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597 results on '"Horny, H."'

5. Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal

Author

Valent, P., Sotlar, K., Sperr, W.R., Escribano, L., Yavuz, S., Reiter, A., George, T.I., Kluin-Nelemans, H.C., Hermine, O., Butterfield, J.H., Hägglund, H., Ustun, C., Hornick, J.L., Triggiani, M., Radia, D., Akin, C., Hartmann, K., Gotlib, J., Schwartz, L.B., Verstovsek, S., Orfao, A., Metcalfe, D.D., Arock, M., and Horny, H.-P.

Published
2014
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6. Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal

Author

Willmann M., Yuzbasiyan-Gurkan V., Marconato L., Dacasto M., Hadzijusufovic E., Hermine O., Sadovnik I., Gamperl S., Schneeweiss-Gleixner M., Gleixner K. V., Bohm T., Peter B., Eisenwort G., Moriggl R., Li Z., Jawhar M., Sotlar K., Jensen-Jarolim E., Sexl V., Horny H. -P., Galli S. J., Arock M., Vail D. M., Kiupel M., Valent P., Willmann M., Yuzbasiyan-Gurkan V., Marconato L., Dacasto M., Hadzijusufovic E., Hermine O., Sadovnik I., Gamperl S., Schneeweiss-Gleixner M., Gleixner K.V., Bohm T., Peter B., Eisenwort G., Moriggl R., Li Z., Jawhar M., Sotlar K., Jensen-Jarolim E., Sexl V., Horny H.-P., Galli S.J., Arock M., Vail D.M., Kiupel M., and Valent P.

Subjects
KIT mutations, canine mast cell neoplasm, classification, grading, staging, targeted therapy, treatment algorithms, KIT mutation, Veterinary Science, Review
Abstract

Mast cell neoplasms are one of the most frequently diagnosed malignancies in dogs. The clinical picture, course, and prognosis vary substantially among patients, depending on the anatomic site, grade and stage of the disease. The most frequently involved organ is the skin, followed by hematopoietic organs (lymph nodes, spleen, liver, and bone marrow) and mucosal sites of the oral cavity and the gastrointestinal tract. In cutaneous mast cell tumors, several grading and staging systems have been introduced. However, no comprehensive classification and no widely accepted diagnostic criteria have been proposed to date. To address these open issues and points we organized a Working Conference on canine mast cell neoplasms in Vienna in 2019. The outcomes of this meeting are summarized in this article. The proposed classification includes cutaneous mast cell tumors and their sub-variants defined by grading- and staging results, mucosal mast cell tumors, extracutaneous/extramucosal mast cell tumors without skin involvement, and mast cell leukemia (MCL). For each of these entities, diagnostic criteria are proposed. Moreover, we have refined grading and staging criteria for mast cell neoplasms in dogs based on consensus discussion. The criteria and classification proposed in this article should greatly facilitate diagnostic evaluation and prognostication in dogs with mast cell neoplasms and should thereby support management of these patients in daily practice and the conduct of clinical trials.

Published
2021

13. Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Author

Valent, P., Akin, C., Hartmann, K., Nilsson, G., Reiter, A., Hermine, O., Sotlar, K., Sperr, W. R., Escribano, L., George, T. I., Kluin-Nelemans, H. C., Ustun, C., Triggiani, M., Brockow, K., Gotlib, J., Orfao, A., Kovanen, P. T., Hadzijusufovic, E., Sadovnik, I., Horny, H. -P., Arock, M., Schwartz, L. B., Frank Austen, K., Metcalfe, D. D., Galli, S. J., Austrian Science Fund, National Institutes of Health (US), United States-Israel Binational Science Foundation, and Stanford University

Subjects
mastocytosis, tryptase, KIT, Cell Differentiation, History, 19th Century, Review, History, 20th Century, histamine, History, 21st Century, humanities, Immunity, Innate, Disease Models, Animal, Histamine, IgE receptor, Mast cell activation, Mastocytosis, Tryptase, Allergy and Immunology, mast cell activation, Hypersensitivity, Animals, Humans, Mast Cells, Molecular Targeted Therapy, Precision Medicine, Immunosuppressive Agents
Abstract

