTIBIOTICS, ORGANIC anion transporters, TOXINS, PHARMACOKINETICS, CEFOTAXIME
Abstract

Indoxyl sulfate (IS), a highly protein-bound nephro-cardiovascular toxin, was poorly removed by hemodialysis. IS exists as anions in the body and the renal excretion is mediated by organic anion transporter 1 (OAT1) and OAT3. Acidic antibiotics such as cephalosporins and fluoroquinolones were putative substrates/inhibitors of OATs. We hypothesized that cephalosporins and fluoroquinolones might compete with IS for OAT1- and/or OAT3-mediated renal excretions. This study investigated the effects of ciprofloxacin, cefuroxime, cefotaxime, cefazolin and ofloxacin on the intravenous pharmacokinetics of IS in rats. IS was intravenously injected with and without each individual antibiotics, and the concentrations of IS in serum and lysate were determined by HPLC. The results showed that ciprofloxacin significantly increased AUC0-t and T1/2 of IS by 272% and 491%, respectively, and decreased the clearance by 71%. However, ofloxacin, cefuroxime, cefotaxime and cefazolin did not alter the pharmacokinetics of IS. Furthermore, cell line study showed that ciprofloxacin inhibited the OAT3-mediated transport of IS. This study indicates 30 mg/kg of ciprofloxacin decreased the clearance of IS through inhibition on the OAT3-mediated transport, whereas 50 mg/kg of ofloxacin, cefuroxime, cefotaxime and cefazolin did not show significant influence. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results