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1. Large-scale EM Analysis of the Drosophila Antennal Lobe with Automatically Computed Synapse Point Clouds

Author

Zhao, Ting, Takemura, Shin-ya, Huang, Gary B., Horne, Jane Anne, Katz, William T., Shinomiya, Kazunori, Scheffer, Louis K., Meinertzhagen, Ian A., Rivlin, Patricia K., and Plaza, Stephen M.

Subjects
Quantitative Biology - Quantitative Methods
Abstract

The promise of extracting connectomes and performing useful analysis on large electron microscopy (EM) datasets has been an elusive dream for many years. Tracing in even the smallest portions of neuropil requires copious human annotation, the rate-limiting step for generating a connectome. While a combination of improved imaging and automatic segmentation will lead to the analysis of increasingly large volumes, machines still fail to reach the quality of human tracers. Unfortunately, small errors in image segmentation can lead to catastrophic distortions of the connectome. In this paper, to analyze very large datasets, we explore different mechanisms that are less sensitive to errors in automation. Namely, we advocate and deploy extensive synapse detection on the entire antennal lobe (AL) neuropil in the brain of the fruit fly Drosophila, a region much larger than any densely annotated to date. The resulting synapse point cloud produced is invaluable for determining compartment boundaries in the AL and choosing specific regions for subsequent analysis. We introduce our methodology in this paper for region selection and show both manual and automatic synapse annotation results. Finally, we note the correspondence between image datasets obtained using the synaptic marker, antibody nc82, and our datasets enabling registration between light and EM image modalities.

Published
2015

2. Measuring confidence after stroke

Author

Horne, Jane

Subjects
616.8, WL Nervous system
Abstract

Introduction: Improving confidence following stroke has been cited as a research priority (Pollock et al 2012). It is difficult to measure a change in confidence levels without valid and reliable measures. This research aims to develop and conduct a psychometric evaluation of a self-reported, confidence after stroke measure [CaSM]. Methods: Items were generated from themes highlighted in the literature review, and from a qualitative interview study, exploring the meaning of confidence. The CaSM was piloted with expert groups to establish face and content validity. The CaSM was administered to a sample of stroke and healthy elderly people recruited from the community. Completed postal questionnaires were analysed for reliability (internal consistency and test-retest), construct validity (factor analysis) and convergent validity. A visual analogue scale, to correlate therapists opinion with CaSM scores was used to assess concurrent validity. Sensitivity to change was assessed by comparing change scores at three time points after a confidence intervention. Case vignettes were used with stroke clinical experts to detect a minimal clinically meaningful change score. Results: Stroke (n=101) and healthy elderly participants (n=101) were recruited. Using item reduction techniques, a 53 item scale was reduced to 27 items. Factor Analysis was used to derive a three factor solution, Self-Confidence, Positive Attitude and Social Confidence, which explained 52% of variance. There was good evidence for internal consistency (α=0.94) and good temporal stability (rs=0.85 p=0.001). There was a small positive correlation between the two variables when assessing concurrent validity (rs=0.18, n=31, p<0.34), and did not demonstrate statistical significance. Four points on the CaSM was recommended by clinical experts as being a clinically important change score. Conclusion: The 27 item CaSM [Appendix 1] was shown to be a valid and reliable measure. The CaSM was designed to be used to identify people with low confidence after stroke in order to facilitate appropriate treatment. The CaSM could be used in research, as a patient reported outcome measure to evaluate strategies to improve confidence after a stroke. Assessment of the CaSM’s ability to detect sensitivity to change needs further assessment.

Published
2016

3. RECENT DEVELOPMENTS IN FIDELITY AND SURETY LAW

Author

Harris, David A., Wynn, Jessica L., Horne, Jane A., Berry, Matthew R., Bilodeau, Kelsey M., DiMatteo, Amanda, Etcheverry, Justin E., Meissner, Noah R., Parr, Dolores A., Weeks, Ryan J., Williams, Scott C., Wilson, Andy O., and Zefferino, Maddalena R.

Subjects
Securities law -- Surveys, Surety bonds -- Surveys, Law
Abstract

I. Surety Law A. Performance Bonds 1. Arbitration 2. Conditions Precedent 3. Surety Liability 4. Proper Claimants 5. Limitations 6. Prevailing Party B. Payment Bonds 1. Jurisdiction, Venue, Arbitration, and [...]

Published
2023

4. RECENT DEVELOPMENTS IN FIDELITY AND SURETY LAW

Author

Harris, David A., Wynn, Jessica L., Shah, Saloni, Berry, Matthew R., Bilodeau, Kelsey M., Etcheverry, Justin E., Horne, Jane A., Macnair, Jenna, Meissner, Noah R., Porrazzo, Alana L., Weeks, Ryan J., Williams, Scott C., and Zefferino, Maddalena R.

Subjects
Surety bonds -- Surveys, Law
Abstract

I. Surety Law A. Performance Bonds 1. Affirmative Claims 2. Conditions Precedent 3. Venue 4. Surety Liability 5. Limitations 6. Principal's Defenses 7. Penal Sum 8. Bad Faith B. Payment [...]

Published
2022

7. Synaptic circuits and their variations within different columns in the visual system of Drosophila

Author

Takemura, Shin-ya, Xu, C. Shan, Lu, Zhiyuan, Rivlin, Patricia K., Parag, Toufiq, Olbris, Donald J., Plaza, Stephen, Zhao, Ting, Katz, William T., Umayam, Lowell, Weaver, Charlotte, Hess, Harald F., Horne, Jane Anne, Nunez-Iglesias, Juan, Aniceto, Roxanne, Chang, Lei-Ann, Lauchie, Shirley, Nasca, Ashley, Ogundeyi, Omotara, Sigmund, Christopher, Takemura, Satoko, Tran, Julie, Langille, Carlie, Le Lacheur, Kelsey, McLin, Sari, Shinomiya, Aya, Chklovskii, Dmitri B., Meinertzhagen, Ian A., and Scheffer, Louis K.

Published
2015

9. FIDELITY AND SURETY LAW

Author

Harris, David A., Berry, Matthew R., Shah, Saloni, Glos, Rebecca S., Horne, Jane A., Kooy, Ralph, Mangum, Craig N., Weeks, Ryan J., Williams, Scott C., and Wynn, Jessica L.

