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49 results on '"Horkay, Irén"'

9. Multiplex actinicus keratosisok kezelése

Author

Gellén, Emese, Szima, Georgina Zita, Rácz, Anita, Szödényi, Annamária, Hegedűs, Csaba, and Horkay, Irén

Subjects
Orvostudományok, Klinikai orvostudományok
Abstract

LB

Published
2017

10. Childhood-onset mild cutaneous porphyria with compound heterozygotic mutations in the uroporphyrinogen decarboxylase gene

Author

Remenyik, Éva, Lecha, M., Badenas, C., Kószó, Ferenc, Vass, V., Herrero, C., To-Figueras, J., Varga, Viktória, Emri, Gabriella, Balogh, A., and Horkay, Irén

Subjects
Adult, Male, Porphyria Cutanea Tarda, Hypertrichosis, Heterozygote, medicine.medical_specialty, Adolescent, Uroporphyrinogen III decarboxylase, Hepatitis C virus, DNA Mutational Analysis, Mutation, Missense, Dermatology, Klinikai orvostudományok, medicine.disease_cause, Compound heterozygosity, Internal medicine, medicine, Humans, Uroporphyrinogen Decarboxylase, Missense mutation, Child, Mutation, business.industry, Orvostudományok, medicine.disease, Hyperpigmentation, Pedigree, Endocrinology, Porphyria, Female, medicine.symptom, business
Abstract

Summary Three children (two boys and one girl) from the same family presented with photosensitivity, hyperpigmentation, hypertrichosis, mild skin fragility, blistering and scarring in childhood. On examination, the cutaneous lesions were found to have improved since their previous examinations. Laboratory tests showed raised plasma and urine carboxyporphyrins and decreased uroporphyrinogen decarboxylase enzyme activity in red blood cells. Triggering factors for porphyria were not detected except for a hepatitis C virus infection in the younger boy. The girl's clinical symptoms recurred in late adolescence, after iron and oestrogen treatments. Mutation analysis of the UROD gene detected two missense mutations, 19 AG M1V (novel) and 703CT P235S (previously reported), in an uncommon compound heterozygous manner in the three siblings.

Published
2008
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13. Corrigendum to 'Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future therapeutic potential' [J. Photochem. Photobiol. B: Biol. 129 (2013) 93?99]

Author

Boros, Gábor, Miko, Edit, Muramatsu, Hiromi, Weissman, Drew, Emri, Eszter, Rózsa, Dávid, Nagy, Georgina, Juhász, Attila, Juhász, István, van der Horst, Gijsbertus, Horkay, Irén, Remenyik, Éva, Karikó, Katalin, Emri, Gabriella, Paraghné dr. Remenyik Éva (1956-) (bőrgyógyász, allergológus, kozmetológus), Bőrgyógyászati Klinika -- 8, ÁOK -- OEC, and Debreceni Egyetem

Subjects
Egészség- és Környezettudomány, idegen nyelvű folyóiratközlemény külföldi lapban
Published
2014

18. Identification of Cyclobutane Pyrimidine Dimer-Responsive Genes Using UVB-Irradiated Human Keratinocytes Transfected with In Vitro-Synthesized Photolyase mRNA

Author

Boros, Gábor, primary, Miko, Edit, additional, Muramatsu, Hiromi, additional, Weissman, Drew, additional, Emri, Eszter, additional, van der Horst, Gijsbertus T. J., additional, Szegedi, Andrea, additional, Horkay, Irén, additional, Emri, Gabriella, additional, Karikó, Katalin, additional, and Remenyik, Éva, additional

Published
2015
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19. Photodermatosisok gyermekkorban

Author

Horkay, Irén, Emri, Gabriella, Varga, Viktória, and Remenyik, Éva

Subjects
Orvostudományok, Klinikai orvostudományok
Abstract

LB

Published
2008

22. A fotodermatológia 15 éve

Author

Horkay, Irén, Emri, Gabriella, Simics, Enikő, Varga, Viktória, and Remenyik, Éva

Subjects
Orvostudományok, Elméleti orvostudományok
Abstract

LB

Published
2007

23. Magreceptorok

Author

Remenyik, Éva, Töröcsik, Dániel, Balogh, Attila, Paragh, György, Dózsa, Anikó, Beke, Lívia, Markó, Lóránt, Emri, Gabriella, and Horkay, Irén

