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Background and aimOnly 10% of pancreatic ductal adenocarcinoma (PDAC) patients survive longer than five years. Factors underlining long-term survivorship in PDAC are not well understood. Therefore, we aimed to identify the key players in the tumor immune microenvironment (TIME) associated with long-term survivorship in PDAC patients.MethodsThe immune-related gene expression profiles of resected PDAC tumors of patients who survived and remained recurrence-free of disease for ≥36 months (long-term survivors, n=10) were compared to patients who had survived ≤6 months (short-term survivors, n=10) due to tumor recurrence. Validation was performed by the spatial protein expression profile of immune cells using the GeoMx™ Digital Spatial Profiler. An independent cohort of samples consisting of 12 long-term survivors and 10 short-term survivors, was used for additional validation. The independent validation was performed by combining qualitative immunohistochemistry and quantitative protein expression profiling.ResultsB cells were found to be significantly increased in the TIME of long-term survivors by gene expression profiling (p=0.018). The high tumor infiltration of B cells was confirmed by spatial protein profiling in the discovery and the validation cohorts (p=0.002 and p=0.01, respectively). The higher number of infiltrated B cells was found mainly in the stromal compartments of PDAC samples and was exclusively found within tumor cells in long-term survivors.ConclusionThis is the first comprehensive study that connects the immune landscape of gene expression profiles and protein spatial infiltration with the survivorship of PDAC patients. We found a higher number and a specific location of B cells in TIME of long-term survivors which emphasizes the importance of B cells and B cell-based therapy for future personalized immunotherapy in PDAC patients.

Abstract One of the most important problems in directional sensor networks is coverage problem. The coverage can be measured in two ways: positional or temporal. In temporal coverage, the directional sensors rotate periodically round themselves in a repetitive process. Thus, in each time slot, those targets that are positioned within the sensor nodes radius receive their desired coverage. In this model, if a target is left uncovered, it is said that the target has remained in darkness. The main task defined for the temporal coverage model is the minimization of the total dark time for all the targets in the network. This problem has been solved by greedy‐based algorithms in last studies. Greedy‐based algorithms are able to solve the temporal coverage problem in real time. Remember that the performance of greedy algorithms is extremely dependent on the closeness of optimal solution and initial candidates. For this reason, greedy algorithms may obtain local minima due to heuristic search. As far as we know meta‐heuristic algorithms have not been used in past researches to solve such problems. For solving this problem, in this paper two algorithms were developed, GA‐based and hybridized model comprising genetic algorithms and tabu search. A new model was suggested for the chromosome in genetic algorithm. To evaluate the performance of the developed algorithms, they were compared with randomized scenario and greedy‐based algorithm presented in last studies. For better comparison, several parameters, including total dark time, number of sensors, number of targets, sector angle, sensing range were taken into account. The results obtained from the comparison of the algorithms indicated that the developed algorithms are effective in solving the temporal coverage problem in terms of minimizing the total dark time of the targets.

Abstract Context Advance Care Planning (ACP), as a process for expressing and recording patients' preferences about end-of-life care, has received increasing attention in recent years. However, implementing ACP has been challenging in Iran. Objectives To assess the readiness for advance care planning and related factors in the general population of Iran. Methods This cross-sectional study was conducted on the general population of Iran in 2022. The data was collected using demographic information questionnaire and The RACP Scale. The purpose and methodology of the research was explained to all participants, and upon their agreement an informed consent was obtained. Participants were invited to fill out the questionnaires wherever is more convenient for them, either alone or if needed, with the help of the researcher to protect their privacy. Chi-square, fisher exact test and multiple logistic Regression model were used to assess the effective factors on the RACP. The data were analyzed by SPSS software version 26. Results A total of 641 people with an average age of 36.85 ± 12.05 years participated in this study. Of those, 377 (58.8%) had high RACP. The logistics model showed an association between the chance of readiness for receiving ACP with participants’ education level, such that the chance of readiness in those with Master's or Ph.D. degrees was three times higher than those with a diploma (p = 0.00, OR:3.178(1.672, 6.043)). However, the chances of readiness in those with bachelor’s degrees was not significantly different from those with a diploma (p = 0.936, OR: 0.984 (0.654, 1.479)). Moreover, the chance of readiness was 1.5 higher in participants over 40 years of age compared with participants under the age of 40 (P = 0.01, OR: 1.571(1.10, 2.23)). Conclusion According to the findings of this study, it can be concluded that there is a relatively RACP among people in Iranian society. The readiness of individuals for ACP increases by their age and education level. Therefore, by holding appropriate training intervention, we can increase the readiness of the public for ACP to improve their end-of-life outcome.