© The author(s)., The origin and functions of mast cells (MCs) have been debated since their description by Paul Ehrlich in 1879. MCs have long been considered 'reactive bystanders' and 'amplifiers' in inflammatory processes, allergic reactions, and host responses to infectious diseases. However, knowledge about the origin, phenotypes and functions of MCs has increased substantially over the past 50 years. MCs are now known to be derived from multipotent hematopoietic progenitors, which, through a process of differentiation and maturation, form a unique hematopoietic lineage residing in multiple organs. In particular, MCs are distinguishable from basophils and other hematopoietic cells by their unique phenotype, origin(s), and spectrum of functions, both in innate and adaptive immune responses and in other settings. The concept of a unique MC lineage is further supported by the development of a distinct group of neoplasms, collectively referred to as mastocytosis, in which MC precursors expand as clonal cells. The clinical consequences of the expansion and/or activation of MCs are best established in mastocytosis and in allergic inflammation. However, MCs have also been implicated as important participants in a number of additional pathologic conditions and physiological processes. In this article, we review concepts regarding MC development, factors controlling MC expansion and activation, and some of the fundamental roles MCs may play in both health and disease. We also discuss new concepts for suppressing MC expansion and/or activation using molecularly-targeted drugs., P.V. was supported by the Austrian Science Fund (FWF), grants F4701-B28, F4704-B28 and P32470-B. DDM is supported by the Division of Intramural Research, NIAID. SJG's research is supported by the NIH, USA, the US-Israel Binational Foundation, and the Department of Pathology and the Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA.

Published
2020

19. Proposed diagnostic algorithm for patients with suspected mastocytosis: a proposal of the European Competence Network on Mastocytosis

Author

Valent, P., Escribano, L., Broesby-Olsen, S., Hartmann, K., Grattan, C., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, J. N. G., Kristensen, T., Butterfield, J. H., Triggiani, M., Alvarez-Twose, I., Reiter, A., Sperr, W. R., Sotlar, K., Yavuz, S., Kluin-Nelemans, H. C., Hermine, O., Radia, D., van Doormaal, J. J., Gotlib, J., Orfao, A., Siebenhaar, F., Schwartz, L. B., Castells, M., Maurer, M., Horny, H.-P., Akin, C., Metcalfe, D. D., and Arock, M.

Published
2014
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22. Systemic mastocytosis with associated myeloproliferative disease and precursor B lymphoblastic leukaemia with t(13;13)(q12;q22) involving FLT3

Author

Tzankov, A., Sotlar, K., Muhlematter, D., Theocharides, A., Went, P., Jotterand, M., Horny, H.-P., and Dirnhofer, S.

Subjects
Mast cell disease -- Diagnosis, Mast cell disease -- Development and progression, Myeloproliferative disorders -- Diagnosis, Myeloproliferative disorders -- Physiological aspects, Leukemia -- Diagnosis, Leukemia -- Physiological aspects, Gene mutations -- Research, Gene mutations -- Physiological aspects, Health
Published
2008

24. Enumeration and immunohistochemical characterisation of bone marrow basophils in myeloproliferative disorders using the basophil specific monoclonal antibody 2D7

Author

Agis, H., Krauth, M.-T., Mosberger, I., Mullauer, L., Simonitsch-Klupp, I., Schwartz, L.B., Printz, D., Bohm, A., Fritsch, G., Horny, H.-P., and Valent, P.

Subjects
Basophils -- Analysis, Myeloproliferative disorders -- Development and progression, Myeloproliferative disorders -- Diagnosis, Monoclonal antibodies -- Usage, Bone marrow cells -- Analysis, Health
Published
2006

25. The tryptase positive compact round cell infiltrate of the bone marrow (TROCI-BM): a novel histopathological finding requiring the application of lineage specific markers

Author

Horny, H.-P., Sotlar, K., Stellmacher, F., Krokowski, M., Agis, H., Schwartz, L.B., and Valent, P.

