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24 results on '"Hossain, Lorraine"'

1. Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks

Author

Liu, Ren, Lee, Jihwan, Tchoe, Youngbin, Pre, Deborah, Bourhis, Andrew M, D'Antonio‐Chronowska, Agnieszka, Robin, Gaelle, Lee, Sang Heon, Ro, Yun Goo, Vatsyayan, Ritwik, Tonsfeldt, Karen J, Hossain, Lorraine A, Phipps, M Lisa, Yoo, Jinkyoung, Nogan, John, Martinez, Jennifer S, Frazer, Kelly A, Bang, Anne G, and Dayeh, Shadi A

Subjects
Engineering, Biomedical Engineering, Cardiovascular, Heart Disease, Biotechnology, cardiomyocytes, culture, intracellular, nanowires, neurons, tissues, cardiomyocyte, nanowire, neuron, tissue, Physical Sciences, Chemical Sciences, Materials, Chemical sciences, Physical sciences
Abstract

We report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. Stable amplitudes of intracellular potentials from 3D tissue-like networks of neurons and cardiomyocytes are obtained. Individual electrical addressability is necessary for high-fidelity intracellular electrophysiological recordings. This study paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms.

Published
2022

2. Ultra-Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks

Author

Liu, Ren, Lee, Jihwan, Tchoe, Youngbin, Pre, Deborah, Bourhis, Andrew M., D'Antonio-Chronowska, Agnieszka, Robin, Gaelle, Lee, Sang Heon, Ro, Yun Goo, Vatsyayan, Ritwik, Tonsfeldt, Karen J., Hossain, Lorraine A., Phipps, M. Lisa, Yoo, Jinkyoung, Nogan, John, Martinez, Jennifer S., Frazer, Kelly A., Bang, Anne G., and Dayeh, Shadi A.

Subjects
Condensed Matter - Materials Science, Physics - Biological Physics, Physics - Medical Physics, Quantitative Biology - Cell Behavior, Quantitative Biology - Neurons and Cognition
Abstract

Intracellular access with high spatiotemporal resolution can enhance our understanding of how neurons or cardiomyocytes regulate and orchestrate network activity, and how this activity can be affected with pharmacology or other interventional modalities. Nanoscale devices often employ electroporation to transiently permeate the cell membrane and record intracellular potentials, which tend to decrease rapidly to extracellular potential amplitudes with time. Here, we report innovative scalable, vertical, ultra-sharp nanowire arrays that are individually addressable to enable long-term, native recordings of intracellular potentials. We report large action potential amplitudes that are indicative of intracellular access from 3D tissue-like networks of neurons and cardiomyocytes across recording days and that do not decrease to extracellular amplitudes for the duration of the recording of several minutes. Our findings are validated with cross-sectional microscopy, pharmacology, and electrical interventions. Our experiments and simulations demonstrate that individual electrical addressability of nanowires is necessary for high-fidelity intracellular electrophysiological recordings. This study advances our understanding of and control over high-quality multi-channel intracellular recordings, and paves the way toward predictive, high-throughput, and low-cost electrophysiological drug screening platforms., Comment: Main manuscript: 33 pages, 4 figures, Supporting information: 43 pages, 27 figures, Submitted to Advanced Materials

Published
2021

3. Correlation Structure in Micro-ECoG Recordings is Described by Spatially Coherent Components.

Author

Rogers, Nicholas, Hermiz, John, Ganji, Mehran, Kaestner, Erik, Kılıç, Kıvılcım, Hossain, Lorraine, Thunemann, Martin, Cleary, Daniel R, Carter, Bob S, Barba, David, Devor, Anna, Halgren, Eric, Dayeh, Shadi A, and Gilja, Vikash

Subjects
Cerebral Cortex, Animals, Humans, Mice, Polymers, Electroencephalography, Records, Electrodes, Implanted, Microelectrodes, Electric Conductivity, Electrophysiological Phenomena, Brain-Computer Interfaces, Electrocorticography, Electrodes, Implanted, Bioinformatics, Mathematical Sciences, Biological Sciences, Information and Computing Sciences
Abstract

