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154 results on '"Hou, Changchun"'

11. Impact of coronary artery disease in patients with hypertrophic cardiomyopathy

Author

Wu, Shaofa, primary, Yang, Lili, additional, Sun, Ning, additional, Luo, Xiaolin, additional, Li, Pingping, additional, Wang, Ke, additional, Li, Pengda, additional, Zhao, Junyong, additional, Wang, Zelan, additional, Zhang, Qiuxia, additional, Wen, Ruizhi, additional, Luo, Wenjian, additional, Gao, Zhichun, additional, Hou, Changchun, additional, Wang, Zebi, additional, Yu, Yang, additional, and Qin, Zhexue, additional

Published
2023
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14. Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model

Author

Qin Enyuan, Xu Mingpeng, Gan Luoman, Gan Jinghua, Li Yu, Li Wentao, Hou Changchun, Li Lihua, Meng Xiaoyan, Zhou Lei, and Liu Guangnan

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Background: Patients with endotracheal intubation or tracheostomy are subject to benign tracheal stenosis (TS), for which current therapies are unsatisfactory. We conducted a preliminary investigation of drugs and drug combinations for the prevention and treatment of TS in a rabbit model. Methods: Fifty-four rabbits were apportioned into nine groups according to treatment: sham-operated control; untreated TS model; amikacin; budesonide; erythromycin; penicillin; amikacin + budesonide; erythromycin + budesonide; and penicillin + budesonide. TS was induced by abrasion during surgery. The drugs were applied for 7 days before and 10 days after the surgery. Rabbits were killed on the eleventh day. Tracheal specimens were processed for determining alterations in the thicknesses of tracheal epithelium and lamina propria via hematoxylin and eosin. The tracheal mRNA (assessed by real-time quantitative polymerase chain reaction) expressions of the following fibrotic-related factors were determined: transforming growth factor-β1 (TGF- β1), collagen type I (COL1A1), collagen type III (COL3A1), and interleukin-17 (IL-17). The protein levels of TGF-β1, COL1A1, and COL3A1 were determined through immunohistochemistry and integrated optical densities. Results: Compared with all other groups, the untreated TS model had significantly thicker tracheal epithelium and lamina propria, and higher mRNA and protein levels of all targeted fibrotic factors. The mRNA and protein levels of the targeted fibrotic factors in all the drug-treated groups were lower than those of the untreated TS model, and differences were most significant in the erythromycin + budesonide group. Conclusions: Erythromycin combined with budesonide may reduce inflammation and modify fibrosis progression in TS after tracheal injury.

Published
2018
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19. Predicting Hospital Readmissions in Patients Receiving Novel-Dose Sacubitril/Valsartan Therapy: A Competing-Risk, Causal Mediation Analysis.

Author

Hou, Changchun, Hao, Xinxin, Sun, Ning, Luo, Xiaolin, Gao, Zhichun, Chen, Ling, Liu, Xi, and Qin, Zhexue

Subjects
PATIENT readmissions, RATINGS of hospitals, ENTRESTO, HOSPITAL patients, VALSARTAN, CHRONIC obstructive pulmonary disease, ARRHYTHMIA
Abstract

Backgrounds: Our study aimed to identify and predict patients with heart failure (HF) taking novel-dose Sacubitril/Valsartan (S/V) at risk for all-cause readmission, as well as investigate the possible role of left ventricular reverse remodeling (LVRR). Methods and results: There were 464 patients recruited from December 2017 to September 2021 in our hospital with a median follow-up of 660 days (range, 17-1494). Competing risk analysis with Gray's Test showed statistically significant differences in all-cause readmission (p-value < .001) across the three different dose groups. Models 1 and 2 were developed based on the results of univariable competing risk analysis, least absolute shrinkage and selection operator approach, backward stepwise regression, and multivariable competing risk analysis. The internal verification (data-splitting method) indicated that Model 1 had better discrimination, calibration, and clinical utility. The corresponding nomogram showed that patients aged 75 years and above, or taking the lowest-dose S/V (≤50 mg twice a day), or diagnosed with ventricular tachycardia, or valvular heart disease, or chronic obstructive pulmonary disease, or diabetes mellitus were at the highest risk of all-cause readmission. In the causal mediation analysis, LVRR was considered as a critical mediator that negatively affected the difference of novel-dose S/V in readmission. Conclusions: A significant association was detected between novel-dose S/V and all-cause readmission in HF patients, in part negatively mediated by LVRR. The web-based nomogram could provide individual prediction of all-cause readmission in HF patients receiving novel-dose S/V. The effects of different novel-dose S/V are still needed to be explored further in the future. [ABSTRACT FROM AUTHOR]

