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Your search keyword '"Hou, Xinfeng"' showing total 17 results
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17 results on '"Hou, Xinfeng"'

3. Translational modelling to predict human pharmacokinetics and pharmacodynamics of a Bruton's tyrosine kinase‐targeted protein degrader BGB‐16673.

Author

Wu, Yue, Meibohm, Bernd, Zhang, Taichang, Hou, Xinfeng, Wang, Haitao, Sun, Xiaona, Jiang, Ming, Zhang, Bo, Zhang, Wenjing, Liu, Ye, Jin, Wei, and Wang, Fan

Subjects
BRUTON tyrosine kinase, SMALL molecules, PROTEOLYSIS, GENETIC translation, CLINICAL pharmacology
Abstract

Background and Purpose: Bifunctional small molecule degraders, which link the target protein with E3 ubiquitin ligase, could lead to the efficient degradation of the target protein. BGB‐16673 is a Bruton's tyrosine kinase (BTK) degrader. A translational PK/PD modelling approach was used to predict the human BTK degradation of BGB‐16673 from preclinical in vitro and in vivo data. Experimental Approach: A simplified mechanistic PK/PD model was used to establish the correlation between the in vitro and in vivo BTK degradation by BGB‐16673 in a mouse model. Human and mouse species differences were compared using the parameters generated from in vitro human or mouse blood, and human or mouse serum spiked TMD‐8 cells. Human PD was then predicted using the simplified mechanistic PK/PD model. Key Results: BGB‐16673 showed potent BTK degradation in mouse whole blood, human whole blood, and TMD‐8 tumour cells in vitro. Furthermore, BGB‐16673 showed BTK degradation in a murine TMD‐8 xenograft model in vivo. The PK/PD model predicted human PD and the observed BTK degradation in clinical studies both showed robust BTK degradation in blood and tumour at clinical dose range. Conclusion and Implications: The presented simplified mechanistic model with reduced number of model parameters is practically easier to be applied to research projects compared with the full mechanistic model. It can be used as a tool to better understand the PK/PD behaviour for targeted protein degraders and increase the confidence when moving to the clinical stage. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Patient satisfaction with humanistic nursing in Chinese secondary and tertiary public hospitals: a cross-sectional survey

Author

Liu, Yilan, primary, Zhang, Fengjian, additional, Guan, Chunyan, additional, Song, Bing, additional, Zhang, Haixin, additional, Fu, Mo, additional, Wang, Fang, additional, Tang, Chenxi, additional, Chen, Huiling, additional, Guo, Qingfeng, additional, Fan, Ling, additional, Hou, Xinfeng, additional, Wang, Hongxia, additional, Wu, Bing, additional, Shan, Geyan, additional, Zhang, Hongmei, additional, Yu, Feifei, additional, Lou, Xiaoping, additional, Xie, Hongzhen, additional, Zhou, Ying, additional, Lu, Gendi, additional, Xin, Xia, additional, Pan, Shaoshan, additional, and Guo, Shujie, additional

Published
2023
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7. P1219: BGB-16673, A BTK DEGRADER, OVERCOMES ON-TARGET RESISTANCE FROM BTK INHIBITORS AND PRESENTS SUSTAINABLE LONG-TERM TUMOR REGRESSION IN LYMPHOMA XENOGRAFT MODELS

Author

Wang, Haitao, primary, Hou, Xinfeng, additional, Zhang, Wenjing, additional, Wang, Yiwen, additional, LI, Lin, additional, LI, Yang, additional, Luweihing, Bruce, additional, XI, Min, additional, Song, Jiayun, additional, Zhu, Xinxin, additional, Zhou, Liyun, additional, Chen, Xiangmei, additional, Yu, Yiling, additional, Jin, Wei, additional, and Shen, Zhirong, additional

Published
2023
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11. Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency

Author

Mao, Fengfeng, primary, Liu, Teng, additional, Hou, Xinfeng, additional, Zhao, Hanqing, additional, He, Wenhui, additional, Li, Cong, additional, Jing, Zhiyi, additional, Sui, Jianhua, additional, Wang, Fengchao, additional, Liu, Xiaohui, additional, Han, Jun, additional, Borchers, Christoph H., additional, Wang, Jian-She, additional, and Li, Wenhui, additional

Published
2019
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13. Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells

Author

Gao, Shuai, primary, Tao, Li, additional, Hou, Xinfeng, additional, Xu, Zijian, additional, Liu, Wenqiang, additional, Zhao, Kun, additional, Guo, Mingyue, additional, Wang, Hong, additional, Cai, Tao, additional, Tian, Jianhui, additional, Gao, Shaorong, additional, and Chang, Gang, additional

Published
2016
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14. Nucleosome organizations in induced pluripotent stem cells reprogrammed from somatic cells belonging to three different germ layers

Author

Tao, Yu, primary, Zheng, Weisheng, additional, Jiang, Yonghua, additional, Ding, Guitao, additional, Hou, Xinfeng, additional, Tang, Yitao, additional, Li, Yueying, additional, Gao, Shuai, additional, Chang, Gang, additional, Zhang, Xiaobai, additional, Liu, Wenqiang, additional, Kou, Xiaochen, additional, Wang, Hong, additional, Jiang, Cizhong, additional, and Gao, Shaorong, additional

Published
2014
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16. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells

Author

Chang, Gang, primary, Gao, Shuai, additional, Hou, Xinfeng, additional, Xu, Zijian, additional, Liu, Yanfeng, additional, Kang, Lan, additional, Tao, Yu, additional, Liu, Wenqiang, additional, Huang, Bo, additional, Kou, Xiaochen, additional, Chen, Jiayu, additional, An, Lei, additional, Miao, Kai, additional, Di, Keqian, additional, Wang, Zhilong, additional, Tan, Kun, additional, Cheng, Tao, additional, Cai, Tao, additional, Gao, Shaorong, additional, and Tian, Jianhui, additional

Published
2013
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17. High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells.

Author

Chang, Gang, Gao, Shuai, Hou, Xinfeng, Xu, Zijian, Liu, Yanfeng, Kang, Lan, Tao, Yu, Liu, Wenqiang, Huang, Bo, Kou, Xiaochen, Chen, Jiayu, An, Lei, Miao, Kai, Di, Keqian, Wang, Zhilong, Tan, Kun, Cheng, Tao, Cai, Tao, Gao, Shaorong, and Tian, Jianhui

Subjects
METHYLATION, PLURIPOTENT stem cells, TETRAPLOIDY, GENE expression, NUCLEOTIDE sequence
Abstract

It remains controversial whether the abnormal epigenetic modifications accumulated in the induced pluripotent stem cells (iPSCs) can ultimately affect iPSC pluripotency. To probe this question, iPSC lines with the same genetic background and proviral integration sites were established, and the pluripotency state of each iPSC line was characterized using tetraploid (4N) complementation assay. Subsequently, gene expression and global epigenetic modifications of '4N-ON' and the corresponding '4N-OFF' iPSC lines were compared through deep sequencing analyses of mRNA expression, small RNA profile, histone modifications (H3K27me3, H3K4me3, and H3K4me2), and DNA methylation. We found that methylation of an imprinted gene, Zrsr1, was consistently disrupted in the iPSC lines with reduced pluripotency. Furthermore, the disrupted methylation could not be rescued by improving culture conditions or subcloning of iPSCs. Moreover, the relationship between hypomethylation of Zrsr1 and pluripotency state of iPSCs was further validated in independent iPSC lines derived from other reprogramming systems. [ABSTRACT FROM AUTHOR]

Published
2014
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