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447 results on '"Horst, Heinz A."'

1. Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial

Author

Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, and Döhner, Konstanze

Published
2020
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2. Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study.

Author

Ravandi, Farhad, Ritchie, Ellen K, Sayar, Hamid, Lancet, Jeffrey E, Craig, Michael D, Vey, Norbert, Strickland, Stephen A, Schiller, Gary J, Jabbour, Elias, Erba, Harry P, Pigneux, Arnaud, Horst, Heinz-August, Recher, Christian, Klimek, Virginia M, Cortes, Jorge, Roboz, Gail J, Odenike, Olatoyosi, Thomas, Xavier, Havelange, Violaine, Maertens, Johan, Derigs, Hans-Günter, Heuser, Michael, Damon, Lloyd, Powell, Bayard L, Gaidano, Gianluca, Carella, Angelo-Michele, Wei, Andrew, Hogge, Donna, Craig, Adam R, Fox, Judith A, Ward, Renee, Smith, Jennifer A, Acton, Gary, Mehta, Cyrus, Stuart, Robert K, and Kantarjian, Hagop M

Subjects
Humans, Neoplasm Recurrence, Local, Thiazoles, Naphthyridines, Cytarabine, Antineoplastic Combined Chemotherapy Protocols, Disease-Free Survival, Treatment Outcome, Remission Induction, Double-Blind Method, Adult, Aged, Aged, 80 and over, Middle Aged, Female, Male, Leukemia, Myeloid, Acute, Kaplan-Meier Estimate, Clinical Research, Cancer, Clinical Trials and Supportive Activities, Hematology, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

BackgroundSafe and effective treatments are urgently needed for patients with relapsed or refractory acute myeloid leukaemia. We investigated the efficacy and safety of vosaroxin, a first-in-class anticancer quinolone derivative, plus cytarabine in patients with relapsed or refractory acute myeloid leukaemia.MethodsThis phase 3, double-blind, placebo-controlled trial was undertaken at 101 international sites. Eligible patients with acute myeloid leukaemia were aged 18 years of age or older and had refractory disease or were in first relapse after one or two cycles of previous induction chemotherapy, including at least one cycle of anthracycline (or anthracenedione) plus cytarabine. Patients were randomly assigned 1:1 to vosaroxin (90 mg/m(2) intravenously on days 1 and 4 in a first cycle; 70 mg/m(2) in subsequent cycles) plus cytarabine (1 g/m(2) intravenously on days 1-5) or placebo plus cytarabine through a central interactive voice system with a permuted block procedure stratified by disease status, age, and geographical location. All participants were masked to treatment assignment. The primary efficacy endpoint was overall survival and the primary safety endpoint was 30-day and 60-day all-cause mortality. Efficacy analyses were done by intention to treat; safety analyses included all treated patients. This study is registered with ClinicalTrials.gov, number NCT01191801.FindingsBetween Dec 17, 2010, and Sept 25, 2013, 711 patients were randomly assigned to vosaroxin plus cytarabine (n=356) or placebo plus cytarabine (n=355). At the final analysis, median overall survival was 7·5 months (95% CI 6·4-8·5) in the vosaroxin plus cytarabine group and 6·1 months (5·2-7·1) in the placebo plus cytarabine group (hazard ratio 0·87, 95% CI 0·73-1·02; unstratified log-rank p=0·061; stratified p=0·024). A higher proportion of patients achieved complete remission in the vosaroxin plus cytarabine group than in the placebo plus cytarabine group (107 [30%] of 356 patients vs 58 [16%] of 355 patients, p

Published
2015

3. Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Author

Rücker, Frank G., Agrawal, Mridul, Corbacioglu, Andrea, Weber, Daniela, Kapp-Schwoerer, Silke, Gaidzik, Verena I., Jahn, Nikolaus, Schroeder, Thomas, Wattad, Mohammed, Lübbert, Michael, Koller, Elisabeth, Kindler, Thomas, Götze, Katharina, Ringhoffer, Mark, Westermann, Jörg, Fiedler, Walter, Horst, Heinz A., Greil, Richard, Schroers, Roland, Mayer, Karin, Heinicke, Thomas, Krauter, Jürgen, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, and Döhner, Konstanze

Published
2019
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4. Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Author

Schlenk, Richard F., Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, and Döhner, Hartmut

Published
2019
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6. Prospective validation of a lymphocyte infiltration prognostic test in stage III colon cancer patients treated with adjuvant FOLFOX

