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5. Pathophysiologie der Azidose bei Sepsis

Author

Hotchkiss, R. S., Lenz, Kurt, editor, Laggner, Anton N., editor, Kleinberger, Gunther, editor, Ritz, Rudolf, editor, Schneeweiß, Bruno, editor, Schuster, Hans-Peter, editor, and Waldhäusl, Werner, editor

Published
1994
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8. Author Correction: A guiding map for inflammation (Nature Immunology, (2017), 18, 8, (826-831), 10.1038/ni.3790)

Author

Netea, M.G. Balkwill, F. Chonchol, M. Cominelli, F. Donath, M.Y. Giamarellos-Bourboulis, E.J. Golenbock, D. Gresnigt, M.S. Heneka, M.T. Hoffman, H.M. Hotchkiss, R. Joosten, L.A.B. Kastner, D.L. Korte, M. Latz, E. Libby, P. Mandrup-Poulsen, T. Mantovani, A. Mills, K.H.G. Nowak, K.L. O’Neill, L.A. Pickkers, P. van der Poll, T. Ridker, P.M. Schalkwijk, J. Schwartz, D.A. Siegmund, B. Steer, C.J. Tilg, H. van der Meer, J.W.M. van de Veerdonk, F.L. Dinarello, C.A.

Subjects
GeneralLiterature_MISCELLANEOUS, ComputingMilieux_MISCELLANEOUS
Abstract

In the version of this article initially published, in the Acknowledgements, the grant number for the Start Grant TWILIGHT awarded to M.A.L. by the European Research Council was omitted. The correct wording is “Supported by...the European Research Council (...Start Grant TWILIGHT (637801) to M.A.L.).” The error has not been corrected in the original article. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

Published
2021

10. Circulating BiP/Grp78 is a novel prognostic marker for sepsis-mediated immune cell death

Author

Doerflinger, M, Reljic, B, Menassa, J, Nedeva, C, Jose, I, Faou, P, Mackiewicz, L, Mansell, A, Pellegrini, M, Hotchkiss, R, Puthalakath, H, Doerflinger, M, Reljic, B, Menassa, J, Nedeva, C, Jose, I, Faou, P, Mackiewicz, L, Mansell, A, Pellegrini, M, Hotchkiss, R, and Puthalakath, H

Abstract

Sepsis remains to be a major contributor to mortality in ICUs, and immune suppression caused by immune cell apoptosis determines the overall patient survival. However, diagnosis of sepsis-induced lymphopenia remains problematic with no accurate prognostic techniques or biomarkers for cell death available. Developing reliable prognostic tools for sepsis-mediated cell death is not only important for identifying patients at increased risk of immune suppression but also to monitor treatment progress of currently trialed immunotherapy strategies. We have previously shown an important role for endoplasmic reticulum stress (ER stress) in inducing sepsis-mediated cell death and here report on the identification of a secreted form of the ER chaperone BiP (immunoglobulin binding protein) as a novel circulating prognostic biomarker for immune cell death and ER stress during sepsis. Using biochemical purification and mass spectrometry coupled with an established in vitro sepsis cell death assay, we identified BiP/Grp78 as a factor secreted by lipopolysaccharide-activated macrophages that is capable of inducing cell death in target cells. Quantitative ELISA analysis showed significantly elevated levels of circulating BiP in mice undergoing polymicrobial sepsis, which was absent in Bim-/- mice that are protected from sepsis-induced lymphopenia. Using blood serum from human sepsis patients, we could detect a significant difference in levels of secreted BiP in sepsis patients compared to nonseptic controls, suggesting that secreted circulating BiP could indeed be used as a prognostic marker that is directly correlative to immune cell death during sepsis.

Published
2021

17. A guiding map for inflammation

Author

Netea, M.G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M.Y., Giamarellos-Bourboulis, E.J., Golenbock, D., Gresnigt, M.S., Heneka, M.T., Hoffman, H.M., Hotchkiss, R., Joosten, L.A.B., Kastner, D.L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K.H., Nowak, K.L., O'Neill, L.A., Pickkers, P., Poll, T. van der, Ridker, P.M., Schalkwijk, J., Schwartz, D.A., Siegmund, B., Steer, C.J., Tilg, H., Meer, J.W.M. van der, Veerdonk, F.L. van de, Dinarello, C.A., Netea, M.G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M.Y., Giamarellos-Bourboulis, E.J., Golenbock, D., Gresnigt, M.S., Heneka, M.T., Hoffman, H.M., Hotchkiss, R., Joosten, L.A.B., Kastner, D.L., Korte, M., Latz, E., Libby, P., Mandrup-Poulsen, T., Mantovani, A., Mills, K.H., Nowak, K.L., O'Neill, L.A., Pickkers, P., Poll, T. van der, Ridker, P.M., Schalkwijk, J., Schwartz, D.A., Siegmund, B., Steer, C.J., Tilg, H., Meer, J.W.M. van der, Veerdonk, F.L. van de, and Dinarello, C.A.

Abstract

Contains fulltext : 177132.pdf (publisher's version ) (Closed access), Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.

Published
2017

18. The skeletal genome anatomy project (SGAP)

Author

Teslovich, T.M., McKeane, D.P., Pearson, K.E., Francomano, C., Hotchkiss, R., and Stephan, D.A.