Subjects
Mast cells -- Research, Bone marrow examination -- Analysis, Biological markers -- Research, Bone marrow -- Biopsy, Bone marrow -- Analysis, Bone marrow -- Diseases, Bone marrow -- Development and progression, Bone marrow -- Diagnosis, Health
Published
2006

30. Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? Immunohistochemical and molecular findings on routinely processed bone marrow biopsy specimens

Author

Horny, H-P, Lange, K, Sotlar, K, and Valent, P

Subjects
Clinical pathology -- Research -- Physiological aspects -- Health aspects, Gene expression -- Physiological aspects -- Research -- Genetic aspects -- Health aspects, Bone marrow -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, Lymphocytes -- Physiological aspects -- Genetic aspects -- Research -- Health aspects, B cells -- Genetic aspects -- Physiological aspects -- Research -- Health aspects, Mast cells -- Genetic aspects -- Physiological aspects -- Health aspects -- Research, Histology, Pathological -- Research -- Health aspects -- Physiological aspects, Mast cell disease -- Health aspects -- Diagnosis -- Research -- Genetic aspects, Health, Diagnosis, Physiological aspects, Research, Genetic aspects, Health aspects
Abstract

Aims: To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with [...]

Published
2003

31. Chymase expressing bone marrow mast cells in mastocytosis and myelodysplastic syndromes: an immunohistochemical and morphometric study. (Original Article)

Author

Horny, H-P, Greschniok, A., Jordan, J-H., Menke, D.M., and Valent, P.

Subjects
Myelodysplastic syndromes -- Physiological aspects, Mast cells -- Physiological aspects, Mast cell disease -- Physiological aspects, Health
Abstract

Background: Two cell specific neutral proteases, tryptase and chymase, are produced by human mast cells (MC). Tryptase is constitutively expressed by all MC, whereas chymase is found only in an [...]

Published
2003

33. Extranodal marginal zone B cell lymphoma of MALT type involving the mucosa of both the urinary bladder and stomach. (Letters to JCP)

Author

Krober, S.M., Aepinus, C., Ruck, P., Muller-Hermelink, H-K, Horny, H-P, and Kaiserling, E.

Subjects
Bladder cancer -- Methods, Lymphomas -- Methods, Surgery -- Methods, Health, Methods
Abstract

Primary lymphoma of the urinary bladder is a very rare tumour. A bladder tumour was found in a 57 year old man with obstructive dysuria. It was found by histological [...]

Published
2002

41. Conut score as a tool for early detection of poor nutritional status in advances forms of SM

Author

Gruchala-Niedoszytko, M., Gorska, A., Nedoszytko, B., Lange, M., Niedoszytko, M., Rabenhorst, A., Sperr, W., Elberink, Oude J., Gleixner, K., Brazzelli, V., Fontana, E., Vos, B., Reiter, A., Schwaab, J., Zanotti, R., Bonadonna, P., Triggiani, M., Gotlib, J., Doubek, M., Jakob, T., Fuchs, D., Sabato, V., Bretterklieber, A., Jaekel, N., Sotlar, K., Horny, H., Fortina, Belloni A., Merante, S., Kluin-Nelemans, H., Hartmann, K., Valent, P., and Arock, M.

Published
2019

44. Standards and standardization in mastocytosis: Consensus Statements on Diagnostics, Treatment Recommendations and Response Criteria

Author

Valent, P., Akin, C., Escribano, L., Födinger, M., Hartmann, K., Brockow, K., Castells, M., Sperr, W. R., Kluin-Nelemans, H. C., Hamdy, N. A. T., Lortholary, O., Robyn, J., van Doormaal, J., Sotlar, K., Hauswirth, A. W., Arock, M., Hermine, O., Hellmann, A., Triggiani, M., Niedoszytko, M., Schwartz, L. B., Orfao, A., Horny, H.-P., and Metcalfe, D. D.

Published
2007

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