Subjects
Suretyship and guaranty -- Surveys, Law
Abstract

I. Surety Law A. Performance Bonds 1. Conditions Precedent 2. Arbitration 3. Venue 4. Attorneys' Fees 5. Principal's Defenses 6. Bad Faith B. Payment Bonds 1. Jurisdiction, Venue, and Arbitration [...]

Published
2021

11. Multifactorial falls prevention programme compared with usual care in UK care homes for older people: Multicentre cluster randomised controlled trial with economic evaluation

Author

Logan, Pip A, Horne, Jane C, Gladman, John R.F., Gordon, Adam L., Robertson, Kate, Sach, Tracey, Clark, Allan, Robinson, Katie, Armstrong, Sarah, Stirling, Sue, Leighton, Paul, Darby, Janet, Allen, Fran, Irvine, Lisa, Wilson, Ed C F, Fox, Chris, Conroy, Simon, Mountain, Gail, McCartney, Karen, Godfrey, Maureen, and Sims, Erika

Abstract

Objectives To determine the clinical and cost effectiveness of a multifactorial fall prevention programme compared with usual care in long term care homes. Design Multicentre, parallel, cluster randomised controlled trial. Setting Long term care homes in the UK, registered to care for older people or those with dementia. Participants 1657 consenting residents and 84 care homes. 39 were randomised to the intervention group and 45 were randomised to usual care. Interventions Guide to Action for Care Homes (GtACH): a multifactorial fall prevention programme or usual care. Main outcome measures Primary outcome measure was fall rate at 91-180 days after randomisation. The economic evaluation measured health related quality of life using quality adjusted life years (QALYs) derived from the five domain five level version of the EuroQoL index (EQ-5D-5L) or proxy version (EQ-5D-5L-P) and the Dementia Quality of Life utility measure (DEMQOL-U), which were self-completed by competent residents and by a care home staff member proxy (DEMQOL-P-U) for all residents (in case the ability to complete changed during the study) until 12 months after randomisation. Secondary outcome measures were falls at 1-90, 181-270, and 271-360 days after randomisation, Barthel index score, and the Physical Activity Measure-Residential Care Homes (PAM-RC) score at 91, 180, 270, and 360 days after randomisation. Results Mean age of residents was 85 years. 32% were men. GtACH training was delivered to 1051/1480 staff (71%). Primary outcome data were available for 630 participants in the GtACH group and 712 in the usual care group. The unadjusted incidence rate ratio for falls between 91 and 180 days was 0.57 (95% confidence interval 0.45 to 0.71, P

Published
2021

12. A multidomain decision support tool to prevent falls in older people: the FinCH cluster RCT

Author

Logan, Philippa A, primary, Horne, Jane C, additional, Allen, Frances, additional, Armstrong, Sarah J, additional, Clark, Allan B, additional, Conroy, Simon, additional, Darby, Janet, additional, Fox, Chris, additional, Gladman, John RF, additional, Godfrey, Maureen, additional, Gordon, Adam L, additional, Irvine, Lisa, additional, Leighton, Paul, additional, McCartney, Karen, additional, Mountain, Gail, additional, Robertson, Kate, additional, Robinson, Katie, additional, Sach, Tracey H, additional, Stirling, Susan, additional, Wilson, Edward CF, additional, and Sims, Erika J, additional

Published
2022
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13. realist evaluation of a multifactorial falls prevention programme in care homes.

Author

Leighton, Paul A, Darby, Janet, Allen, Frances, Cook, Marie, Evley, Rachel, Fox, Chris, Godfrey, Maureen, Gordon, Adam, Gladman, John, Horne, Jane, Robertson, Kate, and Logan, Pip

Subjects
EVALUATION of medical care, EVALUATION of human services programs, FOCUS groups, PROFESSIONS, RESEARCH methodology, ATTITUDES of medical personnel, CHANGE management, INTERVIEWING, NURSING care facilities, HUMAN services programs, PREVENTIVE health services, QUALITATIVE research, RESPONSIBILITY, RANDOMIZED controlled trials, ACCIDENTAL falls, DESCRIPTIVE statistics, PSYCHOSOCIAL factors, THEMATIC analysis, STATISTICAL sampling, MEDICAL needs assessment, NURSING home employees, DIFFUSION of innovations
Abstract

Background falls in care homes are common, costly and hard to prevent. Multifactorial falls programmes demonstrate clinical and cost-effectiveness, but the heterogeneity of the care home sector is a barrier to their implementation. A fuller appreciation of the relationship between care home context and falls programme delivery will guide development and support implementation. Methods this is a multi-method process evaluation informed by a realist approach. Data include fidelity observations, stakeholder interviews, focus groups, documentary review and falls-rate data. Thematic analysis of qualitative data and descriptive statistics are synthesised to generate care home case studies. Results data were collected in six care homes where a falls programme was trialled. Forty-four interviews and 11 focus groups complemented observations and document review. The impact of the programme varied. Five factors were identified: (i) prior practice and (ii) training may inhibit new ways of working; (iii) some staff may be reluctant to take responsibility for falls; (iv) some may feel that residents living with dementia cannot be prevented from falling; and, (v) changes to management may disturb local innovation. In some care homes, training and improved awareness generated a reduction in falls without formal assessments being carried out. Conclusions different aspects of the falls programme sparked different mechanisms in different settings, with differing impact upon falls. The evaluation has shown that elements of a multifactorial falls programme can work independently of each other and that it is the local context (and local challenges faced), which should shape how a falls programme is implemented. [ABSTRACT FROM AUTHOR]

Published
2022
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15. A visual motion detection circuit suggested by Drosophila connectomics

Author

Takemura, Shin-ya, Bharioke, Arjun, Lu, Zhiyuan, Nern, Aljoscha, Vitaladevuni, Shiv, Rivlin, Patricia K., Katz, William T., Olbris, Donald J., Plaza, Stephen M., Winston, Philip, Zhao, Ting, Horne, Jane Anne, Fetter, Richard D., Takemura, Satoko, Blazek, Katerina, Chang, Lei-Ann, Ogundeyi, Omotara, Saunders, Mathew A., Shapiro, Victor, Sigmund, Christopher, Rubin, Gerald M., Scheffer, Louis K., Meinertzhagen, Ian A., and Chklovskii, Dmitri B.