Background and purpose: Activated textiles have created a new field of application apart from standard textile applications. Novel, functions, for example, antimicrobial properties have been enhanced in textiles. New textile application fields have been recognized for particular areas of healthcare as well as industry, sportswear, and, home textiles. Advances in the field of antibacterial textiles have fascinated enhancing attention because those are a means to solve serious health challenges such as bacterial overgrowth. A lot of research has been done in the field of adding synthetic and toxic materials to fabrics, such as nanosilver triclosan or other metals and organic materials to produce antimicrobial fabrics. These fabrics kill bacteria by binding to intracellular proteins and inactivating these proteins. Also, by using these chemicals, the content of heavy metals in these textiles can be increased. The application of heavy metals in antimicrobial textiles is limited by many environmental tags and standards. Therefore, it is recommended to use natural antimicrobial agents, such as nisin and chitosan to produce environmentally friendly and safe antimicrobial fabrics. Nowadays finishing process with the natural antibacterial agents that protect the environment and human health is gaining importance. Therefore, this study aims to produce fabric coated with chitosan and nisin and to investigate its antimicrobial properties. Materials and methods: In this research, chitosan was used to bind nisin to the surface of polypropylene span band non-woven fabric. The fabric samples were coated with a solution containing chitosan and nisin using a pad-dry-cure method. The appearance, color, and softness of the coated fabrics were compared to the uncoated fabric. The nisin and chitosan binding properties on the fabric were explored by using the Fourier-transform infrared (FTIR (technique. The diffusion method in agar and the standard method (ASTME2149-01) were used to check the antimicrobial properties of fabric samples. The antibacterial effectiveness of fabric samples was tested against common bacteria such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, and Enterococcus faecalis. After ten washing cycles, the durability of the antimicrobial properties of these fabrics was checked by the method mentioned above. Also, the toxicity of this fabric on fibroblast cells was determined using the MTT colorimetry method after seven days. Results: Fabrics coated with chitosan and nisin do not differ much from the control sample in terms of appearance and softness. The changes observed in the FTIR spectrum, such as the appearance of new absorption peaks and additional peaks associated with peptide bonds, confirm the successful incorporation of nisin and chitosan into the fabric. Antibacterial results have shown that nisin improved the antibacterial effect of coated fabrics versus B. cereus, S. aureus, and P. aeruginosa. The antimicrobial properties of the fabric coated with chitosan-nisin were maintained at some of the efficacy after washing against B. cereus, S. aureus, E. faecalis, L. monocytogenes, E. coli, and P. aeruginosa respectively. Also, the chitosan-nisin coating showed that it did not cause significant toxicity in fibroblast cells even after one week. Conclusion: However, the results showed that the chitosan/nisin coating might be used for medical textiles and antibacterial textiles. It also offers an innovative solution to protect human health and the environment.

Background: Delayed dyspnea and fatigue are prevalent symptoms among patients with COVID-19, and family caregivers play a crucial role in their care.Objectives: This study aimed to investigate the effects of a health literacy-promoting intervention based on the Family-Centered Empowerment Model (FCEM) on delayed dyspnea and fatigue in patients with COVID-19.Methods: A randomized controlled trial was conducted at Chamran Hospital in Tehran, Iran, in 2022, involving 70 pairs of COVID-19 patients and their primary family caregivers. Patients were randomly assigned to either the intervention group or the control group using a block randomization method. The intervention group received two 30-minute training sessions for primary family caregivers, while the control group received routine training. Data were collected using the Health Literacy Instrument for Adults, the Fatigue Severity Scale, and the Borg Dyspnea Scale before, one week after, and six weeks after the intervention. The chi-square and Fisher's exact tests, Mann-Whitney test, Friedman test, repeated measures analysis of variance, and Pearson correlation test were used to analyze the data.Results: The mean baseline health literacy score was higher in the control group; however, the increase in health literacy was significantly greater in the intervention group (F=75.31; Df=1.73; P

Abstract Type 1 polyketides are a major class of natural products used as antiviral, antibiotic, antifungal, antiparasitic, immunosuppressive, and antitumor drugs. Analysis of public microbial genomes leads to the discovery of over sixty thousand type 1 polyketide gene clusters. However, the molecular products of only about a hundred of these clusters are characterized, leaving most metabolites unknown. Characterizing polyketides relies on bioactivity-guided purification, which is expensive and time-consuming. To address this, we present Seq2PKS, a machine learning algorithm that predicts chemical structures derived from Type 1 polyketide synthases. Seq2PKS predicts numerous putative structures for each gene cluster to enhance accuracy. The correct structure is identified using a variable mass spectral database search. Benchmarks show that Seq2PKS outperforms existing methods. Applying Seq2PKS to Actinobacteria datasets, we discover biosynthetic gene clusters for monazomycin, oasomycin A, and 2-aminobenzamide-actiphenol.

