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1. A comparison of patient pain and visual outcome using topical anesthesia versus regional anesthesia during cataract surgery

Author

Hosoda Y, Kuriyama S, Jingami Y, Hattori H, Hayashi H, and Matsumoto M

Subjects
cataract, anesthesia, topical, intracameral, sub-tenon, Ophthalmology, RE1-994
Abstract

Yoshikatsu Hosoda, Shoji Kuriyama, Yoko Jingami, Hidetsugu Hattori, Hisako Hayashi, Miho Matsumoto Department of Ophthalmology, Otsu Red-Cross Hospital, Otsu, Japan Purpose: The purpose of this study was to compare the level of patient pain during the phacoemulsification and implantation of foldable intraocular lenses while under topical, intracameral, or sub-Tenon lidocaine.Patients and methods: This was a retrospective study. Three hundred and one eyes subjected to cataract surgery were included in this study. All eyes underwent phacoemulsification surgery and intraocular lens implantation using topical, sub-Tenon, or intracameral anesthesia. The topical group received 4% lidocaine drops, and the intracameral group received a 0.1–0.2 cc infusion of 1% preservative-free lidocaine into the anterior chamber through the side port combined with topical drops of lidocaine. The sub-Tenon group received 2% lidocaine. Best-corrected visual acuity, corneal endothelial cell loss, and intraoperative pain level were evaluated. Pain level was assessed on a visual analog scale (range 0–2).Results: There were no significant differences in visual outcome and corneal endothelial cell loss between the three groups. The mean pain score in the sub-Tenon group was significantly lower than that in the topical and intracameral groups (P=0.0009 and P=0.0055, respectively). In 250 eyes without high myopia (

Published
2016

2. Two cases of malignant glaucoma unresolved by pars plana vitrectomy

Author

Hosoda Y, Akagi T, and Yoshimura N

Subjects
Ophthalmology, RE1-994
Abstract

Yoshikatsu Hosoda, Tadamichi Akagi, Nagahisa YoshimuraDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, JapanAbstract: Malignant glaucoma, which is characterized by a shallow or flat anterior chamber with high intraocular pressure, can usually be resolved by pars plana vitrectomy with anterior hyaloidectomy. We describe two cases in which malignant glaucoma was refractory to conventional treatment and complete vitrectomy. Case one an 88-year-old woman with pseudoexfoliation glaucoma underwent trabeculotomy and subsequently developed malignant glaucoma. Four months after transient recovery by pars plana vitrectomy, the malignant glaucoma recurred. She underwent peripheral iridectomy and local zonulectomy with successful control of her intraocular pressure. In case two, an 85-year-old man had a history of pseudoexfoliation glaucoma. Seven months after phacoemulsification and intraocular lens implantation, he developed malignant glaucoma that was refractory to pars plana vitrectomy. He underwent peripheral iridectomy, goniosynechialysis and trabectome surgery resulting in the successful control of his intraocular pressure. In rare cases of malignant glaucoma refractive to vitrectomy, peripheral iridectomy with or without local zonulectomy is a reasonable and minimally invasive surgical procedure.Keywords: malignant glaucoma, pars plana vitrectomy, peripheral iridectomy

Published
2014

4. P418 Dose escalation of oral 5-aminosalicylic acid for ulcerative colitis with Mayo endoscopic subscore of one improves long-term prognosis: a one-year multicentre, open-label, randomized controlled trial

Author

Aoki, Y, primary, Fukuda, T, additional, Kiyohara, H, additional, Yokoyama, A, additional, Nakazawa, A, additional, Yoshimatsu, Y, additional, Sugimoto, S, additional, Nanki, K, additional, Mikami, Y, additional, Fukuhara, K, additional, Mizuno, S, additional, Sujino, T, additional, Mutaguchi, M, additional, Takabayashi, K, additional, Morohoshi, Y, additional, Hosoda, Y, additional, Ogata, H, additional, Iwao, Y, additional, Naganuma, M, additional, and Kanai, T, additional

Published
2023
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5. Progress of divertor simulation research toward the realization of detached plasma using a large tandem mirror device

Author

Nakashima, Y., Takeda, H., Ichimura, K., Hosoi, K., Oki, K., Sakamoto, M., Hirata, M., Ichimura, M., Ikezoe, R., Imai, T., Iwamoto, M., Hosoda, Y., Katanuma, I., Kariya, T., Kigure, S., Kohagura, J., Minami, R., Numakura, T., Takahashi, S., Yoshikawa, M., Asakura, N., Fukumoto, M., Hatayama, A., Hirooka, Y., Kado, S., Kubo, H., Masuzaki, S., Matsuura, H., Nagata, S., Nishino, N., Ohno, N., Sagara, A., Shikama, T., Shoji, M., Tonegawa, A., and Ueda, Y.

