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The healthcare environment faced by nurses is complex, with high workloads and situations of high comorbidity. The integration of nurses into the work environment is a cause for concern, and improvements are sought for their incorporation into the workforce. The benefits of mentoring programs are described not only for nurses but also for patients with safer practices and benefits for the institution due to the increased commitment of its professionals. A methodological article that illustrates the complete process to design and implement a tutoring program for new nurses in an emergency department is presented. The competency profile required for the figure of tutor was developed, including the steps followed for the development of the program and the structure and phases of which it is composed, as well as the validation of the evaluation instruments of the process. A strength was the participation of experts during the in-depth analysis of the competency profile, as well as in the adaptation of the evaluation items, which endorses the pertinence, relevance, usefulness, and clarity of the content of this program. The transparency in this methodology makes it possible to follow the steps for its reproduction and applicability in other hospitals.

Amazonian swamp forests remove large amounts of carbon dioxide (CO2) but produce methane (CH4). Both are important greenhouse gases (GHG). Drought and cultivation cut the CH4 emissions but may release CO2. Varying oxygen content in nitrogen-rich soil produces nitrous oxide (N2O), which is the third most important GHG. Despite the potentially tremendous changes, GHG emissions from wetland soils under different land uses and environmental conditions have rarely been compared in the Amazon. We measured environmental characteristics, and CO2, CH4 and N2O emissions from the soil surface with manual opaque chambers in three sites near Iquitos, Peru from September 2019 to March 2020: a pristine peat swamp forest, a young forest and a slash-and-burn manioc field. The manioc field showed moderate soil respiration and N2O emission. The peat swamp forests under slight water table drawdown emitted large amounts of CO2 and CH4. A heavy post-drought shower created a hot moment of N2O in the pristine swamp forest, likely produced by nitrifiers. All in all, even small changes in soil moisture can create hot moments of GHG emissions from Amazonian wetland soils, and should therefore be carefully monitored.

En el Perú, aún no se han implementado medidas concretas que garanticen los derechos de las mujeres gestantes y con hijos en el sistema penal, siendo fundamental realizar un estudio que permita evaluar la situación actual y proponer acciones específicas que puedan ser incorporadas en las políticas públicas. Por lo que esta investigación tuvo como objetivo analizar la prisión preventiva y las medidas alternativas para mujeres gestantes y con hijos menores de tres años, desarrollándose un estudio de tipo básico, con enfoque cualitativo y hermenéutico de alcance descriptivo basado en la teoría fundamentada, donde se aplicó una entrevista a la muestra integrada por 12 profesionales vinculados al proceso judicial. Los resultados arrojaron que las prisiones preventivas aplicadas vulneran los derechos y garantías penales y procesales de las mujeres, teniendo una repercusión negativa para su salud y bienestar. Se concluyó que en Perú no se están aplicando bien las políticas que protejan adecuadamente a mujeres gestantes y con hijos pequeños en el sistema penal porque, aunque existen opciones alternativas a la prisión preventiva, estas no se usan mucho por la falta de capacitación judicial y la preferencia por enfoques más punitivos.

Introduction: The effect of clothing on the recording of blood pressure in a normotensive and hypertensive population remains essential to diagnosing and managing. Methods: This is a cross-sectional study to measure blood pressure using a validated oscillometric sphygmomanometer in two populations. The records were made over the thicker sleeve arm and non-sleeved arm (either on bare arm or indicating the removal of the outermost garment). Clothing was categorized according to how patients attended the outpatient clinic based on the real world. Results: A total of 75 patients were included with a diagnosis of hypertension whose mean age was 67.1 years (SD ± 16.3). The group of normotension included 63 patients whose mean age was 21.1 years (SD ± 2.2). There was not variability related to technique or inherent to the condition of the subject on the first and second measurements of blood pressure. In the comparative analysis, the group with normotension did not report a significant difference in systolic or diastolic blood pressure due to the effect of clothing during the first or second measurement (p > 0.05). In the group with hypertension, a significant difference was observed in the first measurement, between the group over-the-sleeve and non-sleeved arm (systolic blood pressure, p: 0.021 and diastolic, p: 0.001). However, when the variable order of measurement was analyzed by randomizing the initial registry with or without clothing was not found a statistical difference. Conclusion: Clothing does not a significant difference in the measure of blood pressure in a normotensive or hypertensive population.

IntroductionSoil drought during summer in Central Europe has become more frequent and severe over the last decades. European forests are suffering increasing damage, particularly Norway spruce. Douglas-fir (Pseudotsuga menziesii (Mirbel) Franco), a non-native tree species, is considered as a promising alternative to build drought-resilient forests. The main goal of this study was to investigate the intraannual radial stem growth and sap flow performance of Douglas-fir along a precipitation gradient across Germany under severe drought.Material and methodsSap flow and stem radial changes of up to ten trees each at four sites with different precipitation regimes were measured in combination with volumetric soil water content during the growing season of 2022. Measurements of stem radial changes were used to calculate the trees’ stem water deficit, a proxy for tree water status and drought stress.ResultsThe severe summer drought of 2022 led to an early growth cessation and a significant reduction in daily sap flow at all four sites monitored. We could identify a site-specific threshold in soil water availability ranging between 21.7 and 29.6% of relative extractable water (REW) under which stem water reserves cannot be replenished and thereby inhibiting radial growth. We could also demonstrate that at this threshold, sap flow is heavily reduced to between 43.5 and 53.3%, and for a REW below 50%, sap flow linearly decreases by 1.1–2.0% per 1% reduction in REW. This reduction tends to follow the humidity gradient, being more pronounced at the most oceanic characterized site and suggesting an adaptation to site conditions. Even though Douglas-fir is considered to be more drought stress resistant than Norway spruce, growth and sap flow are greatly reduced by severe summer drought, which became more frequent in recent years and their frequency and intensity is likely to increase.ConclusionsOur results suggest that timber production of Douglas-fir in Central Europe will decline considerably under projected climate change, and thus pointing to site specific growth constraints for a so far promising non-native tree species in Europe.