Abstract For managing water resources and operating reservoirs in dynamic contexts, accurate hydrological forecasting is essential. However, it is difficult to track complex hydrological time series with highly non-linear and non-stationary characteristics. The intricacy of the issue is further increased by the risk and uncertainty that are brought about by the dependence of several factors on the hydrological system’s output. To hydrologically model river outflows, a hybrid GARCH time series model technique has been applied in this study. To improve the precision of the proposed model estimation, this hybrid model employs a controllable fuzzy logic system to explore the impact of various input variables and an Archimedean detail function to account for the uncertainty in the dependence of the variables. The prediction error in this model is minimized by utilizing weighting factors and problem analysis parameters that are calculated using the water cycle algorithm. It was found that the minimum root-mean-square error values for the training and testing modeling stages are RMSE = 1.89 m and 1.92 m, respectively, by looking at the hydrological modeling results for a watershed of the Karaj dam. For extended lead (i.e., a 6-month rainfall lag), the weakest forecasting capacity was found. The modeling of the copula function using a higher percentage of answers in the confidence band and a smaller bandwidth resulted in less uncertainty for the estimation of the suggested model, according to the uncertainty analysis.

Abstract The aim of the current research is to present a model for the implementation of new fintechs in the banking industry (peer-to-peer lending). The research method is applicable in terms of purpose, mixed (qualitative-quantitative) in terms of implementation, and survey in terms of nature and method. The statistical population of the research was the managers, supervisors and employees of the financial and technological fields of banks, experts and specialists in the fintech field in the country; and according to the principles and rules of the unlimited population, 384 people were selected as a sample. Data collection was done by semi-structured interviews in the qualitative part, and by the researcher-made questionnaire in the quantitative part. Coding and MAXQDA software were used in qualitative part data analysis, and SPSS and AMOS software were used in quantitative part. The results of the qualitative data analysis of the research were categorized as follows: In this regard, the extracted categories were categorized as follows: Causal conditions: organizational learning, system attitude, and information technology. Key conditions: communication capital, human capital, and structural capital. Governing platform: partner banks, external theorists, government, and environmental conditions. Intervening conditions: obstacles and challenges including organizational factors, community conditions, individual factors, and lack of education and research. Strategies: policy making, strategic plan, and employee satisfaction and loyalty. Consequence: knowledge-based policy making, knowledge management, innovation, creativity and idea, and knowledge-based organization. The results of the quantitative part showed that the fit indices of the model indicate the confirmation of the model at the confidence level of 99%. Extended Abstract Introduction Among the advantages of strategic cooperation between the banking system and fintech is efficiency in terms of speed, cost, and reaching new customers. The issues and problems of traditional banks include complex structures, high level of formality, increase in operational cost, providing banking services with more cost and time, lack of innovation in service, and failure to meet customer expectations (Soltanee & Tahmasebi Aghbolaghi, 2020). All these factors have led to the decrease in the popularity of the banking system; But on the other side of the field, the increase of people who, for various reasons, cannot use traditional banking services or do not want to use them, has led to the development of fintechs. This trend has confirmed the decreasing popularity of banks, and according to statistics, the average use of fintech globally has reached 33% (Hill, 2018). Peer-to-peer lending in modern banking is a co-product of important business, technological and social processes. One item that has helped to create peer-to-peer lending is the presence of a new generation of freedom advocates. "Technological changes, globalization, and other international processes have reduced the number, size and role of commercial intermediaries in many industrial sectors. These changes have also led to the emergence of peer-to-peer lending. Individuals can become members as lenders by registering on the peer-to-peer lenders website." (Sarhangi et al, 2016). Borrowers also enjoy the benefits of lower costs compared to bank or credit union loans. Fintechs can provide new products and services for peer-to-peer banking customer groups that do not have access to traditional financial services. These conditions are possible through the following ways: improving financial participation, providing simple products with low cost and helping people who do not have easy access to banking services, and improving the customer experience, increasing transparency and improving security, and accommodating retail customers and small and moderate companies to fraudity and cyber-attacks (Wonglimpiyarat, 2017). Due to the importance of this issue, this research seeks to present and propose a suitable model for the implementation of new fintechs in the banking and peer-to-peer lending industry. In this research, we are looking for an answer to this question: what is the implementation model of new fintechs in the banking industry (peer-to-peer lending)? Theoretical Framework fintech The term fintech means financial technology. Fintech refers to companies and representatives of companies that have combined financial services with modern innovative technology. Usually, new participants in the market offer Internet products and application-based products (Anil & Alistair, 2019). Fintech or financial technology is a set of businesses that use software and hardware to provide innovative financial services. The National Center for Digital Research in Dublin, Ireland defines fintech as innovation in financial services (Owzaei & Sohrabi, 2017). Sadraee et al, (2024) examines the presentation of the fintech market development model with an emphasis on existing challenges and strategies. The results of the research showed that the challenges of fintech market development include insufficient infrastructure, regulatory and legislative barriers, difficulty working with public/general customers, mistrust of technology and fintech, low income levels and product pricing challenges, and cultural barriers. Also, fintech market development strategies include community participation in the marketing process, use of social networks, smart and optimal advertising, useful and valuable content production, branding, adaptation of communication strategies to the nature of the fintech market, geographic and cultural segmentation of the market, as well as customer education. Khaled Mohammad et al, (2023) investigated the determinants of fintech adoption: evidence from a representative sample of emerging economies across the country. They identified important characteristics that predict customer fintech adoption among individual respondents. They found that customers were less likely to adopt fintech services if they reported higher levels of concern about security, information privacy, limited government control, and higher levels of perceived service barriers. Evidence showed that these concern factors, for example, are the main determinants of fintech adoption, unlike demographic variables. Our findings have insights for fintech service providers and policy makers. Research methodology The research method is applicable in terms of purpose, mixed (qualitative-quantitative) in terms of implementation, and survey in terms of nature and method. The statistical population of the research was the managers, supervisors and employees of the financial and technological fields of banks, experts and specialists in the fintech field in the country; and according to the principles and rules of the unlimited population, 384 people were selected as a sample. Data collection was done by semi-structured interviews in the qualitative part, and by the researcher-made questionnaire in the quantitative part. Research findings Coding and MAXQDA software were used in qualitative part data analysis, and SPSS and AMOS software were used in quantitative part. The results of the qualitative data analysis of the research were categorized as follows: In this regard, the extracted categories were categorized as follows: Causal conditions: organizational learning, system attitude, and information technology. Key conditions: communication capital, human capital, and structural capital. Governing platform: partner banks, external theorists, government, and environmental conditions. Intervening conditions: obstacles and challenges including organizational factors, community conditions, individual factors, and lack of education and research. Strategies: policy making, strategic plan, and employee satisfaction and loyalty. Consequence: knowledge-based policy making, knowledge management, innovation, creativity and idea, and knowledge-based organization. The results of the quantitative part showed that the fit indices of the model indicate the confirmation of the model at the confidence level of 99%. Conclusion The present study was conducted with the aim of providing a model for the implementation of new fintechs in the banking industry (peer-to-peer lending). The results of this research is aligned with the results of Sadraee et al, (2024), Khaled Mohammad et al, (2023), Khosravani & Bahman (2023), Khazaei et al, (2022), Barrio Oton (2021), Kou et al, (2021), Pazhoheshfar & Biabani (2021), Hammerschlag et al, (2020), Nurjanah et al, (2020), Martinčević et al, (2020), and Zhonging et al, (2019). Zhonging et al, (2019) in a research entitled factors affecting the acceptance of fintech services for bank users and presenting a technology acceptance model, while studying the effect of fintech acceptance on bank service users, presented an innovative technology acceptance model. Also, the results of this research show that the respondents pointed to the popularity and acceptability of the Internet and smart tools among users, perceived ease, usefulness, and government support for innovation as positive and facilitating factors; and the risk of privacy as effective barriers to the use of fintech services by banks. According to the results of this research, the following suggestions are presented: 1-Banking industries should take serious action to improve the implementation of fintechs by strengthening the dimensions of organizational learning which include: individual learning, group level learning, and organizational level learning. 2-a different attitude than the normal one should be used in the organization in order for a better order to prevail and to increase the overall efficiency and performance of it. The attitude required for use in the organization is the system attitude that connects all the elements in the organization to each other and does not examine any element alone because the organization is a system consisting of different elements. Based on the results of this research, it can be said that having a systemic attitude is one of the important factors of using fintechs.