Electrocorticography (ECoG) is becoming more prevalent due to improvements in fabrication and recording technology as well as its ease of implantation compared to intracortical electrophysiology, larger cortical coverage, and potential advantages for use in long term chronic implantation. Given the flexibility in the design of ECoG grids, which is only increasing, it remains an open question what geometry of the electrodes is optimal for an application. Conductive polymer, PEDOT:PSS, coated microelectrodes have an advantage that they can be made very small without losing low impedance. This makes them suitable for evaluating the required granularity of ECoG recording in humans and experimental animals. We used two-dimensional (2D) micro-ECoG grids to record intra-operatively in humans and during acute implantations in mouse with separation distance between neighboring electrodes (i.e., pitch) of 0.4 mm and 0.2/0.25 mm respectively. To assess the spatial properties of the signals, we used the average correlation between electrodes as a function of the pitch. In agreement with prior studies, we find a strong frequency dependence in the spatial scale of correlation. By applying independent component analysis (ICA), we find that the spatial pattern of correlation is largely due to contributions from multiple spatially extended, time-locked sources present at any given time. Our analysis indicates the presence of spatially structured activity down to the sub-millimeter spatial scale in ECoG despite the effects of volume conduction, justifying the use of dense micro-ECoG grids.

Published
2019

4. PEDOT:PSS/Parylene C ECoG Microelectrode Arrays for Multi-Modal Recording of Brain Activity in Birds and Rodents

Author

Hossain, Lorraine Amena

Subjects
Materials Science, Engineering, Neurosciences, electrocorticography, electrophysiology, microelectrode, PEDOT:PSS
Abstract

Understanding cognitive processing in intact brains is the subject of intense research efforts that aim to resolve individual and network activity of neuronal cells across different layers of the brain. While efforts to record a large number of individual cellular activity in intact brains are underway, the network-level coordinated activity of neurons result in long-range, low frequency oscillations that carry significant electrophysiological information and is the gold standard for recording neural correlates of cognition from animals and humans. Recently, recording of individual cellular activity, commonly referred to as single units, with high signal-to-noise ratio from the cortical surface was accomplished. Critical to this milestone in electrophysiology was the use of organic microelectrode arrays that (1) possess superior electrochemical junction characteristics enabling them to have contact diameters that are similar to neuronal sizes yet while maintaining low electrochemical impedances and low noise, and (2) enable conformal coverage of thin parylene C device carrier layers to the brain curvature. The small contact diameter, and therefore listening sphere, its low noise, and its intimate contact with the surface of the brain are all attributed as essential conditions to permit the recording of single unit activity from the brain’s surface. This thesis appraises the development of novel microelectrode arrays that record single units from the brain’s surface, and their application in recording brain activity from anesthetized and awake animal models. The first part of the dissertation discusses the application of Poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, commonly known as PEDOT:PSS – a semiconductive polymer with excellent electrochemical properties – as well as microelectrode contacts that employ large surface area one-dimensional nanostructures, to the electrophysiological investigations in songbird experiments. Significantly, we observed strong correlation of surface-recorded single units with spectrotemporal features of replayed birdsongs across trials and that were also validated with simultaneously implanted depth electrodes. This finding has implications for minimally destructive brain-machine interfaces that can make use of surface-recorded units. Additionally, we carried out systematic investigations to understand the influence of the electrode contact diameter and the contact material on resolving single unit activity from the surface of the brain. Our initial results suggest that contacts with lower impedances result in higher signal amplitude as well as higher biological noise amplitude, due to their sensitivity and that amplitude of single units generally decreases with diameter.While acute recordings can streamline testing of neurotechnologies, chronic recordings are important for applications in which subjects can ultimately engage in behavioral experiments. To this end, the last part of this dissertation concerns with the development and optimization of a chronically stable device form factor. This device leverages the transparency of the parylene C substrate to perform simultaneous electrophysiological recording and multi-photon imaging of neuronal activity in awake mice. We recorded stimulus-evoked calcium indicator responses that correlated with local field potential (LFP) response and higher frequency multi-and single unit activity. This dissertation encompasses advances in the scalable, monolithic fabrication procedure for high-yield PEDOT:PSS microelectrode arrays on parylene C substrates and their utility of electrocorticography (ECoG) recording capability of neuronal activity from intact brains.

