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1. A New Rule for Terminating Resuscitation of Out-of-Hospital Cardiac Arrest Patients in Japan: A Prospective Study

Author

Inokuchi, Sadaki, Masui, Yoshihiro, Miura, Kunihisa, Tsutsumi, Haruhiko, Takuma, Kiyotsugu, Atsushi, Ishihara, Nakano, Minoru, Tanaka, Hiroshi, Ikegami, Keiichi, Arai, Takao, Yaguchi, Arino, Kitamura, Nobuya, Oda, Shigeto, Kobayashi, Kenji, Suda, Takayuki, Ono, Kazuyuki, Morimura, Naoto, Furuya, Ryosuke, Koido, Yuichi, Iwase, Fumiaki, Nagao, Ken, Kanesaka, Shigeru, Okada, Yasusei, Unemoto, Kyoko, Sadahiro, Tomohito, Iyanaga, Masayuki, Muraoka, Asaki, Hayashi, Munehiro, Ishimatsu, Shinichi, Miyake, Yasufumi, Yokokawa, Hideo, Koyama, Yasuaki, Tsuchiya, Asuka, Kashiyama, Tetsuya, Hayashi, Munetaka, Oshima, Kiyohiro, Kiyota, Kazuya, Hamabe, Yuichi, Yokota, Hiroyuki, Hori, Shingo, Inaba, Shin, Sakamoto, Tetsuya, Harada, Naoshige, Kimura, Akio, Kanai, Masayuki, Otomo, Yasuhiro, Sugita, Manabu, Kinoshita, Kosaku, Sakurai, Takatoshi, Kitano, Mitsuhide, Matsuda, Kiyoshi, Tanaka, Kotaro, Yoshihara, Katsunori, Yoh, Kikuo, Suzuki, Junichi, Toyoda, Hiroshi, Mashiko, Kunihiro, Shimizu, Naoki, Muguruma, Takashi, Shimada, Tadanaga, Kobe, Yoshiro, Shoko, Tomohisa, Nakanishi, Kazuya, Shiga, Takashi, Yamamoto, Takefumi, Sekine, Kazuhiko, and Izuka, Shinichi

Published
2017
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11. Relationship Between Institutional Volume of Out-of-Hospital Cardiac Arrest Cases and 1-Month Neurologic Outcomes: A Post Hoc Analysis of a Prospective Observational Study

Author

Kashiura, Masahiro, primary, Amagasa, Shunsuke, additional, Moriya, Takashi, additional, Sakurai, Atsushi, additional, Kitamura, Nobuya, additional, Tagami, Takashi, additional, Takeda, Munekazu, additional, Miyake, Yasufumi, additional, Inokuchi, Sadaki, additional, Masui, Yoshihiro, additional, Miura, Kunihisa, additional, Tsutsumi, Haruhiko, additional, Takuma, Kiyotsugu, additional, Atsushi, Ishihara, additional, Nakano, Minoru, additional, Tanaka, Hiroshi, additional, Ikegami, Keiichi, additional, Arai, Takao, additional, Yaguchi, Arino, additional, Oda, Shigeto, additional, Kobayashi, Kenji, additional, Suda, Takayuki, additional, Ono, Kazuyuki, additional, Morimura, Naoto, additional, Furuya, Ryosuke, additional, Koido, Yuichi, additional, Iwase, Fumiaki, additional, Nagao, Ken, additional, Kanesaka, Shigeru, additional, Okada, Yasusei, additional, Unemoto, Kyoko, additional, Sadahiro, Tomohito, additional, Iyanaga, Masayuki, additional, Muraoka, Asaki, additional, Hayashi, Munehiro, additional, Ishimatsu, Shinichi, additional, Yokokawa, Hideo, additional, Koyama, Yasuaki, additional, Tsuchiya, Asuka, additional, Kashiyama, Tetsuya, additional, Hayashi, Munetaka, additional, Oshima, Kiyohiro, additional, Kiyota, Kazuya, additional, Hamabe, Yuichi, additional, Yokota, Hiroyuki, additional, Hori, Shingo, additional, Inaba, Shin, additional, Sakamoto, Tetsuya, additional, Harada, Naoshige, additional, Kimura, Akio, additional, Kanai, Masayuki, additional, Otomo, Yasuhiro, additional, Sugita, Manabu, additional, Kinoshita, Kosaku, additional, Sakurai, Takatoshi, additional, Kitano, Mitsuhide, additional, B, Kiyoshi F., additional, Tanaka, Kotaro, additional, Yoshihara, Katsunori, additional, Yoh, Kikuo, additional, Suzuki, Junichi, additional, Toyoda, Hiroshi, additional, Mashiko, Kunihiro, additional, Shimizu, Naoki, additional, Muguruma, Takashi, additional, Shimada, Tadanaga, additional, Kobe, Yoshiro, additional, Shoko, Tomohisa, additional, Nakanishi, Kazuya, additional, Shiga, Takashi, additional, Yamamoto, Takefumi, additional, Sekine, Kazuhiko, additional, and Izuka, Shinichi, additional