Published
2023
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22. miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury

Author

Yang, Jing, primary, Do-Umehara, Hanh Chi, additional, Zhang, Qiao, additional, Wang, Huashan, additional, Hou, Changchun, additional, Dong, Huali, additional, Perez, Edith A., additional, Sala, Marc A., additional, Anekalla, Kishore R., additional, Walter, James M., additional, Liu, Shuwen, additional, Wunderink, Richard G., additional, Budinger, G.R. Scott, additional, and Liu, Jing, additional

Published
2021
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23. Fluoride exposure and children’s intelligence: Gene-environment interaction based on SNP-set, gene and pathway analysis, using a case-control design based on a cross-sectional study

Author

Yu, Xingchen, primary, Xia, Lu, additional, Zhang, Shun, additional, Zhou, Guoyu, additional, Li, Yonggang, additional, Liu, Hongliang, additional, Hou, Changchun, additional, Zhao, Qian, additional, Dong, Lixin, additional, Cui, Yushan, additional, Zeng, Qiang, additional, Wang, Aiguo, additional, and Liu, Li, additional

Published
2021
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29. Health risks of PM2.5-bound polycyclic aromatic hydrocarbon (PAH) and heavy metals (PPAH&HM) during the replacement of central heating with urban natural gas in Tianjin, China.

Author

Zhang, Jingwei, Feng, Lihong, Zhao, Yan, Hou, Changchun, and Gu, Qing

Subjects
NATURAL gas, HEALTH risk assessment, ACENAPHTHENE, FLUORANTHENE, PARTICULATE matter, POLYCYCLIC aromatic hydrocarbons, HEAVY metals, ANTHRACENE
Abstract

To investigate the health effects of fine particulate matter (≤ 2.5 μm in aerodynamic diameter; PM2.5)-bound heavy metals and polycyclic aromatic hydrocarbons (PAHs) before and after the implementation of the Urban Natural Gas Heating Project (UNGHP), the lifetime cancer risks, hazard quotients (HQs) of heavy metals and PAHs were calculated. Seven kinds of heavy metals (Al, As, Cd, Cr, Mn, Ni and Se) and 12 kinds of PAHs including acenaphthylene (ANY), acenaphthene (ANA), fluoranthene (FLT), pyrene (PYR), chrysene (CHR), benz[a]anthracene (BaA), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), benzo[a]pyrene (BaP), dibenz[a,h]anthracene (DBA), benzo[ghi]perylene (BPE) and indeno[1,2,3-cd]pyrene (IPY) were analyzed and used for the health risk assessments. It was found that HQ of Mn fell from 1.09 in the coal-burning period to 0.72 in the gas-burning period in the suburban area. And lifetime cancer risks of PAHs fell from 35.7 × 10–6 in the coal-burning period to 17.22 × 10–6 in the gas-burning period in the urban area. It could be concluded that, during the gas-burning period, downward trends were observed for the lifetime cancer risks and HQs of most kinds of heavy metals and PAHs in all regions of Tianjin compared to those during the coal-burning period. The UNGHP was effective, and we should also take other measures to control the pollution. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Thyroid function, intelligence, and low-moderate fluoride exposure among Chinese school-age children

