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1. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Mizuguchi, Yasuhiko, Suzuki, Haruhisa, Ono, Hiroyuki, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Yuki, Maeda, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Naito, Yuji, Yamamoto, Katsumi, Kobayashi, Nozomu, Kawahara, Yoshiro, Hirano, Masaaki, Koizumi, Shigeto, Hori, Shinichiro, Tajika, Masahiro, Hikichi, Takuto, Yao, Kenshi, Yokoi, Chizu, Ohnita, Ken, Hisanaga, Yasuhiro, Sumiyoshi, Tetsuya, Kitamura, Shinji, Tanaka, Hisao, Shimoda, Ryo, Shimazu, Taichi, Takizawa, Kohei, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2023
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2. Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508

Author

Mizuaswa, Junki, Takizawa, Kohei, Aoyama, Ikuo, Ishiyama, Akiyoshi, Kawata, Noboru, Kikuchi, Daisuke, Hanaoka, Noboru, Oda, Ichiro, Morita, Yoshinori, Tajika, Masahiro, Fujiwara, Junko, Yamamoto, Yoshinobu, Katada, Chikatoshi, Hori, Shinichiro, Doyama, Hisashi, Oyama, Tsuneo, Nebiki, Hiroko, Amagai, Kenji, Kubota, Yutaro, Inokuchi, Yasuhiro, Kobayashi, Nozomu, Suzuki, Takuto, Hirasawa, Kingo, Takeuchi, Toshihisa, Kadota, Tomohiro, Nihei, Keiji, Minashi, Keiko, Yano, Tomonori, Shimoda, Tadakazu, Fukuda, Haruhiko, and Muto, Manabu

Published
2023
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3. Efficacy of polyglycolic acid sheeting with fibrin glue for perforations related to gastrointestinal endoscopic procedures: a multicenter retrospective cohort study

Author

Takimoto, Kengo, Matsuura, Noriko, Nakano, Yoshiko, Tsuji, Yosuke, Takizawa, Kohei, Morita, Yoshinori, Nagami, Yasuaki, Hirasawa, Kingo, Araki, Hiroshi, Yamaguchi, Naoyuki, Aoyagi, Hiroyuki, Matsuhashi, Tamotsu, Iizuka, Toshiro, Saegusa, Hisanobu, Yamazaki, Kenji, Hori, Shinichiro, Mannami, Tomohiko, Hanaoka, Noboru, Mori, Hirohito, Kobara, Hideki, Takeuchi, Yoji, and Ono, Hiroyuki

Published
2022
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5. Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial

Author

Nakajima, Takeshi, Sakamoto, Taku, Hori, Shinichiro, Yamada, Shinya, Ikematsu, Hiroaki, Harada, Keita, Chiu, Han-Mo, Kiriyama, Shinsuke, Michida, Tomoki, Hotta, Kinichi, Sakamoto, Naoto, Abe, Takashi, Chino, Akiko, Fukuzawa, Masakatsu, Kobayashi, Nozomu, Fukase, Kazutoshi, Matsuda, Takahisa, Murakami, Yoshitaka, Ishikawa, Hideki, and Saito, Yutaka

Published
2022
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6. Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial

Author

Ishikawa, Hideki, Mutoh, Michihiro, Sato, Yasushi, Doyama, Hisashi, Tajika, Masahiro, Tanaka, Shinji, Horimatsu, Takahiro, Takeuchi, Yoji, Kashida, Hiroshi, Tashiro, Jun, Ezoe, Yasumasa, Nakajima, Takeshi, Ikematsu, Hiroaki, Hori, Shinichiro, Suzuki, Sadao, Otani, Takahiro, Takayama, Tetsuji, Ohda, Yoshio, Mure, Kanae, Wakabayashi, Keiji, and Sakai, Toshiyuki

Published
2021
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7. Short‐term and long‐term outcomes of submucosal dissection for residual or recurrent colorectal tumors after endoscopic resection: Analysis of a multicenter prospective study.

Author

Tanaka, Hirohito, primary, Uraoka, Toshio, additional, Kobayashi, Nozomu, additional, Ohata, Ken, additional, Takeuchi, Yoji, additional, Chino, Akiko, additional, Yamada, Masayoshi, additional, Tsuji, Yosuke, additional, Hotta, Kinichi, additional, Harada, Keita, additional, Ikematsu, Hiroaki, additional, Murakami, Takashi, additional, Tsuji, Shigetsugu, additional, Katagiri, Atsushi, additional, Hori, Shinichiro, additional, Michida, Tomoki, additional, Suzuki, Takuto, additional, Fukuzawa, Masakatsu, additional, Kiriyama, Shinsuke, additional, Fukase, Kazutoshi, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, Nagahara, Akihito, additional, and Saito, Yutaka, additional

Published
2023
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10. Factors associated with technical difficulty of endoscopic submucosal dissection for early gastric cancer that met the expanded indication criteria: post hoc analysis of a multi-institutional prospective confirmatory trial (JCOG0607)

Author

Yano, Tomonori, Hasuike, Noriaki, Ono, Hiroyuki, Boku, Narikazu, Ogawa, Gakuto, Kadota, Tomohiro, Oda, Ichiro, Doyama, Hisashi, Hori, Shinichiro, Iishi, Hiroyasu, Takahashi, Akiko, Takizawa, Kohei, and Muto, Manabu

Published
2020
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11. Efficacy of Endoscopic Resection and Selective Chemoradiotherapy for Stage I Esophageal Squamous Cell Carcinoma

Author

Minashi, Keiko, Nihei, Keiji, Mizusawa, Junki, Takizawa, Kohei, Yano, Tomonori, Ezoe, Yasumasa, Tsuchida, Tomohiro, Ono, Hiroyuki, Iizuka, Toshiro, Hanaoka, Noboru, Oda, Ichiro, Morita, Yoshinori, Tajika, Masahiro, Fujiwara, Junko, Yamamoto, Yoshinobu, Katada, Chikatoshi, Hori, Shinichiro, Doyama, Hisashi, Oyama, Tsuneo, Nebiki, Hiroko, Amagai, Kenji, Kubota, Yutaro, Nishimura, Ken, Kobayashi, Nozomu, Suzuki, Takuto, Hirasawa, Kingo, Takeuchi, Toshihisa, Fukuda, Haruhiko, and Muto, Manabu

Published
2019
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12. Diagnostic performance of linked color imaging for gastric cancer by Helicobacter pylori infection status: A subanalysis of the large‐scale, multicenter randomized controlled trial LCI‐FIND.