Subjects
Neural circuitry -- Testing, Motion detectors -- Research, Electron microscopy -- Usage, Drosophila -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Animal behaviour arises from computations in neuronal circuits, but our understanding of these computations has been frustrated by the lack of detailed synaptic connection maps, or connectomes. For example, despite intensive investigations over half a century, the neuronal implementation of local motion detection in the insect visual system remains elusive. Here we develop a semi-automated pipeline using electron microscopy to reconstruct a connectome, containing 379 neurons and 8,637 chemical synaptic contacts, within the Drosophila optic medulla. By matching reconstructed neurons to examples from light microscopy, we assigned neurons to cell types and assembled a connectome of the repeating module of the medulla. Within this module, we identified cell types constituting a motion detection circuit, and showed that the connections onto individual motion-sensitive neurons in this circuit were consistent with their direction selectivity. Our results identify cellular targets for future functional investigations, and demonstrate that connectomes can provide key insights into neuronal computations., Vision in insects has been subject to intense behavioural (1),physiological (2) and anatomical (3) investigations, yet our understanding of its underlying neural computations is still far from complete. One such [...]

Published
2013
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18. A connectome and analysis of the adult Drosophila central brain

Author

Scheffer, Louis K., Xu, C. Shan, Januszewski, Michal, Lu, Zhiyuan, Takemura, Shin-ya, Hayworth, Kenneth J., Huang, Gary B., Shinomiya, Kazunori, Maitlin-Shepard, Jeremy, Berg, Stuart, Clements, Jody, Hubbard, Philip M., Katz, William T., Umayam, Lowell, Zhao, Ting, Ackerman, David, Blakely, Tim, Bogovic, John, Dolafi, Tom, Kainmueller, Dagmar, Kawase, Takashi, Khairy, Khaled A., Leavitt, Laramie, Li, Peter H., Lindsey, Larry, Neubarth, Nicole, Olbris, Donald J., Otsuna, Hideo, Trautman, Eric T., Ito, Masayoshi, Bates, Alexander S., Goldammer, Jens, Wolff, Tanya, Svirskas, Robert, Schlegel, Philipp, Neace, Erika, Knecht, Christopher J., Alvarado, Chelsea X., Bailey, Dennis A., Ballinger, Samantha, Borycz, Jolanta A., Canino, Brandon S., Cheatham, Natasha, Cook, Michael, Dreher, Marisa, Duclos, Octave, Eubanks, Bryon, Fairbanks, Kelli, Finley, Samantha, Forknall, Nora, Francis, Audrey, Hopkins, Gary Patrick, Joyce, Emily M., Kim, SungJin, Kirk, Nicole A., Kovalyak, Julie, Lauchie, Shirley A., Lohff, Alanna, Maldonado, Charli, Manley, Emily A., McLin, Sari, Mooney, Caroline, Ndama, Miatta, Ogundeyi, Omotara, Okeoma, Nneoma, Ordish, Christopher, Padilla, Nicholas, Patrick, Christopher M., Paterson, Tyler, Phillips, Elliott E., Phillips, Emily M., Rampally, Neha, Ribeiro, Caitlin, Robertson, Madelaine K., Rymer, Jon Thomson, Ryan, Sean M., Sammons, Megan, Scott, Anne K., Scott, Ashley L., Shinomiya, Aya, Smith, Claire, Smith, Kelsey, Smith, Natalie L., Sobeski, Margaret A., Suleiman, Alia, Swift, Jackie, Takemura, Satoko, Talebi, Iris, Tarnogorska, Dorota, Tenshaw, Emily, Tokhi, Temour, Walsh, John J., Yang, Tansy, Horne, Jane Anne, Li, Feng, Parekh, Ruchi, Rivlin, Patricia K., Jayaraman, Vivek, Costa, Marta, Jefferis, Gregory S. X. E., Ito, Kei, Saalfeld, Stephan, George, Reed, Meinertzhagen, Ian A., Rubin, Gerald M., Hess, Harald F., Jain, Viren, Plaza, Stephen M., Scheffer, Louis K., Xu, C. Shan, Januszewski, Michal, Lu, Zhiyuan, Takemura, Shin-ya, Hayworth, Kenneth J., Huang, Gary B., Shinomiya, Kazunori, Maitlin-Shepard, Jeremy, Berg, Stuart, Clements, Jody, Hubbard, Philip M., Katz, William T., Umayam, Lowell, Zhao, Ting, Ackerman, David, Blakely, Tim, Bogovic, John, Dolafi, Tom, Kainmueller, Dagmar, Kawase, Takashi, Khairy, Khaled A., Leavitt, Laramie, Li, Peter H., Lindsey, Larry, Neubarth, Nicole, Olbris, Donald J., Otsuna, Hideo, Trautman, Eric T., Ito, Masayoshi, Bates, Alexander S., Goldammer, Jens, Wolff, Tanya, Svirskas, Robert, Schlegel, Philipp, Neace, Erika, Knecht, Christopher J., Alvarado, Chelsea X., Bailey, Dennis A., Ballinger, Samantha, Borycz, Jolanta A., Canino, Brandon S., Cheatham, Natasha, Cook, Michael, Dreher, Marisa, Duclos, Octave, Eubanks, Bryon, Fairbanks, Kelli, Finley, Samantha, Forknall, Nora, Francis, Audrey, Hopkins, Gary Patrick, Joyce, Emily M., Kim, SungJin, Kirk, Nicole A., Kovalyak, Julie, Lauchie, Shirley A., Lohff, Alanna, Maldonado, Charli, Manley, Emily A., McLin, Sari, Mooney, Caroline, Ndama, Miatta, Ogundeyi, Omotara, Okeoma, Nneoma, Ordish, Christopher, Padilla, Nicholas, Patrick, Christopher M., Paterson, Tyler, Phillips, Elliott E., Phillips, Emily M., Rampally, Neha, Ribeiro, Caitlin, Robertson, Madelaine K., Rymer, Jon Thomson, Ryan, Sean M., Sammons, Megan, Scott, Anne K., Scott, Ashley L., Shinomiya, Aya, Smith, Claire, Smith, Kelsey, Smith, Natalie L., Sobeski, Margaret A., Suleiman, Alia, Swift, Jackie, Takemura, Satoko, Talebi, Iris, Tarnogorska, Dorota, Tenshaw, Emily, Tokhi, Temour, Walsh, John J., Yang, Tansy, Horne, Jane Anne, Li, Feng, Parekh, Ruchi, Rivlin, Patricia K., Jayaraman, Vivek, Costa, Marta, Jefferis, Gregory S. X. E., Ito, Kei, Saalfeld, Stephan, George, Reed, Meinertzhagen, Ian A., Rubin, Gerald M., Hess, Harald F., Jain, Viren, and Plaza, Stephen M.