IntroductionTrees from flooded forests have to adjust their xylem hydraulic structure to face the annual flooding and the climatic conditions of the atmosphere. Usually, this adjustment of anatomical tissues in the tropics is driven by drought events inducing conservative behavior and can be recorded annually in tree rings. However, how the flood pulse and the climatic conditions influence the xylem hydraulic structure in floodplain trees is unknown.MethodsTo fill this gap, we explore if flooded periods and monthly climate variation affect the annual tree growth and xylem anatomy structure for the tree species Hydrochorea corymbosa (Fabaceae) from the várzea flooded forest in the Central Amazon. We developed a 41-year ring width chronology (1971–2018) and a 30-year time series of xylem anatomy parameters (1988–2018) as mean hydraulic vessel diameter (Dh), vessel frequency (VF), and parenchyma quantity (PQ). We correlated the series with monthly hydrological and climatic data.ResultsThe hydrological regime did not correlate with annual tree growth in that species as we previously expected but showed correlations with the xylem anatomical structure. High flood levels during the end of the flooding period induced conservative patterns of the anatomical structure, with a negative correlation with Dh (rho June = −0.40, p < 0.05) and a positive correlation with the PQ (rho September/October = 0.42, p < 0.05). These responses show that these trees are responding to flooding similar to the tree responses to drought. Regarding the climatic variation, the annual tree growth showed a negative correlation with the vapor pressure deficit (VPD), after the second half of the flooded period with the strongest correlation happening during the non-flooded period (rho December = −0.66, p < 0. 01). These conservative patterns in tree behavior also happened when the maximum temperature negatively affected the vessel diameter (rho September = −0.42, p < 0.05).DiscussionIn that case, we recognized two different moments that the environment is inducing conservative patterns in the xylem structure of those trees: 1) increasing the flood levels and 2) the high evaporative demand during the non-flooded period. In this way, the intensification of the hydrological regime, as well as the strong drought conditions during the non-flooded periods, can be a risk for H. corymbosa in the Central Amazonian floodplains.

Abstract The diagnosis of leukemic T-cell malignancies is often challenging, due to overlapping features with reactive T-cells and limitations of currently available T-cell clonality assays. Recently developed therapeutic antibodies specific for the mutually exclusive T-cell receptor constant β chain (TRBC)1 and TRBC2 isoforms provide a unique opportunity to assess for TRBC-restriction as a surrogate of clonality in the flow cytometric analysis of T-cell neoplasms. To demonstrate the diagnostic utility of this approach, we studied 164 clinical specimens with (60) or without (104) T-cell neoplasia, in addition to 39 blood samples from healthy donors. Dual TRBC1 and TRBC2 expression was studied within a comprehensive T-cell panel, in a fashion similar to the routine evaluation of kappa and lambda immunoglobulin light chains for the detection of clonal B-cells. Polytypic TRBC expression was demonstrated on total, CD4+ and CD8+ T-cells from all healthy donors; and by intracellular staining on benign T-cell precursors. All neoplastic T-cells were TRBC-restricted, except for 8 cases (13%) lacking TRBC expression. T-cell clones of uncertain significance were identified in 17 samples without T-cell malignancy (13%) and accounted for smaller subsets than neoplastic clones (median: 4.7 vs. 69% of lymphocytes, p

This study aims to validate a data collection tool's psychometric properties to explore whether business management research's relevance is a high-order construct made up of its perceived interest and perceived relevance. The authors conducted a confirmatory factor analysis to validate a two-factor scale. The sample was composed of 148 MBA students from a Peruvian business school. Results showed the appropriate levels of validity and reliability and confirmed the usefulness of this data set for exploring the relationship between perceived interest and relevance. Businesses and schools can replicate the validated tool for reviewing their curricula and teaching practices, exploring the gap between business and management research results and advancing managers' research literacy and evidence-based practice in business education and training.