Author

Kato, Mototsugu, Ono, Shoko, Kawada, Kenro, Dohi, Osamu, Kitamura, Shinji, Koike, Tomoyuki, Hori, Shinichiro, Kanzaki, Hiromitsu, Murao, Takahisa, Yagi, Nobuaki, Sasaki, Fumisato, Hashiguchi, Keiichi, Oka, Shiro, Katada, Kazuhiro, Shimoda, Ryo, Mizukami, Kazuhiro, Suehiro, Mitsuhiko, Takeuchi, Toshihisa, Katsuki, Shinichi, and Tsuda, Momoko

Subjects
HELICOBACTER pylori infections, RANDOMIZED controlled trials, STOMACH cancer, HELICOBACTER pylori, IMAGE intensifiers, COLOR Doppler ultrasonography, COLORIMETRY
Abstract

Background: Linked color imaging (LCI) is a new image enhancement technology that facilitates the recognition of subtle differences in mucosal color. In the large‐scale, multicenter randomized controlled trial LCI‐FIND, LCI demonstrated good diagnostic performance for the detection of tumor lesions in the upper gastrointestinal tract. The aim of the present study was to exploratively evaluate the diagnostic performance of LCI according to H. pylori infection status as a subanalysis of LCI‐FIND trial. Methods: The patients were randomly allocated to receive white light imaging (WLI) first, followed by LCI (WLI group), or vice versa (LCI group), and the two groups were compared for the detection of tumors. Data from this trial were analyzed by the presence/absence of H. pylori infection and further analyzed by successful or unsuccessful eradication in the H. pylori infection group. Results: The 752 patients in the WLI group and 750 patients in the LCI group who had participated in the LCI‐FIND trial were included. In the successful eradication group, more gastric lesions were detected by primary mode in the LCI group than in the WLI group, indicating that more lesions were missed by WLI. Fisher's exact probability test for the comparison of the WLI and LCI groups yielded a p‐value of 0.0068, with missed gastric lesions being detected 0.136 times (95% confidence interval: 0.020–0.923), significantly less with LCI than with WLI. Conclusion: The current study suggests that LCI should be used for gastric cancer screening, particularly in patients with successful H. pylori eradication. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study

Author

Ishikawa, Hideki, Yamada, Masayoshi, Sato, Yasushi, Tanaka, Shinji, Chino, Akiko, Tajika, Masahiro, Doyama, Hisashi, Takayama, Tetsuji, Ohda, Yoshio, Horimatsu, Takahiro, Sano, Yasushi, Tanakaya, Kohji, Ikematsu, Hiroaki, Saida, Yoshihisa, Ishida, Hideyuki, Takeuchi, Yoji, Kashida, Hiroshi, Kiriyama, Shinsuke, Hori, Shinichiro, Lee, Kyowon, Tashiro, Jun, Kobayashi, Nozomu, Nakajima, Takeshi, Suzuki, Sadao, and Mutoh, Michihiro

Subjects
Gastroenterology
Abstract

Background Total colectomy is the standard treatment for familial adenomatous polyposis (FAP). Recently, an increasing number of young patients with FAP have requested the postponement of surgery or have refused to undergo surgery. We aimed to evaluate the effectiveness of intensive endoscopic removal for downstaging of polyp burden (IDP) in FAP. Method A single-arm intervention study was conducted at 22 facilities. Participants were patients with FAP, aged ≥ 16 years, who had not undergone colectomy or who had undergone colectomy but had ≥ 10 cm of large intestine remaining. For IDP, colorectal polyps of ≥ 10 mm were removed, followed by polyps of ≥ 5 mm. The primary end point was the presence/absence of colectomy during a 5-year intervention period. Results 222 patients were eligible, of whom 166 had not undergone colectomy, 46 had undergone subtotal colectomy with ileorectal anastomosis, and 10 had undergone partial resection of the large intestine. During the intervention period, five patients (2.3 %, 95 % confidence interval [CI] 0.74 %–5.18 %) underwent colectomy, and three patients died. Completion of the 5-year intervention period without colectomy was confirmed in 150 /166 patients who had not undergone colectomy (90.4 %, 95 %CI 84.8 %–94.4 %) and in 47 /56 patients who had previously undergone colectomy (83.9 %, 95 %CI 71.7 %–92.4 %). Conclusion IDP in patients with mild-to-moderate FAP could have the potential to be a useful means of preventing colorectal cancer without implementing colectomy. However, if the IDP protocol was proposed during a much longer term, it may not preclude the possibility that a large proportion of colectomies may still need to be performed.

Published
2022

14. Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults

Author

Yamamoto, Hironori, primary, Sakamoto, Hirotsugu, additional, Kumagai, Hideki, additional, Abe, Takashi, additional, Ishiguro, Shingo, additional, Uchida, Keiichi, additional, Kawasaki, Yuko, additional, Saida, Yoshihisa, additional, Sano, Yasushi, additional, Takeuchi, Yoji, additional, Tajika, Masahiro, additional, Nakajima, Takeshi, additional, Banno, Kouji, additional, Funasaka, Yoko, additional, Hori, Shinichiro, additional, Yamaguchi, Tatsuro, additional, Yoshida, Teruhiko, additional, Ishikawa, Hideki, additional, Iwama, Takeo, additional, Okazaki, Yasushi, additional, Saito, Yutaka, additional, Matsuura, Nariaki, additional, Mutoh, Michihiro, additional, Tomita, Naohiro, additional, Akiyama, Takashi, additional, Yamamoto, Toshiki, additional, Ishida, Hideyuki, additional, and Nakayama, Yoshiko, additional

Published
2023
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15. Data from Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on ADH1B and ALDH2 Genotype in Japanese Familial Adenomatous Polyposis Patients

Author

Mure, Kanae, primary, Ishikawa, Hideki, primary, Mutoh, Michihiro, primary, Horinaka, Mano, primary, Otani, Takahiro, primary, Suzuki, Sadao, primary, Wakabayashi, Keiji, primary, Sakai, Toshiyuki, primary, Sato, Yasushi, primary, Doyama, Hisashi, primary, Tajika, Masahiro, primary, Tanaka, Shinji, primary, Horimatsu, Takahiro, primary, Takeuchi, Yoji, primary, Kashida, Hiroshi, primary, Tashiro, Jun, primary, Ezoe, Yasumasa, primary, Nakajima, Takeshi, primary, Ikematsu, Hiroaki, primary, Hori, Shinichiro, primary, Takayama, Tetsuji, primary, and Ohda, Yoshio, primary

Published
2023
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16. Supplementary Data from Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on ADH1B and ALDH2 Genotype in Japanese Familial Adenomatous Polyposis Patients