Abstract

The neural circuits responsible for animal behavior remain largely unknown. We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. We define cell types, refine computational compartments, and provide an exhaustive atlas of cell examples and types, many of them novel. We provide detailed circuits consisting of neurons and their chemical synapses for most of the central brain. We make the data public and simplify access, reducing the effort needed eLife digest Animal brains of all sizes, from the smallest to the largest, work in broadly similar ways. Studying the brain of any one animal in depth can thus reveal the general principles behind the workings of all brains. The fruit fly Drosophila is a popular choice for such research. With about 100,000 neurons - compared to some 86 billion in humans - the fly brain is small enough to study at the level of individual cells. But it nevertheless supports a range of complex behaviors, including navigation, courtship and learning. Thanks to decades of research, scientists now have a good understanding of which parts of the fruit fly brain support particular behaviors. But exactly how they do this is often unclear. This is because previous studies showing the connections between cells only covered small areas of the brain. This is like trying to understand a novel when all you can see is a few isolated paragraphs. To solve this problem, Scheffer, Xu, Januszewski, Lu, Takemura, Hayworth, Huang, Shinomiya et al. prepared the first complete map of the entire central region of the fruit fly brain. The central brain consists of approximately 25,000 neurons and around 20 million connections. To prepare the map - or connectome - the brain was cut into very thin 8nm slices and photographed with an electron microscope. A three-dimensional

Published
2020

19. Multifactorial Falls Prevention Programme Compared to Routine Care in Long Term Older Care Residents (FinCH): A Multi-Centre Cluster Randomised Controlled Trial with Economic Evaluation

Author

Logan, Philippa Anne, primary, Horne, Jane C., additional, Gladman, John R. F., additional, Gordon, Adam, additional, Robertson, Kate, additional, Sach, Tracey, additional, Clark, Allan, additional, Robinson, Katie, additional, Armstrong, Sarah, additional, Stirling, Sue, additional, Leighton, Paul, additional, Darby, Janet, additional, Allen, Fran, additional, Irvine, Lisa, additional, Wilson, Ed C. F., additional, Fox, Chris, additional, Conroy, Simon, additional, Mountain, Gail, additional, McCartney, Karen, additional, Godfrey, Maureen, additional, and Sims, Erika, additional

Published
2021
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20. A Slowed Classical Pathway Rather Than Kiss-and-Run Mediates Endocytosis at Synapses Lacking Synaptojanin and Endophilin

Author

Dickman, Dion K., Horne, Jane Anne, Meinertzhagen, Ian A., and Schwarz, Thomas L.

Subjects
Proteins, Biological sciences
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cell.2005.09.026 Byline: Dion K. Dickman (1), Jane Anne Horne (2), Ian A. Meinertzhagen (2), Thomas L. Schwarz (1) Abstract: The extent to which a 'kiss-and-run' mode of endocytosis contributes to synaptic-vesicle recycling remains controversial. The only genetic evidence for kiss-and-run at the synapse comes from mutations in the genes encoding synaptojanin and endophilin, proteins that together function to uncoat vesicles in classical clathrin-mediated endocytosis. Here we have characterized the endocytosis that persists in null alleles of Drosophila synaptojanin and endophilin. In response to high-frequency stimulation, the synaptic-vesicle pool can be reversibly depleted in these mutants. Recovery from this depletion is slow and indicates the persistence of an impaired form of classical endocytosis. Steady-state exocytosis rates reveal that endocytosis saturates in mutant neuromuscular terminals at [approximately equal to]80 vesicles/s, 10%-20% of the wild-type rate. Analyses of quantal size, FM1-43 loading, and dynamin function further demonstrate that, even in the absence of synaptojanin or endophilin, vesicles undergo full fusion and re-formation. Therefore, no genetic evidence remains to indicate that synaptic vesicles undergo kiss-and-run. Author Affiliation: (1) Division of Neuroscience, Children's Hospital and Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115 (2) Life Sciences Centre, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada Article History: Received 21 April 2005; Revised 27 July 2005; Accepted 20 September 2005 Article Note: (miscellaneous) Published: November 3, 2005

