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28 results on '"Hori, Tetsuji"'

3. Diverse impact of a probiotic strain, Lacticaseibacillus paracasei Shirota, on peripheral mononuclear phagocytic cells in healthy Japanese office workers: a randomized, double-blind, controlled trial

Author

NAITO, Tomoaki, primary, MORIKAWA, Masatoshi, additional, YAMAMOTO-FUJIMURA, Mayuko, additional, IWATA, Akira, additional, MAKI, Ayaka, additional, KATO-NAGAOKA, Noriko, additional, OANA, Kosuke, additional, KIYOSHIMA-SHIBATA, Junko, additional, MATSUURA, Yumi, additional, KAJI, Rumi, additional, WATANABE, Osamu, additional, SHIDA, Kan, additional, MATSUMOTO, Satoshi, additional, and HORI, Tetsuji, additional

Published
2023
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4. Changes in Immunological Parameters by Aging in Rural Healthy Indian Adults and their Associations with Sex and Lifestyle

Author

Agarwal, Dhiraj, primary, Paul, Sourav, additional, Lele, Pallavi, additional, Piprode, Vikrant, additional, Kawade, Anand, additional, Hajela, Neerja, additional, Bavdekar, Ashish, additional, Parulekar, Varsha, additional, Ginde, Manisha, additional, Paranjape, Gandhali, additional, Hori, Tetsuji, additional, Matsuda, Kazunori, additional, Juvekar, Sanjay, additional, and Lal, Girdhari, additional

Published
2022
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18. Augmentation of Cellular Immunity and Reduction of Influenza Virus Titer in Aged Mice Fed Lactobacillus caseiStrain Shirota

Author

Hori, Tetsuji, Kiyoshima, Junko, Shida, Kan, and Yasui, Hisako

Abstract

ABSTRACTWe investigated whether oral administration of Lactobacillus caseistrain Shirota activates the cellular immune system and ameliorates influenza virus (IFV) titer in the nasal site in upper respiratory IFV infection by using aged mice. Natural killer activity of splenocytes and lung cells of aged mice fed an L. caseistrain Shirota diet (L.caseistrain Shirota group) was significantly (P< 0.01 and P< 0.05) increased compared to those fed a control diet (control group). The increases were 1.5- and 2.5-fold, respectively. In aged mice fed an XL.caseistrain Shirota diet, potent induction of gamma interferon (IFN-?) and tumor necrosis factor alpha (TNF-a), which play a very important role in excluding IFV, was evident in nasal lymphocytes. IFN-? and TNF-a production increased 12- and 3.5-fold, respectively. In this model of upper respiratory IFV infection, the titer of IFV in the nasal washings of aged mice fed an L.caseistrain Shirota diet was significantly (P< 0.05) lower than that in aged mice fed a control diet (101.6 ± 0.6and 102.2 ± 0.5, respectively). These findings suggest that oral administration of L.caseistrain Shirota activates not only systemic cellular immunity but also local cellular immunity and that it ameliorates IFV infection.

Published
2002
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19. Effect of an Oral Administration of Lactobacillus casei Strain Shirota on the Natural Killer Activity of Blood Mononuclear Cells in Aged Mice.

Author

Hori, Tetsuji, Kiyoshima, Junko, and Yasui, Hisako

Subjects
*LACTOBACILLUS casei, *KILLER cells, *BLOOD cells, *MICE, *AGING
Abstract

Investigates the effect of an oral administration of Lactobacillus casei strain Shirota (LcS) on the natural killer (NK) activity of blood mononuclear cells and splenocytes in aged mice. Diminished NK cell activity in aged mice, as compared to that in young mice; Possible mechanism underlying the enhanced NK activity resulting from LcS administration; Role of NK cells in cellular immunity.

Published
2003
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20. Effect of an Oral Administration of Lactobacillus caseiStrain Shirota on the Natural Killer Activity of Blood Mononuclear Cells in Aged Mice

Author

HORI, Tetsuji, KIYOSHIMA, Junko, and YASUI, Hisako

Abstract

The natural killer (NK) activity of blood mononuclear cells and splenocytes in aged mice fed on a diet containing Lactobacillus caseistrain Shirota (LcS group) was significantly (P<0.01) higher than that in mice fed on a diet without LcS. In the LcS group, there was a significant positive correlation (r=0.63, P<0.01) between the NK activity of blood mononuclear cells and the NK activity of splenocytes.