Published
2015
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19. Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium

Author

Wong, Y.L., Hysi, P., Cheung, G., Tedja, M., Hoang, Q.V., Tompson, S.W., Whisenhunt, K.N., Verhoeven, V., Zhao, W., Hess, M., Wong, C.W., Kifley, A., Hosoda, Y., Haarman, A.E.G., Hopf, S., Laspas, P., Sensaki, S., Sim, X., Miyake, M., Tsujikawa, A., Lamoureux, E., Ohno-Matsui, K., Nickels, S., Mitchell, P., Wong, T.Y., Wang, J.J., Hammond, C.J., Barathi, V.A., Cheng, C.Y., Yamashiro, K., Young, T.L., Klaver, C.C.W., Saw, S.M., Wong, Y.L., Hysi, P., Cheung, G., Tedja, M., Hoang, Q.V., Tompson, S.W., Whisenhunt, K.N., Verhoeven, V., Zhao, W., Hess, M., Wong, C.W., Kifley, A., Hosoda, Y., Haarman, A.E.G., Hopf, S., Laspas, P., Sensaki, S., Sim, X., Miyake, M., Tsujikawa, A., Lamoureux, E., Ohno-Matsui, K., Nickels, S., Mitchell, P., Wong, T.Y., Wang, J.J., Hammond, C.J., Barathi, V.A., Cheng, C.Y., Yamashiro, K., Young, T.L., Klaver, C.C.W., and Saw, S.M.

Abstract

Contains fulltext : 208643.pdf (publisher's version ) (Open Access), PURPOSE: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). METHODS: A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study. Highly myopic (spherical equivalent [SE]

Published
2019

20. Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium

Author

Wong, Y.-L. (Yee-Ling), Hysi, P. (Pirro), Cheung, G. (Gemmy), Tedja, M. (Milly), Hoang, Q.V. (Quan V.), Tompson, S.W.J. (Stuart W.J.), Whisenhunt, K.N. (Kristina N.), Verhoeven, V.J.M. (Virginie), Zhao, W. (Wanting), Hess, M. (Moritz), Wong, C.-W. (Chee-Wai), Kifley, A. (Annette), Hosoda, Y. (Yoshikatsu), Haarman, A.E.G. (Annechien E.G.), Hopf, S. (Susanne), Laspas, P. (Panagiotis), Sensaki, S. (Sonoko), Sim, X. (Xueling), Miyake, M. (Masahiro), Tsujikawa, A. (Akitaka), Lamoureux, E.L. (Ecosse), Ohno-Matsui, K. (Kyoko), Nickels, S. (Stefan), Mitchell, P. (Paul), Wong, T.-Y. (Tien-Yin), Wang, J.J. (Jie Jin), Hammond, C.J. (Christopher), Barathi, V.A. (Veluchamy), Cheng, C.-Y. (Ching-Yu), Yamashiro, K. (Kenji), Young, T.L. (Terri), Klaver, C.C.W. (Caroline), Saw, S-M. (Seang-Mei), Wong, Y.-L. (Yee-Ling), Hysi, P. (Pirro), Cheung, G. (Gemmy), Tedja, M. (Milly), Hoang, Q.V. (Quan V.), Tompson, S.W.J. (Stuart W.J.), Whisenhunt, K.N. (Kristina N.), Verhoeven, V.J.M. (Virginie), Zhao, W. (Wanting), Hess, M. (Moritz), Wong, C.-W. (Chee-Wai), Kifley, A. (Annette), Hosoda, Y. (Yoshikatsu), Haarman, A.E.G. (Annechien E.G.), Hopf, S. (Susanne), Laspas, P. (Panagiotis), Sensaki, S. (Sonoko), Sim, X. (Xueling), Miyake, M. (Masahiro), Tsujikawa, A. (Akitaka), Lamoureux, E.L. (Ecosse), Ohno-Matsui, K. (Kyoko), Nickels, S. (Stefan), Mitchell, P. (Paul), Wong, T.-Y. (Tien-Yin), Wang, J.J. (Jie Jin), Hammond, C.J. (Christopher), Barathi, V.A. (Veluchamy), Cheng, C.-Y. (Ching-Yu), Yamashiro, K. (Kenji), Young, T.L. (Terri), Klaver, C.C.W. (Caroline), and Saw, S-M. (Seang-Mei)