Author

Thaler, Josef, Greil, Richard, Gaenzer, Johannes, Eisterer, Wolfgang, Tschmelitsch, Joerg, Keil, Felix, Samonigg, Hellmut, Zabernigg, August, Schmid, Franz, Steger, Günther, Steinacher, Robert, Andel, Johannes, Jagdt, Björn, Lang, Alois, Fridrik, Michael, Függer, Reinhold, Hofbauer, Friedrich, Woell, Ewald, Geissler, Dietmar, Lenauer, Alfred, Prager, Manfred, D'Haens, Geert, Demolin, Gauthier, Kerger, Joseph, Deboever, Guido, Ghillebert, Gilbert, Polus, Marc, Van Cutsem, Eric, Kalantari, Hassan Rezaie, Delaunoit, Thierry, Goeminne, Jean Charles, Peeters, Marc, Vergauwe, Philippe, Houbiers, Ghislain, Humblet, Yves, Janssens, Jos, Schrijvers, Dirk, Vanderstraeten, Erik, Van Laethem, Jean-Luc, Vermorken, Jan, Van Daele, Daniel, Ferrante, Michel, Forget, Frederic, Hendlisz, Alain, Yilmaz, Mette, Nielsen, Svend Erik, Vestermark, Lene, Larsen, Jim, Zawadi, Mohamed-Ayman, Bouche, Olivier, Mineur, Laurent, Bennouna-Louridi, Jaafar, Dourthe, Louis Marie, Ychou, Marc, Boucher, Eveline, Taieb, Julien, Pezet, Denis, Desseigne, Francoise, Ducreux, Michel, Texereau, Patrick, Miglianico, Laurent, Rougier, Philippe, Fratte, Serge, Levache, Charles-Briac, Merrouche, Yacine, Ellis, Stephen, Locher, Christophe, Ramee, Jean-Francois, Garnier, Claire, Viret, Frederic, Chauffert, Bruno, Cojean-Zelek, Isabelle, Michel, Pierre, Lecaille, Cedric, Borel, Christian, Seitz, Jean-Francois, Smith, Denis, Lombard-Bohas, Catherine, Andre, Thierry, Gornet, Jean-Marc, Fein, Francine, Coulon-Sfairi, Marie-Aude, Kaminsky, Marie-Christine, Lagasse, Jean-Paul, Luet, Dominique, Etienne, Pierre-Luc, Gasmi, Mohamed, Vanoli, Andre, Nguyen, Suzanne, Aparicio, Thomas, Perrier, Hervé, Stremsdoerfer, Noel, Laplaige, Philippe, Arsene, Dominique, Auby, Dominique, Bedenne, Laurent, Coriat, Romain, Denis, Bernard, Geoffroy, Patrick, Piot, Gilles, Becouarn, Yves, Bordes, Gilbert, Deplanque, Gael, Dupuis, Olivier, Fruge, Frederic, Guimbaud, Rosine, Lecomte, Thierry, Lledo, Gérard, Sobhani, Iradej, Asnacios, Amani, Azzedine, Ahmed, Desauw, Christophe, Galais, Marie-Pierre, Gargot, Dany, Lam, You-Heng, Abakar-Mahamat, Abakar, Berdah, Jean-Francois, Catteau, Sylviane, Clavero-Fabri, Marie-Christine, Codoul, Jean-Francois, Legoux, Jean-Louis, Goldfain, Denis, Guichard, Pierre, Verge, Denis Pere, Provencal, Jocelyne, Vedrenne, Bruno, Brezault-Bonnet, Catherine, Cleau, Denis, Desir, Jean-Paul, Fallik, David, Garcia, Bruno, Gaspard, Marie-Hélène, Genet, Dominique, Hartwig, Johannes, Krummel, Yves, Budnik, Tamara Matysiak, Palascak-Juif, Vanessa, Randrianarivelo, Harizo, Rinaldi, Yves, Aleba, Albert, Darut-Jouve, Ariane, de Gramont, Aimery, Hamon, Herve, Wendehenne, Frederic, Matzdorff, Axel, Stahl, Michael Konrad, Schepp, Wolfgang, Burk, Martin, Mueller, Lothar, Folprecht, Gunnar, Geissler, Michael, Mantovani-Loeffler, Luisa, Hoehler, Thomas, Asperger, Walter, Kroening, Hendrik, von Weikersthal, Ludwig Fischer, Fuxius, Stefan, Groschek, Matthias, Meiler, Johannes, Trarbach, Tanja, Rauh, Jacqueline, Ziegenhagen, Nicolas, Kretzschmar, Albrecht, Graeven, Ullrich, Nusch, Arnd, von Wichert, Goetz, Hofheinz, Ralf-Dieter, Kleber, Gerhard, Schmidt, Karl-Heinz, Vehling-Kaiser, Ursula, Baum, Claudia, Schuette, Jochen, Haag, Georg