Author

Mure, Kanae, primary, Ishikawa, Hideki, primary, Mutoh, Michihiro, primary, Horinaka, Mano, primary, Otani, Takahiro, primary, Suzuki, Sadao, primary, Wakabayashi, Keiji, primary, Sakai, Toshiyuki, primary, Sato, Yasushi, primary, Doyama, Hisashi, primary, Tajika, Masahiro, primary, Tanaka, Shinji, primary, Horimatsu, Takahiro, primary, Takeuchi, Yoji, primary, Kashida, Hiroshi, primary, Tashiro, Jun, primary, Ezoe, Yasumasa, primary, Nakajima, Takeshi, primary, Ikematsu, Hiroaki, primary, Hori, Shinichiro, primary, Takayama, Tetsuji, primary, and Ohda, Yoshio, primary

Published
2023
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17. A non-randomized confirmatory trial of an expanded indication for endoscopic submucosal dissection for intestinal-type gastric cancer (cT1a): the Japan Clinical Oncology Group study (JCOG0607)

Author

Hasuike, Noriaki, Ono, Hiroyuki, Boku, Narikazu, Mizusawa, Junki, Takizawa, Kohei, Fukuda, Haruhiko, Oda, Ichiro, Doyama, Hisashi, Kaneko, Kazuhiro, Hori, Shinichiro, Iishi, Hiroyasu, Kurokawa, Yukinori, Muto, Manabu, and Gastrointestinal Endoscopy Group of Japan Clinical Oncology Group (JCOG-GIESG)

Published
2018
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18. Clinicopathological Characteristics of Superficial Barrett's Adenocarcinoma in a Japanese Population: A Retrospective, Multicenter Study

Author

Hamada, Kenta, Kanzaki, Hiromitsu, Miyahara, Koji, Nakagawa, Masahiro, Mouri, Hirokazu, Mizuno, Motowo, Takahashi, Sakuma, Hori, Shinichiro, Nasu, Junichiro, Tsuzuki, Takao, Miyaike, Jiro, Takenaka, Ryuta, Yamauchi, Kenji, Kobayashi, Sayo, Toyokawa, Tatsuya, Inoue, Masafumi, Nishimura, Mamoru, Matsubara, Minoru, Tomoda, Jun, Yamasaki, Yasushi, Tanaka, Takehiro, Shirakawa, Yasuhiro, Kawahara, Yoshiro, Fujiwara, Toshiyoshi, Okada, Hiroyuki, and Okayama Gut Study Group

Subjects
Barrett's adenocarcinoma, lesion, surgery, Barrett Esophagus, endoscopic resection, Esophageal Neoplasms, Japan, short -segment Barrett's esophagus, metachronous, Humans, Adenocarcinoma, Retrospective Studies, long -segment Barrett's esophagus
Abstract

Objective Although Barrett's adenocarcinoma (BA) remains a minor disease in Japan, its incidence has been gradually increasing. We analyzed the characteristics of BA in Japanese populations. Methods We retrospectively reviewed medical records and analyzed the clinicopathological differences between short-segment Barrett's esophagus (SSBE) and long-segment Barrett's esophagus (LSBE), as well as metastasis. Local recurrence and metachronous lesions were analyzed only in patients who underwent endoscopic resection (ER). Patients Consecutive patients who had pathological T1 BAs resected by ER or surgery from January 2003 Results A total of 168 patients were analyzed, including 139 with SSBE and 29 with LSBE. In total, 67% of the SSBE lesions and 32% of the LSBE lesions were located between 0 and 3 o'clock (p=0.0014). No patients who achieved pathological margin-free resection (pR0) and 17% of patients who did not achieve pR0 experienced local recurrence (p=0.0131). None of the patients without lymphovascular involvement, a poorly differentiated component, lesion size of >30 mm, and submucosal invasion of >500 mu m experienced metastasis. The 5-year cumulative incidence rate of metachronous BA after ER was 0% in patients with SSBE and 40% in patients with LSBE (p=0.0005). Conclusion Superficial BA was likely to be detected at the right anterior wall of SSBE in the Japanese population. The risk for metachronous BA after ER was high in Japanese patients with LSBE, as in Western patients.

Published
2022

19. Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508

Author

Nihei, Keiji, primary, Minashi, Keiko, additional, Yano, Tomonori, additional, Shimoda, Tadakazu, additional, Fukuda, Haruhiko, additional, Muto, Manabu, additional, Mizuaswa, Junki, additional, Takizawa, Kohei, additional, Aoyama, Ikuo, additional, Ishiyama, Akiyoshi, additional, Kawata, Noboru, additional, Kikuchi, Daisuke, additional, Hanaoka, Noboru, additional, Oda, Ichiro, additional, Morita, Yoshinori, additional, Tajika, Masahiro, additional, Fujiwara, Junko, additional, Yamamoto, Yoshinobu, additional, Katada, Chikatoshi, additional, Hori, Shinichiro, additional, Doyama, Hisashi, additional, Oyama, Tsuneo, additional, Nebiki, Hiroko, additional, Amagai, Kenji, additional, Kubota, Yutaro, additional, Inokuchi, Yasuhiro, additional, Kobayashi, Nozomu, additional, Suzuki, Takuto, additional, Hirasawa, Kingo, additional, Takeuchi, Toshihisa, additional, and Kadota, Tomohiro, additional

Published
2023
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20. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Suzuki, Haruhisa, primary, Ono, Hiroyuki, additional, Hirasawa, Toshiaki, additional, Takeuchi, Yoji, additional, Ishido, Kenji, additional, Hoteya, Shu, additional, Yano, Tomonori, additional, Tanaka, Shinji, additional, Toya, Yosuke, additional, Nakagawa, Masahiro, additional, Toyonaga, Takashi, additional, Takemura, Kenichi, additional, Hirasawa, Kingo, additional, Matsuda, Mitsuru, additional, Yamamoto, Hironori, additional, Tsuji, Yosuke, additional, Hashimoto, Satoru, additional, Yuki, Maeda, additional, Oyama, Tsuneo, additional, Takenaka, Ryuta, additional, Yamamoto, Yoshinobu, additional, Naito, Yuji, additional, Yamamoto, Katsumi, additional, Kobayashi, Nozomu, additional, Kawahara, Yoshiro, additional, Hirano, Masaaki, additional, Koizumi, Shigeto, additional, Hori, Shinichiro, additional, Tajika, Masahiro, additional, Hikichi, Takuto, additional, Yao, Kenshi, additional, Yokoi, Chizu, additional, Ohnita, Ken, additional, Hisanaga, Yasuhiro, additional, Sumiyoshi, Tetsuya, additional, Kitamura, Shinji, additional, Tanaka, Hisao, additional, Shimoda, Ryo, additional, Shimazu, Taichi, additional, Takizawa, Kohei, additional, Tanabe, Satoshi, additional, Kondo, Hitoshi, additional, Iishi, Hiroyasu, additional, Ninomiya, Motoki, additional, Oda, Ichiro, additional, Mashimo, Yumi, additional, Ishigooka, Masahiro, additional, Fukase, Kazutoshi, additional, and Mizuguchi, Yasuhiko, additional