Abstract

Purpose To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). Methods A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study. Highly myopic (spherical equivalent [SE] -5.0 diopters [D]) cases with MMD (N = 348), and two sets of controls were enrolled: (1) the first set included 16,275 emmetropes (SE -0.5 D); and (2) second set included 898 highly myopic subjects (SE -5.0 D) without MMD. MMD was classified based on the International photographic classification for pathologic myopia (META-PM). Results In the first analysis, comprising highly myopic cases with MMD (N = 348) versus emmetropic controls without MMD (N = 16,275), two SNPs were significantly associated with high myopia in adults with HM and MMD: (1) rs10824518 (P = 6.20E-07) in KCNMA1, which is highly expressed in human retinal and scleral tissues; and (2) rs524952 (P = 2.32E-16) near GJD2. In the second analysis, comprising highly myopic cases with MMD (N = 348) versus highly myopic controls without MMD (N = 898), none of the SNPs studied reached Bonferroni-corrected significance. Conclusions Of the 50 myopia-associated loci, we did not find any variant specifically associated with MMD, but the KCNMA1 and GJD2 loci were significantly associated with HM in highly myopic subjects with MMD, compared to emmetropes.

Published
2019
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21. Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.

Author

Yao, Y-G, Wong, Y-L, Hysi, P, Cheung, G, Tedja, M, Hoang, QV, Tompson, SWJ, Whisenhunt, KN, Verhoeven, V, Zhao, W, Hess, M, Wong, C-W, Kifley, A, Hosoda, Y, Haarman, AEG, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, T-Y, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, C-Y, Yamashiro, K, Young, TL, Klaver, CCW, Saw, S-M, Consortium of Refractive Error, Myopia (CREAM), Yao, Y-G, Wong, Y-L, Hysi, P, Cheung, G, Tedja, M, Hoang, QV, Tompson, SWJ, Whisenhunt, KN, Verhoeven, V, Zhao, W, Hess, M, Wong, C-W, Kifley, A, Hosoda, Y, Haarman, AEG, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, T-Y, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, C-Y, Yamashiro, K, Young, TL, Klaver, CCW, Saw, S-M, and Consortium of Refractive Error, Myopia (CREAM)

Abstract

PURPOSE: To evaluate the roles of known myopia-associated genetic variants for development of myopic macular degeneration (MMD) in individuals with high myopia (HM), using case-control studies from the Consortium of Refractive Error and Myopia (CREAM). METHODS: A candidate gene approach tested 50 myopia-associated loci for association with HM and MMD, using meta-analyses of case-control studies comprising subjects of European and Asian ancestry aged 30 to 80 years from 10 studies. Fifty loci with the strongest associations with myopia were chosen from a previous published GWAS study. Highly myopic (spherical equivalent [SE] ≤ -5.0 diopters [D]) cases with MMD (N = 348), and two sets of controls were enrolled: (1) the first set included 16,275 emmetropes (SE ≤ -0.5 D); and (2) second set included 898 highly myopic subjects (SE ≤ -5.0 D) without MMD. MMD was classified based on the International photographic classification for pathologic myopia (META-PM). RESULTS: In the first analysis, comprising highly myopic cases with MMD (N = 348) versus emmetropic controls without MMD (N = 16,275), two SNPs were significantly associated with high myopia in adults with HM and MMD: (1) rs10824518 (P = 6.20E-07) in KCNMA1, which is highly expressed in human retinal and scleral tissues; and (2) rs524952 (P = 2.32E-16) near GJD2. In the second analysis, comprising highly myopic cases with MMD (N = 348) versus highly myopic controls without MMD (N = 898), none of the SNPs studied reached Bonferroni-corrected significance. CONCLUSIONS: Of the 50 myopia-associated loci, we did not find any variant specifically associated with MMD, but the KCNMA1 and GJD2 loci were significantly associated with HM in highly myopic subjects with MMD, compared to emmetropes.