Martin, Holtkamp, Wilhelm, Potenberg, Jochen, Reiber, Tobias, Schliesser, Georg, Schmoll, Hans-Joachim, Schneider-Kappus, Wolfgang, Abenhardt, Wolfgang, Denzlinger, Claudio, Henning, Jan, Marxsen, Bartscht, Derigs, Hans Guenter, Lambertz, Helmut, Becker-Boost, Ingulf, Caca, Karel, Constantin, Christian, Decker, Thomas, Eschenburg, Henning, Gabius, Sigrun, Hebart, Holger, Hoffmeister, Albrecht, Horst, Heinz-August, Kremers, Stephan, Leithaeuser, Malte, Mueller, Sebastian, Wagner, Siegfried, Daum, Severin, Schlegel, Frank, Stauch, Martina, Heinemann, Volker, Maiello, Evaristo, Latini, Luciano, Zaniboni, Alberto, Amadori, Dino, Aprile, Giuseppe, Barni, Sandro, Mattioli, Rodolfo, Martoni, Andrea, Passalacqua, Rodolfo, Nicolini, Mario, Pasquini, Enzo, Rabbi, Carla, Aitini, Enrico, Ravaioli, Alberto, Barone, Carlo, Biasco, Guido, Tamberi, Stefano, Gambi, Angelo, Verusio, Claudio, Marzola, Marina, Lelli, Giorgio, Boni, Corrado, Cascinu, Stefano, Bidoli, Paolo, Vaghi, Massimo, Cruciani, Giorgio, Di Costanzo, Francesco, Sobrero, Alberto, Mini, Enrico, Petrioli, Roberto, Aglietta, Massimo, Alabiso, Oscar, Capuzzo, Federico, Falcone, Alfredo, Corsi, Domenico Cristi, Labianca, Roberto, Salvagni, Stefania, Chiara, Silvana, Ciuffreda, Libero, Ferraù, Francesco, Giuliani, Francesco, Lonardi, Sara, Gebbia, Nicola, Mantovani, Giovanni, Sanches, Evaristo, Mellidez, Juan Carlos, Santos, Pedro, Freire, Joao, Sarmento, Cristina, Costa, Luis, Pinto, Antonio Moreira, Barroso, Sergio, Santo, Jorge Espirito, Guedes, Fátima, Monteiro, Amélia, Sa, Anabela, Furtado, Irene, Salazar, Ramon, Aguilar, Enrique Aranda, Herrero, Fernando Rivera, Tabernero, Josep, Valera, Javier Sastre, Ayerbes, Manuel Valladares, Batlle, Jaime Feliu, Gil, Silvia, Esteve, Albert Abad, Garcia-Giron, Carlos, Vivanco, Guillermo Lopez, Salvia, Antonia Salud, Orduña, Vicente Alonso, Garcia, Ruth Vera, Gallego, Javier, Sureda, Bartomeu Massuti, Remon, Jordi, Safont Aguilera, Maria Jose, Nogueras, Luis Cirera, Merino, Bernado Queralt, Castro, Cristina Gravalos, de Prado, Purificacion Martinez, Pericay, Carlos Pijaume, Figueiras, Manuel Constenla, Jordan, Inmaculada Guasch, Gome Reina, Maria Jose, Garcia, Amelia Lopez-Ladron, Garcia-Ramos, Antonio Arrivi, Cervantes, Andres, Martos, Carlos Fernandez, Gaspar, Eugenio Marcuello, Montero, Ines Cabezas, Emperador, Pilar Escudero, Carbonero, Ana Leon, Castillo, Manuel Gallen, Garcia, Teresa Garcia, Lopez, Jose Garcia, Flores, Encarnacion Gonzalez, Morales, Monica Guillot, Muñoz, Marta Llanos, Martín, Ana López, Maurel, Joan, Camara, Juan Carlos, Garcia, Rosario Dueñas, Salgado, Mercedes, Busquier, Isabel Hernandez, Ruiz, Teresa Checa, Muñoa, Adelaida Lacasta, Aliguer, Miquel Nogue, de Taranco, Amalia Velasco Ortiz, Ureña, Miguel Mendez, Gaspa, Ferran Losa, Ponce, Jose Juan, Roig, Carlos Bosch, Jimenez, Pedro Valero, Brotons, Antonio Galan, Rodriguez, Santiago Albiol, Martinez, Jose Ales, Ruiz, Liliana Canosa, Ruiz, Margarita Centelles, Bridgewater, John, Glynne-Jones, Rob, Tahir, Saad, Hickish, Tamas, Cassidy, Jim, Samuel, Leslie, Emile, Jean-François, Julié, Catherine, Le Malicot, Karine, Lepage, Come, Dimet, Stéphanie, Boulagnon-Rombi, Camille, Allard, Marc-Antoine, Penault-Llorca, Frédérique, Bennouna, Jaafar, and Laurent-Puig, Pierre