Published
2023
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21. Long-term Outcomes After Endoscopic Submucosal Dissection for Large Colorectal Epithelial Neoplasms: A Prospective, Multicenter, Cohort Trial From Japan

Author

Ohata, Ken, primary, Kobayashi, Nozomu, additional, Sakai, Eiji, additional, Takeuchi, Yoji, additional, Chino, Akiko, additional, Takamaru, Hiroyuki, additional, Kodashima, Shinya, additional, Hotta, Kinichi, additional, Harada, Keita, additional, Ikematsu, Hiroaki, additional, Uraoka, Toshio, additional, Murakami, Takashi, additional, Tsuji, Shigetsugu, additional, Abe, Takashi, additional, Katagiri, Atsushi, additional, Hori, Shinichiro, additional, Michida, Tomoki, additional, Suzuki, Takuto, additional, Fukuzawa, Masakatsu, additional, Kiriyama, Shinsuke, additional, Fukase, Kazutoshi, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, and Saito, Yutaka, additional

Published
2022
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23. Assessment of Outcomes From 1-Year Surveillance After Detection of Early Gastric Cancer Among Patients at High Risk in Japan

Author

Yamamoto, Yoshinobu, primary, Yoshida, Naohiro, additional, Yano, Tomonori, additional, Horimatsu, Takahiro, additional, Uedo, Noriya, additional, Kawata, Noboru, additional, Kanzaki, Hiromitsu, additional, Hori, Shinichiro, additional, Yao, Kenshi, additional, Abe, Seiichiro, additional, Katada, Chikatoshi, additional, Yokoi, Chizu, additional, Ohata, Ken, additional, Doyama, Hisashi, additional, Yoshimura, Kenichi, additional, Ishikawa, Hideki, additional, and Muto, Manabu, additional

Published
2022
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24. Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study.

Author

Ishikawa, Hideki, Yamada, Masayoshi, Sato, Yasushi, Tanaka, Shinji, Akiko, Chino, Tajika, Masahiro, Doyama, Hisashi, Takayama, Tetsuji, Ohda, Yoshio, Horimatsu, Takahiro, Sano, Yasushi, Tanakaya, Kohji, Ikematsu, Hiroaki, Saida, Yoshihisa, Ishida, Hideyuki, Takeuchi, Yoji, Kashida, Hiroshi, Kiriyama, Shinsuke, Hori, Shinichiro, and Lee, Kyowon

Subjects
ADENOMATOUS polyposis coli, ENDOSCOPIC surgery, ADENOMATOUS polyps, CLINICAL trials, COLON polyps, LARGE intestine
Abstract

Background Total colectomy is the standard treatment for familial adenomatous polyposis (FAP). Recently, an increasing number of young patients with FAP have requested the postponement of surgery or have refused to undergo surgery. We aimed to evaluate the effectiveness of intensive endoscopic removal for downstaging of polyp burden (IDP) in FAP. Method A single-arm intervention study was conducted at 22 facilities. Participants were patients with FAP, aged ≥ 16 years, who had not undergone colectomy or who had undergone colectomy but had ≥ 10 cm of large intestine remaining. For IDP, colorectal polyps of ≥ 10 mm were removed, followed by polyps of ≥ 5 mm. The primary end point was the presence/absence of colectomy during a 5-year intervention period. Results 222 patients were eligible, of whom 166 had not undergone colectomy, 46 had undergone subtotal colectomy with ileorectal anastomosis, and 10 had undergone partial resection of the large intestine. During the intervention period, five patients (2.3 %, 95 % confidence interval [CI] 0.74 %–5.18 %) underwent colectomy, and three patients died. Completion of the 5-year intervention period without colectomy was confirmed in 150 /166 patients who had not undergone colectomy (90.4 %, 95 %CI 84.8 %–94.4 %) and in 47 /56 patients who had previously undergone colectomy (83.9 %, 95 %CI 71.7 %–92.4 %). Conclusion IDP in patients with mild-to-moderate FAP could have the potential to be a useful means of preventing colorectal cancer without implementing colectomy. However, if the IDP protocol was proposed during a much longer term, it may not preclude the possibility that a large proportion of colectomies may still need to be performed. [ABSTRACT FROM AUTHOR]

Published
2023
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25. LONG-TERM OUTCOMES AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION FOR COLORECTAL EPITHELIAL NEOPLASMS: A JAPANESE PERSPECTIVE MUCTICENTER COHORT TRIAL

Author

Saito, Yutaka, primary, Ohata, Ken, additional, Takeuchi, Yoji, additional, Chino, Akiko, additional, Takamaru, Hiroyuki, additional, Kodashima, Shinya, additional, Hotta, Kinichi, additional, Harada, Keita, additional, Ikematsu, Hiroaki, additional, Uraoka, Toshio, additional, Murakami, Takashi, additional, Doyama, Hisashi, additional, Abe, Takashi, additional, Katagiri, Atsushi, additional, Hori, Shinichiro, additional, Michida, Tomoki, additional, Suzuki, Takuto, additional, Fukuzawa, Masakatsu, additional, Kiriyama, Shinsuke, additional, Fukase, Kazutoshi, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, and Kobayashi, Nozomu, additional

Published
2022
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26. Second gastric cancer after curative endoscopic resection of differentiated-type early gastric cancer: post-hoc analysis of a single-arm confirmatory trial

