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14 results on '"Horsburgh, Brian C."'

4. Translational recoding induced by G-rich mRNA sequences that form unusual structures

Author

Horsburgh, Brian C., Kollmus, Heike, Hauser, Hansjorg, and Coen, Donald M.

Subjects
Herpes simplex virus -- Genetic aspects, Thymidine -- Genetic aspects, Messenger RNA -- Research, Gene expression -- Research, Biological sciences
Abstract

Participatory sequences in the herpes simplex virus thymidine kinase (HSV tk) recoding are determined in a herpesvirus mutant. The findings demonstrate a novel mechanism that relies on the capacity of the G-rich sequences to generate unique inter- or intramolecular structures. Specifically, the sole influence of G-strings to activate a net +1 recoding in cultured cells is determined. On the other hand, mediation of recoding by the G-string structure inside the ribosome is proposed to proceed either by the Hoogsteen or non-Watson-Crick interactions.

Published
1996

14. Translational recoding induced by G-rich sequences that form unusual structures.

Author

Horsburgh, Brian C. and Kollmus, Heike

Subjects
*GENE expression
Abstract

Investigates a herpesvirus mutant that contains a single base insertion in its thymidine kinase gene. Analysis of net + 1 recoding in vitro by a reporter gene system; Association of recoding with G-richness ; Correlation of the ability of G-strings to form unusual structures with recoding.

Published
1996
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