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43. Carvacrol improved learning and memory and attenuated the brain tissue oxidative damage in aged male rats.

Author

Forqani, Mohammad Amin, Akbarian, Mahsan, Amirahmadi, Sabiheh, Soukhtanloo, Mohammad, Hosseini, Mahmoud, and Forouzanfar, Fatemeh

Subjects
SULFHYDRYL group, CARVACROL, MEMORY disorders, LEARNING ability, HERBAL medicine
Abstract

Introduction: Aging is an unavoidable process in the body that is accompanied by impaired tissue homeostasis and various changes. Carvacrol has attracted considerable attention for its wide range of pharmacological activities. Therefore, this study attempted to explore the protective effect of carvacrol in aged rats.Materiel and methods: The aged rats were given carvacrol (15 or 30 mg/kg/day) for 4 weeks. Morris water maze and passive avoidance tests were used to determine the learning and memory abilities of the rats. The hippocampus and cortex samples were taken for biochemical analysis.Results: In comparison to young control rats, aged control rats showed learning and memory deficits. There was improvement in the Morris water navigation test and passive avoidance test performance in the treatment groups versus the aged control group. An increment in malondialdehyde (MDA) and a decrease in total thiol groups in the hippocampus and cortex samples of aged control rats in comparison to the young control group were observed. Carvacrol decreased MDA levels and increased total thiol groups in the hippocampus and cortex samples of aged rats.Conclusion: Carvacrol improved learning and memory in aged rats, probably through its anti-oxidation effects. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Minocycline mitigates sepsis‐induced neuroinflammation and promotes recovery in male mice: Insights into neuroprotection and inflammatory modulation.

Author

Hosseini, Mahmoud, Bardaghi, Zahra, Askarpour, Hedyeh, Rajabian, Arezoo, Mahmoudabady, Maryam, Shabab, Sadegh, Samadi‐Noshahr, Zahra, and Salmani, Hossein

Subjects
*ENCEPHALITIS, *BRAIN injuries, *NEUROLOGICAL disorders, *BRAIN damage, *INTRAPERITONEAL injections
Abstract

Sepsis is associated with brain injury and acute brain inflammation, which can potentially transition into chronic inflammation, triggering a cascade of inflammatory responses that may lead to neurological disorders. Minocycline, recognized for its potent anti‐inflammatory properties, was investigated in this study for its protective effects against sepsis‐induced brain injury. Adult male C57 mice pretreated with minocycline (12.5, 25, and 50 mg/kg) 3 days before sepsis induction. An intraperitoneal injection of 5 mg/kg LPS was used to induce sepsis. Spontaneous locomotor activity (SLA) and weight changes were assessed over several days post‐sepsis to monitor the recovery of the mice. The expression of inflammatory mediators and oxidative stress markers was assessed 24 h post sepsis. Septic mice exhibited significant weight loss and impaired SLA. Initially, minocycline did not attenuate the severity of weight loss (1 day) or SLA (4 h post‐sepsis), but it significantly accelerated the recovery of the mice in later days. Minocycline dose‐dependently mitigated sepsis‐induced brain inflammation and oxidative stress. Our findings demonstrate that pretreatment with minocycline has the potential to prevent brain tissue damage and accelerate recovery from sepsis in mice, suggesting that minocycline may serve as a promising therapeutic intervention to protect against sepsis‐induced neurological complications. [ABSTRACT FROM AUTHOR]

Published
2024
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