Author

Yoshida, Masao, primary, Takizawa, Kohei, additional, Hasuike, Noriaki, additional, Ono, Hiroyuki, additional, Boku, Narikazu, additional, Kadota, Tomohiro, additional, Mizusawa, Junki, additional, Oda, Ichiro, additional, Yoshida, Naohiro, additional, Horiuchi, Yusuke, additional, Hirasawa, Kingo, additional, Morita, Yoshinori, additional, Yamamoto, Yoshinobu, additional, Muto, Manabu, additional, Yoshida, Masao, additional, Doyama, Hisashi, additional, Abe, Seiichiro, additional, Saito, Yutaka, additional, Yano, Tomonori, additional, Sato, Chiko, additional, Shichijo, Satoki, additional, Ishihara, Ryu, additional, Nishide, Norifumi, additional, Hori, Shinichiro, additional, Fujisaki, Junko, additional, Umegaki, Eiji, additional, Fujieda, Shinji, additional, Amagai, Kenji, additional, Takahashi, Akiko, additional, Oyama, Tsuneo, additional, Nishimura, Ken, additional, Motohashi, Osamu, additional, Ishido, Kenji, additional, Tanabe, Satoshi, additional, Tamaoki, Masashi, additional, Konishi, Jun, additional, Kobayashi, Nozomu, additional, Nagino, Kou, additional, Kawagoe, Kei, additional, Takeda, Hiroaki, additional, Fujita, Yuriko, additional, Komatsu, Hirokazu, additional, Akasaka, Iichiro, additional, Kikuchi, Daisuke, additional, Iizuka, Toshiro, additional, Tajika, Masahiro, additional, Yasumasa, Niwa, additional, Kojima, Yuichi, additional, Takeuchi, Toshihisa, additional, Yamamoto, Keiko, additional, Shimizu, Yuichi, additional, Sumiyoshi, Tetsuya, additional, Kondo, Hitoshi, additional, Konda, Kenichi, additional, Kubota, Yutaro, additional, Yamasaki, Tomoaki, additional, Nebiki, Hiroko, additional, Takata, Masashi, additional, and Morita, Masanori, additional

Published
2022
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27. Linked color imaging provides enhanced visibility with a high color difference in upper gastrointestinal neoplasms.

Author

Dohi, Osamu, Ono, Shoko, Kawada, Kenro, Kitamura, Shinji, Hatta, Waku, Hori, Shinichiro, Kanzaki, Hiromitsu, Murao, Takahisa, Yagi, Nobuaki, Sasaki, Fumisato, Hashiguchi, Keiichi, Oka, Shiro, Katada, Kazuhiro, Shimoda, Ryo, Mizukami, Kazuhiro, Suehiro, Mitsuhiko, Takeuchi, Toshihisa, Katsuki, Shinichi, Tsuda, Momoko, and Naito, Yuji

Subjects
LOGISTIC regression analysis, TUMORS
Abstract

Background and Aim: The aim of this post‐hoc analysis in a randomized, controlled, multicenter trial was to evaluate the visibility of upper gastrointestinal (UGI) neoplasms detected using linked color imaging (LCI) compared with those detected using white light imaging (WLI). Methods: The visibility of the detected UGI neoplasm images obtained using both WLI and LCI was subjectively reviewed, and the median color difference (ΔE) between each lesion and the surrounding mucosa according to the CIE L*a*b* color space was evaluated objectively. Multivariate logistic regression analysis was performed to identify factors associated with neoplasms that were missed under WLI and detected under LCI. Results: A total of 120 neoplasms, including 10, 32, and 78 neoplasms in the pharynx, esophagus, and stomach, respectively, were analyzed in this study. LCI enhanced the visibility 80.9% and 93.6% of neoplasms in pharynx/esophagus and stomach compared with WLI, respectively. LCI also achieved a higher ΔE of enhanced neoplasms compared with WLI in the pharynx/esophagus and stomach. The median WLI ΔE values for gastric neoplasms missed under WLI and later detected under LCI were significantly lower than those for gastric neoplasms detected under WLI (8.2 vs 9.6, respectively). Furthermore, low levels of WLI ΔE (odds ratio [OR], 7.215) and high levels of LCI ΔE (OR, 22.202) were significantly associated with gastric neoplasms missed under WLI and later detected under LCI. Conclusion: Color differences were independently associated with missing gastric neoplasms under WLI, suggesting that LCI has an obvious advantage over WLI in enhancing neoplastic visibility. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Outcomes of endoscopic submucosal dissection for colorectal neoplasms: Prospective, multicenter, cohort trial

Author

Kobayashi, Nozomu, primary, Takeuchi, Yoji, additional, Ohata, Ken, additional, Igarashi, Masahiro, additional, Yamada, Masayoshi, additional, Kodashima, Shinya, additional, Hotta, Kinichi, additional, Harada, Keita, additional, Ikematsu, Hiroaki, additional, Uraoka, Toshio, additional, Sakamoto, Naoto, additional, Doyama, Hisashi, additional, Abe, Takashi, additional, Katagiri, Atsushi, additional, Hori, Shinichiro, additional, Michida, Tomoki, additional, Yamaguchi, Takehito, additional, Fukuzawa, Masakatsu, additional, Kiriyama, Shinsuke, additional, Fukase, Kazutoshi, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, and Saito, Yutaka, additional

Published
2022
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29. Diagnostic ability of linked color imaging in ultraslim endoscopy to identify neoplastic lesions in the upper gastrointestinal tract

Author

Haruma, Ken, additional, Kato, Mototsugu, additional, Kawada, Kenro, additional, Murao, Takahisa, additional, Ono, Shoko, additional, Suehiro, Mitsuhiko, additional, Hori, Shinichiro, additional, Sasaki, Fumisato, additional, Koike, Tomoyuki, additional, Kitamura, Shinji, additional, Dohi, Osamu, additional, Kanzaki, Hiromitsu, additional, Yagi, Nobuaki, additional, Hashiguchi, Keiichi, additional, Oka, Shiro, additional, Katada, Kazuhiro, additional, Shimoda, Ryo, additional, Mizukami, Kazuhiro, additional, Takeuchi, Toshihisa, additional, Katsuki, Shinichi, additional, Tsuda, Momoko, additional, Naito, Yuji, additional, Kawano, Tatsuyuki, additional, Mori, Keita, additional, and Ishikawa, Hideki, additional

Published
2022
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30. Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan

Author

Murakami, Kazunari, Furuta, Takahisa, Ando, Takashi, Nakajima, Takeshi, Inui, Yoshikatsu, Oshima, Tadayuki, Tomita, Toshihiko, Mabe, Katsuhiro, Sasaki, Makoto, Suganuma, Takanori, Nomura, Hideyuki, Satoh, Kiichi, Hori, Shinichiro, Inoue, Syuuji, Tomokane, Takeshi, Kudo, Mineo, Inaba, Tomoki, Take, Susumu, Ohkusa, Toshifumi, Yamamoto, Shojiro, Mizuno, Shigeaki, Kamoshida, Toshiro, Amagai, Kenji, Iwamoto, Junichi, Miwa, Jun, Kodama, Masaaki, Okimoto, Tadayoshi, Kato, Mototsugu, Asaka, Masahiro, and For the Japan GAST Study Group.