Diabetes Mellitus (DM) disrupts the body's capability to control blood glucose statuses. Type 1 diabetes mellitus (T1DM) arises from inadequate insulin production and is treated with insulin replacement therapy. Stem cell therapy is a hopeful treatment for T1DM that involves using adult stem cells to generate insulin-producing cells (IPCs). Mesenchymal stem cells (MSCs) are particularly advantageous for generating IPCs. The islet cells require interactions with the extracellular matrix for survival, which is lacking in conventional 2D culture systems. Natural or synthetic polymers create a supportive 3D microenvironment in tissue engineering. We aim to construct superior differentiation conditions employing polyethersulfone (PES)/Fish gelatin scaffolds to differentiate Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) to IPCs. In this study, the PES/fish gelatin scaffold (3D) was manufactured by electrospinning, and then its biocompatibility and non-toxicity were investigated by MTT assay. After that, scaffold-supportive effects on WJ-MSCs differentiation to IPCs were studied at the gene and protein levels. After exposure to the differentiation media, 2D and 3D (PES/Fish gelatin) cultured cells were slowly aggregated and developed spherical-shaped clusters. The viability of cells was found to be comparable in both 2D and 3D cultures. The gene expression analysis showed that efficiency of differentiation was more elevated in 3D culture. Additionally, ELISA results indicated that C-peptide and insulin release were more significant in 3D than in 2D culture. In conclusion, the PES/fish gelatin scaffold is highly promising for pancreatic tissue engineering because it supports the viability, growth, and differentiation of WJ-MSCs into IPCs.