Author

Wang, Mengwei, primary, Liu, Ling, additional, Li, Huijun, additional, Li, Yonggang, additional, Liu, Hongliang, additional, Hou, Changchun, additional, Zeng, Qiang, additional, Li, Pei, additional, Zhao, Qian, additional, Dong, Lixin, additional, Zhou, Guoyu, additional, Yu, Xingchen, additional, Liu, Li, additional, Guan, Qing, additional, Zhang, Shun, additional, and Wang, Aiguo, additional

Published
2020
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40. High mobility group protein B1 (HMGB1) interacts with receptor for advanced glycation end products (RAGE) to promote airway smooth muscle cell proliferation through ERK and NF-κB pathways

Author

Qu, Dongming, Ling, Zhougui, Tan, Xiaoyu, Chen, Yan, Huang, Qinghua, Li, Mengze, Liu, Tangjuan, Hou, Changchun, and Chen, Yiqiang

Subjects
chemical and pharmacologic phenomena, Original Article
Abstract

Background: High-mobility graoup box protein 1 (HMGB1) has been shown to mediate a wide range of pathologic responses by interacting with RAGE (receptor for advanced glycation endproducts) and TLRs (Toll-like receptors). Our previous study showed that HMGB1 has been involved in pathogenesis of airway remodeling in an allergen-induced chronic mice asthma model. Increased airway smooth muscle (ASM) mass is a vital feature of airway remodeling. Objective: To evaluate the effect of HMGB1 on proliferation of ASMs and the underlying mechanisms. Methods: Rat airway smooth muscle cells (RASMs) were obtained by primary explant techniques. We investigated the effect of HMGB1 on the proliferation of RASMs. To identify which receptors and signaling pathways be involved in proliferation of RASMs, we performed western blot and CCK-8 assay by specific receptor blockade and inhibition of MAPK (p38, JNK and ERK) and NF-κB signaling pathways. Results: HMGB1 stimulated RASMs proliferation in a dose- and time-dependent manner and also increased proliferating cell nuclear antigen (PCNA) and RAGE expression of RASMs. The inhibitor of RAGE, but not TLR2 and TLR4, reversed HMGB1-induced RASM proliferation and PCNA expression. Incubation of RASMs with HMGB1 caused a rapid increase in P65 and ERK phosphorylation. RASM proliferation and PCNA expression toward HMGB1 were significantly inhibited by the inhibitors of ERK and NF-κB. Conclusion: HMGB1 induces proliferation of RASMs through a RAGE-dependent activation of ERK and NF-κB signaling pathways.

Published
2019

41. Erythromycin combined with corticosteroid reduced inflammation and modified trauma-induced tracheal stenosis in a rabbit model

Author

Li Wentao, Gan Luoman, Meng Xiaoyan, Qin Enyuan, Liu Guang-nan, Gan Jinghua, Li Lihua, Hou Changchun, Zhou Lei, Li Yu, and Xu Mingpeng

Subjects
Pulmonary and Respiratory Medicine, Male, corticosteroid, medicine.drug_class, medicine.medical_treatment, Anti-Inflammatory Agents, Erythromycin, Inflammation, Endotracheal intubation, tracheostomy, Penicillins, Collagen Type I, intubation, Transforming Growth Factor beta1, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, medicine, Intubation, Animals, Pharmacology (medical), tracheal stenosis, 030223 otorhinolaryngology, Budesonide, Amikacin, Glucocorticoids, Original Research, lcsh:RC705-779, business.industry, fibrosis, lcsh:Diseases of the respiratory system, medicine.disease, Tracheal Stenosis, Anti-Bacterial Agents, Trachea, Disease Models, Animal, Collagen Type III, Gene Expression Regulation, 030220 oncology & carcinogenesis, Anesthesia, Rabbit model, Corticosteroid, Drug Therapy, Combination, Rabbits, medicine.symptom, business, medicine.drug
Abstract

