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50 results on '"Horn, MacKenzie"'

1. Intravenous alteplase versus tenecteplase in patients with acute posterior circulation strokes: A secondary analysis from the AcT randomized controlled trial

Author

Cimflova, Petra, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Benali, Faysal, Buck, Brian H, Catanese, Luciana, Coutts, Prof Shelagh B․, Khosravani, Houman, Appireddy, Ramana, Tkach, Aleksander, Dowlatshahi, Dar, Carpani, Federico, Field, Thalia, Hunter, Gary, Hill, Prof․ Michael D․, Poppe, Alexandre Y․, Ademola, Ayoola, Shamy, Michel, Sajobi, Tolulope T․, Swartz, Richard H․, Almekhlafi, Mohammed A․, Menon, Prof Bijoy K․, and Singh, Nishita

Published
2024
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2. Combining Early Ischemic Change and Collateral Extent for Functional Outcomes After Endovascular Therapy: An Analysis From AcT Trial

Author

Tanaka, Koji, Kaveeta, Chitapa, Pensato, Umberto, Zhang, Jianhai, Bala, Fouzi, Alhabli, Ibrahim, Horn, MacKenzie, Ademola, Ayoola, Almekhlafi, Mohammed, Ganesh, Aravind, Buck, Brian, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Shankar, Jai, Poppe, Alexandre Y., Shamy, Michel, Qiu, Wu, Swartz, Richard H., Hill, Michael D., Sajobi, Tolulope T., Menon, Bijoy K., Demchuk, Andrew M., and Singh, Nishita

Published
2024
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3. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., de Queiroz, J.P., Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, and Hill, Michael D

Published
2024
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4. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Srivastava, Abhilekh, Aljammaz, Ahmed M, Akindotun, Akintomide Femi, Jin, Albert Y, Fraser, Alexander, Khaw, Alexander V, Lemnaru, Alexandru, Southwell, Alisia, Ramji, Alnar, Alvarado-Bolaños, Alonso, Mouminah, Amr, Lahlouh, Amro B, Yu, Amy Y, Alrohimi, Anas, Lavoie, Andre, Rogge, Andrea, Micieli, Andrew, Nguyen, Andrew Linh, Callaghan-Brown, Angelique, Florendo-Cumbermack, Anita, Wadhwa, Ankur, Beaudoin, Ann-Marie, Cayley, Anne, Liddy, Anne Marie, Trivedi, Anurag, Katsanos, Aristeidis H, Shuaib, Ashfaq, Butt, Asif Javed, Bereznyakova, Olena, Beauchamp, Beth, Mahlitz, Breane, Graham, Brett R, Dewar, Brian, Buck, Brian H, Durafourt, Bryce A, Holtby, Caitlin, Jackson-Tarlton, Caitlin S, Bockus, Caitlyn, Stephenson, Caroline, Galloway, Camille, Odier, Céline, Deacon, Charles, Zerna, Charlotte, Vekhande, Chetan C, Bocti, Christian, Stapf, Christian, Hawkes, Christine, Stables, Christine Anne, Bogiatzi, Chrysi, Rodriguez, Claudia, Candale-Radu, Claudia, Murphy, Colleen, Casserly, Courtney Sarah, Fok, Daniel, Boasquevisque, Danielle de Sa, Wile, Daryl, Volders, David, Sahlas, Demetrios J, Shand, Elaine, Cora, Elena Adela, Battista, Eliane Di, Stewart, Eileen, Junk, Emily, Harrison, Emma L, Frenette, Eric, Teleg, Ericka, Abdellah, Eslam, Ghrooda, Esseddeeg, Akthar, Farhana, Evoy, François, Klein, Gary M, Maclean, Genoveva, Jickling, Glen C, Hawthorne, Glenda, Boyd, Gordon, Walker, Gregory, Saposnik, Gustavo, Lau, H Lee, Badr, Hanan E, Toma, Hassanain, Kalashyan, Hayrapet, Marion-Moffet, Hugo, Grant, Ian, Fatakdawala, Idris, Beaulieu-Boire, Isabelle, Williams, Janice, Brar, Jaskiran, Rivest, Jean, Wang, Jeffrey Z, Dawe, Jessica, Stang, Jillian, Day, Joanne, Miller, Jodi, Gorman, Johnathon, Hopyan, Julia Jasmine, Lee, Julian, Kromm, Julie, Foster, Kaitlyn, Ratnayake, Kanchana, Perera, Kanjana S, Murray, Karina Villaluna, Ryckborst, Karla, Lin, Katie, Sage, Kayla, Sivakuma, Keithan, MacDonald, Kelly A, Ng, Kelvin Kuan, Merchant, Ketki, Khan, Khurshid, Ghavami, Kimia, Johnston, Kyra, Mai, Lauren M, White, Leah, Barratt, Lee, Longpre, Linda, Crellin, Lisa, Peeling, Lissa, Piquette, Lori, Lomax, Lysa Boissé, Sadeghi, Mahsa, Kamra, Maneesha, Lavoie-April, Manuel, Moores, Margaret, Bullrich, Maria Bres, McClelland, Marie, Salluzzi, Marina, Wilcox, Mark, Boulos, Mark I, Marko, Martha, Boyko, Matthew, Lantagne-Hurtubise, Maude, AlHamid, May Adel, Shawawrah, Mays, Kelly, Michael E, Thorne, Michael W D, Shamy, Michel, Bussiere, Miguel, Dominc Tse, Ming Yin, Benguzzi, Mowad, Sharma, Mukul, Horton, Myles, Newcommon, Nancy, Simon, Nandy-Shelwine, Parks, Natalie E, Sultan, Nazeem, Markovic, Nevena, Daneault, Nicole, Ishaque, Noman, Fairall, Paige, Kostyrko, Pawel B, Stys, Peter K, Teal, Philip, Couillard, Philippe, King-Azote, Princess, Collier, Quentin, Epp, Rachel, Nair, Radhika, Joundi, Raed A, Jassal, Rajive, Schneider, Raphael, Hosseini, Reza, Bouchard, Rosalie, Whelan, Ruth, Cooley, S Regan, Sujanthan, Sajeevan, Mansoor, Salman, Yip, Samuel, Wasyliw, Sanchea, Taylor, Sean W., Friedman, Sebastian, Mann, Sharan, Maley, Sharleen Weese, Chiasson, Sherry, Hu, Sherry Xueying, Althubait, Shorog, Himed, Shuhira, Chen, Shuo, Bal, Simerpreet S, Page, Stacey A, Beck, Stacey D, Woodroffe, Stephanie, Reiter, Stephanie D, Gaal, Stephen van, Peters, Steven Ray, Darvesh, Sultan, Save, Supriya, Alcock, Susan, Piercey, Susannah, Adam, Suzie, Gosselin, Sylvie, Fitzpatrick, Tess, Perron, Thomas-Louis, Stewart, Tim, Benstead, Timothy J, Naidoo, Vishaya, Wahab, Wasan Abd, Oczkowski, Wiesław, Kingston, William, Leduc, William, To, William T H, Yu, Yeyao Joe, Liu, Zhongyu A, Aljundi, Ziad Ezzat, Menon, Bijoy K, Singh, Nishita, Deschaintre, Yan, Almekhlafi, Mohammed A, Coutts, Shelagh B, Thirunavukkarasu, Sibi, Khosravani, Houman, Appireddy, Ramana, Moreau, Francois, Gubitz, Gord, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Medvedev, George, Mandzia, Jennifer, Pikula, Aleksandra, Shankar, Jai, Williams, Heather, Field, Thalia S, Manosalva, Alejandro, Siddiqui, Muzaffar, Zafar, Atif, Imoukhuede, Oje, Hunter, Gary, Demchuk, Andrew M, Mishra, Sachin, Gioia, Laura C, Jalini, Shirin, Cayer, Caroline, Phillips, Stephen, Elamin, Elsadig, Shoamanesh, Ashkan, Subramaniam, Suresh, Kate, Mahesh, Jacquin, Gregory, Camden, Marie-Christine, Benali, Faysal, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Stotts, Grant, Hill, Michael D, Gladstone, David J, Poppe, Alexandre, Sehgal, Arshia, Zhang, Qiao, Lethebe, Brendan Cord, Doram, Craig, Ademola, Ayoola, Kenney, Carol, Sajobi, Tolulope T, and Swartz, Richard H

Published
2022
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5. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS: Has the Machine Surpassed the Eye?