IntroductionToday, the businesses of the poultry industry are facing many challenges, because this industry has to manage a number of unique processes, methods and risks at the same time. Therefore, identifying the business risks of poultry production units can play an effective role in reducing the level of vulnerability of these businesses. Considering the need to increase the productivity of the poultry industry, one of the basic solutions is to identify the risk and measure the existing risks of this industry. Risk identification and quantification can reduce costs for industry stakeholders, and risk reduction leads to better production planning. In this regard, this study identifies the business risks of poultry production units in Khorasan Razavi province. Materials and MethodsThis study is applied as purpose and descriptive survey in terms of nature and method. This research is based on mixed research, qualitatively and quantitatively. The statistical population is poultry industry experts, 18 of whom were investigated by snowball sampling method as the research sample. This study proposes a new Delphi technique that uses the features of traditional Delphi techniques and the Fuzzy Delphi method. The proposed new Delphi technique is based on the integration of pentagonal fuzzy sets and the Delphi technique. Results and DiscussionThe results of the modified pentagonal Fuzzy Delphi method showed that five main risks and 36 secondary risks out of 58 identified risks are part of the business risks of poultry production units. Identified business risks of poultry production units, in order of priority, include inputs price fluctuations, command pricing, exchange rate fluctuations, sanctions, chicken price fluctuations, delay in accessing inputs, fluctuations in the purchase price of day-old chickens, fluctuations in drug and vaccine prices, imported inputs, lack of government support in the matter of production, fluctuations in subsidies to inputs, lack of animal inputs, import of poultry products, Promulgation of various instructions, poultry diseases, lack of liquidity of poultry farmers, bankruptcy of poultry farmers, fluctuations in current costs, losses, lack of medicine and vaccines, lack of expansion of poultry business, lack of confidence of poultry farmers in the government, fluctuations in profitability, investment, seasonal fluctuations in egg demand, dependence of poultry farmers on Special suppliers, supply of day-old chicks, lack of energy, exclusivity of the livestock and poultry feed supply system, egg price fluctuations, seasonal fluctuations in chicken production, seasonal fluctuations in chicken demand, weakness in providing working capital facilities to poultry farmers, lack of skilled human resources in time Appropriate, lack of technical knowledge of advanced technologies and lack of variety of poultry food ingredients. ConclusionThe business of poultry production units is facing various challenges and risks, and due to the many risks of this industry, production in this industry is facing problems and it is not possible to plan for it, and production will be disrupted in the future. Therefore, in this research, an effort was made to fully identify the business risks of poultry production units. In order to complete and finalize the business risks of poultry production units, the pentagonal Fuzzy Delphi method was used. In this regard, a questionnaire was prepared that included two parts. The first part is about the survey and information about the background of the respondents, and the second part includes the ranking of 54 identified risks. Fuzzy Delphi method in this study was done in two rounds and based on the opinion of experts, 4 more risks were added to the total of 54 risks, and finally 58 risks were analyzed using Fuzzy Delphi method. In Fuzzy Delphi, the selection of risk components among all the components that were identified in the research literature was based on the accepted threshold criterion. The results of the second round of modified pentagonal Fuzzy Delphi showed that there are 36 important sub-risks in the sector of production, market, financial, institutional and personal business risks of poultry production units. Considering the price fluctuations of livestock inputs and exchange rate fluctuations, it is suggested to allocate currency and control it by government policies in order to reduce mentioned fluctuations, or move towards diversifying poultry feed ingredients and formulating new poultry feed rations. Also, in order to avoid fluctuations in the price of chicken or eggs, it is suggested to make the distribution network smarter to prevent these fluctuations. In the poultry market, it is better to set a fair price for each kilogram of chicken according to the production costs of poultry farmers, or not to interfere with the government in the market and allow the government to set the price based on the supply and demand mechanism.