Published
2017
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7. Adding dasatinib to intensive treatment in core-binding factor acute myeloid leukemia—results of the AMLSG 11-08 trial

Author

Paschka, Peter, Schlenk, Richard F, Weber, Daniela, Benner, Axel, Bullinger, Lars, Heuser, Michael, Gaidzik, Verena I, Thol, Felicitas, Agrawal, Mridul, Teleanu, Veronica, Lübbert, Michael, Fiedler, Walter, Radsak, Markus, Krauter, Jürgen, Horst, Heinz-A., Greil, Richard, Mayer, Karin, Kündgen, Andrea, Martens, Uwe, Heil, Gerhard, Salih, Helmut R, Hertenstein, Bernd, Schwänen, Carsten, Wulf, Gerald, Lange, Elisabeth, Pfreundschuh, Michael, Ringhoffer, Mark, Girschikofsky, Michael, Heinicke, Thomas, Kraemer, Doris, Göhring, Gudrun, Ganser, Arnold, Döhner, Konstanze, and Döhner, Hartmut

Published
2018
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9. Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

Author

Topp, Max S, Gökbuget, Nicola, Stein, Anthony S, Zugmaier, Gerhard, O'Brien, Susan, Bargou, Ralf C, Dombret, Hervé, Fielding, Adele K, Heffner, Leonard, Larson, Richard A, Neumann, Svenja, Foà, Robin, Litzow, Mark, Ribera, Josep-Maria, Rambaldi, Alessandro, Schiller, Gary, Brüggemann, Monika, Horst, Heinz A, Holland, Chris, Jia, Catherine, Maniar, Tapan, Huber, Birgit, Nagorsen, Dirk, Forman, Stephen J, and Kantarjian, Hagop M

Published
2015
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10. All-trans retinoic acid as adjunct to intensive treatment in younger adult patients with acute myeloid leukemia: results of the randomized AMLSG 07-04 study

Author

Schlenk, Richard F., Lübbert, Michael, Benner, Axel, Lamparter, Alexander, Krauter, Jürgen, Herr, Wolfgang, Martin, Hans, Salih, Helmut R., Kündgen, Andrea, Horst, Heinz-A., Brossart, Peter, Götze, Katharina, Nachbaur, David, Wattad, Mohammed, Köhne, Claus-Henning, Fiedler, Walter, Bentz, Martin, Wulf, Gerald, Held, Gerhard, Hertenstein, Bernd, Salwender, Hans, Gaidzik, Verena I, Schlegelberger, Brigitte, Weber, Daniela, Döhner, Konstanze, Ganser, Arnold, Döhner, Hartmut, and for the German-Austrian Acute Myeloid Leukemia Study Group

Published
2016
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11. Improved outcome of adult Burkitt lymphoma/leukemia with rituximab and chemotherapy: report of a large prospective multicenter trial

Author

Hoelzer, Dieter, Walewski, Jan, Döhner, Hartmut, Viardot, Andreas, Hiddemann, Wolfgang, Spiekermann, Karsten, Serve, Hubert, Dührsen, Ulrich, Hüttmann, Andreas, Thiel, Eckhard, Dengler, Jolanta, Kneba, Michael, Schaich, Markus, Schmidt-Wolf, IngoG. H., Beck, Joachim, Hertenstein, Bernd, Reichle, Albrecht, Domanska-Czyz, Katarzyna, Fietkau, Rainer, Horst, Heinz-August, Rieder, Harald, Schwartz, Stefan, Burmeister, Thomas, and Gökbuget, Nicola

Published
2014
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12. Differential impact of allelic ratio and insertion site in FLT3-ITD–positive AML with respect to allogeneic transplantation

Author

Schlenk, Richard F., Kayser, Sabine, Bullinger, Lars, Kobbe, Guido, Casper, Jochen, Ringhoffer, Mark, Held, Gerhard, Brossart, Peter, Lübbert, Michael, Salih, Helmut R., Kindler, Thomas, Horst, Heinz A., Wulf, Gerald, Nachbaur, David, Götze, Katharina, Lamparter, Alexander, Paschka, Peter, Gaidzik, Verena I., Teleanu, Veronica, Späth, Daniela, Benner, Axel, Krauter, Jürgen, Ganser, Arnold, Döhner, Hartmut, and Döhner, Konstanze

Published
2014
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13. Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines

Author

Lengfelder, Eva, Görlich, Dennis, Nowak, Daniel, Spiekermann, Karsten, Haferlach, Claudia, Krug, Utz, Kreuzer, Karl‐Anton, Braess, Jan, Schliemann, Christoph, Lindemann, Hans‐Walter, Horst, Heinz A., Schiel, Xaver, Flasshove, Michael, Hecht, Anna, Schnittger, Susanne, Schneider, Stephanie, Wörmann, Bernhard, Hofmann, Wolf‐Karsten, Berdel, Wolfgang E., Bormann, Eike, Sauerland, Cristina, Büchner, Thomas, and Hiddemann, Wolfgang

Published
2018
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15. Secondary genetic lesions in acute myeloid leukemia with inv(16) or t(16;16): a study of the German-Austrian AML Study Group (AMLSG)

Author

Paschka, Peter, Du, Juan, Schlenk, Richard F., Gaidzik, Verena I., Bullinger, Lars, Corbacioglu, Andrea, Späth, Daniela, Kayser, Sabine, Schlegelberger, Brigitte, Krauter, Jürgen, Ganser, Arnold, Köhne, Claus-Henning, Held, Gerhard, von Lilienfeld-Toal, Marie, Kirchen, Heinz, Rummel, Mathias, Götze, Katharina, Horst, Heinz-August, Ringhoffer, Mark, Lübbert, Michael, Wattad, Mohammed, Salih, Helmut R., Kündgen, Andrea, Döhner, Hartmut, and Döhner, Konstanze