Background: Patients with endotracheal intubation or tracheostomy are subject to benign tracheal stenosis (TS), for which current therapies are unsatisfactory. We conducted a preliminary investigation of drugs and drug combinations for the prevention and treatment of TS in a rabbit model. Methods: Fifty-four rabbits were apportioned into nine groups according to treatment: sham-operated control; untreated TS model; amikacin; budesonide; erythromycin; penicillin; amikacin + budesonide; erythromycin + budesonide; and penicillin + budesonide. TS was induced by abrasion during surgery. The drugs were applied for 7 days before and 10 days after the surgery. Rabbits were killed on the eleventh day. Tracheal specimens were processed for determining alterations in the thicknesses of tracheal epithelium and lamina propria via hematoxylin and eosin. The tracheal mRNA (assessed by real-time quantitative polymerase chain reaction) expressions of the following fibrotic-related factors were determined: transforming growth factor-β1 (TGF- β1), collagen type I (COL1A1), collagen type III (COL3A1), and interleukin-17 (IL-17). The protein levels of TGF-β1, COL1A1, and COL3A1 were determined through immunohistochemistry and integrated optical densities. Results: Compared with all other groups, the untreated TS model had significantly thicker tracheal epithelium and lamina propria, and higher mRNA and protein levels of all targeted fibrotic factors. The mRNA and protein levels of the targeted fibrotic factors in all the drug-treated groups were lower than those of the untreated TS model, and differences were most significant in the erythromycin + budesonide group. Conclusions: Erythromycin combined with budesonide may reduce inflammation and modify fibrosis progression in TS after tracheal injury.

Published
2018

46. Dopamine receptor D2 gene polymorphism, urine fluoride, and intelligence impairment of children in China: A school-based cross-sectional study

Author

Cui, Yushan, primary, Zhang, Bin, additional, Ma, Jing, additional, Wang, Yang, additional, Zhao, Liang, additional, Hou, Changchun, additional, Yu, Jingwen, additional, Zhao, Yang, additional, Zhang, Zushan, additional, Nie, Junyan, additional, Gao, Tongning, additional, Zhou, Guoli, additional, and Liu, Hongliang, additional

Published
2018
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48. Interactive effect between temperature and fine particulate matter on chronic disease hospital admissions in the urban area of Tianjin, China.

Author

Zhang, Jingwei, Feng, Lihong, Hou, Changchun, and Gu, Qing

Subjects
CHRONIC diseases, CORONARY disease, HOSPITAL care, METROPOLITAN areas, NITROGEN oxides, TYPE 2 diabetes, STROKE, TEMPERATURE, PARTICULATE matter
Abstract

This study focuses on effects of fine particulate matter (PM2.5) on chronic disease under different levels of temperature. We obtained type 2 diabetes, cerebral stroke and coronary heart disease hospital admissions (HAs) from five hospitals in urban Tianjin as well as the concentrations of PM2.5, nitrogen dioxide (NO2) and sulphur dioxide (SO2). We used distributed lag nonlinear models to explore nonlinear and lag effects of PM2.5. In single-pollutant models, PM2.5 was positively associated with type 2 diabetes, cerebral stroke and coronary heart disease HAs, with strongest effects at lag1, lag0 and lag06, respectively. The corresponding relative risk rates (RR%) were 1.836%, 2.083% and 6.428%. In co-pollutant models, the correlation between PM2.5 and HAs on high-temperature days was generally stronger than that on low-temperature days. This study indicated that PM2.5 can increase HA rates for these chronic diseases, and effects of PM2.5 on high-temperature days were stronger than that on low-temperature days. [ABSTRACT FROM AUTHOR]

Published
2021
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49. Threshold effects of moderately excessive fluoride exposure on children's health: A potential association between dental fluorosis and loss of excellent intelligence

Author

Yu, Xingchen, primary, Chen, Jingwen, additional, Li, Yonggang, additional, Liu, Hongliang, additional, Hou, Changchun, additional, Zeng, Qiang, additional, Cui, Yushan, additional, Zhao, Liang, additional, Li, Pei, additional, Zhou, Ziquan, additional, Pang, Shuo, additional, Tang, Sha, additional, Tian, Kunming, additional, Zhao, Qian, additional, Dong, Lixin, additional, Xu, Chunyan, additional, Zhang, Xiao, additional, Zhang, Shun, additional, Liu, Li, additional, and Wang, Aiguo, additional

Published
2018
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