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19 results on '"Hou, Shule"'

8. Pseudo-Temporal Analysis of Single-Cell RNA Sequencing Reveals Trans-Differentiation Potential of Greater Epithelial Ridge Cells Into Hair Cells During Postnatal Development of Cochlea in Rats

Author

Chen, Jianyong, primary, Gao, Dekun, additional, Chen, Junmin, additional, Hou, Shule, additional, He, Baihui, additional, Li, Yue, additional, Li, Shuna, additional, Zhang, Fan, additional, Sun, Xiayu, additional, Jin, Yulian, additional, Sun, Lianhua, additional, and Yang, Jun, additional

Published
2022
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12. Single-Cell RNA Sequencing Analysis Reveals Greater Epithelial Ridge Cells Degeneration During Postnatal Development of Cochlea in Rats

Author

Chen, Jianyong, primary, Gao, Dekun, additional, Chen, Junmin, additional, Hou, Shule, additional, He, Baihui, additional, Li, Yue, additional, Li, Shuna, additional, Zhang, Fan, additional, Sun, Xiayu, additional, Mammano, Fabio, additional, Sun, Lianhua, additional, Yang, Jun, additional, and Zheng, Guiliang, additional

Published
2021
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13. Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat

Author

Hou, Shule, primary, Chen, Penghui, additional, Chen, Jiarui, additional, Chen, Junmin, additional, Sun, Lianhua, additional, Chen, Jianyong, additional, He, Baihui, additional, Li, Yue, additional, Qin, Huan, additional, Hong, Yuren, additional, Li, Shuna, additional, He, Jingchun, additional, Gao, Dekun, additional, Mammano, Fabio, additional, and Yang, Jun, additional

Published
2020
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14. Failure Of Hearing Acquisition in Mice With Reduced Expression of Connexin 26 Correlates With the Abnormal Phasing of Apoptosis Relative to Autophagy and Defective ATP-Dependent Ca2+ Signaling in Kölliker's Organ.

Author

Sun, Lianhua, Gao, Dekun, Chen, Junmin, Hou, Shule, Li, Yue, Huang, Yuyu, Mammano, Fabio, Chen, Jianyong, and Yang, Jun

Subjects
MICE, HEARING disorders, AUTOPHAGY, LABORATORY mice, CASPASES, COCHLEA physiology, GENETIC mutation
Abstract

Mutations in the GJB2 gene that encodes connexin 26 (Cx26) are the predominant cause of prelingual hereditary deafness, and the most frequently encountered variants cause complete loss of protein function. To investigate how Cx26 deficiency induces deafness, we examined the levels of apoptosis and autophagy in Gjb2 loxP/loxP; ROSA26 CreER mice injected with tamoxifen on the day of birth. After weaning, these mice exhibited severe hearing impairment and reduced Cx26 expression in the cochlear duct. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells were observed in apical, middle, and basal turns of Kölliker's organ at postnatal (P) day 1 (P1), associated with increased expression levels of cleaved caspase 3, but decreased levels of autophagy-related proteins LC3-II, P62, and Beclin1. In Kölliker's organ cells with decreased Cx26 expression, we also found significantly reduced levels of intracellular ATP and hampered Ca2+ responses evoked by extracellular ATP application. These results offer novel insight into the mechanisms that prevent hearing acquisition in mouse models of non-syndromic hearing impairment due to Cx26 loss of function. [ABSTRACT FROM AUTHOR]

Published
2022
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19. Failure Of Hearing Acquisition in Mice With Reduced Expression of Connexin 26 Correlates With the Abnormal Phasing of Apoptosis Relative to Autophagy and Defective ATP-Dependent Ca 2+ Signaling in Kölliker's Organ.

Author

Sun L, Gao D, Chen J, Hou S, Li Y, Huang Y, Mammano F, Chen J, and Yang J

Abstract

Mutations in the GJB2 gene that encodes connexin 26 (Cx26) are the predominant cause of prelingual hereditary deafness, and the most frequently encountered variants cause complete loss of protein function. To investigate how Cx26 deficiency induces deafness, we examined the levels of apoptosis and autophagy in Gjb2 loxP/loxP ; ROSA26 CreER mice injected with tamoxifen on the day of birth. After weaning, these mice exhibited severe hearing impairment and reduced Cx26 expression in the cochlear duct. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells were observed in apical, middle, and basal turns of Kölliker's organ at postnatal (P) day 1 (P1), associated with increased expression levels of cleaved caspase 3, but decreased levels of autophagy-related proteins LC3-II, P62, and Beclin1. In Kölliker's organ cells with decreased Cx26 expression, we also found significantly reduced levels of intracellular ATP and hampered Ca 2+ responses evoked by extracellular ATP application. These results offer novel insight into the mechanisms that prevent hearing acquisition in mouse models of non-syndromic hearing impairment due to Cx26 loss of function., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Sun, Gao, Chen, Hou, Li, Huang, Mammano, Chen and Yang.)

Published
2022
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