Published
2019

22. Correction: Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium.

Author

Wong, Y-L, Hysi, P, Cheung, G, Tedja, M, Hoang, QV, Tompson, SWJ, Whisenhunt, KN, Verhoeven, VJM, Zhao, W, Hess, M, Wong, C-W, Kifley, A, Hosoda, Y, Haarman, AEG, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, T-Y, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, C-Y, Yamashiro, K, Young, TL, Klaver, CCW, Saw, S-M, Consortium of Refractive Error, Myopia (CREAM), Wong, Y-L, Hysi, P, Cheung, G, Tedja, M, Hoang, QV, Tompson, SWJ, Whisenhunt, KN, Verhoeven, VJM, Zhao, W, Hess, M, Wong, C-W, Kifley, A, Hosoda, Y, Haarman, AEG, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, T-Y, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, C-Y, Yamashiro, K, Young, TL, Klaver, CCW, Saw, S-M, and Consortium of Refractive Error, Myopia (CREAM)

Abstract

[This corrects the article DOI: 10.1371/journal.pone.0220143.].

Published
2019

23. Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.

Author

Hosoda, Y, Miyake, M, Schellevis, RL, Boon, CJF, Hoyng, CB, Miki, A, Meguro, A, Sakurada, Y, Yoneyama, S, Takasago, Y, Hata, M, Muraoka, Y, Nakanishi, H, Oishi, A, Ooto, S, Tamura, H, Uji, A, Miyata, M, Takahashi, A, Ueda-Arakawa, N, Tajima, A, Sato, T, Mizuki, N, Shiragami, C, Iida, T, Khor, CC, Wong, TY, Yamada, R, Honda, S, de Jong, EK, Hollander, AID, Matsuda, F, Yamashiro, K, Tsujikawa, A, Hosoda, Y, Miyake, M, Schellevis, RL, Boon, CJF, Hoyng, CB, Miki, A, Meguro, A, Sakurada, Y, Yoneyama, S, Takasago, Y, Hata, M, Muraoka, Y, Nakanishi, H, Oishi, A, Ooto, S, Tamura, H, Uji, A, Miyata, M, Takahashi, A, Ueda-Arakawa, N, Tajima, A, Sato, T, Mizuki, N, Shiragami, C, Iida, T, Khor, CC, Wong, TY, Yamada, R, Honda, S, de Jong, EK, Hollander, AID, Matsuda, F, Yamashiro, K, and Tsujikawa, A

Abstract

The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent Japanese and European cohorts, consisting of 1546 CSC samples and 13,029 controls, identified two novel CSC susceptibility loci: TNFRSF10A-LOC389641 and near GATA5 (rs13278062, odds ratio = 1.35, P = 1.26 × 10-13; rs6061548, odds ratio = 1.63, P = 5.36 × 10-15). A T allele at TNFRSF10A-LOC389641 rs13278062, a risk allele for CSC, is known to be a risk allele for AMD. This study not only identified new susceptibility genes for CSC, but also improves the understanding of the pathogenesis of AMD.

Published
2019

24. Genetic variants linked to myopic macular degeneration in persons with high myopia: CREAM Consortium

Author

Wong, YL, Hysi, P, Cheung, G, Tedja, Milly, Hoang, QV, Tompson, SW, Whisenhunt, KN, Verhoeven, Virginie, Zhao, WT, Hess, M, Wong, CW, Kifley, A, Hosoda, Y, Haarman, Annet, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, TY, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, CY (Ching-Yu), Yamashiro, K, Young, TL, Klaver, Caroline, Saw, SM, Wong, YL, Hysi, P, Cheung, G, Tedja, Milly, Hoang, QV, Tompson, SW, Whisenhunt, KN, Verhoeven, Virginie, Zhao, WT, Hess, M, Wong, CW, Kifley, A, Hosoda, Y, Haarman, Annet, Hopf, S, Laspas, P, Sensaki, S, Sim, X, Miyake, M, Tsujikawa, A, Lamoureux, E, Ohno-Matsui, K, Nickels, S, Mitchell, P, Wong, TY, Wang, JJ, Hammond, CJ, Barathi, VA, Cheng, CY (Ching-Yu), Yamashiro, K, Young, TL, Klaver, Caroline, and Saw, SM

