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6. Abstracts Of Selected Papers Presented At The 75Th General Meeting Of The Japanese Society Of Gastroenterology March 27–29, 1989 — Yokohama, Japan

Author

Tanabe, Satoshi, Saigenji, Katsunori, Asaki, Shigeru, Sato, Akira, Takeda, Isao, Nakano, Satoshi, Inoue, Yoshihiro, Kano, Atsushi, Shiina, Yasubumi, Miwa, Takeshi, Takahashi, Hiroshi, Namatame, Kimio, Sugawa, C., Nakamura, R., Uchida, Hideichi, Kodama, Tadashi, Oka, Shinji, Okazaki, Yukinori, Sato, Nobuhiro, Ogihara, Tatsuo, Niwa, Yasumasa, Nakazawa, Saburo, Azuumi, Yoshiteru, Saigenji, Katsunori, Saito, Yutaka, Sato, Kunio, Iwasaki, Ariyoshi, Abe, Masanao, Miyairi, Mamoru, Suyama, Kyoichiro, Hayakawa, Tetsuo, Suzuki, Toshiyuki, Miyake, Hirofumi, Ochi, Koji, Wakasugi, Hideyuki, Funakoshi, Akihiro, Nakano, Satoshi, Sugiyama, Keiichi, Manabe, Tadao, Baba, Nobuo, Yamamoto, Masahiro, Saitoh, Yoichi, Tamura, Kazutami, Fukuda, Yoshihiro, Sakaki, Nobuhiro, Ietomi, Katsuyuki, Yamada, Masahiro, Ohkusa, Toshifumi, Takahashi, Shinichi, Saito, Shozo, Satoh, Kiichi, Kimura, Ken, Ito, Shigeji, Kohli, Yoshihiro, Koyama, S., Bamba, T., Takagi, A., Kojima, K., Sugiyama, T., Yabana, T., Tada, Masahiro, Shigeeda, Masaki, Yoshida, M., Imoto, I., Hashiguchi, Takafumi, Shibue, Tadashi, Saita, Hiroshi, Murakami, Motonobu, Tsujii, Masahiko, Kawano, Sunao, Shirai, Takayuki, Harasawa, Shigeru, Yamamoto, Tomikazu, Nishio, Akiyoshi, Saeki, Susumu, Oh, Toumei, Tatsuta, Masaharu, Ishii, Hiroyasu, Nishiwaki, Hideki, Satake, Katsusuke, Matsuzaki, Yasushi, Tanaka, Naomi, Knakano, Akira, Fukushima, Tsuneo, Horiuchi, I., Kajiyama, G., Saito, Hideaki, Morioka, Yasuhiko, Miura, Soichiro, Yoshioka, Masahiro, and Takahashi, Naomi

Published
1991
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14. The spectrum and parental origin of de novo mutations of methyl-CpG-binding protein 2 gene (MECP2) in Rett syndrome

Author

Kondo, I., Morishita, R., Fukuda, T., Obata, K., Matsuishi, T., Yamashita, Y., Kuwajima, K., Horiuchi, I., and Omori, I.

Subjects
Genetic disorders -- Research, Syndromes -- Genetic aspects, Rett syndrome -- Genetic aspects, Autism -- Genetic aspects, Speech disorders -- Genetic aspects, Seizures (Medicine) -- Genetic aspects, X chromosome -- Abnormalities, Gene mutations -- Physiological aspects, Carrier proteins -- Research, Cytochemistry -- Research, Biological sciences
Published
2000

18. Tetramethylbenzidine method for monitoring the free available chlorine and microbicidal activity of chloritebased sanitizers under organic-matter-rich environments.

Author

Yamaoka, H., Nakayama‐Imaohji, H., Horiuchi, I., Yamasaki, H., Nagao, T., Fujita, Y., Maeda, H., Goda, H., and Kuwahara, T.