Published
2013
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16. Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia

Author

Kantarjian, Hagop, Stein, Anthony, Gökbuget, Nicola, Fielding, Adele K., Schuh, Andre C., Ribera, Josep-Maria, Wei, Andrew, Dombret, Hervé, Foà, Robin, Bassan, Renato, Arslan, Önder, Sanz, Miguel A., Bergeron, Julie, Demirkan, Fatih, Lech-Maranda, Ewa, Rambaldi, Alessandro, Thomas, Xavier, Horst, Heinz-August, Brüggemann, Monika, Klapper, Wolfram, Wood, Brent L., Fleishman, Alex, Nagorsen, Dirk, Holland, Christopher, Zimmerman, Zachary, and Topp, Max S.

Published
2017
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17. Outcome of relapsed adult lymphoblastic leukemia depends on response to salvage chemotherapy, prognostic factors, and performance of stem cell transplantation

Author

Gökbuget, Nicola, Stanze, Daniel, Beck, Joachim, Diedrich, Helmut, Horst, Heinz-August, Hüttmann, Andreas, Kobbe, Guido, Kreuzer, Karl-Anton, Leimer, Lothar, Reichle, Albrecht, Schaich, Markus, Schwartz, Stefan, Serve, Hubert, Starck, Michael, Stelljes, Matthias, Stuhlmann, Reingard, Viardot, Andreas, Wendelin, Knut, Freund, Mathias, and Hoelzer, Dieter

Published
2012
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18. Sequential treatment with rituximab followed by CHOP chemotherapy in adult B-cell post-transplant lymphoproliferative disorder (PTLD): the prospective international multicentre phase 2 PTLD-1 trial

Author

Trappe, Ralf, Oertel, Stephan, Leblond, Veronique, Mollee, Peter, Sender, Monica, Reinke, Petra, Neuhaus, Ruth, Lehmkuhl, Hans, Horst, Heinz August, Salles, Gilles, Morschhauser, Franck, Jaccard, Arnaud, Lamy, Thierry, Leithäuser, Malte, Zimmermann, Heiner, Anagnostopoulos, Ioannis, Raphael, Martine, Riess, Hanno, and Choquet, Sylvain

Published
2012
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19. Monosomal karyotype in adult acute myeloid leukemia: prognostic impact and outcome after different treatment strategies

Author

Kayser, Sabine, Zucknick, Manuela, Döhner, Konstanze, Krauter, Jürgen, Köhne, Claus-Henning, Horst, Heinz A., Held, Gerhard, von Lilienfeld-Toal, Marie, Wilhelm, Sibylla, Rummel, Mathias, Germing, Ulrich, Götze, Katharina, Nachbaur, David, Schlegelberger, Brigitte, Göhring, Gudrun, Späth, Daniela, Morlok, Carina, Teleanu, Veronica, Ganser, Arnold, Döhner, Hartmut, and Schlenk, Richard F.

Published
2012
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21. Addition of AEG35156 XIAP Antisense Oligonucleotide in Reinduction Chemotherapy Does Not Improve Remission Rates in Patients With Primary Refractory Acute Myeloid Leukemia in a Randomized Phase II Study

Author

Schimmer, Aaron D., Herr, Wolfgang, Hänel, Mathias, Borthakur, Gautham, Frankel, Arthur, Horst, Heinz-August, Martin, Sonja, Kassis, Jeannine, Desjardins, Pierre, Seiter, Karen, Fiedler, Walter, Noppeney, Richard, Giagounidis, Aristoteles, Jacob, Christine, Jolivet, Jacques, Tallman, Martin S., and Koschmieder, Steffen

Published
2011
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22. The impact of therapy-related acute myeloid leukemia (AML) on outcome in 2853 adult patients with newly diagnosed AML

Author

Kayser, Sabine, Döhner, Konstanze, Krauter, Jürgen, Köhne, Claus-Henning, Horst, Heinz A., Held, Gerhard, von Lilienfeld-Toal, Marie, Wilhelm, Sibylla, Kündgen, Andrea, Götze, Katharina, Rummel, Mathias, Nachbaur, David, Schlegelberger, Brigitte, Göhring, Gudrun, Späth, Daniela, Morlok, Carina, Zucknick, Manuela, Ganser, Arnold, Döhner, Hartmut, and Schlenk, Richard F.

