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145 results on '"Horita, Hiroki"'

4. Antiresorptive agent-related osteonecrosis of the jaw (ARONJ) in urological malignancies: a multi-center retrospective study

Author

Sakai, Yasuyuki, Shindo, Tetsuya, Sato, Shunsuke, Takahashi, Atsushi, Kunishima, Yasuharu, Kato, Ryuichi, Itoh, Naoki, Okada, Manabu, Tachiki, Hitoshi, Taguchi, Keisuke, Takayanagi, Akio, Hotta, Hiroshi, Horita, Hiroki, Matsukawa, Masanori, Matsuki, Masahiro, Nishiyama, Koyo, Miyazaki, Akihiro, Hashimoto, Kohei, Tanaka, Toshiaki, and Masumori, Naoya

Published
2021
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5. Pre-first-line chemotherapy risk stratification for overall survival in advanced urothelial carcinoma in sequential therapy era.

Author

Shindo, Tetsuya, Hashimoto, Kohei, Fujino, Keiko, Takahashi, Atsushi, Hotta, Hiroshi, Maeda, Toshihiro, Kunishima, Yasuharu, Fukuta, Fumimasa, Ito, Naoki, Wanifuchi, Atsushi, Kato, Ryuichi, Okada, Manabu, Matsukawa, Masanori, Horita, Hiroki, Takayanagi, Akio, Kobayashi, Ko, Tanaka, Toshiaki, and Masumori, Naoya

Subjects
TRANSITIONAL cell carcinoma, OVERALL survival, NEUTROPHIL lymphocyte ratio, IMMUNE checkpoint inhibitors, MANN Whitney U Test
Abstract

Purpose: To explore pre-treatment risk factors for overall survival (OS) in advanced urothelial carcinoma (UC) patients treated with first-line (1L) chemotherapy in sequential therapy (ST) era. Additionally, to evaluate the proportion of patients who were not able to undergo subsequent immune checkpoint inhibitor (ICI) therapy according to the subgroups stratified by the risk factors. Methods: A multicenter retrospective study was conducted. Metastatic or locally advanced UC patients treated between 2017 and 2022 were included. The Kaplan–Meier method with the log-rank test and multivariate Cox regression models were used to address OS. Results: Three hundred and fourteen patients treated with 1L chemotherapy were included in the study and 57 (18.2%) patients were not able to proceed to subsequent ICI therapy. Pre-chemotherapy risk factors for OS in 314 patients were ECOG-PS 1 or more, having no primary site resection, C-reactive protein (CRP) level of 3 mg/dL or more, and non-cisplatin-based regimen. Patients having 3 or 4 risk factors had higher risk for not being able to receive ST (Mann–Whitney U test, P < 0.001). As risk factors for OS in 230 patients who were able to receive ST, having no primary site resection, a neutrophil to lymphocyte ratio of 3 or more, and the presence of liver metastasis were identified. Conclusion: We reported the risk factors for OS in advanced UC patients treated with 1L chemotherapy in ST era. Patients with high risk for OS may not be able to proceed to subsequent ICI therapy even in the ST era. [ABSTRACT FROM AUTHOR]

Published
2024
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12. A BCI System Based on Orthogonalized EEG Data and Multiple Multilayer Neural Networks in Parallel Form

Author

Nakayama, Kenji, Horita, Hiroki, Hirano, Akihiro, Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Pandu Rangan, C., Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Diamantaras, Konstantinos, editor, Duch, Wlodek, editor, and Iliadis, Lazaros S., editor

Published
2010
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13. Neural Network Based BCI by Using Orthogonal Components of Multi-channel Brain Waves and Generalization

Author

Nakayama, Kenji, Horita, Hiroki, Hirano, Akihiro, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Kůrková, Véra, editor, Neruda, Roman, editor, and Koutník, Jan, editor

Published
2008
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29. Effect of the nitric oxide level in the medial preoptic area on male copulatory behavior in rats