Background: Encyclia, is a genus with more than 200 species in the Neotropics, eight of which have been previously reported from Peru. During the evaluation of the orchid flora in the forests of the Sicchez district, a small population of an Encyclia species was found that could not be unequivocally matched to any previously known species in the country. Questions: Will the recent explorations of Northern Peru result in the reporting of new taxa for the country? Studied species: Orchidaceae, Laeliinae, Encyclia Hook, Encyclia naranjapatensis Dodson Study site and dates: Sicchez District, Ayabaca Province, Piura Department, Peru, 2022-2023. Methods: Specimens were collected and determined by consulting botanical collections available online, taxonomic treatments, checklists, and specialized literature. The conservation status was assessed according to IUCN methodology. Results: We report a novelty for Peru, Encyclia naranjapatensis, and an updated description including morphological information on relevant structures that will be used to diagnose this entity. In addition, E. naranjapatensis is part of a basal clade referred to as the E. diurna species group. The conservation status assessment results in Endangered and the species is linked to the Seasonally Dry Tropical Forest, an endangered ecosystem throughout the Neotropics. Conclusions: The recent entity located in Peru correspond to Encyclia naranjapatensis. This discovery allows us to investigate the geographical limits, discuss the phylogenetic and ecological affinities, update the original description, and evaluate its conservation status.

La relación entre gestión pública y desarrollo sostenible ha sido estudiada a fondo mediante una revisión literaria global. Este análisis exploratorio examinó 50 artículos de revistas profesionales entre 2019 y 2021, seleccionados por criterios estrictos en temas de participación ciudadana y gestión pública. Los resultados revelaron cómo la gestión pública se vincula con los objetivos de desarrollo sostenible a través de fases clave como la prospectiva, estrategia e institucionalización, junto con el seguimiento. Se concluyó que centrarse en la gestión pública y su integración con el desarrollo sostenible es crucial para el funcionamiento efectivo de las instituciones gubernamentales, con énfasis en la planificación, control y ejecución adecuados, así como el mantenimiento sostenible de servicios públicos y una administración eficiente de recursos económicos.

Context: In the Peruvian context, generic drugs are those pharmaceutical products whose names correspond to the active ingredient of the drug and are not identified by a brand name; brand name drugs, on the other hand, are pharmaceutical products whose names are determined by the drug manufacturer. Aims: To know the perception of generic drugs by a Peruvian population. Methods: The type of research was applied, deductive method, non-experimental design, quantitative approach and cross-sectional. The sample consisted of 218 inhabitants, who were submitted to a questionnaire where the study variable was measured. Results: The main results showed that the level of information on generic drugs among the study sample was low (74,3%), as was consumption (66,5%), the level of confidence in these drugs was low (64,7%) and, finally, the inhabitants indicated that they had little access to generic drugs in their area (68,8%). Conclusions: The general perception of the study population towards generic drugs was low.

This paper proposes two types of electro-refractive optical modulator structures as a fully CMOS-compatible alternative solution. These modulators leverage the properties of amorphous (top) and crystalline (bottom) silicon films surrounding silicon nitride waveguides operating in the C-band communications range at a wavelength of 1550 nm. Various structures have been demonstrated and explored to compete with or surpass the current state-of-the-art performance of thermal tuners, the most widely used tuning mechanism in silicon nitride integrated photonics. Designs utilizing vertical and lateral p–n junctions with amorphous or crystalline films have been simulated and proposed. For the lateral p–n junctions, modulator lengths to achieve a π phase shift smaller than 287 μm have been demonstrated for the TE mode and that smaller than 1937 μm for the TM mode, reaching 168 μm in the case of a lateral p–n junction that is completely a p-doped region over or under the waveguide for TE, and 1107 μm for TM. Power consumption is higher for the TM modes than for the TE, being in the order of 100 mW for the former and lower than 23 mW for the latter. The modulators exhibit higher losses for amorphous material compared to crystalline, with losses smaller than 10.21 dB and 3.2 dB, respectively. The vertical p–n junctions present a larger footprint than the lateral ones, 5.03 mm for TE and 38.75 mm for TM, with losses lower than 3.16 dB and 3.95 dB, respectively, for the crystalline silicon. Also, their power consumption is on the order of 21 mW for TE and 164 mW for TM.

Estudiar la conducta antisocial en adolescentes que realizan trabajo infantil, tiene un significado potencial al conocer el comportamiento considerando diversas variables sociodemográficas. El objetivo de esta investigación fue identificar los niveles de la conducta antisocial en adolescentes que están expuestos al trabajo infantil, considerando el sexo, grado de instrucción y grupo etario. Fue un estudio aplicado con un diseño descriptivo comparativo, participaron 151 adolescentes de la ciudad de Trujillo-Perú a quienes se les administró un cuestionario que mide la conducta antisocial y delictiva compuesto de 40 ítems. Los hallazgos más importantes demuestran que los adolescentes presentan niveles regulares y altos de comportamiento antisocial, los que no estudian, tienen tendencia a presentar mayor comportamiento antisocial, los adolescentes de 15 y 16 años presentan con más prevalencia este tipo de comportamiento. Por lo tanto, es importante desarrollar actividades de prevención con adolescentes entre las edades de 11 años tratando de instaurar estilos de vida más adaptativos y entrenamiento en habilidades sociales que les permitan tener una mayor calidad en las relaciones interpersonales, y con los adolescentes mayores 15 años, ayudaría mucho desarrollar estrategias de afrontamiento para tener un mejor desarrollo personal.