Published
2013
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31. ID: 3526954 FOUR-YEAR PROGNOSIS SURVEY AFTER COLORECTAL ESD -MULTICENTER PROSPECTIVE STUDY AMONG JAPANESE FOREFRONT-

Author

Harada, Keita, primary, Kobayashi, Nozomu, additional, Ohata, Ken, additional, Takeuchi, Yoji, additional, Chino, Akiko, additional, Yamada, Masayoshi, additional, Tsuji, Yosuke, additional, Hotta, Kinichi, additional, Ikematsu, Hiroaki, additional, Uraoka, Toshio, additional, Murakami, Takashi, additional, Doyama, Hisashi, additional, Abe, Takashi, additional, Katagiri, Atsushi, additional, Hori, Shinichiro, additional, Michida, Tomoki, additional, Suzuki, Takuto, additional, Fukuzawa, Masakatsu, additional, Kiriyama, Shinsuke, additional, Fukase, Kazutoshi, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, and Saito, Yutaka, additional

Published
2021
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32. Transoral surgery for superficial head and neck cancer: National Multi‐Center Survey in Japan

Author

Katada, Chikatoshi, primary, Muto, Manabu, additional, Fujii, Satoshi, additional, Yokoyama, Tetsuji, additional, Yano, Tomonori, additional, Watanabe, Akihito, additional, Iizuka, Toshiro, additional, Yoshinaga, Shigetaka, additional, Tateya, Ichiro, additional, Mitani, Hiroki, additional, Shimizu, Yuichi, additional, Takahashi, Akiko, additional, Kamijo, Tomoyuki, additional, Hanaoka, Noboru, additional, Abe, Makoto, additional, Shiotani, Akihiro, additional, Kano, Koichi, additional, Asada, Yukinori, additional, Matsuhashi, Tamotsu, additional, Umeno, Hirohito, additional, Okami, Kenji, additional, Goda, Kenichi, additional, Hori, Shinichiro, additional, Ono, Yoichiro, additional, Terai, Shuji, additional, Nagami, Yasuaki, additional, Takemura, Kenichi, additional, Kawada, Kenro, additional, Ando, Mizuo, additional, Shimeno, Naoto, additional, Arai, Akihito, additional, Sakamoto, Yasutoshi, additional, Ichinoe, Masaaki, additional, Nemoto, Tetsuo, additional, Fujita, Masahiro, additional, Watanabe, Hidenobu, additional, Shimoda, Tadakazu, additional, Ochiai, Atsushi, additional, Kato, Takakuni, additional, and Hayashi, Ryuichi, additional

Published
2021
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33. Optimal surveillance interval after piecemeal endoscopic mucosal resection for large colorectal neoplasia: a multicenter randomized controlled trial

Author

Nakajima, Takeshi, primary, Sakamoto, Taku, additional, Hori, Shinichiro, additional, Yamada, Shinya, additional, Ikematsu, Hiroaki, additional, Harada, Keita, additional, Chiu, Han-Mo, additional, Kiriyama, Shinsuke, additional, Michida, Tomoki, additional, Hotta, Kinichi, additional, Sakamoto, Naoto, additional, Abe, Takashi, additional, Chino, Akiko, additional, Fukuzawa, Masakatsu, additional, Kobayashi, Nozomu, additional, Fukase, Kazutoshi, additional, Matsuda, Takahisa, additional, Murakami, Yoshitaka, additional, Ishikawa, Hideki, additional, and Saito, Yutaka, additional

Published
2021
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34. Linked Color Imaging Focused on Neoplasm Detection in the Upper Gastrointestinal Tract

Author

Ono, Shoko, primary, Kawada, Kenro, additional, Dohi, Osamu, additional, Kitamura, Shinji, additional, Koike, Tomoyuki, additional, Hori, Shinichiro, additional, Kanzaki, Hiromitsu, additional, Murao, Takahisa, additional, Yagi, Nobuaki, additional, Sasaki, Fumisato, additional, Hashiguchi, Keiichi, additional, Oka, Shiro, additional, Katada, Kazuhiro, additional, Shimoda, Ryo, additional, Mizukami, Kazuhiro, additional, Suehiro, Mitsuhiko, additional, Takeuchi, Toshihisa, additional, Katsuki, Shinichi, additional, Tsuda, Momoko, additional, Naito, Yuji, additional, Kawano, Tatsuyuki, additional, Haruma, Ken, additional, Ishikawa, Hideki, additional, Mori, Keita, additional, and Kato, Mototsugu, additional

Published
2021
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35. Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study

Author

Hamada, Kenta, primary, Kanzaki, Hiromitsu, additional, Inoue, Masafumi, additional, Ishiyama, Shuhei, additional, Yamauchi, Kenji, additional, Miyahara, Koji, additional, Toyokawa, Tatsuya, additional, Tsuzuki, Takao, additional, Miyaike, Jiro, additional, Matsubara, Minoru, additional, Takahashi, Sakuma, additional, Nishimura, Mamoru, additional, Takenaka, Ryuta, additional, Yunoki, Naoko, additional, Hori, Shinichiro, additional, Kobayashi, Sayo, additional, Yamasaki, Yasushi, additional, Kawahara, Yoshiro, additional, Ishikawa, Hideki, additional, and Okada, Hiroyuki, additional

Published
2020
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37. Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging

Author

Yoshida, Naohiro, primary, Doyama, Hisashi, additional, Yano, Tomonori, additional, Horimatsu, Takahiro, additional, Uedo, Noriya, additional, Yamamoto, Yoshinobu, additional, Kakushima, Naomi, additional, Kanzaki, Hiromitsu, additional, Hori, Shinichiro, additional, Yao, Kenshi, additional, Oda, Ichiro, additional, Katada, Chikatoshi, additional, Yokoi, Chizu, additional, Ohata, Ken, additional, Yoshimura, Kenichi, additional, Ishikawa, Hideki, additional, and Muto, Manabu, additional

Published
2020
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39. Long-Term Outcome in Patients with a Solitary Peutz-Jeghers Polyp

Author

Iwamuro, Masaya, primary, Aoyama, Yuki, additional, Suzuki, Seiyuu, additional, Kobayashi, Sayo, additional, Toyokawa, Tatsuya, additional, Moritou, Yuki, additional, Hori, Shinichiro, additional, Matsueda, Kazuhiro, additional, Yoshioka, Masao, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2019
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40. Factors associated with technical difficulty of endoscopic submucosal dissection for early gastric cancer that met the expanded indication criteria: post hoc analysis of a multi-institutional prospective confirmatory trial (JCOG0607)