Published
2019

33. CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy

Author

Hosoda, Y, Yoshikawa, M, Miyake, M, Tabara, Y, Ahn, J, Woo, SJ, Honda, S, Sakurada, Y, Shiragami, C, Nakanishi, H, Oishi, A, Ooto, S, Miki, A, Iida, T, Iijima, H, Nakamura, M, Khor, CC, Wong, TY, Song, K, Park, KH, Yamada, R, Matsuda, F, Tsujikawa, A, Yamashiro, K, Hosoda, Y, Yoshikawa, M, Miyake, M, Tabara, Y, Ahn, J, Woo, SJ, Honda, S, Sakurada, Y, Shiragami, C, Nakanishi, H, Oishi, A, Ooto, S, Miki, A, Iida, T, Iijima, H, Nakamura, M, Khor, CC, Wong, TY, Song, K, Park, KH, Yamada, R, Matsuda, F, Tsujikawa, A, and Yamashiro, K

Abstract

Central serous chorioretinopathy (CSC) is a common disease affecting younger people and may lead to vision loss. CSC shares phenotypic overlap with age-related macular degeneration (AMD). As recent studies have revealed a characteristic increase of choroidal thickness in CSC, we conducted a genome-wide association study on choroidal thickness in 3,418 individuals followed by TaqMan assays in 2,692 subjects, and we identified two susceptibility loci: CFH rs800292, an established AMD susceptibility polymorphism, and VIPR2 rs3793217 (P = 2.05 × 10-10 and 6.75 × 10-8, respectively). Case-control studies using patients with CSC confirmed associations between both polymorphisms and CSC (P = 5.27 × 10-5 and 5.14 × 10-5, respectively). The CFH rs800292 G allele is reportedly a risk allele for AMD, whereas the A allele conferred risk for thicker choroid and CSC development. This study not only shows that susceptibility genes for CSC could be discovered using choroidal thickness as a defining variable but also, deepens the understanding of differences between CSC and AMD pathophysiology.

Published
2018

38. Recent Results of Divertor Simulation Experiments Using D-Module in the GAMMA 10/PDX Tandem Mirror

Author

Nakashima, Y., primary, Sakamoto, M., additional, Takeda, H., additional, Ichimura, K., additional, Hosoda, Y., additional, Iwamoto, M., additional, Shimizu, K., additional, Hosoi, K., additional, Oki, K., additional, Yoshikawa, M., additional, Hirata, M., additional, Ikezoe, R., additional, Imai, T., additional, Kariya, T., additional, Katanuma, I., additional, Kohagura, J., additional, Minami, R., additional, Numakura, T., additional, Wang, X., additional, and Ichimura, M., additional

Published
2015
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40. Electron Temperature and Density Distributions in a Divertor Simulation Experimental Module with Gas Injection in GAMMA 10/PDX

Author

Oki, K., primary, Sakamoto, M., additional, Nakashima, Y., additional, Yoshikawa, M., additional, Nohara, R., additional, Nojiri, K., additional, Terakado, A., additional, Mizuguchi, M., additional, Ichimura, K., additional, Takeda, H., additional, Iwamoto, M., additional, Hosoda, Y., additional, Shimizu, K., additional, Kohagura, J., additional, Imai, T., additional, and Ichimura, M., additional

Published
2015
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41. The 15-Country Collaborative Study of Cancer Risk Among Radiation Workers in the Nuclear Industry: design, epidemiological methods and descriptive results

Author

Martine Vrijheid, J. M. Bae, M. Moser, Fernando Rodríguez-Artalejo, P. Ashmore, Ethel S. Gilbert, M. Telle-Lamberton, Juozas Kurtinaitis, Rima R. Habib, Geoffrey R. Howe, T. Yoshimura, Elisabeth Cardis, Hosoda Y, Catherine Hill, Agnès Rogel, H. Tardy, I. Turai, Y. O. Ahn, Mary K. Schubauer-Berigan, Matti Hakama, John M. Kaldor, M. Usel, Anssi Auvinen, H. Engels, Maria Blettner, Colin R. Muirhead, H. Malker, K. Veress, G. Gulis, American University of Beirut [Beyrouth] (AUB), Swiss Federal Office of Public Health, Universidad Autonoma de Madrid (UAM), EDF (EDF), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Semmelweis University of Medicine [Budapest], National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), University of Tampere [Finland], Finnish Cancer Registry, Institut Gustave Roussy (IGR), Épidémiologie des radiations, épidémiologie clinique des cancers et survie (U1018 (Équipe 3) ), Institut Gustave Roussy (IGR)-Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Columbia Mailman School of Public Health, National Centre in HIV Epidemiology and Clinical Research, Health Protection Agency, National Institute for Occupational Safety and Health [Cincinnati] (NIOSH), Centers for Disease Control and Prevention (CDC), University of Occupational and Environmental Health [Kitakyushu] (UEOH), College of Medicine, Seoul National University, Radiation Protection Bureau, Health Canada, McLaughlin Centre for Population Health Risk Assessment, University of Ottawa [Ottawa], Radiation and Nuclear Safety Authority [Helsinki] (STUK), and Centre d'Etude de l'Energie Nucléaire (SCK-CEN)