Published
2005

22. A connectome and analysis of the adult Drosophila central brain

Author

Scheffer, Louis K, primary, Xu, C Shan, additional, Januszewski, Michal, additional, Lu, Zhiyuan, additional, Takemura, Shin-ya, additional, Hayworth, Kenneth J, additional, Huang, Gary B, additional, Shinomiya, Kazunori, additional, Maitlin-Shepard, Jeremy, additional, Berg, Stuart, additional, Clements, Jody, additional, Hubbard, Philip M, additional, Katz, William T, additional, Umayam, Lowell, additional, Zhao, Ting, additional, Ackerman, David, additional, Blakely, Tim, additional, Bogovic, John, additional, Dolafi, Tom, additional, Kainmueller, Dagmar, additional, Kawase, Takashi, additional, Khairy, Khaled A, additional, Leavitt, Laramie, additional, Li, Peter H, additional, Lindsey, Larry, additional, Neubarth, Nicole, additional, Olbris, Donald J, additional, Otsuna, Hideo, additional, Trautman, Eric T, additional, Ito, Masayoshi, additional, Bates, Alexander S, additional, Goldammer, Jens, additional, Wolff, Tanya, additional, Svirskas, Robert, additional, Schlegel, Philipp, additional, Neace, Erika, additional, Knecht, Christopher J, additional, Alvarado, Chelsea X, additional, Bailey, Dennis A, additional, Ballinger, Samantha, additional, Borycz, Jolanta A, additional, Canino, Brandon S, additional, Cheatham, Natasha, additional, Cook, Michael, additional, Dreher, Marisa, additional, Duclos, Octave, additional, Eubanks, Bryon, additional, Fairbanks, Kelli, additional, Finley, Samantha, additional, Forknall, Nora, additional, Francis, Audrey, additional, Hopkins, Gary Patrick, additional, Joyce, Emily M, additional, Kim, SungJin, additional, Kirk, Nicole A, additional, Kovalyak, Julie, additional, Lauchie, Shirley A, additional, Lohff, Alanna, additional, Maldonado, Charli, additional, Manley, Emily A, additional, McLin, Sari, additional, Mooney, Caroline, additional, Ndama, Miatta, additional, Ogundeyi, Omotara, additional, Okeoma, Nneoma, additional, Ordish, Christopher, additional, Padilla, Nicholas, additional, Patrick, Christopher M, additional, Paterson, Tyler, additional, Phillips, Elliott E, additional, Phillips, Emily M, additional, Rampally, Neha, additional, Ribeiro, Caitlin, additional, Robertson, Madelaine K, additional, Rymer, Jon Thomson, additional, Ryan, Sean M, additional, Sammons, Megan, additional, Scott, Anne K, additional, Scott, Ashley L, additional, Shinomiya, Aya, additional, Smith, Claire, additional, Smith, Kelsey, additional, Smith, Natalie L, additional, Sobeski, Margaret A, additional, Suleiman, Alia, additional, Swift, Jackie, additional, Takemura, Satoko, additional, Talebi, Iris, additional, Tarnogorska, Dorota, additional, Tenshaw, Emily, additional, Tokhi, Temour, additional, Walsh, John J, additional, Yang, Tansy, additional, Horne, Jane Anne, additional, Li, Feng, additional, Parekh, Ruchi, additional, Rivlin, Patricia K, additional, Jayaraman, Vivek, additional, Costa, Marta, additional, Jefferis, Gregory SXE, additional, Ito, Kei, additional, Saalfeld, Stephan, additional, George, Reed, additional, Meinertzhagen, Ian A, additional, Rubin, Gerald M, additional, Hess, Harald F, additional, Jain, Viren, additional, and Plaza, Stephen M, additional

Published
2020
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23. Author response: A connectome and analysis of the adult Drosophila central brain

Author

Scheffer, Louis K, primary, Xu, C Shan, additional, Januszewski, Michal, additional, Lu, Zhiyuan, additional, Takemura, Shin-ya, additional, Hayworth, Kenneth J, additional, Huang, Gary B, additional, Shinomiya, Kazunori, additional, Maitlin-Shepard, Jeremy, additional, Berg, Stuart, additional, Clements, Jody, additional, Hubbard, Philip M, additional, Katz, William T, additional, Umayam, Lowell, additional, Zhao, Ting, additional, Ackerman, David, additional, Blakely, Tim, additional, Bogovic, John, additional, Dolafi, Tom, additional, Kainmueller, Dagmar, additional, Kawase, Takashi, additional, Khairy, Khaled A, additional, Leavitt, Laramie, additional, Li, Peter H, additional, Lindsey, Larry, additional, Neubarth, Nicole, additional, Olbris, Donald J, additional, Otsuna, Hideo, additional, Trautman, Eric T, additional, Ito, Masayoshi, additional, Bates, Alexander S, additional, Goldammer, Jens, additional, Wolff, Tanya, additional, Svirskas, Robert, additional, Schlegel, Philipp, additional, Neace, Erika, additional, Knecht, Christopher J, additional, Alvarado, Chelsea X, additional, Bailey, Dennis A, additional, Ballinger, Samantha, additional, Borycz, Jolanta A, additional, Canino, Brandon S, additional, Cheatham, Natasha, additional, Cook, Michael, additional, Dreher, Marisa, additional, Duclos, Octave, additional, Eubanks, Bryon, additional, Fairbanks, Kelli, additional, Finley, Samantha, additional, Forknall, Nora, additional, Francis, Audrey, additional, Hopkins, Gary Patrick, additional, Joyce, Emily M, additional, Kim, SungJin, additional, Kirk, Nicole A, additional, Kovalyak, Julie, additional, Lauchie, Shirley A, additional, Lohff, Alanna, additional, Maldonado, Charli, additional, Manley, Emily A, additional, McLin, Sari, additional, Mooney, Caroline, additional, Ndama, Miatta, additional, Ogundeyi, Omotara, additional, Okeoma, Nneoma, additional, Ordish, Christopher, additional, Padilla, Nicholas, additional, Patrick, Christopher M, additional, Paterson, Tyler, additional, Phillips, Elliott E, additional, Phillips, Emily M, additional, Rampally, Neha, additional, Ribeiro, Caitlin, additional, Robertson, Madelaine K, additional, Rymer, Jon Thomson, additional, Ryan, Sean M, additional, Sammons, Megan, additional, Scott, Anne K, additional, Scott, Ashley L, additional, Shinomiya, Aya, additional, Smith, Claire, additional, Smith, Kelsey, additional, Smith, Natalie L, additional, Sobeski, Margaret A, additional, Suleiman, Alia, additional, Swift, Jackie, additional, Takemura, Satoko, additional, Talebi, Iris, additional, Tarnogorska, Dorota, additional, Tenshaw, Emily, additional, Tokhi, Temour, additional, Walsh, John J, additional, Yang, Tansy, additional, Horne, Jane Anne, additional, Li, Feng, additional, Parekh, Ruchi, additional, Rivlin, Patricia K, additional, Jayaraman, Vivek, additional, Costa, Marta, additional, Jefferis, Gregory SXE, additional, Ito, Kei, additional, Saalfeld, Stephan, additional, George, Reed, additional, Meinertzhagen, Ian A, additional, Rubin, Gerald M, additional, Hess, Harald F, additional, Jain, Viren, additional, and Plaza, Stephen M, additional

Published
2020
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24. Protocol for the process evaluation of the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), following changes required by the COVID-19 pandemic