Subjects
Genomes -- Research, Genetic disorders -- Research, Musculoskeletal diseases -- Genetic aspects, Biological sciences
Published
2001

19. DETERMINING IRRIGATION CANAL SEEPAGE WITH ELECTRICAL RESISTIVITY

Author

Hotchkiss, R. H., Wingert, C. B., and Kelly, W. E.

Subjects
Seepage -- Measurement, Irrigation canals and flumes -- Management, Engineering and manufacturing industries, Science and technology
Abstract

Procedures were developed and tested for quantifying seepage losses in unlined irrigation canals for reaches on the order of 100 ft (30 m). The procedure is appropriate for trapezoidal canal sections underlain by clay with a layer of more permeable material at depth. These conditions prevail throughout much of the Central Nebraska Public Power and Irrigation District (Central) canal system. The procedure uses electrical resistivity (ER) measurements while canals are in service to determine the resistivity of the underlying clay layer. ER data were correlated to canal depth and then to seepage rate. Seepage rates were determined using seepage meters. Field test sites showed seepage rates from 0.07 to 0.62 ([ft.sup.3] [multiplied by] s) (ft width [multiplied by] mi) [0.0041 to 0.036 ([m.sup.3] [multiplied by] s) (m width [multiplied by] km)]. Accuracy is approximately [+ or -] 20%, comparable to that achieved using stream-gauge methods, which can achieve a [+ or -] 5% error of total canal discharge. The ER approach, however, can easily pinpoint seepage zones more precisely than accomplished using stream gauging and will allow Central to reduce the length of canal lining projects. The methods outlined in this paper are simple, relatively quick, and can provide seepage estimates for short reaches in extensive conveyance systems. Such information will be valuable to managers as they make decisions regarding water conservation and ground-water management and where to invest limited resources.

Published
2001

23. Ultrasonic water measurement in irrigation pipelines with disturbed flow

Author

Johnson, A. L., Benham, Brian L., Eisenhauer, D. E., Hotchkiss, R. H., Biological Systems Engineering, and Virginia Tech

Subjects
Water measurement, Irrigation pipeline, Metering, education, Agricultural engineering, Ultrasonic measurement system
Abstract

Ultrasonicflow meter accuracy was investigated over a range of flow conditions (3 pipe materials, 2 pipe sizes, 4 Reynolds numbers, 7 flow-disturbing devices) commonly found in irrigation systems. Flow rate measurements were taken at five locations downstream from a flow disturbance. The measurement accuracy was within +/-5% of actual flow at a minimum of 10 pipe diameters downstream from the flow disturbances. Errors as high as 36.5% occurred when measurements were taken close to some flow disturbances. A multiplier was developed to correct for directional bias for devices that fell into the Group I category (single elbow, two elbows, check valve, and 50% open butterfly valve with vertical and horizontal orientation). Applying the multiplier at 4.5 pipe diameters and higher resulted in accuracies within +/-4% of actual flow. The regression analysis performed on Group I devices showed that the USFM performance was not significantly different for the three pipe materials, two pipe diameters, and four flow rates.

Published
2001

24. Sampling Local Fungal Diversity in an Undergraduate Laboratory using DNA Barcoding

Author

Harrington, A. H., primary, Bigott, A., additional, Anderson, B., additional, Boone, M., additional, Brick, S., additional, delSol, J., additional, Hotchkiss, R., additional, Huddleston, R., additional, Kasper, E., additional, McGrady, J., additional, McKinnie, M., additional, Ottenlips, M., additional, Skinner, N., additional, Spatz, K., additional, Steinberg, A., additional, van den Broek, F., additional, Wilson, C., additional, Wofford, A., additional, and Willyard, A., additional

Published
2014
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27. Project Edison: SMART-DC

Author

Williamson, B. J., primary, Redfern, M. A., additional, Aggarwal, R. K., additional, Allinson, J., additional, Harris, C., additional, Bowley, P., additional, and Hotchkiss, R., additional

Published
2011
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31. Ultrasonic water measurement in irrigation pipelines with disturbed flow

Author

Biological Systems Engineering, Johnson, A. L., Benham, Brian L., Eisenhauer, D. E., Hotchkiss, R. H., Biological Systems Engineering, Johnson, A. L., Benham, Brian L., Eisenhauer, D. E., and Hotchkiss, R. H.

Abstract

Ultrasonicflow meter accuracy was investigated over a range of flow conditions (3 pipe materials, 2 pipe sizes, 4 Reynolds numbers, 7 flow-disturbing devices) commonly found in irrigation systems. Flow rate measurements were taken at five locations downstream from a flow disturbance. The measurement accuracy was within +/-5% of actual flow at a minimum of 10 pipe diameters downstream from the flow disturbances. Errors as high as 36.5% occurred when measurements were taken close to some flow disturbances. A multiplier was developed to correct for directional bias for devices that fell into the Group I category (single elbow, two elbows, check valve, and 50% open butterfly valve with vertical and horizontal orientation). Applying the multiplier at 4.5 pipe diameters and higher resulted in accuracies within +/-4% of actual flow. The regression analysis performed on Group I devices showed that the USFM performance was not significantly different for the three pipe materials, two pipe diameters, and four flow rates.

Published
2001

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