Author

Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Möhlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, and Brehm, Alex

Published
2021
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6. Quality of Life After Intravenous Thrombolysis for Acute Ischemic Stroke: Results From the AcT Randomized Controlled Trial

Author

Sajobi, Tolulope T., primary, Arimoro, Olayinka I., additional, Ademola, Ayoola, additional, Singh, Nishita, additional, Bala, Fouzi, additional, Almekhlafi, Mohammed A., additional, Deschaintre, Yan, additional, Coutts, Shelagh B., additional, Thirunavukkarasu, Sibi, additional, Khosravani, Houman, additional, Appireddy, Ramana, additional, Moreau, François, additional, Gubitz, Gordon J., additional, Tkach, Aleksander, additional, Catanese, Luciana, additional, Dowlatshahi, Dar, additional, Medvedev, George, additional, Mandzia, Jennifer, additional, Pikula, Aleksandra, additional, Shankar, Jai Shiva, additional, Williams, Heather, additional, Field, Thalia S., additional, Manosalva, Alejandro, additional, Siddiqui, Muzaffar, additional, Zafar, Atif, additional, Imoukhuede, Oje, additional, Hunter, Gary, additional, Demchuk, Andrew M., additional, Mishra, Sachin M., additional, Gioia, Laura C., additional, Jalini, Shirin, additional, Cayer, Caroline, additional, Phillips, Stephen J., additional, Elamin, Elsadig, additional, Shoamanesh, Ashkan, additional, Subramaniam, Suresh, additional, Kate, Mahesh P., additional, Jacquin, Gregory, additional, Camden, Marie-Christine, additional, Benali, Faysal, additional, Alhabli, Ibrahim, additional, Horn, MacKenzie, additional, Stotts, Grant, additional, Hill, Michael D., additional, Gladstone, David J., additional, Poppe, Alexandre Y., additional, Sehgal, Arshia, additional, Zhang, Qiao, additional, Lethebe, Brendan, additional, Doram, Craig, additional, Shamy, Michel, additional, Kenney, Carol, additional, Buck, Brian H., additional, Swartz, Richard H., additional, and Menon, Bijoy K., additional

Published
2024
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7. Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial

Author

Nair, Radhika, primary, Singh, Nishita, additional, Kate, Mahesh, additional, Asdaghi, Negar, additional, Sarmiento, Robert, additional, Bala, Fouzi, additional, Coutts, Shelagh B, additional, Horn, MacKenzie, additional, Poppe, Alexandre Y, additional, Williams, Heather, additional, Ademola, Ayoola, additional, Alhabli, Ibrahim, additional, Benali, Faysal, additional, Khosravani, Houman, additional, Hunter, Gary, additional, Tkach, Aleksander, additional, Manosalva Alzate, Herbert Alejandro, additional, Pikula, Aleksandra, additional, Field, Thalia, additional, Trivedi, Anurag, additional, Dowlatshahi, Dar, additional, Catanese, Luciana, additional, Shuaib, Ashfaq, additional, Demchuk, Andrew, additional, Sajobi, Tolulope, additional, Almekhlafi, Mohammed A, additional, Swartz, Richard H, additional, Menon, Bijoy, additional, and Buck, Brian H, additional

Published
2024
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8. Timing of Spot Sign Appearance, Spot Sign Volume, and Leakage Rate among Phases of Multiphase CTA Predict Intracerebral Hemorrhage Growth.

Author

Horn, MacKenzie, Teleg, Ericka, Koji Tanaka, Al Sultan, Abdulaziz, Kasickova, Linda, Tomoyuki Ohara, Ojha, Piyush, Wasyliw, Sanchea, Marzoughi, Sina, Banerjee, Ankur, Kulkarni, Girish, Horn, Kennedy, Bobyn, Amy, Neweduk, Anneliese, Singh, Nishita, Wu Qiu, Rodriguez-Luna, David, Dowlatshahi, Dar, Goyal, Mayank, and Menon, Bijoy K.

Published
2024
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9. Total intracranial hemorrhage volume measurement summating all compartments best in traumatic and nontraumatic intracranial bleeding.

Author

Horn, MacKenzie, Banerjee, Ankur, Kasickova, Linda, Volny, Ondrej, Choi, Hyun Seok, Letteri, Federica, Ohara, Tomoyuki, Tanaka, Koji, Connolly, Stuart, Ladenvall, Per, Crowther, Mark, Beyer‐Westendorf, Jan, Shoamanesh, Ashkan, Demchuk, Andrew M., and Al Sultan, Abdulaziz S.

Subjects
*INTRACRANIAL hemorrhage, *VOLUME measurements, *MEASUREMENT errors, *HEMORRHAGE, *VOLUMETRIC analysis
Abstract

Background and purpose: The ANNEXA‐4 trial measured hemostatic efficacy of andexanet alfa in patients with major bleeding taking factor Xa inhibitors. A proportion of this was traumatic and nontraumatic intracranial bleeding. Different measurements were applied in the trial including volumetrics to assess for intracranial bleeding depending on the compartment involved. We aimed to determine the most reliable way to measure intracranial hemorrhage (ICrH) volume by comparing individual brain compartment and total ICrH volume. Methods: Thirty patients were randomly selected from the ANNEXA‐4 database to assess measurement of ICrH volume by compartment and in total. Total and compartmental hemorrhage volumes were measured by five readers using Quantomo software. Each reader measured baseline hemorrhage volumes twice separated by 1 week. Twenty‐eight different ANNEXA‐4 subjects were also randomly selected to assess intra‐rater reliability of total ICrH volume measurement change at baseline and 12‐h follow up, performed by three readers twice to assess hemostatic efficacy categories used in ANNEXA‐4. Results: Compartmental minimal detectable change percentages (MDC%) ranged between 9.72 and 224.13, with the greatest measurement error occurring in patients with a subdural hemorrhage. Total ICrH volume measurements had the lowest MDC%, which ranged between 6.57 and 33.52 depending on the reader. Conclusion: Measurement of total ICrH volumes is more accurate than volume by compartment with less measurement error. Determination of hemostatic efficacy was consistent across readers, and within the same reader, as well as when compared to consensus read. Volumetric analysis of intracranial hemostatic efficacy is feasible and reliable when using total ICrH volumes. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial

Author

Bala, Fouzi, primary, Almekhlafi, Mohammed, additional, Singh, Nishita, additional, Alhabli, Ibrahim, additional, Ademola, Ayoola, additional, Coutts, Shelagh B, additional, Deschaintre, Yan, additional, Khosravani, Houman, additional, Appireddy, Ramana, additional, Moreau, Francois, additional, Phillips, Stephen, additional, Gubitz, Gord, additional, Tkach, Aleksander, additional, Catanese, Luciana, additional, Dowlatshahi, Dar, additional, Medvedev, George, additional, Mandzia, Jennifer, additional, Pikula, Aleksandra, additional, Shankar, Jay, additional, Williams, Heather, additional, Field, Thalia S, additional, Manosalva, Alejandro, additional, Siddiqui, Muzaffar, additional, Zafar, Atif, additional, Imoukhoude, Oje, additional, Hunter, Gary, additional, Benali, Faysal, additional, Horn, MacKenzie, additional, Hill, Michael D, additional, Shamy, Michel, additional, Sajobi, Tolulope T, additional, Buck, Brian H, additional, Swartz, Richard H, additional, Menon, Bijoy K, additional, and Poppe, Alexandre Y, additional

Published
2023
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12. Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment: The INTERRSeCT Study

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, MacKenzie, Najm, Mohamed, Al-Sultan, Abdulaziz, Puig, Josep, Dowlatshahi, Dar, Calleja Sanz, Ana I., Sohn, Sung-Il, Ahn, Seong H., Poppe, Alexandre Y., Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Letteri, Federica, Dey, Sadanand, Evans, James W., Goyal, Mayank, Hill, Michael D., Almekhlafi, Mohammed, and Demchuk, Andrew M.

Published
2021
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15. Effect of Needle-To-Puncture Time on Reperfusion Outcome in Acute Ischemic Stroke

Author

Chen, Chih-Hao, primary, Bala, Fouzi, additional, Najm, Mohamed, additional, Alhabli, Ibrahim, additional, Singh, Nishita, additional, Kashani, Nima, additional, McDonough, Rosalie V., additional, Horn, MacKenzie, additional, Stang, Jilian, additional, Demchuk, Andrew M., additional, Menon, Bijoy K., additional, Hill, Michael D., additional, and Almekhlafi, Mohammed A., additional

Published
2023
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16. Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open label, phase 3 superiority trial