Subjects
Gerontology, Male, Neoplasms, Radiation-Induced, [SDV]Life Sciences [q-bio], International Cooperation, radiation exposure, nuclear industry, cancer risk, Whole-Body Counting, 030218 nuclear medicine & medical imaging, Cohort Studies, 0302 clinical medicine, Nuclear Reactors, Risk Factors, Neoplasms, cancer mortality, Epidemiology of cancer, Medicine, education.field_of_study, Radiation, article, methodology, cohort analysis, 3. Good health, Occupational Diseases, Survival Rate, priority journal, risk factor, statistics, Research Design, 030220 oncology & carcinogenesis, epidemiology, Female, light, radiation dose, Risk assessment, cancer epidemiology, radiation injury, Cohort study, Adult, Employment, Population, Biophysics, Occupational disease, Epidemiological method, Radiation Dosage, survival, Risk Assessment, 03 medical and health sciences, Environmental health, Occupational Exposure, follow up, Humans, Industry, Radiology, Nuclear Medicine and imaging, human, education, industrial worker, business.industry, Retrospective cohort study, medicine.disease, Collective dose, mortality, Survival Analysis, whole body counting, Radiation-Induced, occupational disease, nuclear reactor, business, Epidemiologic Methods
Abstract

International audience; Radiation protection standards are based mainly on risk estimates from studies of atomic bomb survivors in Japan. The validity of extrapolations from the relatively high-dose acute exposures in this population to the low-dose, protracted or fractionated environmental and occupational exposures of primary public health concern has long been the subject of controversy. A collaborative retrospective cohort study was conducted to provide direct estimates of cancer risk after low-dose protracted exposures. The study included nearly 600,000 workers employed in 154 facilities in 15 countries. This paper describes the design, methods and results of descriptive analyses of the study. The main analyses included 407,391 nuclear industry workers employed for at least 1 year in a participating facility who were monitored individually for external radiation exposure and whose doses resulted predominantly from exposure to higher-energy photon radiation. The total duration of follow-up was 5,192,710 person-years. There were 24,158 deaths from all causes, including 6,734 deaths from cancer. The total collective dose was 7,892 Sv. The overall average cumulative recorded dose was 19.4 mSv. A strong healthy worker effect was observed in most countries. This study provides the largest body of direct evidence to date on the effects of low-dose protracted exposures to external photon radiation. © 2007 by Radiation Research Society.

Published
2006

43. Simulation of Radiation Cooling Effects in the GAMMA 10 West End-Cell Using Fluid Model

Author

Takeda, H., primary, Nakashima, Y., additional, Iida, Y., additional, Hosoi, K., additional, Furuta, T., additional, Toma, M., additional, Hatayama, A., additional, Ichimura, K., additional, Ueda, H., additional, Iwamoto, M., additional, Hosoda, Y., additional, Yoshikawa, M., additional, Sakamoto, M., additional, Ichimura, M., additional, and Imai, T., additional

Published
2014
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44. 169. A new approach to lymphedema research – LINF (Lymphatic Imaging with Non Radioactive Fluorescent Tracer) observation of the upper extremities after axillary lymphnode dissection in breast cancer surgery

Author

Tsunekawa, S., primary, Taki, Y., additional, Awane, M., additional, Inoue, N., additional, Kohmoto, I., additional, Esaki, H., additional, Hosoda, Y., additional, Ikeda, A., additional, Imamura, M., additional, and Shuji, N., additional