Published
2020
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16. Characterization of energy metabolism and blood flow distribution in myocardial ischemia in hemorrhagic shock

Author

Miyazaki, Koji, Hori, Shingo, Inoue, Sohshin, Adachi, Takeshi, Bessho, Motoaki, Kuwahira, Ichiro, Mori, Hidezo, Nakazawa, Hiroe, Aikawa, Naoki, and Ogawa, Satoshi

Subjects
Metabolism -- Research, Ischemia -- Research, Hemorrhagic shock -- Research, Blood flow -- Research, Biological sciences
Abstract

The characterization of energy metabolism and blood flow distribution in myocardial ischemia in hemorrhagic shock was investigated to determine the initiating events before the deterioration of cardiac function. The study utilized a specially designed sampling device to cross section and halt clamping of the beating heart. Results of the study revealed that myocardial ischemia in early hemorrhagic shock was characterized by only a minimal transmural heterogeneity.

Published
1997

22. Diagnostic Implications of Elevated Levels of Smooth-Muscle Myosin Heavy-Chain Protein in Acute Aortic Dissection: The Smooth Muscle Myosin Heavy Chain Study

Author

Suzuki, Toru, Katoh, Hirohisa, Tsuchio, Yasuhiro, Hasegawa, Akira, Kurabayashi, Masahiko, Ohira, Atsushi, Hiramori, Katsuhiko, Sakomura, Yasunari, Kasanuki, Hiroshi, Hori, Shingo, Aikawa, Naoki, Abe, Satoshi, Tei, Chuwa, Nakagawa, Yoshihisa, Nobuyoshi, Masakiyo, Misu, Kazuhiko, Sumiyoshi, Tetsuya, and Nagai, Ryozo

Published
2000

28. Interleukin 8 in ARDS.

Author

Fujishima, Seitaro, Sasaki, Jun-ichi, Shinozawa, Yotaro, Takuma, Kiyotsugu, Hori, Shingo, and Aikawa, Naoki.

Published
1993

35. The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction ― First Pilot Study in Humans ―

Author

Katsumata, Yoshinori, primary, Sano, Fumiya, additional, Abe, Takayuki, additional, Tamura, Tomoyoshi, additional, Fujisawa, Taishi, additional, Shiraishi, Yasuyuki, additional, Kohsaka, Shun, additional, Ueda, Ikuko, additional, Homma, Koichiro, additional, Suzuki, Masaru, additional, Okuda, Shigeo, additional, Maekawa, Yuichiro, additional, Kobayashi, Eiji, additional, Hori, Shingo, additional, Sasaki, Junichi, additional, Fukuda, Keiichi, additional, and Sano, Motoaki, additional

Published
2017
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38. Generation of kidney tubular organoids from human pluripotent stem cells

Author

Yamaguchi, Shintaro, primary, Morizane, Ryuji, additional, Homma, Koichiro, additional, Monkawa, Toshiaki, additional, Suzuki, Sayuri, additional, Fujii, Shizuka, additional, Koda, Muneaki, additional, Hiratsuka, Ken, additional, Yamashita, Maho, additional, Yoshida, Tadashi, additional, Wakino, Shu, additional, Hayashi, Koichi, additional, Sasaki, Junichi, additional, Hori, Shingo, additional, and Itoh, Hiroshi, additional

Published
2016
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40. Emergency medicine as a specialty in Asia

Author

Pek, Jen Heng, Lim, Swee Han, Ho, Hiu Fai, Ramakrishnan, T. V., Jamaluddin, Sabariah Faizah, Mesa‐Gaerlan, Faith Joan C., Tiru, Mohan, Hwang, Sung Oh, Choi, Wai‐Mau, Kanchanasut, Somchai, Khruekarnchana, Pairoj, Avsarogullari, Levent, Shimazu, Takeshi, and Hori, Shingo

Subjects
Original Articles
Abstract

We aim to examine the similarities and differences in areas of EM development, workload, workforce, and capabilities and support in the Asia region. Emerging challenges faced by our EM community are also discussed.The National Societies for Emergency Medicine of Hong Kong, India, Japan, Malaysia, Philippines, Singapore, South Korea, Taiwan, Thailand and Turkey participated in the joint Japanese Association of Acute Medicine (JAAM) and Asian Conference of Emergency Medicine (ACEM) Special Symposium held in October 2013 at Tokyo, Japan. The findings are reviewed in this paper.Emergency medicine (EM) has over the years evolved into a distinct and recognized medical discipline requiring a unique set of cognitive, administrative and technical skills for managing all types of patients with acute illness or injury. EM has contributed to healthcare by providing effective, safe, efficient and cost-effective patient care. Integrated systems have developed to allow continuity of emergency care from the community into emergency departments. Structured training curriculum for undergraduates, and specialty training programs for postgraduates are in place to equip trainees with the knowledge and skills required for the unique practice of EM.The practice of EM still varies among the Asian countries. However, as a region, we strive to continue in our efforts to develop the specialty and improve the delivery of EM.