Author

Coutts, Shelagh B, Ankolekar, Sandeep, Appireddy, Ramana, Arenillas, Juan F, Assis, Zarina, Bailey, Peter, Barber, Philip A, Bazan, Rodrigo, Buck, Brian H, Butcher, Ken S, Camden, Marie-Christine, Campbell, Bruce C V, Casaubon, Leanne K, Catanese, Luciana, Chatterjee, Kausik, Choi, Philip M C, Clarke, Brian, Dowlatshahi, Dar, Ferrari, Julia, Field, Thalia S, Ganesh, Aravind, Ghia, Darshan, Goyal, Mayank, Greisenegger, Stefan, Halse, Omid, Horn, Mackenzie, Hunter, Gary, Imoukhuede, Oje, Kelly, Peter J, Kennedy, James, Kenney, Carol, Kleinig, Timothy J, Krishnan, Kailash, Lima, Fabricio, Mandzia, Jennifer L, Marko, Martha, Martins, Sheila O, Medvedev, George, Menon, Bijoy K, Mishra, Sachin M, Molina, Carlos, Moussaddy, Aimen, Muir, Keith W, Parsons, Mark W, Penn, Andrew M W, Pille, Arthur, Pontes-Neto, Octávio M, Roffe, Christine, Serena, Joaquin, Simister, Robert, Singh, Nishita, Spratt, Neil, Strbian, Daniel, Tham, Carol H, Wiggam, M Ivan, Williams, David J, Willmot, Mark R, Wu, Teddy, Yu, Amy Y X, Zachariah, George, Zafar, Atif, Zerna, Charlotte, Hill, Michael D, Salluzzi, Marina, Blenkin, Nicole, Dueck, Ashley, Doram, Craig, Zhang, Qiao, Kenney, Carol, Ryckborst, Karla, Bohn, Shelly, Collier, Quentin, Taylor, Frances, Lethebe, B. Cord, Jambula, Anitha, Sage, Kayla, Toussaint, Lana, Save, Supryia, Lee, Jaclyn, Laham, N, Sultan, A.A., Deepak, A., Sitaram, A., Demchuk, Andrew M., Lockey, A., Micielli, A., Wadhwa, A., Arabambi, B., Graham, B., Bogiatzi, Chrysi, Doshi, Darshan, Chakraborty, D., Kim, Diana, Vasquez, D, Singh, D, Tse, Dominic, Harrison, E., Smith, E.E., Teleg, E., Klourfeld, E., Klein, G., Sebastian, I.A., Evans, J, Hegedus, J, Kromm, J, Lin, K, Ignacio, K, Ghavami, Kimia, Ismail, M., Moores, M., Panzini, M.A., Boyko, M., Almekhlafi, M.A., Newcommon, Nancy, Maraj, N., Imoukhuede, O., Volny, O., Stys, Peter, Couillard, Phillipe, Ojha, P., Eswaradass, P., Joundi, Raed, Singh, R., Asuncion, R.M., Muir, R.T., Dey, S., Mansoor, S., Wasyliw, S., Nagendra, S., Hu, Sherry, Althubait, S., Chen, S., Bal, S., Van Gaal, Stephen, Peters, Steven, Ray, Sucharita, Chaturvedi, S., Subramaniam, Suresh, Fu, Vivian, Villaluna, K., Maclean, G., King-Azote, P., Ma, C., Plecash, A., Murphy, C., Gorman, J., Wilson, L., Zhou, L., Benevente, O., Teal, P., Yip, S., Mann, S., Dewar, B., Demetroff, M., Shamloul, R., Beardshaw, R., Roberts, S., Blaquiere, D., Stotts, G., Shamy, M., Bereznyakova, O., Fahed, R., Alesefir, W., Lavoie, Suzy, Hache, A., Collard, K, Mackey, A., Gosselin-Lefebvre, S., Verreault, S., Beauchamp, B., Lambourn, L., Khaw, A., Mai, L., Sposato, L., Bres Bullrich, M., Azarpazhooh, R., Fridman, S., Kapoor, A., Southwell, A., Bardi, E., Fatakdawala, I., Kamra, M, Lopes, K., Popel, N., Norouzi, V., Liu, A., Liddy, A.M., Ghoari, B., Hawkes, C., Enriquez, C.A., Gladstone, D.J., Manosalva Alzate, H.A., Khosravani, H., Hopyan, J.J., Sivakumar, K., Son, M., Boulos, M.I., Hamind, M.A., Swartz, R.H., Murphy, R., Reiter, S., Fitzpatrick, T., Bhandari, V., Good, J., Penn, M., Naylor, M., Frost, S., Cayley, A., Akthar, F., Williams, J., Kalman, L., Crellin, L., Wiegner, R., Singh, R.S., Stewart, T., To, W., Singh, S., Pikula, A., Jaigobin, C., Carpani, F., Silver, F., Janssen, H., Schaafsma, J., del Campo, M., Alskaini, M., Rajendram, P., Fairall, P., Granfield, B., Crawford, D., Jabs, J., White, L., Sivakumar, L., Piquette, L., Nguyen, T., Nomani, A., Wagner, A., Alrohimi, A., Butt, A., D'Souza, A., Gajurel, B., Vekhande, C., Kamble, H., Kalashyan, H., Lloret, M., Benguzzi, M., Arsalan, N., Ishaque, N., Ashayeriahmadabad, R., Samiento, R., Hosseini, S., Kazi, S., Das, S., Sugumar, T., Selchen, D., Kostyrko, P., Muccilli, A., Saposnik, A.G., Vandervelde, C., Ratnayake, K., McMillan, S., Katsanos, A., Shoamanesh, A., Sahlas, D.J., Naidoo, V., Todorov, V., Toma, H., Brar, J., Lee, J., Horton, M., Chen, S., Shand, E., Weatherby, S., Jin, A., Durafourt, B., Jalini, S., Gardner, A., Tyson, C., Junk, E., Foster, K., Bolt, K., Sylvain, N., Maley, S., Urroz, L., Peeling, L., Kelly, M., Whelan, R., Cooley, R., Teitelbaum, J., Boutayeb, A., Moore, A., Cole, E., Waxman, L., Ben-Amor, N., Sanchez, R., Khalil, S., Nehme, A., Legault, C., Tampieri, D., Ehrensperger, E., Vieira, L., Cortes, M., Angle, M., Hannouche, M., Badawy, M., Werner, K., Wieszmuellner, S., Langer, A., Gisold, A., Zach, H., Rommer, P., Macher, S., Blechinger, S., Marik, W., Series, W., Baumgartinger, M., Krebs, S., Koski, J., Eirola, S., Ivanoff, T., Erakanto, A., Kupari, L., Sibolt, G., Panula, J., Tomppo, L., Tiainen, M., Ahlstrom, M., Martinez Majander, N., Suomalainen, O., Raty, S., Levi, C., Kerr, E., Allen, J., Kaauwai, L.P., Belevski, L., Russell, M., Ormond, S., Chew, A., Loiselle, A., Royan, A., Hughes, B., Garcia Esperon, C., Pepper, E., Miteff, F., He, J., Lycett, M., Min, M., Murray, N., Pavey, N., Starling de Barros, R., Gangadharan, S., Dunkerton, S., Waller, S., Canento Sanchez, T., Wellings, T., Edmonds, G., Whittaker, K.A., Ewing, M., Lee, P., Singkang, R., McDonald, A., Dos Santos, A., Shin, C., Jackson, D., Tsoleridis, J., Fisicchia, L., Parsons, N., Shenoy, N., Smith, S., Sharobeam, A., Balabanski, A., Park, A., Williams, C., Pavlin-Premri, D., Rodrigues, E., Alemseged, F., Ng, F., Zhao, H., Beharry, J., Ng, J.L., Williamson, J., Wong, J.Z.W., Li, K., Kwan, M.K., Valente, M., Yassi, N., Cooley, R., Yogendrakumar, V., McNamara, B., Buchanan, C., McCarthy, C., Thomas, G., Stephens, K., Chung, M., Chung, M.F., Tang, M., Busch, T., Frost, T., Lee, R., Stuart, N., Pachani, N., Menon, A., Borojevic, B., Linton, C.M., Garcia, G., Callaly, E.P., Dewey, H., Liu, J., Chen, J., Wong, J., Nowak, K., To, K., Lizak, N.S., Bhalala, O., Park, P., Tan, P., Martins, R., Cody, R., Forbes, R., Chen, S.K., Ooi, S., Tu, S., Dang, Y.L., Ling, Z., Cranefield, J., Drew, R., Tan, A., Kurunawai, C., Harvey, J., Mahadevan, J.J., Cagi, L., Palanikumar, L., Chia, L.N., Goh, R., El-Masri, S., Urbi, B., Rapier, C., Berrill, H., McEvoy, H., Dunning, R., Kuriakose, S., Chad, T., Sapaen, V., Sabet, A., Shah, D., Yeow, D., Lilley, K., Ward, K., Mozhy Mahizhnan, M., Tan, M., Lynch, C., Coveney, S., Tobin, K., McCabe, J., Marnane, M., Murphy, S., Large, M., Moynihan, B., Boyle, K., Sanjuan, E., Sanchis, M., Boned, S., Pancorbo, O., Sala, V., Garcia, L., Garcia-Tornel, A., Juega, J., Pagola, J., Santana, K., Requena, M., Muchada, M., Olive, M., Lozano, P.J., Rubiera, M., Deck, M., Rodriguez, N., Gomez, B., Reyes Munoz, F.J., Gomez, A.S., Sanz, A.C., Garcia, E.C., Penacoba, G., Ramos, M.E., de Lera Alfonso, M., Feliu, A, Pardo, L., Ramirez, P., Murillo, A., Lopez Dominguez, D., Rodriguez, J., Terceno Izaga, M., Reina, M., Viturro, S.B., Bojaryn, U., Vera Monge, V.A., Silva Blas, Y., R Siew, R., Agustin, S J, Seet, C., Tianming, T., d'Emden, A., Murray, A., Welch, A., Hatherley, K., Day, N., Smith, W., MacRae, E., Mitchell, E.S., Mahmood, A., Elliot, J., Neilson, S., Biswas, V., Brown, C., Lewis, A., Ashton, A., Werring, D., Perry, R., Muhammad, R., Lee, Y.C., Black, A., Robinson, A., Williams, A., Banaras, A., Cahoy, C., Raingold, G., Marinescu, M., Atang, N., Bason, N., Francia, N., Obarey, S., Feerick, S., Joseph, J., Schulz, U., Irons, R., Benjamin, J., Quinn, L., Jhoots, M., Teal, R., Ford, G., Harston, G., Bains, H., Gbinigie, I., Mathieson, P., Irons, R., Sim, C.H., Hayter, E., Kennedy, K., Binnie, L., Priestley, N., Williams, R., Ghatala, R., Stratton, S., Blight, A., Zhang, L., Davies, A., Duffy, H., Roberts, J., Homer, J., Roberts, K., Dodd, K., Cawley, K., Martin, M., Leason, S., Cotgreave, S., Taylor, T., Nallasivan, A., Haider, S., Chakraborty, T., Webster, T., Gil, A., Martin, B., Joseph, B., Cabrera, C., Jose, D., Man, J., Aquino, J., Sebastian, S., Osterdahl, M., Kwan, M., Matthew, M., Ike, N., Bello, P., Wilding, P., Fuentes, R., Shah, R., Mashate, S., Patel, T., Nwanguma, U., Dave, V., Haber, A., Lee, A., O'Sullivan, A., Drumm, B., Dawson, A.C., Matar, T., Biswas, V., Roberts, D., Taylor, E., Rounis, E., El-Masry, A., O'Hare, C., Kalladka, D., Jamil, S., Auger, S., Raha, O., Evans, M., Vonberg, F., Kalam, S., Ali Sheikh, A., Jenkins, I.H., George, J., Kwan, J., Blagojevic, J., Saeed, M., Haji-Coll, M., Tsuda, M., Sayed, M., Winterkron, N., Thanbirajah, N., Vittay, O., Karim, R., Smail, R.C., Gauhar, S., Elmamoun, S., Malani, S., Pralhad Kelavkar, S., Hiden, J., Ferdinand, P., Sanyal, R., Varquez, R., Smith, B., Okechukwu, C., Fox, E., Collins, E., Courtney, K., Tauro, S., Patterson, C., McShane, D., Kerr, E., Roberts, G., McIImoyle, J., McGuire, K., Fearon, P., Gordon, P., Isaacs, K., Lucas, K., Smith, L., Dews, L., Bates, M., Lawrence, S., Heeley, S., Patel, V., Chin, Y.M., Sims, D., Littleton, E., Khaira, J., Nadar, K., Kieliszkowska, A., Sari, B., Domingos Belo, C., Smith, E., Manolo, E.Y., Aeron-Thomas, J., Doheny, M., Garcia Pardo, M., Recaman, M., Tibajia, M.C., Aissa, M., Mah, Y., Yu, T., Patel, V., Meenakshisundaram, S., Heller, S., Alsukhni, R., Williams, O., Farag, M., Benger, M., Engineer, A., Aissa, M., Bayhonan, S., Conway, S., Bhalla, A., Nouvakis, D., Theochari, E., Boyle, F., Teo, J., King-Robson, J., Law, K.Y., Sztriha, L., Ismail, M., McGovern, A., Day, D., Mitchell-Douglas, J., Francis, J., Iqbal, A., Punjabivaryani, P., Anonuevo Reyes, J., Anonuevo Reyes, M., Pauls, M., Buch, A., Hedstrom, A., Hutchinson, C., Kirkland, C., Newham, J., Wilkes, G., Fleming, L., Fleck, N., Franca, A., Chwal, B., Oldoni, C., Mantovani, G., Noll, G., Zanella, L., Soma, M., Secchi, T., Borelli, W., Rimoli, B.P., da Cunha Silva, G.H., Machado Galvao Mondin, L.A., Barbosa Cerantola, R., Imthon, A.K., Esaki, A.S., Camilo, M., Vincenzi, O.C., ds Cruz, R.R., Morillos, M.B., Riccioppa Rodrigues, G.G., Santos Ferreira, K., Pazini, A.M., Pena Pereira, M.A., de Albuquerque, A.L.A., Massote Fontanini, C.E., Matinez Rubio, C.F., dos Santos, D.T., Dias, F.A., Alves, F.F.A., Milani, C., Pegorer Santos, B., Winckler, F., De Souza, J.T., Bonome, L.A.M., Cury Silva, V.A., Teodoro, R.S., Modolo, G.P., Ferreira, N.C., Barbosa dos Santos, D.F., dos Santos Moreira, J.C., Cruz Guedes de Morais, A.B., Vieira, J., Mendes, G., and de Queiroz, J.P.