Author

Di Lorito, Claudio, primary, Bosco, Alessandro, additional, Goldberg, Sarah E, additional, Nair, Roshan, additional, O'Brien, Rebecca, additional, Howe, Louise, additional, van der Wardt, Veronika, additional, Pollock, Kristian, additional, Booth, Vicky, additional, Logan, Pip, additional, Godfrey, Maureen, additional, Dunlop, Marianne, additional, Horne, Jane, additional, and Harwood, Rowan H, additional

Published
2020
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25. A Connectome and Analysis of the Adult Drosophila Central Brain

Author

Scheffer, Louis K., primary, Xu, C. Shan, additional, Januszewski, Michal, additional, Lu, Zhiyuan, additional, Takemura, Shin-ya, additional, Hayworth, Kenneth J., additional, Huang, Gary B., additional, Shinomiya, Kazunori, additional, Maitin-Shepard, Jeremy, additional, Berg, Stuart, additional, Clements, Jody, additional, Hubbard, Philip, additional, Katz, William, additional, Umayam, Lowell, additional, Zhao, Ting, additional, Ackerman, David, additional, Blakely, Tim, additional, Bogovic, John, additional, Dolafi, Tom, additional, Kainmueller, Dagmar, additional, Kawase, Takashi, additional, Khairy, Khaled A., additional, Leavitt, Laramie, additional, Li, Peter H., additional, Lindsey, Larry, additional, Neubarth, Nicole, additional, Olbris, Donald J., additional, Otsuna, Hideo, additional, Trautman, Eric T., additional, Ito, Masayoshi, additional, Goldammer, Jens, additional, Wolff, Tanya, additional, Svirskas, Robert, additional, Schlegel, Philipp, additional, Neace, Erika R., additional, Knecht, Christopher J., additional, Alvarado, Chelsea X., additional, Bailey, Dennis A., additional, Ballinger, Samantha, additional, Borycz, Jolanta A, additional, Canino, Brandon S., additional, Cheatham, Natasha, additional, Cook, Michael, additional, Dreher, Marisa, additional, Duclos, Octave, additional, Eubanks, Bryon, additional, Fairbanks, Kelli, additional, Finley, Samantha, additional, Forknall, Nora, additional, Francis, Audrey, additional, Hopkins, Gary Patrick, additional, Joyce, Emily M., additional, Kim, SungJin, additional, Kirk, Nicole A., additional, Kovalyak, Julie, additional, Lauchie, Shirley A., additional, Lohff, Alanna, additional, Maldonado, Charli, additional, Manley, Emily A., additional, McLin, Sari, additional, Mooney, Caroline, additional, Ndama, Miatta, additional, Ogundeyi, Omotara, additional, Okeoma, Nneoma, additional, Ordish, Christopher, additional, Padilla, Nicholas, additional, Patrick, Christopher, additional, Paterson, Tyler, additional, Phillips, Elliott E., additional, Phillips, Emily M., additional, Rampally, Neha, additional, Ribeiro, Caitlin, additional, Robertson, Madelaine K, additional, Rymer, Jon Thomson, additional, Ryan, Sean M., additional, Sammons, Megan, additional, Scott, Anne K., additional, Scott, Ashley L., additional, Shinomiya, Aya, additional, Smith, Claire, additional, Smith, Kelsey, additional, Smith, Natalie L., additional, Sobeski, Margaret A., additional, Suleiman, Alia, additional, Swift, Jackie, additional, Takemura, Satoko, additional, Talebi, Iris, additional, Tarnogorska, Dorota, additional, Tenshaw, Emily, additional, Tokhi, Temour, additional, Walsh, John J., additional, Yang, Tansy, additional, Horne, Jane Anne, additional, Li, Feng, additional, Parekh, Ruchi, additional, Rivlin, Patricia K., additional, Jayaraman, Vivek, additional, Ito, Kei, additional, Saalfeld, Stephan, additional, George, Reed, additional, Meinertzhagen, Ian A., additional, Rubin, Gerald M., additional, Hess, Harald F., additional, Jain, Viren, additional, and Plaza, Stephen M., additional

Published
2020
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26. A Connectome of the Adult Drosophila Central Brain

Author

Xu, C. Shan, primary, Januszewski, Michal, additional, Lu, Zhiyuan, additional, Takemura, Shin-ya, additional, Hayworth, Kenneth J., additional, Huang, Gary, additional, Shinomiya, Kazunori, additional, Maitin-Shepard, Jeremy, additional, Ackerman, David, additional, Berg, Stuart, additional, Blakely, Tim, additional, Bogovic, John, additional, Clements, Jody, additional, Dolafi, Tom, additional, Hubbard, Philip, additional, Kainmueller, Dagmar, additional, Katz, William, additional, Kawase, Takashi, additional, Khairy, Khaled A., additional, Leavitt, Laramie, additional, Li, Peter H., additional, Lindsey, Larry, additional, Neubarth, Nicole, additional, Olbris, Donald J., additional, Otsuna, Hideo, additional, Troutman, Eric T., additional, Umayam, Lowell, additional, Zhao, Ting, additional, Ito, Masayoshi, additional, Goldammer, Jens, additional, Wolff, Tanya, additional, Svirskas, Robert, additional, Schlegel, Philipp, additional, Neace, Erika R., additional, Knecht, Christopher J., additional, Alvarado, Chelsea X., additional, Bailey, Dennis A., additional, Ballinger, Samantha, additional, Borycz, Jolanta A, additional, Canino, Brandon S., additional, Cheatham, Natasha, additional, Cook, Michael, additional, Dreher, Marisa, additional, Duclos, Octave, additional, Eubanks, Bryon, additional, Fairbanks, Kelli, additional, Finley, Samantha, additional, Forknall, Nora, additional, Francis, Audrey, additional, Hopkins, Gary Patrick, additional, Joyce, Emily M., additional, Kim, SungJin, additional, Kirk, Nicole A., additional, Kovalyak, Julie, additional, Lauchie, Shirley A., additional, Lohff, Alanna, additional, Maldonado, Charli, additional, Manley, Emily A., additional, McLin, Sari, additional, Mooney, Caroline, additional, Ndama, Miatta, additional, Ogundeyi, Omotara, additional, Okeoma, Nneoma, additional, Ordish, Christopher, additional, Padilla, Nicholas, additional, Patrick, Christopher, additional, Paterson, Tyler, additional, Phillips, Elliott E., additional, Phillips, Emily M., additional, Rampally, Neha, additional, Ribeiro, Caitlin, additional, Robertson, Madelaine K, additional, Rymer, Jon Thomson, additional, Ryan, Sean M., additional, Sammons, Megan, additional, Scott, Anne K., additional, Scott, Ashley L., additional, Shinomiya, Aya, additional, Smith, Claire, additional, Smith, Kelsey, additional, Smith, Natalie L., additional, Sobeski, Margaret A., additional, Suleiman, Alia, additional, Swift, Jackie, additional, Takemura, Satoko, additional, Talebi, Iris, additional, Tarnogorska, Dorota, additional, Tenshaw, Emily, additional, Tokhi, Temour, additional, Walsh, John J., additional, Yang, Tansy, additional, Horne, Jane Anne, additional, Li, Feng, additional, Parekh, Ruchi, additional, Rivlin, Patricia K., additional, Jayaraman, Vivek, additional, Ito, Kei, additional, Saalfeld, Stephan, additional, George, Reed, additional, Meinertzhagen, Ian, additional, Rubin, Gerald M., additional, Hess, Harald F., additional, Scheffer, Louis K., additional, Jain, Viren, additional, and Plaza, Stephen M., additional