Published
2003
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21. Nippon Jibiinkoka Gakkai Kaiho

Author

ISHIDA, MINORU, primary, HORI, TETSUJI, additional, TAMAKI, HIROMITSU, additional, MATSUNAGA, TORU, additional, OZAKI, MASAYOSHI, additional, HARADA, TAMOTSU, additional, YOSHINO, KUNITOSHI, additional, NAKAO, TUZO, additional, and OMOTO, TATSUYA, additional

Published
1982
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24. Nippon Jibiinkoka Gakkai Kaiho

Author

HORI, TETSUJI, primary, ISHIDA, MINORU, additional, OOHIRA, SHINJI, additional, TAMAKI, HIROMITSU, additional, MATSUNAGA, TORU, additional, and OOMOTO, TATSUYA, additional

Published
1982
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27. Reduction of influenza virus titer and protection against influenza virus infection in infant mice fed Lactobacillus casei Shirota.

Author

Yasui H, Kiyoshima J, and Hori T

Subjects
Administration, Oral, Age Factors, Animals, Animals, Newborn, Disease Models, Animal, Humans, Interleukin-12 immunology, Killer Cells, Natural immunology, Mice, Nasal Lavage Fluid virology, Orthomyxoviridae immunology, Respiratory Tract Infections immunology, Lacticaseibacillus casei immunology, Orthomyxoviridae Infections prevention & control, Respiratory Tract Infections prevention & control, Respiratory Tract Infections virology
Abstract

We investigated whether oral administration of Lactobacillus casei strain Shirota to neonatal and infant mice ameliorates influenza virus (IFV) infection in the upper respiratory tract and protects against influenza infection. In a model of upper respiratory IFV infection, the titer of virus in the nasal washings of infant mice administered L. casei Shirota (L. casei Shirota group) was significantly (P < 0.05) lower than that in infant mice administered saline (control group) (10(2.48) +/- 10(0.31) and 10(2.78) +/- 10(0.4), respectively). Further, the survival rate of the L. casei Shirota group was significantly (P < 0.05) higher than that of the control group (14.3 versus 40.0%). One day after infection, pulmonary NK cell activity and interleukin-12 production by mediastinal lymph node cells of mice in the L. casei Shirota group were significantly greater than those of mice in the control group. These findings suggest that oral administration of L. casei Shirota activates the immature immune system of neonatal and infant mice and protects against IFV infection. Therefore, oral administration of L. casei Shirota may accelerate the innate immune response of the respiratory tract and protect against various respiratory infections in neonates, infants, and children, a high risk group for viral and bacterial infections.

Published
2004
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28. Augmentation of cellular immunity and reduction of influenza virus titer in aged mice fed Lactobacillus casei strain Shirota.

Author

Hori T, Kiyoshima J, Shida K, and Yasui H

Subjects
Administration, Oral, Aging immunology, Animals, Female, Immunity, Cellular, Interferon-gamma biosynthesis, Killer Cells, Natural immunology, Lung immunology, Mice, Mice, Inbred BALB C, Nasal Mucosa immunology, Nasal Mucosa virology, Orthomyxoviridae isolation & purification, Tumor Necrosis Factor-alpha biosynthesis, Lacticaseibacillus casei immunology, Orthomyxoviridae Infections immunology
Abstract

We investigated whether oral administration of Lactobacillus casei strain Shirota activates the cellular immune system and ameliorates influenza virus (IFV) titer in the nasal site in upper respiratory IFV infection by using aged mice. Natural killer activity of splenocytes and lung cells of aged mice fed an L. casei strain Shirota diet (L.casei strain Shirota group) was significantly (P < 0.01 and P < 0.05) increased compared to those fed a control diet (control group). The increases were 1.5- and 2.5-fold, respectively. In aged mice fed an XL.casei strain Shirota diet, potent induction of gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha), which play a very important role in excluding IFV, was evident in nasal lymphocytes. IFN-gamma and TNF-alpha production increased 12- and 3.5-fold, respectively. In this model of upper respiratory IFV infection, the titer of IFV in the nasal washings of aged mice fed an L.casei strain Shirota diet was significantly (P < 0.05) lower than that in aged mice fed a control diet (10(1.6 +/- 0.6) and 10(2.2 +/- 0.5), respectively). These findings suggest that oral administration of L.casei strain Shirota activates not only systemic cellular immunity but also local cellular immunity and that it ameliorates IFV infection.

Published
2002
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