‌ ∴ Introduction ∴ ‌ The legal framework within which public and private entities operate is foundational to their legitimacy and functionality. This analysis delves into the specific realm of "Government-Approved Statutes" within the Islamic Republic of Iran, focusing on the legislative nature of these documents and the oversight mechanisms in place. The statutes in question are essential for the operation, duties, and authorities of legal persons and entities, both governmental and non-governmental. Their importance is underscored by the requirement for such statutes as a prerequisite for the registration and formal recognition of companies. This study is particularly concerned with statutes related to government and government-affiliated organizations, given their significant impact on the country's administrative system and citizens' rights. The legislative framework for these statutes was established under Article (85) of the Iranian Constitution in 1989, allowing for the delegation of statute approval to relevant commissions of parliament or directly to the government. This research aims to elucidate the nature of these statutes, the processes involved in their amendment or modification, and the authorities responsible for their oversight. ‌ ∴ Research Question ∴ ‌ The primary inquiries of this study revolve around three pivotal questions: - What is the nature of the statutes whose approval has been delegated by the Islamic Consultative Assembly to the Government of the Islamic Republic of Iran? - How are these statutes amended or modified? - Which authorities are tasked with overseeing these statutes? These questions aim to uncover the legislative and operational dynamics of government-approved statutes and the institutional checks and balances that govern them. ‌ ∴ Research Hypothesis ∴ ‌ This research operates under the hypothesis that the statutes approved by the Parliament and delegated to the government for oversight are essentially "governmental decrees." As such, they are posited to fall under the scrutiny of the Guardian Council, the Speaker of the Parliament, and the court of administrative justice, according to the principles laid out in the Constitution of Iran. This hypothesis suggests a structured mechanism of oversight and amendment, ensuring that these statutes align with constitutional mandates and effectively serve their intended purpose within the legal and administrative framework of the country. ‌ ∴ Methodology & Framework, if Applicable ∴ ‌ The methodology adopted for this research is descriptive-analytical, utilizing a comprehensive review of library sources alongside a detailed examination of legal practices in Iran. This approach involves an analysis of documentation from the Guardian Council, the court of administrative justice, the Islamic Consultative Assembly (Parliament), and the cabinet. The study also reviews the historical background and discussions surrounding the approval of article (85) of the constitution, aiming to provide a clear understanding of the legislative intent and the practical application of these statutes. This framework allows for a thorough exploration of the statutes' nature, the process of their amendment or modification, and the extent and quality of their oversight by designated authorities. By systematically addressing the research questions and hypothesis through this methodology, the study seeks to contribute novel insights into the legislative nature of government-approved statutes in Iran and the oversight mechanisms that ensure their alignment with constitutional and legal principles. The findings of this research are anticipated to have significant implications for the understanding of legal governance and administrative oversight in the context of Iranian law, with potential broader applications in comparative legal studies. ‌ ∴ Results & Discussion ∴ ‌ The investigation into the nature and oversight of "Government-Approved Statutes" within the Islamic Republic of Iran reveals several key findings, grounded in the constitutional provisions, particularly article (85). The distinction drawn by the constitutional review council between the legislative authority of the Parliament and the delegated approval powers for statutes of governmental organizations and companies underscores a nuanced approach to legislative delegation. This delegation is justified by practical needs for expedited approval processes, the complexity of statutes, the necessity for content coherence, and confidentiality concerns in certain cases. The analysis delineates the approval of statutes by the cabinet under article (85) as constituting "governmental decrees" rather than conventional laws or legal statutes. This classification has profound implications for the oversight mechanisms applicable to these decrees. The dual oversight by the Guardian Council for conformity with Sharia and the Constitution, and by the Speaker of the Parliament for alignment with ordinary laws, is complemented by the jurisdiction of the court of administrative justice. This court's practice underscores a layered oversight model, where it primarily addresses issues related to the execution of laws, jurisdictional overreach, and the protection of rights, without encroaching on the purviews reserved for the Guardian Council or the interpretation of Sharia and constitutional compliance. The study highlights a significant operational challenge within the oversight framework, particularly the potential for conflicting interpretations between the Speaker of the Parliament and the court of administrative justice rulings. Such conflicts can lead to ambiguity and confusion within the executive branch, underscoring the necessity for legislative refinement. The "Law on the Implementation of articles (85) and (138) of the Constitution of Iran" is identified as requiring amendments to introduce clear deadlines for the Speaker of the Parliament's opinions, aiming to mitigate the risks of operational discord among governmental agencies. ‌ ∴ Conclusion ∴ ‌ The findings of this research elucidate the intricate nature of "Government-Approved Statutes" in Iran and the sophisticated oversight framework designed to ensure their conformity with the broader legal and constitutional framework. The statutes approved by the Cabinet under Article (85) embody a distinct category of governmental decrees, necessitating a multifaceted oversight mechanism involving the Guardian Council, the Speaker of the Parliament, and the court of administrative justice. This oversight is pivotal in maintaining the decrees' alignment with Sharia, the Constitution, and ordinary laws, while also safeguarding individual and institutional rights against governmental overreach and misinterpretation of powers. However, the research identifies critical areas for improvement within this oversight structure, particularly the need for clearer procedural guidelines to resolve potential conflicts between oversight authorities. The recommendation for legislative amendments to specify a deadline for the Speaker of the Parliament's opinion is a constructive step towards enhancing the clarity and efficiency of the oversight process. Moreover, the study advocates for a comprehensive review and redefinition of the oversight scope by the involved authorities to address the evolving challenges within Iran's legal and administrative landscape. In sum, while the legal framework for "Government-Approved Statutes" in Iran is robust, navigating its complexities requires ongoing attention to detail, legislative refinement, and an adaptive approach to oversight. This research contributes to a deeper understanding of the statutory approval and oversight processes, offering insights that are pertinent not only to legal scholars and practitioners but also to policymakers engaged in the refinement of Iran's legislative and administrative systems.