Published
2020
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30. RECENT DEVELOPMENTS IN FIDELITY AND SURETY LAW.

Author

Harris, David A., Berry, Matthew R., Shah, Saloni, Glos, Rebecca S., Horne, Jane A., Kooy, Ralph, Mangum, Craig N., Weeks, Ryan J., Williams, Scott C., and Wynn, Jessica L.

Subjects
SURETY & fidelity insurance, INSURANCE law, BUSINESS insurance, CRIME insurance, COMPUTER fraud, EMPLOYEE theft
Abstract

The article reports on developments pertaining to fidelity and surety law in the U.S. as of April 1, 2021. Topics discussed include performance bonds, payment bonds, and financial institution bonds. Also mentioned are rights of surety, crime coverage, computer fraud, employee theft, and business insurance policy.

Published
2021

31. Benchmarking the prevalence of care problems in UK care homes using the LPZ-i: a feasibility study

Author

Darby, Janet, Horne, Jane, Lewin, John, Crocker, Cheryl, Coates, Emma, McEwan, Karen, Schols, Jos, Halfens, Ruud, Lohrmann, Christa, Eglseer, Doris, Gladman, John R.F., and Gordon, Adam L.

Subjects
Benchmarking, Incontinence, Homes for the aged, Nursing homes, Quality improvement, Pressure ulcers
Abstract

Background: UK care homes have no mechanism for counting, collating or analyzing prevalence of care problems to benchmark quality of care. This study investigated the feasibility of the International Prevalence Measurement of Quality of Care (LPZ-i) for benchmarking in UK care homes and described facilitators and challenges to implementation.Method: The pressure care and incontinence modules of the LPZ-i were implemented in a purposive sample of UK care homes. Interviews and focus groups with regional co-ordinators, NHS and care home staff who had been involved in implementation. Data were analysed using a framework approach.Results: 26 care homes and 489 residents implemented the LPZ-I modules. 60 pressure ulcers were reported in 41 (8.4%) of residents.325(66% of residents were incontinent of urine, faeces or both. It was demonstrated that it was possible to use prevalence data to benchmark care between UK care homes and against homes overseas. 38 participants took part in focus groups and interviews which revealed the importance of existing relational working with care homes as a basis for implementation. Care homes reported improved identification and management of pressure ulcers and incontinence in response to the audit. However, care home staff could not interpret or analyse data from the audit or use it to drive quality improvement.Conclusion: Implementing the LPZ-i was possible, delivered data appropriate for benchmarking, was well received by care home and NHS staff, and appeared to lead to changes in practice. More widespread implementation of the LPZ-i is feasible, subject to improving the data and quality improvement competencies amongst care home staff.

Published
2017

37. Becoming a mother: a study exploring occupational change in first-time motherhood

Author

Horne, Jane, Corr, Susan, and Sarah Earle

Abstract

Having a first baby is considered a major life event, due to significant role change impacting on the ordinary and familiar activities the new mother performs every day. The aim of this study was to explore changes in the occupational lives of first time mothers. A concurrent nested strategy of enquiry was used. Quantitative data via the Modified Interest Checklist and the Role Checklist was nested within the predominantly qualitative data collection in the form of semi-structured interviews. Six first time mothers, who were two and a half years post motherhood and aged between 28 and 42 years, participated in this study. The findings indicate that 'new mothers' engaging in a balanced lifestyle pre-motherhood in the areas of self-care, leisure, productivity and rest experience a period of occupational disruption and occupational imbalance before adapting into motherhood through activities, tasks and finally occupations. These mothers' occupational lives are productivity dominant with most of their time being spent in paid employment and/or performing homecare/family care activities. Their occupational lives are also obligatory dominant, for example, they are performing activities they need to do to enable them to fulfil their role as mother, as opposed to activities they choose to do. Also evident is a daily process of change as individuals adapt into motherhood.

Published
2005

38. Rehabilitation aimed at improving outdoor mobility for people after stroke: a multicentre randomised controlled study (the Getting out of the House Study)

Author

Logan, Philippa A, primary, Armstrong, Sarah, additional, Avery, Tony J, additional, Barer, David, additional, Barton, Garry R, additional, Darby, Janet, additional, Gladman, John RF, additional, Horne, Jane, additional, Leach, Simon, additional, Lincoln, Nadina B, additional, Mehta, Samir, additional, Newell, Ossie, additional, O’Neil, Kathleen, additional, Sach, Tracey H, additional, Walker, Marion F, additional, Williams, Hywel C, additional, Woodhouse, Lisa J, additional, and Leighton, Mat P, additional

Published
2014
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40. The DRESS trial: a feasibility randomized controlled trial of a neuropsychological approach to dressing therapy for stroke inpatients

Author

Walker, Marion F, primary, Sunderland, Alan, additional, Fletcher-Smith, Joanna, additional, Drummond, Avril, additional, Logan, Pip, additional, Edmans, Judi A, additional, Garvey, Katherine, additional, Dineen, Robert A, additional, Ince, Paul, additional, Horne, Jane, additional, Fisher, Rebecca J, additional, and Taylor, Jenny L, additional

Published
2011
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41. Synaptic circuits and their variations within different columns in the visual system of Drosophila.