Abstract

Individuals with minor ischaemic stroke and intracranial occlusion are at increased risk of poor outcomes. Intravenous thrombolysis with tenecteplase might improve outcomes in this population. We aimed to test the superiority of intravenous tenecteplase over non-thrombolytic standard of care in patients with minor ischaemic stroke and intracranial occlusion or focal perfusion abnormality.

Published
2024
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17. Effect of Needle-To-Puncture Time on Reperfusion Outcome in Acute Ischemic Stroke.

Author

Chen, Chih-Hao, Bala, Fouzi, Najm, Mohamed, Alhabli, Ibrahim, Singh, Nishita, Kashani, Nima, McDonough, Rosalie V., Horn, MacKenzie, Stang, Jilian, Demchuk, Andrew M., Menon, Bijoy K., Hill, Michael D., and Almekhlafi, Mohammed A.

Subjects
ISCHEMIC stroke, REPERFUSION, ENDOVASCULAR surgery, CEREBRAL infarction, STROKE
Abstract

Introduction: The aim of the study was to investigate the impact of time interval between start of intravenous thrombolysis (IVT) to start of endovascular thrombectomy (EVT) on stroke outcomes. Methods: Data from the Quality Improvement and Clinical Research (QuICR) provincial stroke registry from Alberta, Canada, were used to identify stroke patients who received IVT and EVT from January 2015 to December 2019. We assessed the impact of the time interval between IVT bolus to EVT puncture (needle-to-puncture times [NPT]) on outcomes. Radiological outcomes included successful initial recanalization (revised Arterial Occlusive Lesion 2b–3), successful initial and final reperfusion (modified thrombolysis in cerebral infarction 2b–3). Clinical outcomes were 90-day modified Rankin Scale (mRS) and mortality. Results: Of the 680 patients, 233 patients (median age: 73, 41% females) received IVT + EVT. Median NPT was 38 min (IQR, 24–60). Arrival during working hours was independently associated with shorter NPT (p < 0.001). Successful initial recanalization and initial and final reperfusion were observed in 12%, 10%, and 83% of patients, respectively. NPT was not associated with initial successful recanalization (OR 0.97 for every 10-min increase of NPT, 95% CI: 0.91–1.04), initial successful reperfusion (OR 1.01, 95% CI: 0.96–1.07), or final successful reperfusion (OR: 1.03, 95% CI: 0.97–1.08). Every 10-min delay in NPT was associated with lower odds of functional independence at 90 days (mRS ≤2; OR: 0.93; 95% CI, 0.88–0.97). Patients with shorter NPT (≤38 min) had lower 90-day mRS scores (median 1 vs. 3; OR: 0.54 [0.31–0.91]) and had lower mortality (6.1% vs. 21.2%; OR, 0.23 [0.10–0.57]) than the longer NPT group. Conclusion: Shorter NPT did not impact reperfusion outcomes but was associated with better clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Abstract WP113: Feasibility Of Non-invasive Brain Temperature Measurement In Acute Ischemic Stroke: A Comparison Study Of MR Thermometry Vs. Zero-Heat-Flux Sensors

Author

Horn, MacKenzie, primary, Meulenbroek, Nathan, additional, Chu, Tak-Ho, additional, Singh, Nishita, additional, Tanaka, Koji, additional, Menon, Bijoy K, additional, Diprose, William, additional, Pichardo, Samuel, additional, Demchuk, Andrew M, additional, and Almekhlafi, Mohammed, additional

Published
2023
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21. Abstract WP126: Predictors Of Intracranial Hemorrhage Volume Expansion In Patients Receiving Factor Xa Inhibitors In The Annexa-4 Trial

Author

Concha, Mauricio, primary, Hu, Lizhen, additional, Horn, MacKenzie, additional, Ohara, Tomoyuki, additional, Nakamya, Juliet, additional, Beyer-, Jan, additional, Shoamanesh, Askan, additional, Cohen, Alexander T, additional, Ladenvall, Per, additional, Connolly, Stuart J, additional, and Demchuk, Andrew M, additional

Published
2023
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22. Prediction of 90 day home time among patients with low baseline ASPECTS undergoing endovascular thrombectomy: results from Alberta's Provincial Stroke Registry (QuICR).

Author

Singh, Nishita, Holodinsky, Jessalyn K., Kashani, Nima, McDonough, Rosalie V., Bala, Fouzi, Horn, MacKenzie, Stang, Jillian, Demchuk, Andrew M., Hill, Michael D., and Almekhlafi, Mohammed A.

Subjects
BLOOD vessels, TIME, RANDOM forest algorithms, REGRESSION analysis, THROMBECTOMY, STROKE patients, QUALITY assurance, DESCRIPTIVE statistics, RESEARCH funding, ENDOVASCULAR surgery, PREDICTION models, COMPUTED tomography
Abstract

Background The benefit of endovascular thrombectomy (EVT) in stroke patients with a low baseline Alberta Stroke Program Early CT Score (ASPECTS, ≤5) is uncertain. We aim to use random forest regression modeling to predict 90 day home time in patients with low ASPECTS. Methods We used the Quality Improvement and Clinical Research (QuICR) provincial stroke registry and administrative data from southern Alberta to identify patients who underwent EVT in our center from July 2015 to November 2020. Baseline ASPECTS on non-contrast CT and CT angiography data were scored by a two physician consensus. The primary outcome was the predicted 90 day home time (the number of nights a patient is back at their premorbid living situation without an increase in level of care within 90 days of the stroke) using random forests regression. Estimates were generated using 200 bootstrapped datasets. Covariate contribution to home time was determined using partial dependence plots. Results Of 657 EVT patients, 85 (12.9%) had baseline ASPECTS ≤5 (mean age 70.9 years, 44.7% women, 93.9% good-moderate collaterals, 60% M1-middle cerebral artery occlusion). Using partial dependence estimates, mean predicted home times were similar in the low ASPECTS (44.3 days) versus higher ASPECTS (43.1) groups. Factors predicting lower 90 day home time in this population were diabetes mellitus (-8.8 days), hypertension (-5.7 days), and atrial fibrillation (-3.6 days). There was no meaningful difference in predicted 90 day home time by sex, baseline National Institutes of Health Stroke Severity Scale score, occlusion site, tandem lesion, collateral grade or thrombolysis. Conclusions Patients with low ASPECTS who are selected for EVT using demographic and clinical profiles similar to higher ASPECTS patients achieved comparable outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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24. Prediction of 90 day home time among patients with low baseline ASPECTS undergoing endovascular thrombectomy: results from Alberta’s Provincial Stroke Registry (QuICR)

Author

Singh, Nishita, primary, Holodinsky, Jessalyn K, additional, Kashani, Nima, additional, McDonough, Rosalie V, additional, Bala, Fouzi, additional, Horn, MacKenzie, additional, Stang, Jillian, additional, Demchuk, Andrew M, additional, Hill, Michael D, additional, and Almekhlafi, Mohammed A, additional

Published
2022
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25. Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Author