Published
2020

5. Imaging through Windansee electrode arrays reveals a small fraction of local neurons following surface MUA

Author

Thunemann, Martin, primary, Hossain, Lorraine, additional, Ness, Torbjørn V., additional, Rogers, Nicholas, additional, Lee, Keundong, additional, Lee, Sang Heon, additional, Kılıç, Kıvılcım, additional, Oh, Hongseok, additional, Economo, Michael N., additional, Gilja, Vikash, additional, Einevoll, Gaute T., additional, Dayeh, Shadi A., additional, and Devor, Anna, additional

Published
2022
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6. Scalable Thousand Channel Penetrating Microneedle Arrays on Flex for Multimodal and Large Area Coverage BrainMachine Interfaces (Adv. Funct. Mater. 25/2022)

Author

Lee, Sang Heon, primary, Thunemann, Martin, additional, Lee, Keundong, additional, Cleary, Daniel R., additional, Tonsfeldt, Karen J., additional, Oh, Hongseok, additional, Azzazy, Farid, additional, Tchoe, Youngbin, additional, Bourhis, Andrew M., additional, Hossain, Lorraine, additional, Ro, Yun Goo, additional, Tanaka, Atsunori, additional, Kılıç, Kıvılcım, additional, Devor, Anna, additional, and Dayeh, Shadi A., additional

Published
2022
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7. Ultra‐Sharp Nanowire Arrays Natively Permeate, Record, and Stimulate Intracellular Activity in Neuronal and Cardiac Networks

Author

Liu, Ren, primary, Lee, Jihwan, additional, Tchoe, Youngbin, additional, Pre, Deborah, additional, Bourhis, Andrew M., additional, D'Antonio‐Chronowska, Agnieszka, additional, Robin, Gaelle, additional, Lee, Sang Heon, additional, Ro, Yun Goo, additional, Vatsyayan, Ritwik, additional, Tonsfeldt, Karen J., additional, Hossain, Lorraine A., additional, Phipps, M. Lisa, additional, Yoo, Jinkyoung, additional, Nogan, John, additional, Martinez, Jennifer S., additional, Frazer, Kelly A., additional, Bang, Anne G., additional, and Dayeh, Shadi A., additional

Published
2021
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8. Microscale Physiological Events on the Human Cortical Surface

Author

Paulk, Angelique C, primary, Yang, Jimmy C, additional, Cleary, Daniel R, additional, Soper, Daniel J, additional, Halgren, Mila, additional, O’Donnell, Alexandra R, additional, Lee, Sang Heon, additional, Ganji, Mehran, additional, Ro, Yun Goo, additional, Oh, Hongseok, additional, Hossain, Lorraine, additional, Lee, Jihwan, additional, Tchoe, Youngbin, additional, Rogers, Nicholas, additional, Kiliç, Kivilcim, additional, Ryu, Sang Baek, additional, Lee, Seung Woo, additional, Hermiz, John, additional, Gilja, Vikash, additional, Ulbert, István, additional, Fabó, Daniel, additional, Thesen, Thomas, additional, Doyle, Werner K, additional, Devinsky, Orrin, additional, Madsen, Joseph R, additional, Schomer, Donald L, additional, Eskandar, Emad N, additional, Lee, Jong Woo, additional, Maus, Douglas, additional, Devor, Anna, additional, Fried, Shelley I, additional, Jones, Pamela S, additional, Nahed, Brian V, additional, Ben-Haim, Sharona, additional, Bick, Sarah K, additional, Richardson, Robert Mark, additional, Raslan, Ahmed M, additional, Siler, Dominic A, additional, Cahill, Daniel P, additional, Williams, Ziv M, additional, Cosgrove, G Rees, additional, Dayeh, Shadi A, additional, and Cash, Sydney S, additional

Published
2021
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12. Microscale physiological events on the human cortical surface detected with PEDOT:PSS Electrodes