This work aimed to purify the proteins that cause blood coagulation in the venom of the Iranian Echis carinatus snake species in a comprehensive manner. Gel filtration chromatography (GFC), Ion exchange chromatography (IEC), and Size Exclusion High-Performance Liquid Chromatography (SEC-HPLC) were utilized in the purification of the coagulation factors. The prothrombin clotting time (PRCT) and SDS-PAGE electrophoresis were performed to confirm the coagulative fractions. The fraction with the shortest coagulation time was selected. The components of this designated fraction were identified through matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF) following thorough purification. Circular dichroism (CD) was employed to determine the second structure of the coagulation factor. The crude venom (CV) was analyzed and had a total protein concentration of 97%.Furthermore, the PRCT of the crude venom solution at a concentration of 1 mg/ml was determined to be 24.19 ± 1.05 s. The dosage administered was found to be a factor in the venom's capacity to induce hemolysis. According to CD analysis, the protein under investigation had a helical structure of 16.7%, a beta structure of 41%, and a turn structure of 9.8%. CHNS proved that the purified coagulant protein had a Carbon content of 77.82%, 5.66% Hydrogen, 3.19% Nitrogen, and 0.49% Sulphur. In the present investigation, a particular type of snake venom metalloproteinase (SVMP) has undergone the process of purification and characterization and has been designated as EC-124. This purified fraction shows significant efficacy as a procoagulant. Our findings have shown that this compound has a function similar to factor X and most likely it can cause blood coagulation by activating factor II (FII).

The increasing concern of consumers about the quality and safety of agricultural products all over the world has caused organic products to become one of the most popular options for healthy. The increasing trend and consumption of organic agricultural products has led to the increasing growth of the market of these products in the last two decades. Due to the importance of entering and gaining a share of this growing market, this study investigates the factors affecting the international organic products market entry and determines the appropriate strategy for entering it using structural equation modeling. The data of this study was obtained by collecting 90 questionnaires from producers of organic saffron, pistachio, and raisin products in the year 2021 with available sampling method in Khorasan Razavi province. The obtained results indicate that the variables of risk and motivation to enter the international market directly and the production and marketing ownership indirectly and through influencing the motivation to enter the international market, influence the international market entry strategy. Based on this, the appropriate strategy for entering the international market of organic products, indirect, cooperative and non-attendance strategies such as indirect export, contract production and joint investment was obtained. Therefore, it is suggested that the government should remove or reduce the risks caused by sanctions and obstacles to enter the market for the direct presence of organic product producers in international markets.

Abstract Background Health-promoting behaviors have been noticed recently as one of the most critical factors in raising life expectancy, which can be formed during adolescence. Thus, the current scoping review aimed to identify the key factors affecting health-promoting behaviors among adolescents. Methods In this scoping review, we searched multiple English online databases, including PubMed, Web of Science, Science Direct, ProQuest, and Scopus, for articles published between 1977 and 2020. All eligible studies describing health-promoting behaviors in adolescents were included. We followed the JBI guideline for conducting a scoping review and increasing the study’s rigor. Extracted data were synthesized through inductive approaches. Results A total of 3199 articles were identified during the first phase. After the screening process, 20 articles were found eligible for final inclusion. Educational factors (individualized education and school health promotion programs), Economic factors (income, economic incentives and national health insurance), Social factors (support system, responsibility and peers), Spiritual, Psychological and Personal factors (gender, family structure, patterns of living, and medical problems) were found effective in health-promoting behaviors among adolescents. Conclusions Health-promoting behaviors among adolescents require careful consideration. The current review identified some fundamental factors affecting health-promoting behaviors in adolescents. Based on the findings, it is recommended that policymakers and healthcare providers develop several interventions based on identified factors to increase adolescent’s health-promoting behaviors among adolescents.