Brindar un servicio educativo de calidad implica el esfuerzo de las personas gestoras administrativas y docentes, con el fin de ofrecer servicios de educación básica de calidad, en aras de una formación completa de estudiantes. Es por eso que este artículo de revisión tiene la finalidad de destacar la evidencia disponible sobre la gestión administrativa en unidades de gestión educativa. Como metodología se realizó una revisión de artículos de la literatura científica en las bases de datos de Scielo, Scopus, Redalyc y Latindex, se tomaron en cuenta artículos cuyo contexto se ha desarrollado en países latinoamericanos. Como resultado se obtuvieron 10 artículos: 4 son de Scielo, 3 de Latindex y 3 de Redalyc, los cuales contienen las ideas más relevantes y cumplieron con los objetivos de esta revisión. Asimismo, el 20 % de los artículos seleccionados fueron investigaciones realizadas en Costa Rica, el 20 % en Colombia, el 10 % en Ecuador y el 50 % en Perú. Finalmente, se concluye que una buena gestión administrativa ayuda a liderar, comunicar y hacer pleno uso de los recursos humanos para lograr una educación de calidad y satisfacción laboral entre el personal docente. De igual manera, se espera que este artículo de revisión contribuya en investigaciones futuras.

Purpose. The article studies the convergence between the regions of Ukraine in terms of the basic foodstuff consumption per capita during 2000–2019, taking into account the effects of spatial interaction across regions. Methodology / approach. The convergence analysis between regions of Ukraine is based on the concept of β-convergence which can be tested using spatial econometric models namely spatial autoregressive models and spatial error models. The need for considering spatial interaction can be explained by the fact that regions are characterized by constant interaction with each other. Therefore, region should not be considered as isolated objects in space in empirical research with usage of panel data. Ignoring the spatial interaction between regions and using standard evaluation procedures can reduce the reliability and validity of the obtained results to some extent. Results. The results of our calculation confirm the process of β-convergence of average per capita consumption of all food groups, which means that food consumption in regions with an initial low level of consumption is growing faster than in regions with high initial levels of consumption. Also, as part of the use of spatial econometric models the convergence process was determined to be influenced by spatial interaction between regions while the influence of neighbouring regions has a positive effect on food consumption in particular region. Originality / scientific novelty. The article further develops the main ideas of modeling interregional differentiation based on convergence theory and for the first time, spatial econometric models were used to estimate β-convergence of Ukrainian regions by the levels of consumption of basic foodstuffs. Practical value / implications. The approach proposed by the authors and the obtained results can be used both by state authorities on agrarian policy and food issues, and by enterprises of the agricultural sector in the analysis and forecasting of trends in the consumption of basic foodstuffs at the regional level; when planning the production, processing and delivery of agricultural products, when planning state or regional trade policy in the field of food. At the same time, the inclusion of spatial effects in the model of evaluating convergence will allow policymakers to take into account the geographical features of the convergence process and, accordingly, make more informed decisions to reduce the differentiation of regions of Ukraine by the levels of consumption of basic foodstuffs.

Abstract Despite widespread vaccination, Bordetella pertussis continues to cause pertussis infections worldwide, leaving infants at the highest risk of severe illness and death, while people around them are likely the main sources of infection and rapidly spread the disease. Rapid and less complex molecular testing for the specific and timely diagnosis of pertussis remains a challenge that could help to prevent the disease from worsening and prevent its transmission. We aimed to develop and validate a colorimetric loop-mediated isothermal amplification (LAMP) assay using a new target uvrD_2 informed by the pangenome for the specific and early detection of B. pertussis. Compared to that of multitarget quantitative polymerase chain reaction (multitarget qPCR) using a large clinical DNA specimen (n = 600), the diagnostic sensitivity and specificity of the uvrD_2 LAMP assay were 100.0% and 98.6%, respectively, with a 99.7% degree of agreement between the two assays. The novel colorimetric uvrD_2 LAMP assay is highly sensitive and specific for detecting B. pertussis DNA in nasopharyngeal swabs and showed similar diagnostic accuracy to complex and high-cost multitarget qPCR, but it is faster, simpler, and inexpensive, which makes it very helpful for the reliable and timely diagnosis of pertussis in primary health care and resource-limited settings.

A small number of extraordinary “Major Evolutionary Transitions” (METs) have attracted attention among biologists. They comprise novel forms of individuality and information, and are defined in relation to organismal complexity, irrespective of broader ecosystem-level effects. This divorce between evolutionary and ecological consequences qualifies unicellular eukaryotes, for example, as a MET although they alone failed to significantly alter ecosystems. Additionally, this definition excludes revolutionary innovations not fitting into either MET type (e.g., photosynthesis). We recombine evolution with ecology to explore how and why entire ecosystems were newly created or radically altered – as Major System Transitions (MSTs). In doing so, we highlight important morphological adaptations that spread through populations because of their immediate, direct-fitness advantages for individuals. These are Major Competitive Transitions, or MCTs. We argue that often multiple METs and MCTs must be present to produce MSTs. For example, sexually-reproducing, multicellular eukaryotes (METs) with anisogamy and exoskeletons (MCTs) significantly altered ecosystems during the Cambrian. Therefore, we introduce the concepts of Facilitating Evolutionary Transitions (FETs) and Catalysts as key events or agents that are insufficient themselves to set a MST into motion, but are essential parts of synergies that do. We further elucidate the role of information in MSTs as transitions across five levels: (I) Encoded; (II) Epigenomic; (III) Learned; (IV) Inscribed; and (V) Dark Information. The latter is ‘authored’ by abiotic entities rather than biological organisms. Level IV has arguably allowed humans to produce a MST, and V perhaps makes us a FET for a future transition that melds biotic and abiotic life into one entity. Understanding the interactive processes involved in past major transitions will illuminate both current events and the surprising possibilities that abiotically-created information may produce.

