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2. Vascular dementia: pharmacological treatment approaches and perspectives.

Author

Baskys, Andrius and Hou, Anthony C

Subjects
Brain Ischemia: complications, drug therapy, metabolism, Cholinesterase Inhibitors: therapeutic use, Cognition: drug effects, Dementia, Vascular: drug therapy, etiology, metabolism, Excitatory Amino Acid Antagonists: therapeutic use, Glutamic Acid: metabolism, Humans, Nerve Degeneration: complications, drug therapy, etiology, metabolism, Neuroprotective Agents: pharmacology, therapeutic use, Nootropic Agents: pharmacology, therapeutic use, Receptors, Glutamate: drug effects, metabolism, Treatment Outcome
Abstract

Vascular dementia is a common condition for which there are no effective approved pharmacological treatments available. Absence of effective treatments creates a difficult situation for those suffering from the disease, their caregivers, and healthcare providers. This review will address our current understanding of the mechanisms of nerve cell damage due to ischemia and summarize available clinical trial data on several commonly used compounds including memantine, donepezil, galantamine, rivastigmine, nimodipine, hydergine, nicergoline, CDP-choline, folic acid, as well as such nonpharmacological approaches as validation therapy.

Published
2007

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