Author

Paulk, Angelique C., Yang, Jimmy C., Cleary, Daniel R., Soper, Daniel J., Lee, Sang Heon, Ganji, Mehran, Ro, Yun Goo, Oh, Hongseok, Hossain, Lorraine, Rogers, Nick, Kiliç, Kivilcim, Ryu, Sang Baek, Lee, Seung Woo, Hermiz, John, Gilja, Vikash, Lee, Jong Woo, Maus, Douglas, Devor, Anna, Fried, Shelley I., Jones, Pamela S., Nahed, Brian V., Ben-Haim, Sharona, Raslan, Ahmed M. T., Siler, Dominic A., Cahill, Daniel P., Williams, Ziv M., Cosgrove, G. Rees, Dayeh, Shadi A., and Cash, Sydney S.

Abstract

Summary Efforts to deepen our understanding of the nervous system depends on high resolution sampling of neuronal activity. We leveraged clinically necessary intracranial monitoring performed during surgical resections to record from the cortical surface (N=30) using high spatial resolution, low impedance PEDOT:PSS microelectrodes. We identified three classes of activity. The first included relatively fast repeated waveforms with kinetics similar to, but not perfectly matching, extracellular single unit activity. The other two discrete unitary events with slower waveforms had event frequencies which were selectively modulated by auditory stimuli, electrical stimuli, pharmacological manipulation, and cold saline application. Furthermore, different classes had small but significant causal co-occurrences. We speculate that these different events could reflect axonal action potentials, dendritic calcium spikes, backpropagating action potentials or pre and post-synaptic phenomena, opening the possibility that we can sample information beyond typical extracellular somatic action potentials via high-density, low impedance electrodes on the cortical surface.

Published
2019
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13. Microscale physiological events on the human cortical surface

Author

Paulk, Angelique C., primary, Yang, Jimmy C., additional, Cleary, Daniel R., additional, Soper, Daniel J., additional, Halgren, Milan, additional, O’Donnell, Alexandra R., additional, Lee, Sang Heon, additional, Ganji, Mehran, additional, Ro, Yun Goo, additional, Oh, Hongseok, additional, Hossain, Lorraine, additional, Lee, Jihwan, additional, Tchoe, Youngbin, additional, Rogers, Nicholas, additional, Kiliç, Kivilcim, additional, Ryu, Sang Baek, additional, Lee, Seung Woo, additional, Hermiz, John, additional, Gilja, Vikash, additional, Ulbert, István, additional, Fabó, Daniel, additional, Devinsky, Orrin, additional, Madsen, Joseph R., additional, Schomer, Donald L., additional, Eskandar, Emad N., additional, Lee, Jong Woo, additional, Maus, Douglas, additional, Devor, Anna, additional, Fried, Shelley I., additional, Jones, Pamela S., additional, Nahed, Brian V., additional, Ben-Haim, Sharona, additional, Bick, Sarah K., additional, Richardson, Robert Mark, additional, Raslan, Ahmed M. T., additional, Siler, Dominic A., additional, Cahill, Daniel P., additional, Williams, Ziv M., additional, Cosgrove, G. Rees, additional, Dayeh, Shadi A., additional, and Cash, Sydney S., additional

Published
2019
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14. Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces

Author

Ganji, Mehran, primary, Paulk, Angelique C., additional, Yang, Jimmy C., additional, Vahidi, Nasim W., additional, Lee, Sang Heon, additional, Liu, Ren, additional, Hossain, Lorraine, additional, Arneodo, Ezequiel M., additional, Thunemann, Martin, additional, Shigyo, Michiko, additional, Tanaka, Atsunori, additional, Ryu, Sang Baek, additional, Lee, Seung Woo, additional, Tchoe, Youngbin, additional, Marsala, Martin, additional, Devor, Anna, additional, Cleary, Daniel R., additional, Martin, Joel R., additional, Oh, Hongseok, additional, Gilja, Vikash, additional, Gentner, Timothy Q., additional, Fried, Shelley I., additional, Halgren, Eric, additional, Cash, Sydney S., additional, and Dayeh, Shadi A., additional

Published
2019
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17. Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces

Author

Ganji, Mehran, Paulk, Angelique C., Yang, Jimmy C., Vahidi, Nasim W., Lee, Sang Heon, Liu, Ren, Hossain, Lorraine, Arneodo, Ezequiel M., Thunemann, Martin, Shigyo, Michiko, Tanaka, Atsunori, Ryu, Sang Baek, Lee, Seung Woo, Tchoe, Youngbin, Marsala, Martin, Devor, Anna, Cleary, Daniel R., Martin, Joel R., Oh, Hongseok, Gilja, Vikash, Gentner, Timothy Q., Fried, Shelley I., Halgren, Eric, Cash, Sydney S., and Dayeh, Shadi A.