The objective of this research was to determine the effect of absenteeism and presenteeism on the academic performance of undergraduate students from the Business and Engineering Schools in Peruvian Universities. The study is based on a self-report survey of 8,203 students from the business and engineering schools of Peruvian universities. Scales were used to analyze absenteeism, presenteeism and academic performance that showed suitable psychometric properties. The results showed that presenteeism has a higher impact on the academic performance of students ([beta] = 0.628) compared to absenteeism ([beta] = 0.101). Absenteeism has a greater effect on courses and disapproved terms (Beta = 0.163) and presenteeism, on the evolution of academic performance ([beta] = -0.145). Finally, by means of a model of structural equations, the causal structure of the academic performance decrease from absenteeism and presenteeism is proven.

This research demonstrates the impact of equitable management as a protective factor against workplace sexual harassment (WSH) and its consequences on labor productivity. It also shows that there are invisible costs for colleagues who witness WSH, through counterproductive behaviors, such as sabotage or production deviance, with an indirect decrease in labor productivity. We used a structured questionnaire that was answered by 827 women from 37 small, medium, and large private companies in the Lima Metropolitan Area, Peru. We designed a conceptual model and tested it using structural covariance equations. The results indicate that 33.5 % of women have been sexually harassed over the last 12 months, an average of 6.6 times, while 18.9 % of women have supported co-workers who were victims of WSH. Being sexually harassed at work decreases labor productivity by 43.1 % and increases the intention to desert the company by 15.2 %. Witnessing WSH increases the intention to drop out by 11.3 % and increases counterproductive behaviors by 39.6 %. We found that equitable management is a preventative factor for WSH. Equitable management not only decreases the probability of the occurrence of WSH by 2.2 times but also—if it exists—reduces its pernicious impact on productivity through various indirect effects. Equitable management can reduce the labor productivity costs caused by WSH by 4.6 times.

Intimate partner violence (IPV) against women and girls is recognized as a human rights problem with little understanding of its ripple effects on the workplace. While the literature has attempted to understand the impacts of IPV on the workplace in high-income countries, relatively, literature on low and middle-income countries is very scant. Using primary survey data collected from 16,921 workers in 257 businesses in Ghana, South Sudan, Bolivia, and Paraguay, this is the largest ever study of its kind that highlights the invisible costs businesses incur due to IPV experienced by female employees. IPV’s economic impact on labor productivity is based on tardiness, absenteeism, and presenteeism. Unlike the common perception that violence affects only the survivors, this study also estimates the effects on perpetrators. The results show that IPV exists in all the businesses surveyed, leading to enormous productivity losses due to both the experience and perpetration of IPV.

For several decades, calamitous debris flows have inflicted profound negative impact on Peruvian rainforest society, encompassing both economic losses and human casualties. To address this concern, this study proposes a methodological tool to assess vulnerability while focusing on intercultural nuances. The contextual analysis of the incident reports identifies La Merced (Junín, Perú) as a severely affected locality, thereby justifying its selection for a detailed case study on the Pampa del Carmen sector. The study conducted a thorough systematic review of parameters such as diglossia, poverty, and origin that are crucial for vulnerability assessment. Moreover, these parameters aided in developing a structured digital survey. The integration of survey data into the analytic hierarchy process revealed high levels of vulnerability in the sector, emphasizing the imminent need for targeted interventions. The intercultural approach is significant as it facilitates future risk mitigation strategies based on effective integration and genuine acknowledgment of social dynamics and individual freedoms within the region for devising impactful risk management policies and plans.

ABSTRACT: The objective of this study was to evaluate the effect of a novel consensus bacterial 6-phytase variant (PhyG) on egg productivity, eggshell quality, and body composition of laying hens fed inorganic phosphate-free diets with reduced energy and nutrients from 23 to 72 wk of age. Five treatments were randomly assigned, performing 28 replicates per treatment with 4 hens each, totaling 560 Hy-Line W80 birds. A positive control (PC) feed was formulated to contain adequate levels of energy and nutrients. A negative control (NC) feed was formulated without added inorganic phosphate (0.12% nonphytic phosphorus [nPP]) and reduced in Ca, Na, dig AA, and metabolizable energy in comparison with PC feed. Phytase was supplemented in the NC feed at 0, 300, 600, and 900 FTU/kg of feed. The responses evaluated were performance, egg quality, economic analysis, body composition, and tibia composition. Data were analyzed by a 2-factor (diet and age) repeated measure analysis. Overall, the feed intake, hen-day egg production, egg mass, and egg revenue were reduced by the complete removal of dicalcium phosphate (DCP) (P < 0.05). Supplement phytase in the NC diet elicits a positive response on each one of those variables. Laying hens consuming the NC feed with 900 FTU/kg of phytase produced more eggs per hen-housed compared with the phytase dosages of 300 and 600 FTU/kg. Body composition was not affected by dietary nPP, Ca, Na, dig AA, and energy reductions (P > 0.05). At 72-wk-old, tibia ash was reduced in hens consuming the NC diet vs. PC (P < 0.05) and no difference was observed between hens supplemented with phytase and the PC feed. Margin over feeding cost increased in a dose-dependent manner with phytase supplementation. Supplementation with 900 FTU/kg of phytase is recommended to improve the number of eggs produced per hen-housed and the number of marketable eggs produced through 23 to 72 wk of age, under this dietary setting.