Author

Yano, Tomonori, primary, Hasuike, Noriaki, additional, Ono, Hiroyuki, additional, Boku, Narikazu, additional, Ogawa, Gakuto, additional, Kadota, Tomohiro, additional, Oda, Ichiro, additional, Doyama, Hisashi, additional, Hori, Shinichiro, additional, Iishi, Hiroyasu, additional, Takahashi, Akiko, additional, Takizawa, Kohei, additional, and Muto, Manabu, additional

Published
2019
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41. Tu1981 LINKED COLOR IMAGING IMPROVES THE DETECTION RATE OF UPPER GASTROINTESTINAL NEOPLASMS: A PROSPECTIVE, MULTICENTER, RANDOMIZED, CONTROLLED TRIAL (LCI-FIND TRIAL)

Author

Dohi, Osamu, primary, Ono, Shoko, additional, Kawada, Kenro, additional, Kitamura, Shinji, additional, Koike, Tomoyuki, additional, Hori, Shinichiro, additional, Okada, Hiroyuki, additional, Shiotani, Akiko, additional, Yagi, Nobuaki, additional, Sasaki, Fumisato, additional, Nakao, Kazuhiko, additional, Tanaka, Shinji, additional, Katada, Kazuhiro, additional, Shimoda, Ryo, additional, Murakami, Kazunari, additional, Higuchi, Kazuhide, additional, Haruma, Ken, additional, Katsuki, Shinichi, additional, Ishikawa, Hideki, additional, and Kato, Mototsugu, additional

Published
2019
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42. Mo1335 DETECTION OF EARLY GASTRIC CANCER USING SECOND-GENERATION NARROW BAND IMAGING: A MULTICENTER RANDOMIZED CONTROLLED TRIAL

Author

Ito, Renma, primary, Yoshida, Naohiro, additional, Doyama, Hisashi, additional, Oono, Yasuhiro, additional, Yano, Tomonori, additional, Horimatsu, Takahiro, additional, Uetake, Hiroyuki, additional, Yamamoto, Yoshinobu, additional, Kakushima, Naomi, additional, Kanzaki, Hiromitsu, additional, Hori, Shinichiro, additional, Yao, Kenshi, additional, Oda, Ichiro, additional, Tanabe, Satoshi, additional, Yokoi, Chizu, additional, Ohata, Ken, additional, Yoshimura, Ken-ichi, additional, Ishikawa, Hideki, additional, and Muto, Manabu, additional

Published
2019
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43. Su1366 A NON-RANDOMIZED SINGLE-ARM CONFIRMATORY TRIAL OF ENDOSCOPIC SUBMUCOSAL DISSECTION TO EXPAND ITS INDICATION FOR EARLY GASTRIC CANCER OF UNDIFFERENTIATED TYPE: JAPAN CLINICAL ONCOLOGY GROUP STUDY (JCOG1009/1010)

Author

Takizawa, Kohei, primary, Ono, Hiroyuki, additional, Hasuike, Noriaki, additional, Takashima, Atsuo, additional, Minashi, Keiko, additional, Boku, Narikazu, additional, Kushima, Ryoji, additional, Katayama, Hiroshi, additional, Ogawa, Gakuto, additional, Fukuda, Haruhiko, additional, Fujisaki, Junko, additional, Oda, Ichiro, additional, Yano, Tomonori, additional, Hori, Shinichiro, additional, Doyama, Hisashi, additional, Hirasawa, Kingo, additional, Yamamoto, Yoshinobu, additional, Ishihara, Ryu, additional, Tanabe, Satoshi, additional, Niwa, Yasumasa, additional, Nakagawa, Masahiro, additional, Terashima, Masanori, additional, and Muto, Manabu, additional

Published
2019
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45. A nonrandomized, single-arm confirmatory trial of expanded endoscopic submucosal dissection indication for undifferentiated early gastric cancer: Japan Clinical Oncology Group study (JCOG1009/1010).

Author

Takizawa, Kohei, Ono, Hiroyuki, Hasuike, Noriaki, Takashima, Atsuo, Minashi, Keiko, Boku, Narikazu, Kushima, Ryoji, Katayama, Hiroshi, Ogawa, Gakuto, Fukuda, Haruhiko, Fujisaki, Junko, Oda, Ichiro, Yano, Tomonori, Hori, Shinichiro, Doyama, Hisashi, Hirasawa, Kingo, Yamamoto, Yoshinobu, Ishihara, Ryu, Tanabe, Satoshi, and Niwa, Yasumasa

Abstract

Background: While endoscopic submucosal dissection (ESD) is recognized as a minimally invasive standard treatment for differentiated early gastric cancers (EGCs), it has not been indicated for undifferentiated EGC (UD-EGC) because of a relatively high risk of lymph node metastasis (LNM). However, patients with surgically resected mucosal (cT1a) UD-EGC ≤ 2 cm in size with no lymphovascular invasion or ulceration are reported to be at a very low risk of LNM. This multicenter, single-arm, confirmatory trial was conducted to evaluate the efficacy and safety of ESD for UD-EGC. Methods: The key eligibility criteria were endoscopically diagnosed cT1a/N0/M0, single primary lesion, size ≤ 2 cm, no ulceration and histologically proven components of undifferentiated adenocarcinoma on biopsy. Based on the histological findings after ESD, additional gastrectomy was indicated if the criteria for curative resection were not satisfied. The subjects of the primary analysis were patients with UD-EGC as the dominant component. The primary endpoint was 5-year overall survival (OS) of patients with UD-EGC. Results: Three hundred 46 patients were enrolled from 49 institutions. The proportion of en bloc resection was 99%. No ESD-related Grade 4 adverse events were noted. Delayed bleeding and intraoperative and delayed perforation occurred in 25 (7.3%), 13 (3.8%), and 6 (1.7%) patients, respectively. Among the 275 patients who were the subjects of the primary analysis, curative resection was achieved in 195 patients (71%), and 5-year OS was 99.3% (95% CI: 97.1–99.8). Conclusions: ESD can be a curative and less invasive treatment for UD-EGC for patients meeting the eligibility criteria of this study. [ABSTRACT FROM AUTHOR]

Published
2021
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46. Final analysis of single-arm confirmatory study of diagnostic endoscopic resection(ER) plus selective chemoradiotherapy (CRT) for stage I esophageal squamous cell carcinoma (ESCC): JCOG0508.