Author

Shin-ya Takemura, C. Shan Xu, Zhiyuan Lu, Rivlin, Patricia K., Parag, Toufiq, Olbris, Donald J., Plaza, Stephen, Ting Zhao, Katz, William T., Umayam, Lowell, Weaver, Charlotte, Hess, Harald F., Horne, Jane Anne, Nunez-Iglesias, Juan, Aniceto, Roxanne, Lei-Ann Chang, Lauchie, Shirley, Nasca, Ashley, Ogundeyi, Omotara, and Sigmund, Christopher

Subjects
NEURAL circuitry, STEREOTYPY (Psychiatry), BIOLOGICAL errors, NEUROPILINS, SYNAPSES
Abstract

We reconstructed the synaptic circuits of seven columns in the second neuropil or medulla behind the fly's compound eye. These neurons embody some of the most stereotyped circuits in one of the most miniaturized of animal brains. The reconstructions allow us, for the first time to our knowledge, to study variations between circuits in the medulla's neighboring columns. This variation in the number of synapses and the types of their synaptic partners has previously been little addressed because methods that visualize multiple circuits have not resolved detailed connections, and existing connectomic studies, which can see such connections, have not so far examined multiple reconstructions of the same circuit. Here, we address the omission by comparing the circuits common to all seven columns to assess variation in their connection strengths and the resultant rates of several different and distinct types of connection error. Error rates reveal that, overall, <1% of contacts are not part of a consensus circuit, and we classify those contacts that supplement (E+) or are missing from it (E-). Autapses, in which the same cell is both presynaptic and postsynaptic at the same synapse, are occasionally seen; two cells in particular, Dm9 and Mi1, form ≥20-fold more autapses than do other neurons. These results delimit the accuracy of developmental events that establish and normally maintain synaptic circuits with such precision, and thereby address the operation of such circuits. They also establish a precedent for error rates that will be required in the new science of connectomics. [ABSTRACT FROM AUTHOR]

Published
2015
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45. Morphological and functional effects of altered cysteine string protein at the Drosophila larval neuromuscular junction.

Author

Dawson-Scully, Ken, Lin, Yongqi, Imad, Mays, Zhang, Jinhui, Marin, Leo, Horne, Jane A., Meinertzhagen, Ian A., Karunanithi, Shanker, Zinsmaier, Konrad E., and Atwood, Harold L.

Abstract

The synaptic vesicle-associated cysteine string protein (CSP) is critical for neurotransmitter release at the neuromuscular junction (NMJ) of Drosophila, where the ∼4% of mutant flies lacking CSP that survive to adulthood exhibit spastic jumping and shaking, temperature-sensitive paralysis, and premature death. Previously, it has been shown that CSP is also required for nerve terminal growth and the prevention of neurodegeneration in Drosophila and mice. At larval csp null mutant NMJs of Drosophila, intracellular recordings from the muscle showed that evoked release is significantly reduced at room temperature. However, it remained unclear whether the reduction in evoked release might be due to a loss of synaptic boutons, loss of synapses, and alterations in trafficking of vesicles to synapses. To resolve these issues, we have examined synaptic structure and function of csp null mutant NMJs at the level of single boutons. csp null mutations proportionally reduce the number of synaptic boutons of both motor neurons (1s and 1b) innervating larval muscles 6 and 7, while the number of synapses per bouton remains normal. However, focal recordings from individual synaptic boutons show that nerve-evoked neurotransmitter release is also impaired in both 1s and 1b boutons. Further, our ultrastructural analyses show that the reduction in evoked release at low stimulation frequencies is not due to a loss of synapses or to alterations in docked vesicles at synapses. Together, these data suggest that CSP promotes synaptic growth and evoked neurotransmitter release by mechanistically independent signaling pathways. Synapse 61:1-16, 2007. © 2006 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR]

Published
2007
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46. Endophilin Promotes a Late Step in Endocytosis at Glial Invaginations in Drosophila Photoreceptor Terminals.

Author

Fabian-Fine, Ruth, Verstreken, Patrik, Hiesinger, P. Robin, Horne, Jane Anne, Kostyleva, Rita, Yi Zhou, Bellen, Hugo J., Meinertzhagen, Ian A., R. F.-F., Ian A., and P. V.

Subjects
NEURONS, NEUROTRANSMITTERS, NEUROCHEMISTRY, ENDOCYTOSIS, PHOTORECEPTORS
Abstract

Retrieval of synaptic vesicles from the membrane of neurons is crucial to maintain normal rates of neurotransmitter release. Photoreceptor terminais of the fly's eye release neurotransmitter in a tonic manner. They therefore rely heavily on vesicle regeneration. Null mutations in endophilin (endo) block clathrin-mediated endocytosis at the Drosophila neuromuscular junction, where previous analysis of hypomorphic mutations has suggested a function for Endophilin (Endo) before vesicle fission, during membrane bending. Here, at fly photoreceptor synapses, we show that Endo is localized to synaptic vesicles at sites of endocytosis that are glial invaginations called capitate projections, and that when the photoreceptor synapses lack Endo they are impaired in their ability to release neurotransmitter. Detailed ultrastructural analysis of endo null mutant photoreceptor synapses fails to reveal a defect at early stages of vesicle reformation but, instead, reveals an accumulation of clusters of electron-dense, apparently nonfunctional, late endocytotic vesicles. Using dynamin; endo double-mutant photoreceptors, we provide further evidence that ultimately the function of Endophilin is required late in endocytosis, allowing vesicles to progress through the synaptic vesicle cycle. [ABSTRACT FROM AUTHOR]

Published
2003
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47. Circadian photoreceptor organs in Limulus.

Author

Horne, Jane and Renninger, George

Abstract

The circadian rhythm in the ERG amplitude of the lateral compound eye of Limulus can be phase shifted either by general illumination or by illuminating combinations of the photoreceptor organs. [ABSTRACT FROM AUTHOR]

Published
1988
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