En esta revisión sistemática, se examinaron los enfoques y técnicas utilizados por las empresas para proteger su información y cumplir con las expectativas de los clientes. Siguiendo una metodología rigurosa que involucró una investigación sistemática en bases de datos y un análisis exhaustivo de los artículos seleccionados, se identificaron seis estudios relevantes que proporcionaron información valiosa. Los hallazgos resaltaron la relevancia de incorporar la seguridad informática en la estrategia general de gestión de servicios y la necesidad de involucrar a todas las partes interesadas. Además, se enfatiza el papel crucial del elemento humano en la protección de la información y se recomienda invertir en programas de capacitación y concientización, asimismo se resalta la importancia de un enfoque holístico dentro de la gestión de servicios. El documento ofrece una visión integral y recomendaciones efectivas para fortalecer las prácticas de seguridad y protección de datos empresariales, siendo relevante para las organizaciones que buscan mejorar su enfoque en la protección de los datos en un entorno empresarial dinámico y en continua transformación.

La colonización fecal en lactantes por bacterias resistentes a los antimicrobianos es un potencial riesgo para futuras terapias antibióticas. Nuestro objetivo fue determinar la frecuencia y características sociodemográficas de lactantes portadores fecales de enterobacterias resistentes a ciprofloxacina (PFRC) y sus genes de resistencia asociados. Analizamos muestras fecales de 41 niños lactantes residentes en el distrito de Talara-Piura, Perú, en 2019. Evaluamos la presencia de 3 genes de resistencia a quinolonas: aac(6’)-Ib-cr, qnrB y oqxA y 2 de betalactamasas: blaCTX-M, blaPER-2.El 68% de lactantes fueron PFRC, Escherichia coli (83,3%) fue el más frecuente. El análisis genotípico detectó: oqxA (41,1%), qnrB (26,7%) y aac(6’)-Ib-cr (20%) y al gen blaCTX-M en el 93,3% de los aislados con betalactamasas. La elevada frecuencia de PFRC nos alertan sobre el potencial riesgo en la pérdida de utilidad de esta familia antibiótica en el área de estudio.

Resumen: Objetivo: Analizar los factores sociales asociados a la salud autopercibida durante el confinamiento en la población residente en Chile según la perspectiva de género. Método: Estudio transversal realizado mediante encuesta online durante el confinamiento por la COVID-19 entre el 17 de mayo y el 17 de agosto de 2020. Se analizó la salud autopercibida en población de 18 años o más en relación con variables sociales. Se construyeron modelos de regresión logística multivariante para evaluar la asociación entre las variables independientes con la salud autopercibida, a través de odds ratio ajustadas (ORa). Los análisis se estratificaron por sexo (H: hombres; M: mujeres). Resultados: Se analizaron 5981 personas (el 63,9% mujeres). El 29,6% de las mujeres y el 19,2% de los hombres reportaron mala salud autopercibida. En las mujeres, empeora al aumentar la edad. La peor salud autopercibida se asoció principalmente con la falta de apoyo social (ORa H: 2,05; ORa M: 2,34), la preocupación por la convivencia en el hogar (ORa H: 1,66; ORa M: 1,38), percibir inadecuadas condiciones de la vivienda (ORa H: 1,89; ORa M: 2,63) y el desacuerdo con las medidas gubernamentales (ORa H: 2,80; ORa M: 1,82). En las mujeres, además, se asoció al trabajo informal o estar inactivas laboralmente (ORa: 2,11). En los hombres, una peor salud autopercibida se asoció a ser trabajador independiente (autónomo) (ORa: 1,65; intervalo de confianza [IC]: 1,11-2,45) y tener educación secundaria (ORa: 2,81; IC: 1,32-5,98). Conclusiones: El impacto social del confinamiento en la salud autopercibida se relaciona con el género, la edad, el trabajo de cuidados y las condiciones socioeconómicas, así como con el desacuerdo con las medidas implementadas para gestionar la pandemia. Abstract: Objective: To analyse the social factors associated with self-perceived health during the COVID-19 lockdown in the Chilean resident population according to gender perspective. Method: Cross-sectional study conducted during the COVID-19 lockdown between May 17 and August 17, 2020 with an online survey. Self-perceived health was analysed in the population aged 18 years or older in relation to social variables. Multivariate logistic regression models were constructed to assess the association between independent variables with self-perceived health, through adjusted odds ratio (aOR). Analyses were stratified by sex (M: men; W: women). Results: 5981 persons were analysed (women: 63.9%). 29.6% of women and 19.2% of men reported poor self-perceived health. In women it worsens with increasing age. Worse self-perceived health was mainly associated with lack of social support (ORa M: 2.05; ORa W: 2.34), concern about living together at home (ORa M: 1.66; ORa W: 1.38), perceived inadequate housing conditions (ORa M: 1.89; ORa W: 2.63), and disagreement with government measures (ORa M: 2.80; ORa W: 1.82). In women, it was also associated with informal work or being inactive in the labour market (ORa: 2.11). In men worse self-perceived health was associated with being self-employed (ORa: 1.65; confidence interval [CI]: 1.11–2.45) and has secondary education (ORa: 2.81; CI: 1.32–5.98). Conclusions: The social impact of lockdown in self-perceived health is related to gender, age, care work, and socioeconomic conditions, as well as, by disagreement with the measures implemented to manage the pandemic.