Abstract

The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain–machine interfaces.

Published
2024
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19. Highly Scalable, Atomically Thin WSe2 Grown via Metal–Organic Chemical Vapor Deposition

Author

Eichfeld, Sarah M., primary, Hossain, Lorraine, additional, Lin, Yu-Chuan, additional, Piasecki, Aleksander F., additional, Kupp, Benjamin, additional, Birdwell, A. Glen, additional, Burke, Robert A., additional, Lu, Ning, additional, Peng, Xin, additional, Li, Jie, additional, Azcatl, Angelica, additional, McDonnell, Stephen, additional, Wallace, Robert M., additional, Kim, Moon J., additional, Mayer, Theresa S., additional, Redwing, Joan M., additional, and Robinson, Joshua A., additional

Published
2015
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22. Rapid, non-destructive evaluation of ultrathin WSe2 using spectroscopic ellipsometry.

Author

Eichfeld, Sarah M., Eichfeld, Chad M., Yu-Chuan Lin, Hossain, Lorraine, and Robinson, Joshua A.

Subjects
TUNGSTEN, ELLIPSOMETRY, SOLID state physics, ATOMIC force microscopy, BAND gaps
Abstract

The utilization of tungsten diselenide (WSe2) in electronic and optoelectronic devices depends on the ability to understand and control the process-property relationship during synthesis. We demonstrate that spectroscopic ellipsometry is an excellent technique for accurate, non-destructive determination of ultra-thin (<30 nm) WSe2 properties. The refractive index (n) and extinction coefficient (k) were found to be independent of thickness down to 1.3 nm, and were used to determine film thickness, which was confirmed to be within 9% of values found via atomic force microscopy. Finally, the optical bandgap was found to closely correlate with thickness, ranging from 1.2 to 1.55 eV as the WSe2 is thinned to the equivalent of 2 atomic layers. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Highly Scalable, Atomically Thin WSe2Grown viaMetal–Organic Chemical Vapor Deposition

Author

Eichfeld, Sarah M., Hossain, Lorraine, Lin, Yu-Chuan, Piasecki, Aleksander F., Kupp, Benjamin, Birdwell, A. Glen, Burke, Robert A., Lu, Ning, Peng, Xin, Li, Jie, Azcatl, Angelica, McDonnell, Stephen, Wallace, Robert M., Kim, Moon J., Mayer, Theresa S., Redwing, Joan M., and Robinson, Joshua A.

Abstract

Tungsten diselenide (WSe2) is a two-dimensional material that is of interest for next-generation electronic and optoelectronic devices due to its direct bandgap of 1.65 eV in the monolayer form and excellent transport properties. However, technologies based on this 2D material cannot be realized without a scalable synthesis process. Here, we demonstrate the first scalable synthesis of large-area, mono and few-layer WSe2viametal–organic chemical vapor deposition using tungsten hexacarbonyl (W(CO)6) and dimethylselenium ((CH3)2Se). In addition to being intrinsically scalable, this technique allows for the precise control of the vapor-phase chemistry, which is unobtainable using more traditional oxide vaporization routes. We show that temperature, pressure, Se:W ratio, and substrate choice have a strong impact on the ensuing atomic layer structure, with optimized conditions yielding >8 μm size domains. Raman spectroscopy, atomic force microscopy (AFM), and cross-sectional transmission electron microscopy (TEM) confirm crystalline monoto-multilayer WSe2is achievable. Finally, TEM and vertical current/voltage transport provide evidence that a pristine van der Waals gap exists in WSe2/graphene heterostructures.

Published
2015
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