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1. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Author

Horlein, Andreas J., Naar, Anders M., Heinzel, Thorsten, Torchia, Joseph, Gloss, Bernd, Kurokawa, Riki, Ryan, Aimee, Kamei, Yasutomi, Soderstrom, Mats, Glass, Christopher K., and Rosenfeld, Michael G.

Subjects
Hormone receptors -- Research, Genetic regulation -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Thyroid-hormone and retinoic-acid receptors, attached to the retinoid-X receptor as heterodimers to cognate DNA positions, mediate ligand-independent transcriptional repression by effecting both positive and negative gene expression when their ligands are present or absent. A 270 K protein, named the nuclear receptor co-repressor, mediates ligand-independent transcriptional repression similar to the processes in yeast and Drosophila.

Published
1995

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