Objetivo. Desarrollar y evaluar un método de bajo costo basado en celulosa para la purificación rápida y amplificación directa de ADN de Bordetella pertussis de hisopados nasofaríngeos. Materiales y métodos. Se prepararon discos de celulosa y se evaluaron diferentes parámetros (buffers de lisis/lavado, número de discos y elución de ADN). El método se acopló a una amplificación directa por PCR en tiempo real (qPCR) y se es­timó el rendimiento utilizando hisopados nasofaríngeos que fueron positivos (n=100) y negativos (n=50) para ADN B. pertussis por qPCR, comparado con el método basado en columnas de sílice. Se calculó el grado de concordancia, sensibilidad, especificidad, valor predictivo positivo (VPP) y valor predictivo negativo (VPN). Se evaluó la factibilidad del método rápido para ser acoplado a un ensayo colorimétrico de amplificación isotérmica mediada por lazo (LAMP). Resultados. El método rápido con un disco de celulosa y buffer de lisis y lavado conteniendo PVP-40 y Tween 20, respectivamente, mostró una mayor capacidad para purificar ADN amplificable de B. pertussis. El método tuvo una sensibilidad de 89,0% (IC95%, 80,2%-94,9%) y una especificidad de 98,5% (IC95%, 92,1%-100,0%), con un buen grado de concordancia (Kappa=0,867; IC95% 0,788 – 0,946), respecto al método referencial. Los VPP y VPN fueron 98,6% (IC95%, 92,7,2%-100,0%) y 88,2% (IC95%, 78,7%-94,4%), respectivamente. Se evidenció una amplificación exitosa por LAMP, y se obtuvieron resultados comparables con el método por columnas de sílice. Conclusión. El método desarrollado es simple, de bajo costo y libre de equipos para la obtención rápida (60 segundos) de ADN en el punto de atención, y puede ser implementado en diversas técnicas moleculares orientados al diagnóstico oportuno y al estudio epidemiológico de tos ferina

BackgroundDespite recent advances in the treatment of aggressive lymphomas, a significant fraction of patients still succumbs to their disease. Thus, novel therapies are urgently needed. As the anti-CD20 antibody rituximab and the CD19-targeting antibody tafasitamab share distinct modes of actions, we investigated if dual-targeting of aggressive lymphoma B-cells by combining rituximab and tafasitamab might increase cytotoxic effects.MethodsAntibody single and combination efficacy was determined investigating different modes of action including direct cytotoxicity, antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) in in vitro and in vivo models of aggressive B-cell lymphoma comprising diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL).ResultsThree different sensitivity profiles to antibody monotherapy or combination treatment were observed in in vitro models: while 1/11 cell lines was primarily sensitive to tafasitamab and 2/11 to rituximab, the combination resulted in enhanced cell death in 8/11 cell lines in at least one mode of action. Treatment with either antibody or the combination resulted in decreased expression of the oncogenic transcription factor MYC and inhibition of AKT signaling, which mirrored the cell line-specific sensitivities to direct cytotoxicity. At last, the combination resulted in a synergistic survival benefit in a PBMC-humanized Ramos NOD/SCID mouse model.ConclusionThis study demonstrates that the combination of tafasitamab and rituximab improves efficacy compared to single-agent treatments in models of aggressive B-cell lymphoma in vitro and in vivo.

In recent years, social assistive robots have gained significant acceptance in healthcare settings, particularly for tasks such as patient care and monitoring. This paper offers a comprehensive overview of the expressive humanoid robot, Qhali, with a focus on its industrial design, essential components, and validation in a controlled environment. The industrial design phase encompasses research, ideation, design, manufacturing, and implementation. Subsequently, the mechatronic system is detailed, covering sensing, actuation, control, energy, and software interface. Qhali’s capabilities include autonomous execution of routines for mental health promotion and psychological testing. The software platform enables therapist-directed interventions, allowing the robot to convey emotional gestures through joint and head movements and simulate various facial expressions for more engaging interactions. Finally, with the robot fully operational, an initial behavioral experiment was conducted to validate Qhali’s capability to deliver telepsychological interventions. The findings from this preliminary study indicate that participants reported enhancements in their emotional well-being, along with positive outcomes in their perception of the psychological intervention conducted with the humanoid robot.

