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8 results on '"Horiguchi, Yukiko"'

4. Comparative Study on Bioresorbability of Chelate-Setting Cements with Various Calcium-Phosphate Phase Using Rabbit Model

Author

Konishi, Toshiisa, primary, Takahashi, Shuhei, additional, Mizumoto, Minori, additional, Honda, Michiyo, additional, Kida, Koki, additional, Horiguchi, Yukiko, additional, Oribe, Kazuya, additional, Ishii, Ken, additional, Morisue, Hikaru, additional, Toyama, Yoshiaki, additional, Matsumoto, Morio, additional, and Aizawa, Mamoru, additional

Published
2012
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8. Inhibition of gastric emptying by chinoform and its relation to strain differences in acute toxicity of chinoform in mice

Author

Tohyama Kiyoshi, Horiguchi Yukiko, and Takeda Yasushi

Subjects
Male, Mice, Inbred C3H, Gastric emptying, Strain (chemistry), Chemistry, Significant difference, Clioquinol, General Medicine, Pharmacology, Toxicology, Median lethal dose, Acute toxicity, Mice, Inbred C57BL, Mice, Gastric Emptying, Intestinal Absorption, Species Specificity, Anesthesia, Intestine, Small, Toxicity, Intestinal transit, Hydroxyquinolines, Animals, Oral toxicity
Abstract

Significant difference in oral LD 50 of chinoform in mice was observed between strains C57BL/6 and C 3 H/He. C57BL mice were more sensitive to oral toxicity of chinoform than C3H mice. Doses of 200 mg/kg of chinoform gave a more rapid and prolonged inhibition of gastric emptying in C57BL mice than in C3H mice. Small intestinal transit in C57BL mice was slower than that in C3H mice. The delayed gastric emptying and slow small intestinal transit in C57BL mice affected the blood levels of chinoform, and these factors may be, at least partly, responsible for the difference in the lethal toxicity of chinoform between the two strains.

Published
1983

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