Subjects
Orvostudományok, Elméleti orvostudományok
Abstract

LB

Published
2007

25. A melaninpigmentáció patofiziológiája

Author

Remenyik, Éva, Emri, Gabriella, Balogh, Attila, Bégány, Ágnes, Hunyadi, János, and Horkay, Irén

Subjects
Orvostudományok, Klinikai orvostudományok
Abstract

LB

Published
2005

26. Effects of non-toxic zinc exposure on human epidermal keratinocytes

Author

Emri, Eszter, primary, Miko, Edit, additional, Bai, Péter, additional, Boros, Gábor, additional, Nagy, Georgina, additional, Rózsa, Dávid, additional, Juhász, Tamás, additional, Hegedűs, Csaba, additional, Horkay, Irén, additional, Remenyik, Éva, additional, and Emri, Gabriella, additional

Published
2015
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29. Porphyria cutanea tarda és hepatitis C-vírus

Author

Emri, Gabriella, Tornai, István, Pósán, Emőke, Seszták, Tímea, Varga, Viktória, and Horkay, Irén

Subjects
Orvostudományok, Klinikai orvostudományok
Published
2001

34. Corrigendum to “Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future therapeutic potential” [J. Photochem. Photobiol. B: Biol. 129 (2013) 93–99]

Author

Boros, Gábor, primary, Miko, Edit, additional, Muramatsu, Hiromi, additional, Weissman, Drew, additional, Emri, Eszter, additional, Rózsa, Dávid, additional, Nagy, Georgina, additional, Juhász, Attila, additional, Juhász, István, additional, van der Horst, Gijsbertus, additional, Horkay, Irén, additional, Remenyik, Éva, additional, Karikó, Katalin, additional, and Emri, Gabriella, additional

Published
2014
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49. [The role of free radicals in the UV-induced skin damage. Photo-aging].

Author

Emri G, Horkay I, and Remenyik E

Subjects
Antioxidants therapeutic use, DNA Damage, Free Radicals immunology, Free Radicals radiation effects, Humans, Lipid Peroxidation, Skin Neoplasms immunology, Skin Neoplasms metabolism, Skin Neoplasms prevention & control, Free Radicals metabolism, Skin metabolism, Skin radiation effects, Skin Aging radiation effects, Skin Neoplasms etiology, Ultraviolet Rays adverse effects
Abstract

The natural (intrinsic) ageing of the skin is enhanced by environmental factors (extrinsic ageing). One of the most important exogenous factors is the solar UV exposure, which results in photo-aging. Besides this, epidemiological and experimental data show a rapid increase in the incidence of human skin cancers, which is also in relation to the increased sunlight exposure of the skin. In the background of these processes there are cell biological effects, photochemical reactions, membrane receptor changes, lipid- and protein modifications, DNA-damage induced by UV. The qualities and quantities of them are wavelength dependent. The UVB photons are absorbed mostly by the DNA of the epidermal keratinocytes, therefore this spectrum is more relevant for photocarcinogenesis. The effect of UVA-irradiation is mainly manifested in the induction of free radicals, which have not only DNA-damaging, but also immunomodulating effect, which also can influence on tumour development. Furthermore, the free radicals cause dermal connective tissue damage as well via activating transcription factors, inducing matrix metalloproteinases, diminishing the procollagen I and fibrillin-1 synthesis. These processes are augmented by mitochondrial DNA mutations, protein oxidation, apoptosis induction. Therefore the enzymes neutralising free radicals and antioxidant molecules, respectively, have an important role in the defence mechanisms. In the therapy of photo-aging the local retinoids lived up to expectations, but the clinical effectiveness of antioxidant vitamins is lower than expected. The most important factor in the prevention of the photo-aging and photocarcinogenesis is the sun protection at present.

Published
2006

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