This empirical study sought to understand the drivers behind civil protest participation in authoritarian contexts, explicitly focusing on Cuba. The data were sourced from 658 respondents via online surveys facilitated by CubaData, an independent social research agency specializing in Cuban studies, employing a secure panel system that guarantees the confidentiality and anonymity of participants. Our research primarily investigated the role of satisfaction with government policies in terms of the intention to participate in civil protests, introducing subjective well-being as a moderating variable. Utilizing the Process module of SMART-PLS 4 to emulate Process Model 58 for moderated mediation analysis, we accounted for measurement errors to ensure robust findings. Further controls were incorporated for age and political self-efficacy. The results revealed that subjective well-being significantly moderates the link between satisfaction with government policies and actual participation in civil protests. These findings suggest that the happiness level can change resistance dynamics within authoritarian settings. This research has implications for academic understandings of political behavior in autocratic regimes and practical applications in policy making and activism in Cuba.

Immune therapy for cancer patients is a new and promising area that in the future may complement traditional chemotherapy. The cell expansion phase is a critical part of the process chain to produce a large number of high-quality, genetically modified immune cells from an initial sample from the patient. Smart sensors augment the ability of the control and monitoring system of the process to react in real-time to key control parameter variations, adapt to different patient profiles, and optimize the process. The aim of the current work is to develop and calibrate smart sensors for their deployment in a real bioreactor platform, with adaptive control and monitoring for diverse patient/donor cell profiles. A set of contrasting smart sensors has been implemented and tested on automated cell expansion batch runs, which incorporate advanced data-driven machine learning and statistical techniques to detect variations and disturbances of the key system features. Furthermore, a ‘consensus’ approach is applied to the six smart sensor alerts as a confidence factor which helps the human operator identify significant events that require attention. Initial results show that the smart sensors can effectively model and track the data generated by the Aglaris FACER bioreactor, anticipate events within a 30 min time window, and mitigate perturbations in order to optimize the key performance indicators of cell quantity and quality. In quantitative terms for event detection, the consensus for sensors across batch runs demonstrated good stability: the AI-based smart sensors (Fuzzy and Weighted Aggregation) gave 88% and 86% consensus, respectively, whereas the statistically based (Stability Detector and Bollinger) gave 25% and 42% consensus, respectively, the average consensus for all six being 65%. The different results reflect the different theoretical approaches. Finally, the consensus of batch runs across sensors gave even higher stability, ranging from 57% to 98% with an average consensus of 80%.

El artículo presentado es una revisión sistemática para poder responder a las preguntas como: ¿Cuáles son las reflexiones sobre la implementación de las plataforma virtuales durante la pandemia COVID-19? y ¿Qué papel cumple las plataformas virtuales en el rendimiento académico de los estudiantes?, con el objetivo: determinar el papel de las Plataformas virtuales en el rendimiento académico en los estudiantes durante la pandemia. Material y método: el presente estudio es una revisión sistemática de 16 artículos que presenta un enfoque cualitativo, con una metodología no experimental, bibliográfica. Para la recolección de la información se realizó el proceso de búsqueda en dos fases para codificación de los datos se realizó el diagrama de flujo PRISMA. Conclusiones: Las plataformas virtuales deben ser creadas según las necesidades del estudiante para facilitar el proceso de enseñanza y aprendizaje con enfoque inclusivo. El 34% de los estudiantes se resisten al cambio ya que el entorno virtual es más frio siendo la adaptación a esta nueva forma de aprendizaje más lenta. El 81% de los estudiantes afirman que frecuentemente hay mala señal de internet dificultando el proceso de enseñanza y aprendizaje.

Esta investigación tuvo como objetivo determinar la relación directa entre la Responsabilidad Social Empresarial con la percepción de los clientes de los bancos comerciales en Perú; para ello, se identificaron factores que se relacionan con cada una de las variables. El diseño fue no experimental de tipo transversal – correlacional, se utilizó la técnica de la encuesta con su instrumento el cuestionario, dónde se aplicó un muestreo probabilístico de tipo aleatorio simple representado por 385 clientes de los bancos comerciales. Asimismo, se utilizó el análisis de confiabilidad de la escala mediante la estimación del Alpha de Cronbach y el chi-cuadrado que permitió comprobar la hipótesis que se planteó. Los resultados permitieron identificar que 77.14% de los clientes encuestados considera que si un banco comercial realiza actividades de RSE mejora su imagen institucional. Se concluyó que la Responsabilidad Social Empresarial tiene una relación directa en la percepción de los clientes de los bancos comerciales en Perú.

Objective This study aimed to evaluate the effect of the ad libitum and restricted feeding regimen on fasting heat production (FHP) and body composition. Methods Twelve Hubbard broilers breeders were selected with the same body weight and submitted in two feeding regimes: Restricted (T1) with feed intake of 150 g/bird/d and ad libitum (T2). The birds were randomly distributed on the treatments in two runs with three replications per treatment (per run). The birds were adapted to the feed regimens for ten days. After that, they were allocated in the open-circuit chambers and kept for three days for adaptation. On the last day, oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured by 30 h under fasting. The respiratory quotient (RQ) was calculated as the VCO2/VO2 ratio, and the heat production (HP) was obtained using the Brower equation (1985). The FHP was estimated throughout the plateau of HP 12 hours after the feed deprivation. The body composition was analyzed by dual-energy X-ray absorptiometry scanning at the end of each period. Data were analyzed for one-way analysis of variance using the Minitab software. Results The daily feed intake was 30 g higher to T2 (p