Menon, Bijoy K, primary, Buck, Brian H, additional, Singh, Nishita, additional, Deschaintre, Yan, additional, Almekhlafi, Mohammed A, additional, Coutts, Shelagh B, additional, Thirunavukkarasu, Sibi, additional, Khosravani, Houman, additional, Appireddy, Ramana, additional, Moreau, Francois, additional, Gubitz, Gord, additional, Tkach, Aleksander, additional, Catanese, Luciana, additional, Dowlatshahi, Dar, additional, Medvedev, George, additional, Mandzia, Jennifer, additional, Pikula, Aleksandra, additional, Shankar, Jai, additional, Williams, Heather, additional, Field, Thalia S, additional, Manosalva, Alejandro, additional, Siddiqui, Muzaffar, additional, Zafar, Atif, additional, Imoukhuede, Oje, additional, Hunter, Gary, additional, Demchuk, Andrew M, additional, Mishra, Sachin, additional, Gioia, Laura C, additional, Jalini, Shirin, additional, Cayer, Caroline, additional, Phillips, Stephen, additional, Elamin, Elsadig, additional, Shoamanesh, Ashkan, additional, Subramaniam, Suresh, additional, Kate, Mahesh, additional, Jacquin, Gregory, additional, Camden, Marie-Christine, additional, Benali, Faysal, additional, Alhabli, Ibrahim, additional, Bala, Fouzi, additional, Horn, MacKenzie, additional, Stotts, Grant, additional, Hill, Michael D, additional, Gladstone, David J, additional, Poppe, Alexandre, additional, Sehgal, Arshia, additional, Zhang, Qiao, additional, Lethebe, Brendan Cord, additional, Doram, Craig, additional, Ademola, Ayoola, additional, Shamy, Michel, additional, Kenney, Carol, additional, Sajobi, Tolulope T, additional, Swartz, Richard H, additional, Srivastava, Abhilekh, additional, Aljammaz, Ahmed M, additional, Akindotun, Akintomide Femi, additional, Jin, Albert Y, additional, Fraser, Alexander, additional, Khaw, Alexander V, additional, Lemnaru, Alexandru, additional, Southwell, Alisia, additional, Ramji, Alnar, additional, Alvarado-Bolaños, Alonso, additional, Mouminah, Amr, additional, Lahlouh, Amro B, additional, Yu, Amy Y, additional, Alrohimi, Anas, additional, Lavoie, Andre, additional, Rogge, Andrea, additional, Micieli, Andrew, additional, Nguyen, Andrew Linh, additional, Callaghan-Brown, Angelique, additional, Florendo-Cumbermack, Anita, additional, Wadhwa, Ankur, additional, Beaudoin, Ann-Marie, additional, Cayley, Anne, additional, Liddy, Anne Marie, additional, Trivedi, Anurag, additional, Katsanos, Aristeidis H, additional, Shuaib, Ashfaq, additional, Butt, Asif Javed, additional, Bereznyakova, Olena, additional, Beauchamp, Beth, additional, Mahlitz, Breane, additional, Graham, Brett R, additional, Dewar, Brian, additional, Durafourt, Bryce A, additional, Holtby, Caitlin, additional, Jackson-Tarlton, Caitlin S, additional, Bockus, Caitlyn, additional, Stephenson, Caroline, additional, Galloway, Camille, additional, Odier, Céline, additional, Deacon, Charles, additional, Zerna, Charlotte, additional, Vekhande, Chetan C, additional, Bocti, Christian, additional, Stapf, Christian, additional, Hawkes, Christine, additional, Stables, Christine Anne, additional, Bogiatzi, Chrysi, additional, Rodriguez, Claudia, additional, Candale-Radu, Claudia, additional, Murphy, Colleen, additional, Casserly, Courtney Sarah, additional, Fok, Daniel, additional, Boasquevisque, Danielle de Sa, additional, Wile, Daryl, additional, Volders, David, additional, Sahlas, Demetrios J, additional, Shand, Elaine, additional, Cora, Elena Adela, additional, Battista, Eliane Di, additional, Stewart, Eileen, additional, Junk, Emily, additional, Harrison, Emma L, additional, Frenette, Eric, additional, Teleg, Ericka, additional, Abdellah, Eslam, additional, Ghrooda, Esseddeeg, additional, Akthar, Farhana, additional, Evoy, François, additional, Klein, Gary M, additional, Maclean, Genoveva, additional, Jickling, Glen C, additional, Hawthorne, Glenda, additional, Boyd, Gordon, additional, Walker, Gregory, additional, Saposnik, Gustavo, additional, Lau, H Lee, additional, Badr, Hanan E, additional, Toma, Hassanain, additional, Kalashyan, Hayrapet, additional, Marion-Moffet, Hugo, additional, Grant, Ian, additional, Fatakdawala, Idris, additional, Beaulieu-Boire, Isabelle, additional, Williams, Janice, additional, Brar, Jaskiran, additional, Rivest, Jean, additional, Wang, Jeffrey Z, additional, Dawe, Jessica, additional, Stang, Jillian, additional, Day, Joanne, additional, Miller, Jodi, additional, Gorman, Johnathon, additional, Hopyan, Julia Jasmine, additional, Lee, Julian, additional, Kromm, Julie, additional, Foster, Kaitlyn, additional, Ratnayake, Kanchana, additional, Perera, Kanjana S, additional, Murray, Karina Villaluna, additional, Ryckborst, Karla, additional, Lin, Katie, additional, Sage, Kayla, additional, Sivakuma, Keithan, additional, MacDonald, Kelly A, additional, Ng, Kelvin Kuan, additional, Merchant, Ketki, additional, Khan, Khurshid, additional, Ghavami, Kimia, additional, Johnston, Kyra, additional, Mai, Lauren M, additional, White, Leah, additional, Barratt, Lee, additional, Longpre, Linda, additional, Crellin, Lisa, additional, Peeling, Lissa, additional, Piquette, Lori, additional, Lomax, Lysa Boissé, additional, Sadeghi, Mahsa, additional, Kamra, Maneesha, additional, Lavoie-April, Manuel, additional, Moores, Margaret, additional, Bullrich, Maria Bres, additional, McClelland, Marie, additional, Salluzzi, Marina, additional, Wilcox, Mark, additional, Boulos, Mark I, additional, Marko, Martha, additional, Boyko, Matthew, additional, Lantagne-Hurtubise, Maude, additional, AlHamid, May Adel, additional, Shawawrah, Mays, additional, Kelly, Michael E, additional, Thorne, Michael W D, additional, Bussiere, Miguel, additional, Dominc Tse, Ming Yin, additional, Benguzzi, Mowad, additional, Sharma, Mukul, additional, Horton, Myles, additional, Newcommon, Nancy, additional, Simon, Nandy-Shelwine, additional, Parks, Natalie E, additional, Sultan, Nazeem, additional, Markovic, Nevena, additional, Daneault, Nicole, additional, Ishaque, Noman, additional, Fairall, Paige, additional, Kostyrko, Pawel B, additional, Stys, Peter K, additional, Teal, Philip, additional, Couillard, Philippe, additional, King-Azote, Princess, additional, Collier, Quentin, additional, Epp, Rachel, additional, Nair, Radhika, additional, Joundi, Raed A, additional, Jassal, Rajive, additional, Schneider, Raphael, additional, Hosseini, Reza, additional, Bouchard, Rosalie, additional, Whelan, Ruth, additional, Cooley, S Regan, additional, Sujanthan, Sajeevan, additional, Mansoor, Salman, additional, Yip,, Samuel, additional, Wasyliw, Sanchea, additional, Taylor, Sean W., additional, Friedman, Sebastian, additional, Mann, Sharan, additional, Maley, Sharleen Weese, additional, Chiasson, Sherry, additional, Hu, Sherry Xueying, additional, Althubait, Shorog, additional, Himed, Shuhira, additional, Chen, Shuo, additional, Bal, Simerpreet S, additional, Page, Stacey A, additional, Beck, Stacey D, additional, Woodroffe, Stephanie, additional, Reiter, Stephanie D, additional, Gaal, Stephen van, additional, Peters, Steven Ray, additional, Darvesh, Sultan, additional, Save, Supriya, additional, Alcock, Susan, additional, Piercey, Susannah, additional, Adam, Suzie, additional, Gosselin, Sylvie, additional, Fitzpatrick, Tess, additional, Perron, Thomas-Louis, additional, Stewart, Tim, additional, Benstead, Timothy J, additional, Naidoo, Vishaya, additional, Wahab, Wasan Abd, additional, Oczkowski, Wiesław, additional, Kingston, William, additional, Leduc, William, additional, To, William T H, additional, Yu, Yeyao Joe, additional, Liu, Zhongyu A, additional, and Aljundi, Ziad Ezzat, additional

Published
2022
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26. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS

Author

Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Möhlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, and Brehm, Alex

Subjects
Aged, 80 and over, Male, Acute ischemic stroke, Collaterals, Perfusion imaging, Brain Ischemia, Cerebral Angiography, Stroke, Automation, Treatment Outcome, Patient selection, Cerebrovascular Circulation, Reperfusion, Humans, Original Article, Female, Tomography, X-Ray Computed, Vision, Ocular, Automated evaluation, Aged, Retrospective Studies, Thrombectomy
Abstract

Purpose Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3‑month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. Methods This retrospective, multicenter cohort study (2015–2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3‑month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. Results A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3‑month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3‑month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID −3.2 ml. Conclusion Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution. Electronic supplementary material The online version of this article (10.1007/s00062-020-00974-3) contains supplementary material, which is available to authorized users.