Subjects
BIOLOGICAL monitoring, CHLORINE, BACTERICIDES, DISINFECTION & disinfectants, SANITATION, FOOD chemistry
Abstract

Chlorine is a principal disinfectant for food and environmental sanitation. Monitoring of free available chlorine (FAC) is essential for ensuring the efficacy of food disinfection processes that rely on chlorine. N,N-diethyl-pphenylenediamine (DPD) is commonly used for FAC monitoring. However, here, we show that upon contact with bovine serum albumin (BSA) or broiler carcasses, chlorite (HClO2)-based sanitizers acquire a pink colour, which can interfere with measurement of oxidized DPD absorbance at 513-550 nm. Alternatively, the pink colour did not interfere with 3,3',5,5'- tetramethylbenzidine (TMB)-based FAC monitoring. The FAC levels of NaClO and weakly acidified chlorous acid water (WACAW) were first adjusted by the TMB method and the killing activity of these sanitizers towards methicillinresistant Staphylococcus aureus (MRSA) and feline calicivirus (FCV) was compared in the presence or absence of 0.5% BSA. At 200 ppm FAC, NaClO lost its bactericidal activity against MRSA after 10-min incubation with 0.5% BSA. Meanwhile, under the same conditions WACAW reduced the number of bacteria to below the detection limit. Similar results were obtained with FCV, indicating that the chlorite-based WACAW sanitizer is relatively stable under organicmatter- rich conditions. Moreover, TMB is suitable for in situ FAC monitoring of chlorite-based sanitizers in food and environmental disinfection processes. [ABSTRACT FROM AUTHOR]

Published
2016
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24. IL-12 Production Induced byAgaricus blazeiFraction H (ABH) Involves Toll-like Receptor (TLR)

Author

Kasai, H., primary, He, L. M., additional, Kawamura, M., additional, Yang, P. T., additional, Deng, X. W., additional, Munkanta, M., additional, Yamashita, A., additional, Terunuma, H., additional, Hirama, M., additional, Horiuchi, I., additional, Natori, T., additional, Koga, T., additional, Amano, Y., additional, Yamaguchi, N., additional, and Ito, M., additional

Published
2004
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31. The absence of differentiation-promoting response of astroglioma cells to glia maturation factor

Author

Ishikawa K, Jiro Ito, Kanefusa Kato, Ryo Tanaka, Kano-Tanaka K, Takasumi Kato, Shigeo Wakabayashi, Mizutani K, and Horiuchi I

Subjects
Glia Maturation Factor, Mixed Glioma, medicine.medical_specialty, medicine.medical_treatment, Glycerolphosphate Dehydrogenase, Nerve Tissue Proteins, Astrocytoma, Biology, Glia maturation factor, Cell Line, Intermediate Filament Proteins, Internal medicine, Glial Fibrillary Acidic Protein, medicine, Animals, Growth Substances, Molecular Biology, Cell growth, General Neuroscience, Growth factor, S100 Proteins, Cell Differentiation, Rats, Inbred Strains, DNA, Neoplasm, Glioma, Rats, Cell biology, Chemically defined medium, Endocrinology, Cell culture, Astrocytes, Neurology (clinical), Astroglioma, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Neurilemmoma, Intracellular, Developmental Biology
Abstract

The effects of glia maturation factor (GMF) on cell proliferation and differentiation were investigated with 3 astroglioma cells (GE-12, C6, and GA-1), Schwannoma-like cells (354A), and mixed glioma cells (LRM-55). In the exponentially growing phase the growth rates of all glioma cells were enhanced by GMF regardless of the presence or absence of serum, but the factor failed to make the saturation density surpass the control level observed in the medium without GMF even in the chemically defined medium (N2 medium). GMF markedly lowered the saturation density of Schwannoma-like cells in N2 medium. Although GMF increased the intracellular content of S-100 protein 10-fold and 2′,3′-cyclic nucleotide phosphohydrolase activity 1.5-fold in Schwannoma-like cells, GMF conversely decreased the S-100 contents and glycerol phosphate dehydrogenase activity in astroglioma cells. All the astroglioma cells secreted into the culture medium large quantities of a growth-promoting factor(s) which had similar chemical properties to those of GMF and stimulated the proliferation of normal glioblasts; but Schwannoma-like cells did not, although they produced a small amount of such a factor(s). These findings imply that astroglioma cells are deprived of the differentiation-promoting response to GMF while Schwannoma-like cells still preserve the response in addition to the proliferative response to GMF.

