175 results on '"Hou, Xinjun"'
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2. Probing the chemical ‘reactome’ with high-throughput experimentation data
3. Different mechanisms of X-ray irradiation-induced male and female sterility in Aedes aegypti
4. Optimal designs for pairwise calculation: An application to free energy perturbation in minimizing prediction variability
5. Adaptive region algorithm based on ternary optical computer
6. The Interplay Between Nutrition and the Dynamics of the Midgut Microbiome of the MosquitoAedes aegyptiReveals Putative Symbionts
7. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis
8. Chitosan used as a specific coupling agent to modify starch in preparation of adhesive film
9. N-Ethyl-N-Nitrosourea Induced Leukaemia in a Mouse Model: Protective Effect of Icaritin via Inhibition of IL-6/JAK2/STAT3 Pathway Causes Apoptosis
10. Ligand biological activity predicted by cleaning positive and negative chemical correlations
11. Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration
12. Development and Comprehensive Benchmark of a High Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
13. Probing the Chemical "Reactome" with High Throughput Experimentation Data
14. Development and Comprehensive Benchmark of a High Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
15. Development and Comprehensive Benchmark of a High-Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation
16. Author Correction: Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
17. Probing the Chemical "Reactome" with High Throughput Experimentation Data
18. Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs
19. Application of functionalized carboxymethyl cellulose in development of hierarchical lamellar aluminophosphate for the industrial fabrication of wood based panels
20. Computational Tools for Structure Based Drug Design
21. Hierarchical Lamellar Aluminophosphate Inorganic Materials for Medium Density Fiberboard with Good Fire Performance
22. Harnessing Preclinical Data as a Predictive Tool for Human Brain Tissue Targeting
23. Molecular Modeling and Structure-Based Design of Direct Calcineurin Inhibitors
24. Current and Future Roles of Artificial Intelligence in Medicinal Chemistry Synthesis
25. Influence of Mesoporous Inorganic Al–B–P Amphiprotic Surfactant Material Resistances of Wood against Brown and White-Rot Fungi (Part 1)
26. Optimal designs for pairwise calculation: An application to free energy perturbation in minimizing prediction variability
27. Alkalilacustris brevis gen. nov., sp. nov., isolated from a soda lake
28. Optimal Designs of Pairwise Calculation: an Application to Free Energy Perturbation in Minimizing Prediction Variability
29. Molecular Transformer unifies reaction prediction and retrosynthesis across pharma chemical space
30. Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
31. Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates
32. Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
33. Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket
34. Dihedral Angle-Based Sampling of Natural Product Polyketide Conformations: Application to Permeability Prediction
35. Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors
36. Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability
37. Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
38. Constant pH Molecular Dynamics Reveals pH-Modulated Binding of Two Small-Molecule BACE1 Inhibitors
39. The Discovery and Characterization of the α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Potentiator N-{(3S,4S)-4-[4-(5-Cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242)
40. Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors
41. Structure-based design of novel human Pin1 inhibitors (II)
42. PDEs as CNS Targets: PDE9 Inhibitors for Cognitive Deficit Diseases
43. The discovery of a structurally novel class of inhibitors of the type 1 glycine transporter
44. Structure-based design of novel human Pin1 inhibitors (I)
45. Discovery and Characterization of a Novel Dihydroisoxazole Class of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators
46. Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand
47. Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics
48. Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors
49. Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition
50. Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders
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