Published
2020

27. Safety and Efficacy of Tenecteplase Compared With Alteplase in Patients With Large Vessel Occlusion Stroke: A Prespecified Secondary Analysis of the ACT Randomized Clinical Trial

Author

Bala, Fouzi, Singh, Nishita, Buck, Brian, Ademola, Ayoola, Coutts, Shelagh B., Deschaintre, Yan, Khosravani, Houman, Appireddy, Ramana, Moreau, Francois, Phillips, Stephen, Gubitz, Gord, Tkach, Aleksander, Catanese, Luciana, Dowlatshahi, Dar, Medvedev, George, Mandzia, Jennifer, Pikula, Aleksandra, Shankar, Jai Jai, Williams, Heather, Field, Thalia S., Manosalva Alzate, Alejandro, Siddiqui, Muzaffar, Zafar, Atif, Imoukhoude, Oje, Hunter, Gary, Alhabli, Ibrahim, Benali, Faysal, Horn, MacKenzie, Hill, Michael D., Shamy, Michel, Sajobi, Tolulope T., Swartz, Richard H., Menon, Bijoy K., and Almekhlafi, Mohammed

Abstract

IMPORTANCE: It is unknown whether intravenous thrombolysis using tenecteplase is noninferior or preferable compared with alteplase for patients with acute ischemic stroke. OBJECTIVE: To examine the safety and efficacy of tenecteplase compared to alteplase among patients with large vessel occlusion (LVO) stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a prespecified analysis of the Intravenous Tenecteplase Compared With Alteplase for Acute Ischaemic Stroke in Canada (ACT) randomized clinical trial that enrolled patients from 22 primary and comprehensive stroke centers across Canada between December 10, 2019, and January 25, 2022. Patients 18 years and older with a disabling ischemic stroke within 4.5 hours of symptom onset were randomly assigned (1:1) to either intravenous tenecteplase or alteplase and were monitored for up to 120 days. Patients with baseline intracranial internal carotid artery (ICA), M1-middle cerebral artery (MCA), M2-MCA, and basilar occlusions were included in this analysis. A total of 1600 patients were enrolled, and 23 withdrew consent. EXPOSURES: Intravenous tenecteplase (0.25 mg/kg) vs intravenous alteplase (0.9 mg/kg). MAIN OUTCOMES AND MEASURES: The primary outcome was the proportion of modified Rankin scale (mRS) score 0-1 at 90 days. Secondary outcomes were an mRS score from 0 to 2, mortality, and symptomatic intracerebral hemorrhage. Angiographic outcomes were successful reperfusion (extended Thrombolysis in Cerebral Infarction scale score 2b-3) on first and final angiographic acquisitions. Multivariable analyses (adjusting for age, sex, National Institute of Health Stroke Scale score, onset-to-needle time, and occlusion location) were carried out. RESULTS: Among 1577 patients, 520 (33.0%) had LVO (median [IQR] age, 74 [64-83] years; 283 [54.4%] women): 135 (26.0%) with ICA occlusion, 237 (45.6%) with M1-MCA, 117 (22.5%) with M2-MCA, and 31 (6.0%) with basilar occlusions. The primary outcome (mRS score 0-1) was achieved in 86 participants (32.7%) in the tenecteplase group vs 76 (29.6%) in the alteplase group. Rates of mRS 0-2 (129 [49.0%] vs 131 [51.0%]), symptomatic intracerebral hemorrhage (16 [6.1%] vs 11 [4.3%]), and mortality (19.9% vs 18.1%) were similar in the tenecteplase and alteplase groups, respectively. No difference was noted in successful reperfusion rates in the first (19 [9.2%] vs 21 [10.5%]) and final angiogram (174 [84.5%] vs 177 [88.9%]) among 405 patients who underwent thrombectomy. CONCLUSIONS AND RELEVANCE: The findings in this study indicate that intravenous tenecteplase conferred similar reperfusion, safety, and functional outcomes compared to alteplase among patients with LVO.

Published
2023
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32. Vertebral to Basilar Thrombus Migration Post Intravenous Thrombolysis

Author

Banerjee, Ankur, Marzoughi, Sina, Ohara, Tomoyuki, Horn, MacKenzie, Zerna, Charlotte, Menon, Bijoy K., and Demchuk, Andrew M.

Abstract

ABSTRACT:Recombinant tissue plasminogen activator improves outcomes in acute ischemic stroke. Alteplase may result in thrombus migration (TM) distally to a critical arterial supply that can worsen perfusion to eloquent brain tissue. Alteplase-related stroke recanalization and clot migration in vertebral artery (VA) occlusion whereby the clot migrates to the basilar artery (BA) may be harmful. We identified seven subjects with isolated symptomatic vertebral occlusion. Two cases suffered early neurologic deterioration due to TM from VA to BA following alteplase. Precautionary transfer to thrombectomy centers may be warranted in alteplase-treated symptomatic VA occlusions in case of migration to basilar occlusion.

Published
2023
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35. Abstract 77: Ongoing Leakage Revealed by Second Phase Spot Sign Volume Expansion in Multi-Phase Computed Tomography Angiography Strongly Predicts Intracranial Hemorrhage Growth

Author

Al Sultan, Abdulaziz, primary, Teleg, Ericka, additional, Horn, MacKenzie, additional, Ojha, Piyush, additional, Kasickova, Linda, additional, Marzoughi, Sina, additional, Ohara, Tomoyuki, additional, Banerjee, Ankur, additional, Kulkarni, Girish, additional, Bobyn, Amy, additional, Neweduk, Anneliese, additional, Horn, Kennedy, additional, Rodriguez-Luna, David, additional, Goyal, Mayank, additional, Menon, Bijoy K, additional, and Demchuk, Andrew M, additional

Published
2020
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36. Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, Mackenzie, Al Sultan, Abdulaziz S., Letteri, Federica, Dey, Sadanand, Evans, James, Najm, Mohamed, Puig, Josep, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Goyal, Mayank, Michael Hill, Almekhlafi, Mohammed, Demchuk, Andrew M., and ASİL, Talip

Subjects
Ohara T., Menon B. K. , Al-Ajlan F. S. , Horn M., Al Sultan A. S. , Letteri F., Dey S., Evans J., Najm M., Puig J., et al., -Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions.-, American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium, Hawaii, Amerika Birleşik Devletleri, 6 - 08 Şubat 2019, cilt.50
Published
2019

37. Semi-automatic measurement of intracranial hemorrhage growth on non-contrast CT

Author

Chung, Kevin J, primary, Kuang, Hulin, additional, Federico, Alyssa, additional, Choi, Hyun Seok, additional, Kasickova, Linda, additional, Al Sultan, Abdulaziz Sulaiman, additional, Horn, MacKenzie, additional, Crowther, Mark, additional, Connolly, Stuart J, additional, Yue, Patrick, additional, Curnutte, John T, additional, Demchuk, Andrew M, additional, Menon, Bijoy K, additional, and Qiu, Wu, additional

Published
2019
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38. Semi-automatic measurement of intracranial hemorrhage growth on non-contrast CT.

Author

Chung, Kevin J, Kuang, Hulin, Federico, Alyssa, Choi, Hyun Seok, Kasickova, Linda, Al Sultan, Abdulaziz Sulaiman, Horn, MacKenzie, Crowther, Mark, Connolly, Stuart J, Yue, Patrick, Curnutte, John T, Demchuk, Andrew M, Menon, Bijoy K, and Qiu, Wu

Subjects
HEMORRHAGE, INTRACLASS correlation, IMAGE databases
Abstract

Background: Manual segmentations of intracranial hemorrhage on non-contrast CT images are the gold-standard in measuring hematoma growth but are prone to rater variability. Aims: We demonstrate that a convex optimization-based interactive segmentation approach can accurately and reliably measure intracranial hemorrhage growth. Methods: Baseline and 16-h follow-up head non-contrast CT images of 46 subjects presenting with intracranial hemorrhage were selected randomly from the ANNEXA-4 trial imaging database. Three users semi-automatically segmented intracranial hemorrhage to measure hematoma volume for each timepoint using our proposed method. Segmentation accuracy was quantitatively evaluated compared to manual segmentations by using Dice similarity coefficient, Pearson correlation, and Bland–Altman analysis. Intra- and inter-rater reliability of the Dice similarity coefficient and intracranial hemorrhage volumes and volume change were assessed by the intraclass correlation coefficient and minimum detectable change. Results: Among the three users, the mean Dice similarity coefficient, Pearson correlation, and mean difference ranged from 76.79% to 79.76%, 0.970 to 0.980 (p < 0.001), and −1.5 to −0.4 ml, respectively, for all intracranial hemorrhage segmentations. Inter-rater intraclass correlation coefficients between the three users for Dice similarity coefficient and intracranial hemorrhage volume were 0.846 and 0.962, respectively, and the corresponding minimum detectable change was 2.51 ml. Inter-rater intraclass correlation coefficient for intracranial hemorrhage volume change ranged from 0.915 to 0.958 for each user compared to manual measurements, resulting in an minimum detectable change range of 2.14 to 4.26 ml. Conclusions: We spatially and volumetrically validate a novel interactive segmentation method for delineating intracranial hemorrhage on head non-contrast CT images. Good spatial overlap, excellent volume correlation, and good repeatability suggest its usefulness for measuring intracranial hemorrhage volume and volume change on non-contrast CT images. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Abstract WP62: Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy

Author

Al Sultan, Abdulaziz S, primary, Al-Ajlan, Fahad S, additional, Najm, Mohammed, additional, Casault, Colin, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Field, Thalia S, additional, Puig, Josep, additional, Castellanos, Mar, additional, Dowlatshahi, Dar, additional, Sohn, Sung-II, additional, Ahn, Seong H, additional, Poppe, Alex, additional, Mikulik, Robert, additional, Asdaghi, Negar, additional, Boulanger, Jean-Martin, additional, Asil, Talip, additional, Calleja, Ana I, additional, Goyal, Mayank, additional, Hill, Michael D, additional, Demchuk, Andrew M, additional, and Menon, Bijoy K, additional

Published
2018
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40. Abstract TP64: Visual Perception, Cognition, and Non-Contrast CT Aspects

Author

Wilson, Alexis T, primary, Dey, Sadanand, additional, Evans, James, additional, Tham, Carol, additional, Assis, Zarina, additional, Teleg, Ericka, additional, Pordeli, Pooneh, additional, Eswaradass, Prasanna, additional, van Gaal, Stephen, additional, Najm, Mohamed, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Kuang, Hulin, additional, Hafeez, Moiz, additional, Qiu, Wu, additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, Hill, Michael D, additional, and Menon, Bijoy, additional

Published
2018
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41. Abstract WP55: Through Thick and Thin: Improved Aspects Grading and Dense Vessel Detection Using Simple Ncct Post-processing

Author

Evans, James W, primary, Dey, Sadanand, additional, Eesa, Muneer, additional, Eswaradass, Prasanna, additional, Lun, Ronda, additional, Horn, MacKenzie, additional, Neweduk, Anneliese, additional, Mcdougall, Brooklyn, additional, Pordeli, Pooneh, additional, Jayaraman, Mahesh V, additional, McTaggart, Ryan A, additional, Najm, Mohamed, additional, Goyal, Mayank, additional, Demchuk, Andrew M, additional, and Menon, Bijoy K, additional

Published
2017
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42. Abstract TP51: When Can Aspects be Read Reliably?