Published
1984
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43. Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation

Author

Akakura N, Masanobu Kobayashi, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura Ki, Hosokawa M, and Asaka M

Subjects
Glucose Transporter Type 1, Monosaccharide Transport Proteins, Cell Survival, Mice, Nude, Nuclear Proteins, Apoptosis, Hypoxia-Inducible Factor 1, alpha Subunit, Transfection, Cell Hypoxia, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Oxygen, Pancreatic Neoplasms, Mice, Glucose, Fructose-Bisphosphate Aldolase, Tumor Cells, Cultured, Animals, Humans, Hypoxia-Inducible Factor 1, RNA, Messenger, Cell Division, Carcinoma, Pancreatic Ductal, Transcription Factors
Abstract

Hypovasculature is an outstanding characteristic of pancreatic cancers in imaging diagnosis, suggesting that blood supply is poor in pancreatic cancer tissues. Despite poor blood supply, pancreatic cancer cells survive and proliferate in severe hypoxia and nutrient deprivation. To demonstrate how pancreatic cancer cells adapt themselves to hypoxia and nutrient deprivation, we investigated the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and HIF-1-inducible genes in human pancreatic cancer cell lines in comparison with other cancer cell lines. We found that HIF-1alpha protein was constitutively expressed in 15 of 20 pancreatic cancer cell lines (75%) but in none of other cancer cell lines tested in this study. The cells with constitutive expression of HIF-1alpha were more resistant to apoptosis induced by hypoxia and glucose deprivation than those without constitutive expression of HIF-1alpha. Transfection with HIF-1alpha transformed the latter cells resistant to apoptosis and increased in vivo tumorigenicity. Furthermore, anaerobic metabolism-associated genes, Glut1 and aldolase A, were more highly expressed in the cells with constitutive expression of HIF-1alpha than in the cells without it. These results suggest that constitutive expression of HIF-1alpha contributes to the survival and proliferation of pancreatic cancer cells in hypoxia and glucose deprivation through the activation of anaerobic metabolism.

47. Chemical composition and thermal stability of GaAs oxides grown by AFM anodic oxidation for site-controlled growth of InAs quantum dots.

Author

Cha, K. M., Shibata, K., Horiuchi, I., Kamiko, M., Yamamoto, R., and Hirakawa, K.

Subjects
GALLIUM arsenide semiconductors, QUANTUM dots, INDIUM arsenide, THERMAL analysis, METALLIC oxides, ATOMIC force microscopy, MICROFABRICATION, ELECTROLYTIC oxidation
Abstract

We have fabricated GaAs oxides by using atomic force microscope (AFM)-assisted anodic oxidation at various bias voltages, Vox, and studied their chemical compositions and thermal stabilities. The oxides grown at bias voltages less than 30 V desorbed after standard thermal cleaning in molecular beam epitaxy, while the oxide patterns fabricated at Vox≥40 V survived on the surface. We have further investigated the chemical composition of the oxides by X-ray photoemission spectroscopy. It has been found that the AFM oxides grown at Vox∼10 V predominantly consist of Ga2O and GaO, whereas those grown at Vox∼50 V contain a Ga2O3-component. This result indicates that the better thermal stability of AFM oxides grown at Vox≥40 V can be attributed to the formation of Ga2O3. We grew a GaAs buffer layer on the oxide nanomasks and obtained nanoholes. After supplying InAs, selective dot nucleation took place in the nanoholes, resulting in successful formation of site-controlled QDs. [ABSTRACT FROM AUTHOR]

Published
2011
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48. IL-12 Production Induced by Agaricus blazei Fraction H (ABH) Involves Toll-like Receptor (TLR)

Author

Kasai, H., M. He, L., Kawamura, M., T. Yang, P., W. Deng, X., Munkanta, M., Yamashita, A., Terunuma, H., Hirama, M., Horiuchi, I., Natori, T., Koga, T., Amano, Y., Yamaguchi, N., and Ito, M.

Abstract

Agaricus blazei Murill is an edible fungus used in traditional medicine, which has various well-documented medicinal properties. In the present study, we investigated the effects of hemicellulase-derived mycelia extract (Agaricus blazei fraction H: ABH) on the immune system. First, we examined the cytokine-inducing activity of ABH on human peripheral mononuclear cells (PBMC). The results indicated that ABH induced expression of IL-12, a cytokine known to be a critical regulator of cellular immune responses. Flow cytometric analysis demonstrated the induction of IL-12 production by the CD14-positive cell population, consisting of monocytes/macrophages (Mo/Mφ). Furthermore, the elimination of Mo/Mφ attenuated IL-12 production in PBMC. ABH-induced IL-12 production was inhibited by anti-CD14 and anti-TLR4 antibodies but not by anti-TLR2 antibody. The activity of ABH was not inhibited by polymyxin B, while the activity of lipopolysaccharide used as a reference was inhibited. Oral administration of ABH enhanced natural killer (NK) activity in the spleen. These findings suggest that ABH activated Mo/Mφ in a manner dependent on CD14/TLR4 and NK activity.

Published
2004
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