Published
2012
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46. POSTER VIEWING SESSION - REPRODUCTIVE (EPI) GENETICS

Author

Acar-Perk, B., primary, Weimer, J., additional, Koch, K., additional, Salmassi, A., additional, Arnold, N., additional, Mettler, L., additional, Schmutzler, A. G., additional, Ottolini, C. S., additional, Griffin, D. K., additional, Handyside, A. H., additional, Summers, M. C., additional, Thornhill, A. R., additional, Montjean, D., additional, Benkhalifa, M., additional, Cohen-Bacrie, P., additional, Siffroi, J. P., additional, Mandelbaum, J., additional, Berthaut, I., additional, Bashamboo, A., additional, Ravel, C., additional, McElreavey, K., additional, Ao, A., additional, Zhang, X. Y., additional, Yilmaz, A., additional, Chung, J. T., additional, Demirtas, E., additional, Son, W. Y., additional, Dahan, M., additional, Buckett, W., additional, Holzer, H., additional, Tan, S. L., additional, Perheentupa, A., additional, Vierula, M., additional, Jorgensen, N., additional, Skakkebaek, N. E., additional, Chantot-Bastaraud, S., additional, Toppari, J., additional, Muzii, L., additional, Magli, M. C., additional, Gioia, L., additional, Mattioli, M., additional, Ferraretti, A. P., additional, Gianaroli, L., additional, Koscinski, I., additional, Elinati, E., additional, Fossard, C., additional, Kuentz, P., additional, Kilani, Z., additional, Demirol, A., additional, Gurgan, T., additional, Schmitt, F., additional, Velez de la Calle, J., additional, Iqbal, N., additional, Louanjli, N., additional, Pasquier, M., additional, Carre-Pigeon, F., additional, Muller, J., additional, Barratt, C., additional, Viville, S., additional, Magli, C., additional, Grugnetti, C., additional, Castelletti, E., additional, Paviglianiti, B., additional, Pepas, L., additional, Braude, P., additional, Grace, J., additional, Bolton, V., additional, Khalaf, Y., additional, El-Toukhy, T., additional, Galeraud-Denis, I., additional, Bouraima, H., additional, Sibert, L., additional, Rives, N., additional, Carreau, S., additional, Janse, F., additional, de With, L. M., additional, Fauser, B. C. J. M., additional, Lambalk, C. B., additional, Laven, J. S. E., additional, Goverde, A. J., additional, Giltay, J. C., additional, De Leo, V., additional, Governini, L., additional, Quagliariello, A., additional, Margollicci, M. A., additional, Piomboni, P., additional, Luddi, A., additional, Miyamura, H., additional, Nishizawa, H., additional, Ota, S., additional, Suzuki, M., additional, Inagaki, A., additional, Egusa, H., additional, Nishiyama, S., additional, Kato, T., additional, Nakanishi, I., additional, Fujita, T., additional, Imayoshi, Y., additional, Markoff, A., additional, Yanagihara, I., additional, Udagawa, Y., additional, Kurahashi, H., additional, Alvaro Mercadal, B., additional, Imbert, R., additional, Demeestere, I., additional, De Leener, A., additional, Englert, Y., additional, Costagliola, S., additional, Delbaere, A., additional, Velilla, E., additional, Colomar, A., additional, Toro, E., additional, Chamosa, S., additional, Alvarez, J., additional, Lopez-Teijon, M., additional, Fernandez, S., additional, Hosoda, Y., additional, Hasegawa, A., additional, Morimoto, N., additional, Wakimoto, Y., additional, Ito, Y., additional, Komori, S., additional, Sati, L., additional, Zeiss, C., additional, Demir, R., additional, McGrath, J., additional, Ku, S. Y., additional, Kim, Y. J., additional, Kim, Y. Y., additional, Kim, H. J., additional, Park, K. E., additional, Kim, S. H., additional, Choi, Y. M., additional, Moon, S. Y., additional, Minor, A., additional, Chow, V., additional, Ma, S., additional, Martinez Mendez, E., additional, Gaytan, M., additional, Linan, A., additional, Pacheco, A., additional, San Celestino, M., additional, Nogales, C., additional, Ariza, M., additional, Cernuda, D., additional, Bronet, F., additional, Lendinez Ramirez, A. M., additional, Palomares, A. R., additional, Perez-Nevot, B., additional, Urraca, V., additional, Ruiz