Inspired by Williamson’s knowledge-first epistemology, I propose a position on practical knowledge that can be called the ‘know-how-first view’; yet whereas Williamson is one of the pioneers of the new intellectualism about know-how, I employ the know-how-first view to argue against intellectualism and instead develop a know-how-first version of anti-intellectualism. Williamson argues that propositional knowledge is a sui generis unanalyzable mental state that comes first in the epistemic realm; in parallel, I propose that know-how is a sui generis unanalyzable power that comes first in the practical realm. To motivate this suggestion, I put forward two arguments: (1) drawing on dispositionalist ideas, I argue that the practical component of know-how is unanalyzable; (2) based on an investigation of the natures of intentionality and intelligence, I argue that know-how is prior to intentional and intelligent abilities in the order of explanation of agential action. Deploying this know-how-first anti-intellectualism, I then set out know-how-first solutions to two challenging problems for anti-intellectualism: the sufficiency problem and the necessary condition problem. [ABSTRACT FROM AUTHOR]

It has been argued that virtue reliabilism faces difficulties in explaining why the "because-of" relation between true belief and the relevant competence is absent in Gettier cases. However, prominent proponents of this view such as Sosa and Turri suggest that these difficulties can be overcome by invoking the manifestation relation. In his Judgment and Agency, Sosa supports this claim based on an analogy between Gettier cases and what in the literature on dispositions is called mimic cases. While there are initial motivations for the alleged analogy, I claim there are at least two arguments against it: 1. there is an asymmetry in the nature of context-sensitivity between the problem of mimicking and the Gettier problem; 2. while causal deviance and double luck can be found in both the mimic case and the Gettier case, their causal processes are different in important respects, making it challenging to see them as both falling under the same category. If these arguments are on the right track, the upshot is that virtue reliablists such as Sosa and Turri who describe the "because-of" relation in terms of the manifestation relation still owe us an account of why the manifestation relation is absent in Gettier cases. [ABSTRACT FROM AUTHOR]

BACKGROUND: Nursing students are at risk of violence. When nursing students encounter violence in clinical environments, their functional abilities and their desire to stay in this profession are impressed. This research determines the relationship between violence in the workplace and the attitude towards the nursing profession (NP) among Iranian nursing students in 2021. MATERIALS AND METHODS: This cross-sectional research was conducted as an online survey in 2021, and 512 nursing students were selected using the convenience method. Data collection tools included a demographic information form, a professional attitude questionnaire, and a workplace violence questionnaire. Chi-square tests, one-way analysis of variance (ANOVA), sample t-test, and multiple regression were used to analyze the data. RESULTS: The average age was 23.19 ± 4.58 years. Students with high violence experiences had a more negative attitude towards the profession (P = 0.000). The perpetrators of violence were mainly hospital employees (52.42). It was followed by patients and companions (45.86) and instructors (43.95). A significant relationship was found between gender (P = 0.03), age (P = 0.00), academic year (P = 0.005), and marital status (P = 0.008) with attitude towards profession. The findings of this research showed that the variables of gender (boy) and age have an inverse effect on the attitude with a predictive power of 37%; however, the attitude towards the profession becomes positive by increasing the academic year. CONCLUSION: This research provides data to nursing schools to develop intervention and prevention strategies to support students in dealing with the experience of violence. Holding related training courses in violence prevention techniques reduces the other party’s anger and can help improve the situation.

Abstract Introduction Achieving good death is among the objectives of palliative care in patients with cancer. There should be an instrument for evaluating the quality of palliative care provided by family members at the end of life. This study was done to assess the psychometric properties of good death inventory- short form according to the perspective of family of patients with cancer. Method This methodological study was done in 2022 at two hospitals in Tehran. The translation was done via forward-backward method. Face validity was examined through cognitive interviewing with 10 family members. The content validation, were used by assessment the opinions of 10 palliative care specialists. The construct validity was explored through exploratory factor analysis and examination of convergent validation with care evaluation scale 2.0, as well as inspection of correlation by answering two general questions of satisfaction with treatment and end of life quality of life. The scale’s reliability, internal consistency was calculated using Cronbach’s alpha coefficient and stability via test-retest. Results Overall, 204 family members of patients with cancer were included. In the exploratory factor analysis, three factors of peace, hope, and value as well as quality of care were extracted with cumulative variance of 41.8%.A significant and suitable correlation between the total scores of the participants Good death inventory-short form and care evaluation scale2.0 (r = 0.459, P

Abstract The target coverage problem is considered as one of the major issues in directional sensor networks (DSNs), which is caused by the nature of these networks, including their limited angle of view. Due to the fault tolerance characteristic of some coverage applications, the target coverage is required to be performed using multiple sensors. This challenge is discussed in the literature under the title of k‐coverage problem. Under certain conditions, the number of sensors may suffer some changes due to various factors such as power depletion of the sensors, sensors' malfunctioning, and harshness of the environment. This can result in unavailability of adequate sensors for providing k‐coverage for all targets. The network suffering from such problem is referred to as under‐provisioned network. This paper was aimed at studying such networks by adopting the network conditions to the real environments. To solve this problem, the present paper proposes a hybrid model integrating the genetic algorithm (GA) and Tabu search (TS). The proposed algorithm generally aimed to identify a subset of sensors with appropriate working directions in order to provide a balanced coverage for all the targets available in the network. In order to evaluate the performance of the algorithm several experiments were conducted and the results have been compared with greedy and learning automat‐abased algorithms. . The results of the experiments show the superiority of the algorithm.