Published
2011
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23. Correction to: Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005–2017

Author

Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Jörg Janne, and ClinSurv Study Group

Subjects
ddc:610
Abstract

Correction to: Infection (2020) 48:723–733 https://doi.org/10.1007/s15010-020-01469-6. The original version of this article unfortunately contained a mistake. In this article the authors Dirk Schürmann at affiliation Charité, University Medicine, Berlin, Olaf Degen at affiliation University Clinic Hamburg Eppendorf, Hamburg and Heinz-August Horst at affiliation University Hospital Schleswig–Holstein, Kiel, Germany were missing from the author list. The original article has been corrected.

Published
2021

25. Outcome of elderly patients with acute promyelocytic leukemia: results of the German Acute Myeloid Leukemia Cooperative Group

Author

Lengfelder, Eva, Hanfstein, Benjamin, Haferlach, Claudia, Braess, Jan, Krug, Utz, Spiekermann, Karsten, Haferlach, Torsten, Kreuzer, Karl-Anton, Serve, Hubert, Horst, Heinz A., Schnittger, Susanne, Aul, Carlo, Schultheis, Beate, Erben, Philipp, Schneider, Stephanie, Müller-Tidow, Carsten, Wörmann, Bernhard, Berdel, Wolfgang E., Sauerland, Cristina, Heinecke, Achim, Hehlmann, Rüdiger, Hofmann, Wolf-Karsten, Hiddemann, Wolfgang, Büchner, Thomas, and for the German Acute Myeloid Leukemia Cooperative Group (AMLCG)

Published
2013
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26. Adjunctive Volasertib in Patients With Acute Myeloid Leukemia not Eligible for Standard Induction Therapy: A Randomized, Phase 3 Trial

Author

Döhner, Hartmut, primary, Symeonidis, Argiris, additional, Deeren, Dries, additional, Demeter, Judit, additional, Sanz, Miguel A., additional, Anagnostopoulos, Achilles, additional, Esteve, Jordi, additional, Fiedler, Walter, additional, Porkka, Kimmo, additional, Kim, Hee-Je, additional, Lee, Je-Hwan, additional, Usuki, Kensuke, additional, D'Ardia, Stefano, additional, Won Jung, Chul, additional, Salamero, Olga, additional, Horst, Heinz-August, additional, Recher, Christian, additional, Rousselot, Philippe, additional, Sandhu, Irwindeep, additional, Theunissen, Koen, additional, Thol, Felicitas, additional, Döhner, Konstanze, additional, Teleanu, Veronica, additional, DeAngelo, Daniel J., additional, Naoe, Tomoki, additional, Sekeres, Mikkael A., additional, Belsack, Valerie, additional, Ge, Miaomiao, additional, Taube, Tillmann, additional, and Ottmann, Oliver G., additional

Published
2021
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27. Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017 (vol 48, pg 723, 2020)

Author

Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schuermann, Dirk, Degen, Olaf, Horst, Heinz-August, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Joerg Janne, Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schuermann, Dirk, Degen, Olaf, Horst, Heinz-August, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Joerg Janne

Published
2021

28. Correction to: Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005–2017

Author

ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Jörg Janne, ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Jörg Janne

Abstract

Correction to: Infection (2020) 48:723–733 https://doi.org/10.1007/s15010-020-01469-6. The original version of this article unfortunately contained a mistake. In this article the authors Dirk Schürmann at affiliation Charité, University Medicine, Berlin, Olaf Degen at affiliation University Clinic Hamburg Eppendorf, Hamburg and Heinz-August Horst at affiliation University Hospital Schleswig–Holstein, Kiel, Germany were missing from the author list. The original article has been corrected.

Published
2021

29. Blinatumomab as first salvage versus second or later salvage in adults with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia: Results of a pooled analysis

Author

Topp, Max S., primary, Stein, Anthony S., additional, Gökbuget, Nicola, additional, Horst, Heinz‐August, additional, Boissel, Nicolas, additional, Martinelli, Giovanni, additional, Kantarjian, Hagop, additional, Brüggemann, Monika, additional, Chen, Yuqi, additional, and Zugmaier, Gerhard, additional

Published
2021
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30. Liposomal amphotericin B as initial therapy for invasive mold infection: a randomized trial comparing a high-loading dose regimen with standard dosing (AmBiLoad Trial)

Author

Cornely, Oliver A., Maertens, Johan, Bresnik, Mark, Ebrahimi, Ramin, Ullmann, Andrew J., Bouza, Emilio, Heussel, Claus Peter, Lortholary, Olivier, Rieger, Christina, Boehme, Angelika, Aoun, Mickael, Horst, Heinz-August, Thiebaut, Anne, Ruhnke, Markus, Reichert, Dietmar, Vianelli, Nicola, Krause, Stefan W., Olavarria, Eduardo, and Herbrecht, Raoul

Subjects
Amphotericin B -- Dosage and administration, Amphotericin B -- Research, Aspergillosis -- Care and treatment, Health, Health care industry
Published
2007

31. Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia

Author

Gökbuget, Nicola, Zugmaier, Gerhard, Dombret, Hervé, Stein, Anthony, Bonifacio, Massimiliano, Graux, Carlos, Faul, Christoph, Brüggemann, Monika, Taylor, Kate, Mergen, Noemi, Reichle, Albrecht, Horst, Heinz August, Havelange, Violaine, Topp, Max S., Bargou, Ralf C., Gökbuget, Nicola, Zugmaier, Gerhard, Dombret, Hervé, Stein, Anthony, Bonifacio, Massimiliano, Graux, Carlos, Faul, Christoph, Brüggemann, Monika, Taylor, Kate, Mergen, Noemi, Reichle, Albrecht, Horst, Heinz August, Havelange, Violaine, Topp, Max S., and Bargou, Ralf C.