Martin, A., additional, Reche, A., additional, Ruiz Galdon, M., additional, Reyes-Engel, A., additional, Treff, N. R., additional, Tao, X., additional, Taylor, D., additional, Levy, B., additional, Ferry, K. M., additional, Scott Jr., R. T., additional, Vasan, S., additional, Acharya, K. K., additional, Vasan, B., additional, Yalaburgi, R., additional, Ganesan, K. K., additional, Darshan, S. C., additional, Neelima, C. H., additional, Deepa, P., additional, Akhilesh, B., additional, Sravanthi, D., additional, Sreelakshmi, K. S., additional, Deepti, H., additional, van Doorninck, J. H., additional, Eleveld, C., additional, van der Hoeven, M., additional, Birnie, E., additional, Steegers, E. A. P., additional, Galjaard, R. J., additional, van den Berg, I. M., additional, Fiorentino, F., additional, Spizzichino, L., additional, Bono, S., additional, Biricik, A., additional, Kokkali, G., additional, Rienzi, L., additional, Ubaldi, F. M., additional, Iammarrone, E., additional, Gordon, A., additional, Pantos, K., additional, Oitmaa, E., additional, Tammiste, A., additional, Suvi, S., additional, Punab, M., additional, Remm, M., additional, Metspalu, A., additional, Salumets, A., additional, Rodrigo, L., additional, Mir, P., additional, Cervero, A., additional, Mateu, E., additional, Mercader, A., additional, Vidal, C., additional, Giles, J., additional, Remohi, J., additional, Pellicer, A., additional, Martin, J., additional, Rubio, C., additional, Mozdarani, H., additional, Moghbeli Nejad, S., additional, Behmanesh, M., additional, Alleyasin, A., additional, Ghedir, H., additional, Ibala-Romdhane, S., additional, Mamai, O., additional, Brahem, S., additional, Elghezal, H., additional, Ajina, M., additional, Gribaa, M., additional, Saad, A., additional, Martinez, M. C., additional, Peinado, V., additional, Milan, M., additional, Al-Asmar, N., additional, Buendia, P., additional, Delgado, A., additional, Escrich, L., additional, Amorocho, B., additional, Simon, C., additional, Petrussa, L., additional, Van de Velde, H., additional, De Munck, N., additional, De Rycke, M., additional, Altmae, S., additional, Martinez-Conejero, J. A., additional, Esteban, F. J., additional, Ruiz-Alonso, M., additional, Stavreus-Evers, A., additional, Horcajadas, J. A., additional, Bug, B., additional, Raabe-Meyer, G., additional, Bender, U., additional, Zimmer, J., additional, Schulze, B., additional, Vogt, P. H., additional, Laisk, T., additional, Peters, M., additional, Grabar, V., additional, Feskov, A., additional, Zhilkova, E., additional, Sugawara, N., additional, Maeda, M., additional, Seki, T., additional, Manome, T., additional, Nagai, R., additional, Araki, Y., additional, Georgiou, I., additional, Lazaros, L., additional, Xita, N., additional, Chatzikyriakidou, A., additional, Kaponis, A., additional, Grigoriadis, N., additional, Hatzi, E., additional, Grigoriadis, I., additional, Sofikitis, N., additional, Zikopoulos, K., additional, Gunn, M., additional, Brezina, P. R., additional, Benner, A., additional, Du, L., additional, Kearns, W. G., additional, Shen, X., additional, Zhou, C., additional, Xu, Y., additional, Zhong, Y., additional, Zeng, Y., additional, Zhuang, G., additional, Gunn, M. C., additional, Richter, K., additional, Andreeva, P., additional, Dimitrov, I., additional, Konovalova, M., additional, Kyurkchiev, S., additional, Shterev, A., additional, Daser, A., additional, Day, E., additional, Turley, H., additional, Immesberger, A., additional, Haaf, T., additional, Hahn, T., additional, Dear, P. H., additional, Schorsch, M., additional, Don, J., additional, Golan, N., additional, Eldar, T., additional, and Yaverboim, R., additional

Published
2011
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50. Company talks

Author

Hosoda, Y., primary, Sumida, N., additional, Mita, T., additional, Matsukawa, Y., additional, Yamamoto, D., additional, Shibatani, N., additional, and Takayama, L., additional

Published
2010
Full Text
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