Author

Dey, Sadanand, primary, Evans, James, additional, Tham, Carol, additional, Assis, Zarina, additional, Teleg, Ericka, additional, Pordeli, Pooneh, additional, Eswaradass, Prasanna, additional, Najm, Mohamed, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, and Menon, Bijoy, additional

Published
2017
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43. Co-localization of NCCT hypodensity and CTA spot sign predicts substantial intracerebral hematoma expansion: The Black-&-White sign

Author

Pensato, Umberto, Tanaka, Koji, Horn, MacKenzie, Teleg, Ericka, Al Sultan, Abdulaziz Sulaiman, Kasickova, Linda, Ohara, Tomoyuki, Ojha, Piyush, Marzoughi, Sina, Banerjee, Ankur, Kulkarni, Girish, Dowlatshahi, Dar, Goyal, Mayank, Menon, Bijoy K., and Demchuk, Andrew M.

Abstract

Background: Existing radiological markers of hematoma expansion (HE) show modest predictive accuracy. We aim to investigate a novel radiological marker that co-localizes findings from non-contrast CT (NCCT) and CT angiography (CTA) to predict HE.Methods: Consecutive acute intracerebral hemorrhage patients admitted at Foothills Medical Centre in Calgary, Canada, were included. The Black-&-White sign was defined as any visually identified spot sign on CTA co-localized with a hypodensity sign on the corresponding NCCT. The primary outcome was hematoma expansion (⩾6 mL or ⩾33%). Secondary outcomes included absolute (<3, 3–6, 6–12, ⩾12 mL) and relative (0%, <25%, 25%–50%, 50%–75%, or >75%) hematoma growth scales.Results: Two-hundred patients were included, with 50 (25%) experiencing HE. Forty-four (22%) showed the spot sign, 69 (34.5%) the hypodensity sign, and 14 (7%) co-localized both as the Black-&-White sign. Those with the Black-&-White sign had higher proportions of HE (100% vs 19.4%, p< 0.001), greater absolute hematoma growth (23.37 mL (IQR = 15.41–30.27) vs 0 mL (IQR = 0–2.39), p< 0.001) and relative hematoma growth (120% (IQR = 49–192) vs 0% (0–15%), p< 0.001). The Black-&-White sign had a specificity of 100% (95%CI = 97.6%–100%), a positive predictive value of 100% (95%CI = 76.8%–100%), and an overall accuracy of 82% (95%CI = 76%–87.1%). Among the 14 patients with the Black-&-White sign, 13 showed an absolute hematoma growth ⩾12 mL, and 10 experienced a HE exceeding 75% of the initial volume. The inter-rater agreement was excellent (kappa coefficient = 0.84).Conclusion: The Black-&-White sign is a robust predictor of hematoma expansion occurrence and severity, yet further validation is needed to confirm these compelling findings.

Published
2024
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44. Favorable Clot Characteristics Predict Smaller Infarct Volume in Acute Ischemic Stroke Patients Treated With Reperfusion Therapy

Author

Al Sultan, Abdulaziz S., Al-Ajlan, Fahad S., Najm, Mohammed, Casault, Colin, Neweduk, Anneliese, Horn, Mackenzie, Field, Thalia S., Puig, Josep, Castellanos, Mar, Dowlatshahi, Dar, Sohn, Sung-Ii, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Boulanger, Jean-Martin, Asil, Talip, Calleja, Ana I., Goyal, Mayank, Michael Hill, Demchuk, Andrew M., and Menon, Bijoy K.

45. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS Has the Machine Surpassed the Eye?

Author

Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Moehlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, Brehm, Alex, Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Moehlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, and Brehm, Alex

Abstract

Purpose Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3-month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. Methods This retrospective, multicenter cohort study (2015-2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3-month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. Results A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3-month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3-month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID -3.2 ml. Conclusion Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution.

46. Automated Perfusion Calculations vs. Visual Scoring of Collaterals and CBV-ASPECTS Has the Machine Surpassed the Eye?

Author

Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Moehlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, Brehm, Alex, Psychogios, Marios-Nikos, Sporns, Peter B., Ospel, Johanna, Katsanos, Aristeidis H., Kabiri, Reza, Flottmann, Fabian A., Menon, Bijoy K., Horn, Mackenzie, Liebeskind, David S., Honda, Tristan, Ribo, Marc, Ruiz, Manuel Requena, Kabbasch, Christoph, Lichtenstein, Thorsten, Maurer, Christoph J., Berlis, Ansgar, Hellstern, Victoria, Henkes, Hans, Moehlenbruch, Markus A., Seker, Fatih, Ernst, Marielle S., Liman, Jan, Tsivgoulis, Georgios, and Brehm, Alex

Abstract

Purpose Use of automated perfusion software has gained importance for imaging of stroke patients for mechanical thrombectomy (MT). We aim to compare four perfusion software packages: 1) with respect to their association with 3-month functional outcome after successful reperfusion with MT in comparison to visual Cerebral Blood Volume - Alberta Stroke Program Early CT Score (CBV-ASPECTS) and collateral scoring and 2) with respect to their agreement in estimation of core and penumbra volume. Methods This retrospective, multicenter cohort study (2015-2019) analyzed data from 8 centers. We included patients who were functionally independent before and underwent successful MT of the middle cerebral artery. Primary outcome measurements were the relationship of core and penumbra volume calculated by each software, qualitative assessment of collaterals and CBV-APECTS with 3-month functional outcome and disability (modified Rankin scale >2). Quantitative differences between perfusion software measurements were also assessed. Results A total of 215 patients (57% women, median age 77 years) from 8 centers fulfilled the inclusion criteria. Multivariable analyses showed a significant association of RAPID core (common odds ratio, cOR 1.02; p = 0.015), CBV-ASPECTS (cOR 0.78; p = 0.007) and collaterals (cOR 0.78; p = 0.001) with 3-month functional outcome (shift analysis), while RAPID core (OR 1.02; p = 0.018), CBV-ASPECTS (OR 0.77; p = 0.024), collaterals (OR 0.78; p = 0.007) and OLEA core (OR 1.02; p = 0.029) were significantly associated with 3-month functional disability. Mean differences on core estimates between VEOcore and RAPID were 13.4 ml, between syngo.via and RAPID 30.0 ml and between OLEA and RAPID -3.2 ml. Conclusion Collateral scoring, CBV-ASPECTS and RAPID were independently associated with functional outcome at 90 days. Core and Penumbra estimates using automated software packages varied significantly and should therefore be used with caution.

47. The treatment effect across ASPECTS in acute ischemic stroke: Analysis from the AcT trial.

Author

Kaveeta, Chitapa, Alhabli, Ibrahim, Bala, Fouzi, Horn, MacKenzie, Benali, Faysal, Coutts, Shelagh B, Zafar, Atif, Bereznyakova, Olena, Khaw, Alexander, Khosravani, Houman, Hunter, Gary, Tkach, Aleksander, Dowlatshahi, Dar, Catanese, Luciana, Bogiatzi, Chrysi, Appireddy, Ramana, Buck, Brian H, Swartz, Richard H, Sajobi, Tolulope T, and Almekhlafi, Mohammed

Subjects
*ISCHEMIC stroke, *STROKE, *ENDOVASCULAR surgery, *CEREBRAL hemorrhage, *TREATMENT effectiveness
Abstract

Early ischemic changes on baseline imaging are commonly evaluated for acute stroke decision-making and prognostication.We assess the association of early ischemic changes on clinical outcomes and whether it differs between intravenous tenecteplase and Alteplase.Data are from the phase 3, Alteplase compared to Tenecteplase (AcT) trial. Subjects with anterior circulation stroke were included. Early ischemic changes were assessed using the Alberta Stroke Program Early CT score (ASPECTS). Efficacy outcomes included modified Rankin scale (mRS) 0–1, mRS 0–2, and ordinal mRS at 90 days. Safety outcomes included 24-h symptomatic intracerebral hemorrhage (sICH), any hemorrhage on follow-up scan, and 90-day mortality rate. Mixed-effects logistic regression was used to assess the association of ASPECTS (continuous and categorical (0–4 vs 5–7 vs 8–10)) with outcomes and if these associations were modified by thrombolytic type after adjusting for age, sex, and baseline stroke severity.Of the 1577 patients in the trial, 901 patients (56.3%; median age 75 years (IQR 65–84), 50.8% females, median National Institute of Health Stroke Scale (NIHSS) 14 (IQR 17–19)) with anterior circulation stroke were included. mRS 0–1 at 90 days was achieved in 1/14 (0.3%), 43/160 (14.7%), and 252/726 (85.1%) in the ASPECTS 0–4, 5–7, and 8–10 groups respectively. Every one-point decrease in ASPECTS was associated with 2.7% and 1.9% decrease in chances of mRS 0–1 and mRS 0–2 at 90 days, respectively, and 1.9% chances of increase in mortality at 90 days. Subgroup analysis in endovascular thrombectomy (EVT)-treated population showed similar results. Thrombolytic type did not modify this association between ASPECTS and 90-day mRS 0–1 (P-interaction 0.75). There was no significant interaction by thrombolytic type with any other outcomes.Similar to prior studies, we found that every one-point decrease in ASPECTS was associated with poorer clinical and safety outcomes. This effect did not differ between alteplase and tenecteplase.Data shall made available on reasonable request from the PI (BMM). [ABSTRACT FROM AUTHOR]

Published
2024
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48. Timing of Spot Sign Appearance, Spot Sign Volume, and Leakage Rate among Phases of Multiphase CTA Predict Intracerebral Hemorrhage Growth.