Abstract

Minimal residual disease (MRD) is the strongest predictor of relapse in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In BLAST study (NCT01207388), adults with BCP-ALL in remission with MRD after chemotherapy received blinatumomab, a CD19 BiTE® immuno-oncotherapy, 15 µg/m2/day for up to four 6-week cycles (4 weeks continuous infusion, 2 weeks off). Survival was evaluated for 110 patients, including 74 who received HSCT in continuous complete remission. With a median follow-up of 59·8 months, median survival (months) was 36·5 (95% CI: 22.0–not reached [NR]). Median survival was NR (29.5–NR) for complete MRD responders (n = 84) and 14.4 (3.8–32.3) for MRD non-responders (n = 23; p = 0.002); after blinatumomab and HSCT, median survival was NR (25.7–NR) (n = 61) and 16.5 (1.1–NR) (n = 10; p = 0.065), respectively. This final analysis suggests complete MRD response during blinatumomab treatment is curative. Post-hoc analysis of study data suggests while post blinatumomab HSCT may be beneficial in appropriate patients, long-term survival without HSCT is also possible.

Published
2020

35. Curative outcomes following blinatumomab in adults with minimal residual disease B-cell precursor acute lymphoblastic leukemia

Author

Gökbuget, Nicola, primary, Zugmaier, Gerhard, additional, Dombret, Hervé, additional, Stein, Anthony, additional, Bonifacio, Massimiliano, additional, Graux, Carlos, additional, Faul, Christoph, additional, Brüggemann, Monika, additional, Taylor, Kate, additional, Mergen, Noemi, additional, Reichle, Albrecht, additional, Horst, Heinz-August, additional, Havelange, Violaine, additional, Topp, Max S., additional, and Bargou, Ralf C., additional

Published
2020
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37. Gemtuzumab Ozogamicin in NPM1-Mutated Acute Myeloid Leukemia: Early Results From the Prospective Randomized AMLSG 09-09 Phase III Study

Author

Schlenk, Richard F., primary, Paschka, Peter, additional, Krzykalla, Julia, additional, Weber, Daniela, additional, Kapp-Schwoerer, Silke, additional, Gaidzik, Verena I., additional, Leis, Claudia, additional, Fiedler, Walter, additional, Kindler, Thomas, additional, Schroeder, Thomas, additional, Mayer, Karin, additional, Lübbert, Michael, additional, Wattad, Mohammed, additional, Götze, Katharina, additional, Horst, Heinz A., additional, Koller, Elisabeth, additional, Wulf, Gerald, additional, Schleicher, Jan, additional, Bentz, Martin, additional, Greil, Richard, additional, Hertenstein, Bernd, additional, Krauter, Jürgen, additional, Martens, Uwe, additional, Nachbaur, David, additional, Abu Samra, Maisun, additional, Girschikofsky, Michael, additional, Basara, Nadezda, additional, Benner, Axel, additional, Thol, Felicitas, additional, Heuser, Michael, additional, Ganser, Arnold, additional, Döhner, Konstanze, additional, and Döhner, Hartmut, additional

Published
2020
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38. First transmission of human immunodeficiency virus Type 1 by a cellular blood product after mandatory nucleic acid screening in Germany

Author

Schmidt, Michael, Korn, Klaus, Nübling, Micha C., Chudy, Michael, Kress, Julia, Horst, Heinz A., Geusendam, Geert, Hennig, Holger, Sireis, Walid, Rabenau, Holger F., Doerr, Hans Wilhelm, Berger, Annemarie, Hourfar, Michael Kai, Gubbe, Knut, Karl, Andreas, Fickenscher, Helmut, Tischer, Karsten B., Babiel, Reiner, Seifried, Erhard, and Gürtler, Lutz

Published
2009
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40. Erratum to 'Gökbuget N, Dombret H, Bonifacio M, et al. Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia'[Blood. 2018;131(14):1522-1531]

Author

Gökbuget, Nicola, Dombret, Hervé, Bonifacio, Massimiliano, Reichle, Albrecht, Graux, Carlos, Faul, Christoph, Diedrich, Helmut, Topp, Max S, Brüggemann, Monika, Horst, Heinz-August, Havelange, Violaine, Stieglmaier, Julia, Wessels, Hendrik, Haddad, Vincent, Benjamin, Jonathan E, Zugmaier, Gerhard, Nagorsen, Dirk, Bargou, Ralf C, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - SSS/DDUV - Institut de Duve, UCL - SSS/DDUV/MEXP - Médecine expérimentale, UCL - (MGD) Service d'hématologie, UCL - (SLuc) Service d'hématologie, and UCL - (SLuc) Centre du cancer

Abstract

On page 1526 of the 5 April 2018 issue, the scale of Figure 3B’s y-axis is inaccurate. The corrected Figure 3B is shown below. The error has been corrected in the online version of the article.