Author

Minashi, Keiko, primary, Nihei, Keiji, additional, Ogawa, Gakuto, additional, Takizawa, Kohei, additional, Yano, Tomonori, additional, Amanuma, Yusuke, additional, Tsuchida, Tomohiro, additional, Ono, Hiroyuki, additional, Iizuka, Toshiro, additional, Shichijyo, Satoki, additional, Oda, Ichiro, additional, Morita, Yoshinori, additional, Tajika, Masahiro, additional, Fujiwara, Junko, additional, Yamamoto, Yoshinobu, additional, Katada, Chikatoshi, additional, Hori, Shinichiro, additional, Doyama, Hisashi, additional, Fukuda, Haruhiko, additional, and Muto, Manabu, additional

Published
2018
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47. The characteristics and outcomes of small bowel adenocarcinoma: a multicentre retrospective observational study

Author

Sakae, Hiroyuki, primary, Kanzaki, Hiromitsu, additional, Nasu, Junichiro, additional, Akimoto, Yutaka, additional, Matsueda, Kazuhiro, additional, Yoshioka, Masao, additional, Nakagawa, Masahiro, additional, Hori, Shinichiro, additional, Inoue, Masafumi, additional, Inaba, Tomoki, additional, Imagawa, Atsushi, additional, Takatani, Masahiro, additional, Takenaka, Ryuta, additional, Suzuki, Seiyu, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2017
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48. Early gastric cancer detection in high-risk patients: a multicentre randomised controlled trial on the effect of second-generation narrow band imaging

Author

Yoshida, Naohiro, Doyama, Hisashi, Yano, Tomonori, Horimatsu, Takahiro, Uedo, Noriya, Yamamoto, Yoshinobu, Kakushima, Naomi, Kanzaki, Hiromitsu, Hori, Shinichiro, Yao, Kenshi, Oda, Ichiro, Katada, Chikatoshi, Yokoi, Chizu, Ohata, Ken, Yoshimura, Kenichi, Ishikawa, Hideki, and Muto, Manabu

Abstract

ObjectiveEarly detection of gastric cancer has been the topic of major efforts in high prevalence areas. Whether advanced imaging methods, such as second-generation narrow band imaging (2G-NBI) can improve early detection, is unknown.DesignThis open-label, randomised, controlled tandem trial was conducted in 13 hospitals. Patients at increased risk for gastric cancer were randomly assigned to primary white light imaging (WLI) followed by secondary 2G-NBI (WLI group: n=2258) and primary 2G-NBI followed by secondary WLI (2G-NBI group: n=2265) performed by the same examiner. Suspected early gastric cancer (EGC) lesions in both groups were biopsied. Primary endpoint was the rate of EGC patients in the primary examination. The main secondary endpoint was the positive predictive value (PPV) for EGC in suspicious lesions detected (primary examination).ResultsEGCs were found in 44 (1.9%) and 53 (2.3%; p=0.412) patients in the WLI and 2G-NBI groups, respectively, during primary EGD. In a post hoc analysis, the overall rate of lesions detected at the second examination was 25% (n=36/145), with no significant differences between groups. PPV for EGC in suspicious lesions was 13.5% and 20.9% in the WLI (50/371 target lesions) and 2G-NBI groups (59/282 target lesions), respectively (p=0.015).ConclusionThe overall sensitivity of primary endoscopy for the detection of EGC in high-risk patients was only 75% and should be improved. 2G-NBI did not increase EGC detection rate over conventional WLI. The impact of a slightly better PPV of 2G-NBI has to be evaluated further.Trial registration numberUMIN000014503.

Published
2021
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49. Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of theMALT1gene

Author

Iwamuro, Masaya, primary, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Moritou, Yuki, additional, Saito, Shunsuke, additional, Hori, Shinichiro, additional, Inaba, Tomoki, additional, Kawai, Yoshinari, additional, Toyokawa, Tatsuya, additional, Tanaka, Takehiro, additional, Yoshino, Tadashi, additional, and Okada, Hiroyuki, additional

Published
2017
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50. Evaluation of an e-learning system for diagnosis of gastric lesions using magnifying narrow-band imaging: a multicenter randomized controlled study

Author

Nakanishi, Hiroyoshi, additional, Doyama, Hisashi, additional, Ishikawa, Hideki, additional, Uedo, Noriya, additional, Gotoda, Takuji, additional, Kato, Mototsugu, additional, Nagao, Shigeaki, additional, Nagami, Yasuaki, additional, Aoyagi, Hiroyuki, additional, Imagawa, Atsushi, additional, Kodaira, Junichi, additional, Mitsui, Shinya, additional, Kobayashi, Nozomu, additional, Muto, Manabu, additional, Takatori, Hajime, additional, Abe, Takashi, additional, Tsujii, Masahiko, additional, Watari, Jiro, additional, Ishiyama, Shuhei, additional, Oda, Ichiro, additional, Ono, Hiroyuki, additional, Kaneko, Kazuhiro, additional, Yokoi, Chizu, additional, Ueo, Tetsuya, additional, Uchita, Kunihisa, additional, Matsumoto, Kenshi, additional, Kanesaka, Takashi, additional, Morita, Yoshinori, additional, Katsuki, Shinichi, additional, Nishikawa, Jun, additional, Inamura, Katsuhisa, additional, Kinjo, Tetsu, additional, Yamamoto, Katsumi, additional, Yoshimura, Daisuke, additional, Araki, Hiroshi, additional, Kashida, Hiroshi, additional, Hosokawa, Ayumu, additional, Mori, Hirohito, additional, Yamashita, Haruhiro, additional, Motohashi, Osamu, additional, Kobayashi, Kazuhiko, additional, Hirayama, Michiaki, additional, Kobayashi, Hiroyuki, additional, Endo, Masaki, additional, Yamano, Hiroo, additional, Murakami, Kazunari, additional, Koike, Tomoyuki, additional, Hirasawa, Kingo, additional, Miyaoka, Youichi, additional, Hamamoto, Hidetaka, additional, Hikichi, Takuto, additional, Hanabata, Norihiro, additional, Shimoda, Ryo, additional, Hori, Shinichiro, additional, Sato, Tadashi, additional, Kodashima, Shinya, additional, Okada, Hiroyuki, additional, Mannami, Tomohiko, additional, Yamamoto, Shojiro, additional, Niwa, Yasumasa, additional, Yashima, Kazuo, additional, Tanabe, Satoshi, additional, Satoh, Hiro, additional, Sasaki, Fumisato, additional, Yamazato, Tetsuro, additional, Ikeda, Yoshiou, additional, Nishisaki, Hogara, additional, Nakagawa, Masahiro, additional, Matsuda, Akio, additional, Tamura, Fumio, additional, Nishiyama, Hitoshi, additional, Arita, Keiko, additional, Kawasaki, Keisuke, additional, Hoppo, Kazushige, additional, Oka, Masashi, additional, Ishihara, Shinichi, additional, Mukasa, Michita, additional, Minamino, Hiroaki, additional, and Yao, Kenshi, additional

Published
2017
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