Author

Horn M, Teleg E, Tanaka K, Al Sultan A, Kasickova L, Ohara T, Ojha P, Wasyliw S, Marzoughi S, Banerjee A, Kulkarni G, Horn K, Bobyn A, Neweduk A, Singh N, Qiu W, Rodriguez-Luna D, Dowlatshahi D, Goyal M, Menon BK, and Demchuk AM

Subjects
Humans, Male, Female, Aged, Retrospective Studies, Middle Aged, Hematoma diagnostic imaging, Computed Tomography Angiography methods, Aged, 80 and over, Cerebral Angiography methods, Disease Progression, Predictive Value of Tests, Cerebral Hemorrhage diagnostic imaging
Abstract

Background and Purpose: The presence of spot sign is associated with a high risk of hematoma growth. Our aim was to investigate the timing of the appearance, volume, and leakage rate of the spot sign for predicting hematoma growth in acute intracerebral hemorrhage using multiphase CTA., Materials and Methods: In this single-center retrospective study, multiphase CTA in 3 phases was performed in acute intracerebral hemorrhage (defined as intraparenchymal ± intraventricular hemorrhages). Phases of the spot sign first appearance, spot sign volumes (microliter), and leakage rates among phases (microliter/second) were measured. Associations between baseline clinical and imaging variables including spot sign volume parameters (volume and leakage rate divided by median) and hematoma growth (>6 mL) were investigated using regression models. Receiver operating characteristic analysis was used as appropriate., Results: Two hundred seventeen patients (131 men; median age, 70 years) were included. The spot sign was detected in 21.7%, 30.0%, and 29.0% in the first, second, and third phases, respectively, with median volumes of 19.7, 31.4, and 34.8 μl in these phases. Hematoma growth was seen in 44 patients (20.3%). By means of modeling, the following variables, namely the spot sign appearing in the first phase, first phase spot sign volume, spot sign appearing in the second or third phase, and spot sign positive and negative leakage rates, were associated with hematoma growth. Among patients with a spot sign, the absolute leakage rate accounting for both positive and negative leakage rates was also associated with hematoma growth (per 1-μl/s increase; OR, 1.26; 95% CI, 1.04-1.52). Other hematoma growth predictors were stroke history, baseline NIHSS score, onset-to-imaging time, and baseline hematoma volume (all P values < .05)., Conclusions: The timing of the appearance of the spot sign, volume, and leakage rate were all associated with hematoma growth. Development of automated software to generate these spot sign volumetric parameters would be an important next step to maximize the potential of temporal intracerebral hemorrhage imaging such as multiphase CTA for identifying those most at risk of hematoma growth., (© 2024 by American Journal of Neuroradiology.)

Published
2024
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49. Tenecteplase Versus Alteplase in Medium Vessel Occlusion Ischemic Stroke: A Secondary Analysis of the Alteplase Compared to Tenecteplase Randomized Trial.

Author

Bala F, Singh N, Ignacio K, Alhabli I, Ademola A, Alrohimi A, Khosravani H, Tkach A, Catanese L, Dowlatshahi D, Field T, Hunter G, Benali F, Horn M, Demchuk A, Hill M, Sajobi T, Buck B, Swartz R, Almekhlafi M, and Menon BK

Abstract

Background and Purpose: The safety and efficacy of tenecteplase in patients with ischemic stroke due to medium vessel occlusion (MeVO) are not well studied. We aimed to compare tenecteplase with alteplase in stroke due to MeVO., Methods: Patients with baseline M2-middle cerebral artery (MCA), M3/M4-MCA, P2/P3/P4-posterior cerebral artery (PCA), A2/A3/A4-anterior cerebral artery (ACA) occlusions from the Alteplase Compared to Tenecteplase (AcT) trial were included. Primary outcome was the proportion of 90-day modified Rankin Scale (mRS) 0-1. Secondary outcomes were 90-day mRS 0-2, ordinal mRS, mortality, quality of life measures (EuroQol 5-Dimension 5-Level, EuroQol visual analog scale), and symptomatic intracerebral hemorrhage (sICH). Initial and final successful reperfusion were reported in patients undergoing endovascular thrombectomy (EVT)., Results: Among 1,558 patients with available baseline computed tomography angiography; 455 (29.2%) had MeVO of which 27.5% (125/455) were proximal M2; 16.3% (74/455) were distal M2; 35.2% (160/455) were M3/M4; 7.5% (34/455) were A2/A3/A4; and 13.6% (62/455) were P2/P3/P4 occlusions. EVT was performed in 87/455 (19.1%) patients. mRS 0-1 at 90 days was achieved in 37.9% in the tenecteplase versus 34.7% in the alteplase group (adjusted risk ratio [aRR] 1.07; 95% confidence interval [CI] 0.91-1.25). Rates of 90-day mRS 0-2, sICH, and mortality were similar in both groups. No statistical difference was noted in initial successful reperfusion rates (13.0% vs. 7.5%) among the 87 patients who underwent endovascular thrombectomy. However, final successful reperfusion was higher in the tenecteplase group (71.7% vs. 60.0%, aRR 1.29, 95% CI 1.04-1.61)., Conclusion: Intravenous tenecteplase had comparable safety, functional outcomes and quality of life compared to intravenous alteplase among patients with MeVO. Among those treated with EVT, tenecteplase was associated with higher successful reperfusion rates than alteplase.

Published
2024
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50. Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial.

Author

Bala F, Almekhlafi M, Singh N, Alhabli I, Ademola A, Coutts SB, Deschaintre Y, Khosravani H, Appireddy R, Moreau F, Phillips S, Gubitz G, Tkach A, Catanese L, Dowlatshahi D, Medvedev G, Mandzia J, Pikula A, Shankar J, Williams H, Field TS, Manosalva A, Siddiqui M, Zafar A, Imoukhoude O, Hunter G, Benali F, Horn M, Hill MD, Shamy M, Sajobi TT, Buck BH, Swartz RH, Menon BK, and Poppe AY

Subjects
Humans, Constriction, Pathologic, Fibrinolytic Agents adverse effects, Tenecteplase therapeutic use, Thrombectomy methods, Tissue Plasminogen Activator adverse effects, Treatment Outcome, Arterial Occlusive Diseases, Brain Ischemia therapy, Endovascular Procedures methods, Stroke therapy
Abstract

Background: Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15-20% of acute stroke with large vessel occlusion., Aims: We investigated the safety and efficacy of intravenous tenecteplase (0.25 mg/kg) versus intravenous alteplase (0.9 mg/kg) in patients with carotid TL., Methods: This is a substudy of the alteplase compared with the tenecteplase trial. Patients with ⩾70% stenosis of the extracranial internal carotid artery (ICA) and concomitant occlusion of the intracranial ICA, M1 or M2 segments of the middle cerebral artery on baseline computed tomography angiography (CTA) were included. Primary outcome was 90-day-modified Rankin Scale (mRS) 0-1. Secondary outcomes were mRS 0-2, mortality, and symptomatic ICH (sICH). Angiographic outcomes were successful recanalization (revised Arterial Occlusive Lesion (rAOL) 2b-3) on first and successful reperfusion (eTICI 2b-3) on final angiographic acquisitions. Multivariable mixed-effects logistic regression was performed., Results: Among 1577 alteplase versus tenecteplase randomized controlled trial (AcT) patients, 128 (18.8%) had carotid TL. Of these, 93 (72.7%) underwent intravenous thrombolysis plus endovascular thrombectomy (IVT + EVT), while 35 (27.3%) were treated with IVT alone. In the IVT + EVT group, tenecteplase was associated with higher odds of 90-day-mRS 0-1 (46.0% vs. 32.6%, adjusted OR (aOR) 3.21; 95% CI = 1.06-9.71) compared with alteplase. No statistically significant differences in rates of mRS 0-2 (aOR 1.53; 95% CI = 0.51-4.55), initial rAOL 2b-3 (16.3% vs. 28.6%), final eTICI 2b-3 (83.7% vs. 85.7%), and mortality (18.0% vs. 16.3%) were found. SICH only occurred in one patient. There were no differences in outcomes between thrombolytic agents in the IVT-only group., Conclusion: In patients with carotid TL treated with EVT, intravenous tenecteplase may be associated with similar or better clinical outcomes, similar angiographic reperfusion rates, and safety outcomes as compared with alteplase., Competing Interests: Declaration of conflicting interestsThe author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: A.Y.P. is the Principal investigator of the EASI-TOC trial of carotid stenting, partially funded by Stryker, Brain Canada, Heart and Stroke Foundation of Canada, and the Canadian Stroke Consortium and is in the advisory board of and receives speaker honoraria from Roche Canada. Other authors report no conflict of interest.

Published
2024
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