Published
2019

46. Effects of interleukin-2 plus highly active antiretroviral therapy on HIV-1 replication and proviral DNA (COSMIC trial)

Author

Stellbrink, Hans-Jürgen, van Lunzen, Jan, Westby, Michael, O'Sullivan, Eithne, Schneider, Claus, Adam, Axel, Weitner, Lutwin, Kuhlmann, Birger, Hoffmann, Christian, Fenske, Stefan, Aries, Philipp S., Degen, Olaf, Eggers, Christian, Petersen, Heiko, Haag, Friedrich, Horst, Heinz A., Dalhoff, Klaus, Möcklinghoff, Christiane, Cammack, Nick, Tenner-Racz, Klara, and Racz, Paul

Published
2002

48. Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1) RUNX1-RUNX1T1 Identifies Patients at High Risk of Relapse: Results of the AML Study Group (AMLSG)

Author

Rücker, Frank G., primary, Agrawal, Mridul, additional, Corbacioglu, Andrea, additional, Weber, Daniela, additional, Kapp-Schwoerer, Silke, additional, Gaidzik, Verena I., additional, Jahn, Nikolaus, additional, Schroeder, Thomas, additional, Wattad, Mohammad, additional, Lübbert, Michael, additional, Koller, Elisabeth, additional, Kindler, Thomas, additional, Götze, Katharina, additional, Ringhoffer, Mark, additional, Westermann, Jörg, additional, Fiedler, Walter, additional, Horst, Heinz A., additional, Greil, Richard, additional, Schroers, Roland, additional, Mayer, Karin, additional, Heinicke, Thomas, additional, Krauter, Jürgen, additional, Schlenk, Richard F., additional, Thol, Felicitas, additional, Heuser, Michael, additional, Ganser, Arnold, additional, Bullinger, Lars, additional, Paschka, Peter, additional, Döhner, Hartmut, additional, and Döhner, Konstanze, additional

Published
2019
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49. Hematopoietic stem cell involvement in BCR-ABL1–positive ALL as a potential mechanism of resistance to blinatumomab therapy

Author

Nagel, Inga, Bartels, Marius, Duell, Johannes, Oberg, Hans-Heinrich, Ussat, Sandra, Bruckmueller, Henrike, Ottmann, Oliver, Pfeifer, Heike, Trautmann, Heiko, Gökbuget, Nicola, Caliebe, Almuth, Kabelitz, Dieter, Kneba, Michael, Horst, Heinz-August, Hoelzer, Dieter, Topp, Max S., Cascorbi, Ingolf, Siebert, Reiner, and Brüggemann, Monika

Published
2017
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50. Physical and mental health in HIV-infected patients with virological success and long-term exposure to antiretroviral therapy.

Author

Sabranski, Michael, Erdbeer, Gesa, Sonntag, Ina, Stoehr, Albrecht, Horst, Heinz-August, Plettenberg, Andreas, Lebherz, Lisa, Stellbrink, Hans-Jürgen, and Hoffmann, Christian

Subjects
HIV-positive persons, HEALTH facilities, VIRAL load, CROSS-sectional method, MULTIVARIATE analysis, MENTAL health, ANTIRETROVIRAL agents, LIFE skills, QUALITY of life, QUESTIONNAIRES, EMPLOYMENT, PSYCHOSOCIAL factors
Abstract

In people living with HIV (PLWH), a decade-long antiretroviral therapy (ART) poses new challenges regarding physical and mental health. The aim of this cross-sectional study is to investigate the health-related quality of life (HRQOL) in adult HIV-infected patients with viral suppression and an ART exposure for at least 5 years in three German HIV centers. Patients were evaluated by the ACTG Augmented Symptoms Distress Module (ASDM) and the SF-12 Health Survey. Among 894 patients, symptom-related distress was highly prevalent. The most common symptoms were fatigue, insomnia, sadness and depression, sexual dysfunction, and changes in body appearance. In the multivariate analysis, ART duration, age and depression were significantly associated with a higher overall symptom summary score. Self-reported mean SF-12 scores were lower for mental health and younger patients compared to the standard random sample of a healthy German population. Depression and occupational status were significantly related to a lower physical component summary score, by contrast older age was associated with higher scores in the mental component summary, implying more favorable mental health status. In this large group of PLWH, the degree of symptom-related distress was high. Mental and physical health should be considered an integral part of ongoing HIV care. [ABSTRACT FROM AUTHOR]

Published
2021
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