Author

Sato, Yoshikazu, Horita, Hiroki, Kurohata, Toshie, Adachi, Hideki, and Tsukamoto, Taiji

Subjects
Nitric oxide -- Physiological aspects, Rats -- Sexual behavior, Biological sciences
Abstract

The effect of the extracellular oxide level on male copulatory behavior in rats was studied. The mount rate of male rats substantially increased during infusion of L-arginine in the medial preoptic area (MPOA) while administration of the NO synthase inhibitor N(super G)-monomethyl-L-arginine decreased the mount rate. Results showed that an increase in extracellular NO in the MPOA improves male sexual behavior in rats which a decrease leads to the opposite.

Published
1998

45. Regioselective Coordination toward Silver(I) Ions by Bis- and Tris(Tetra-Armed Cyclen)s via Differential Electron Density of Aromatic Side Arms

Author

Horita, Hiroki, Park, Ki-Min, Ikeda, Mari, Kuwahara, Shunsuke, and Habata, Yoichi

Abstract

Four types of bis- and tris(tetra-armed cyclen)s were prepared. 2MFis a bis(tetra-armed cyclen) with electron-rich side arms (three 4-methoxybenzyl groups) and electron-deficient side arms (three 3,5-difluorobenzyl groups), connected by a 4,4′-dimethyl-1,1′-biphenyl moiety. 3MFMis a tris(tetra-armed cyclen) with 4-methoxybenzyl and 3,5-difluorobenzyl groups introduced on both ends and the central cyclen, respectively. 4MFMis a V-shaped analogue of 3MFM. 3FMFis a tris(tetra-armed cyclen) where the aromatic side arms at both ends and the central cyclen of 3MFMare exchanged. The regioselective coordination of silver(I) ions by these ligands is reported. Initially, we added Ag+ions to a compound (2MF) that consists of tetra-armed cyclen with 4-methoxybenzyl groups as an electron-donating substituent on the aromatic rings and 3,5-difluorobenzyl groups as an electron-withdrawing substituent. 1H NMR and 19F{1H} NMR spectroscopy exhibited that the cyclen with the 4-methoxybenzyl groups formed a complex with Ag+ions first, followed by the cyclen with the 3,5-difluorobenzyl groups. Next, we employed a compound (3MFM) with three cyclen units, where the cyclen at each end was functionalized with three 4-methoxybenzyl groups, and the central cyclen was functionalized with two 3,5-difluorobenzyl groups. Upon adding Ag+ions, we observed that the cyclen units at both ends formed complexes with Ag+ions initially, followed by the central cyclen forming a complex with Ag+ions. When we used 4MFM, which is a V-shaped compound, the Ag+-induced-1H NMR chemical shift changes are almost the same results as the 3MFM. Furthermore, we synthesized a compound (3FMF) by interchanging the substituents on the cyclen units at the ends and the center. Interestingly, the order of the complex formation was reversed in this compound. These results demonstrated that tuning the electron density on the aromatic side arms through substituents makes it possible to achieve regioselective coordination with Ag+ions in bis- or tris(tetra-armed cyclen)s.

Published
2023
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46. Pyogenic psoas muscle abscess: report of three cases

Author

Takagi, Seiji, Tsukamoto, Taiji, Kumamoto, Yoshiaki, Satoh, Takashi, Horita, Hiroki, Koroku, Mikio, Takagi, Seiji, Tsukamoto, Taiji, Kumamoto, Yoshiaki, Satoh, Takashi, Horita, Hiroki, and Koroku, Mikio

Abstract

We report three cases of primary psoas muscle abscess. Two of these cases were treated by open drainage through a lumbar incision and the other was by ultrasonography (USG)-guided percutaneous aspiration of the abscess. Antibiotic therapy was also instituted in all cases. Post-operatively, the patients recovered well with no sign of recurrence. USG-guided percutaneous drainage combined with appropriate antibiotic therapy appears to be the first choice procedure for treatment of the primary psoas abscess if correct diagnosis is promptly made and the procedure can be performed.

Published
1994

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