Published
2015

42. Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression

Author

Sato, Yukio, primary, Mabuchi, Yo, additional, Miyamoto, Kenichi, additional, Araki, Daisuke, additional, Niibe, Kunimichi, additional, Houlihan, Diarmaid D., additional, Morikawa, Satoru, additional, Nakagawa, Taneaki, additional, Nakajima, Toshihiro, additional, Akazawa, Chihiro, additional, Hori, Shingo, additional, Okano, Hideyuki, additional, and Matsuzaki, Yumi, additional

Published
2016
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43. Notch2 Signaling Regulates the Proliferation of Murine Bone Marrow-Derived Mesenchymal Stem/Stromal Cells via c-Myc Expression

Author

Sato Yukio, Mabuchi Yo, MIYAMOTO, Kenichi, Araki Daisuke, Niibe Kunimichi, Houlihan Diarmaid D., Morikawa Satoru, Nakagawa Taneaki, Nakajima Toshihiro, Akazawa Chihiro, Hori Shingo, Okano Hideyuki, MATSUZAKI, Yumi, Sato Yukio, Mabuchi Yo, MIYAMOTO, Kenichi, Araki Daisuke, Niibe Kunimichi, Houlihan Diarmaid D., Morikawa Satoru, Nakagawa Taneaki, Nakajima Toshihiro, Akazawa Chihiro, Hori Shingo, Okano Hideyuki, and MATSUZAKI, Yumi

Published
2016

44. Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase

Author

HATTAN, NAOICHIRO, BAN, KAZUNOBU, TANAKA, ETSURO, ABE, SUMIHISA, SEKKA, TAKAFUMI, SUGIO, YOSHINORI, MOHAMMED, MINHAZ U., SATO, ERIKO, SHINOZAI, YOSHIRO, ONISHI, YOZO, SUMA, HISAYOSHI, HANDA, SHUNNOSUKE, KAWADA, SHIAKI, HORI, SHINGO, IIDA, ATSUO, NAKAZAWA, HIROE, and MORI, HIDEZO

Subjects
Myocardial revascularization -- Research, Ischemia -- Research, Fluorescence -- Measurement, Enzymes -- Usage, Biological sciences
Abstract

Transmyocardial revascularization aggravates myocardial ischemia around the channels in the immediate phase. Am J Physiol Heart Circ Physiol 279: H1392-H1396, 2000.--We examined whether transmyocardial revascularization (TMR) relieves myocardial ischemia by increasing regional perfusion via the transmural channels in acute canine experiments. Regional blood flow during transient coronary ligation (2 min) was compared before and 30 min after TMR, and at the third transient ischemia the mid-left ventricle (LV) was cut and immediately frozen along the short axis for the analysis of NADH fluorescence in the regions around the TMR channels. In low-resolution analysis (2-4 g tissue or 2-3 [cm.sup.2] area), regional perfusion was not significantly altered after TMR, and NADH fluorescence was observed throughout the ischemic region without significant spatial variation. High-resolution analysis (2.8 mg, 1 mm x 1 mm) revealed that the flow after TMR was lower, and NADH fluorescence was higher in the regions close to the channels (1-2 mm) than in the regions 3-4 mm away from them. Creating TMR channels did not improve the regional perfusion and rather aggravated the local ischemia in the vicinity of the channels in the immediate phase. regional blood flow; microspheres; NADH fluorescence

Published
2000

45. Bathing and Indoor thermal environment: Modeling body temperature and preventing heat stroke

Author

ikaga, toshiharu, Hori, Shingo, Suzuki, Masaru, and Umishio, Wataru

Abstract

In Japan, the number of deaths from bathing-related heat stroke has increased rapidly over the last few years. Bathwater temperature and bathing duration have a major impact on body temperature, and extreme changes in body temperature can result in death. However, safe bathing habits have not been fully studied. Therefore, an existing human physiological model was extended to accurately predict body temperature during bathing. Furthermore, data from a field survey conducted in the 2012-2013 winter were analyzed and bathing habits were found to be affected by room temperature. The results of this study will be useful for promoting safe bathing habits that accommodate individual differences and show that heating of bathing-related rooms is recommended for preventing heat stroke due to bathing.

Published
2014

47. Feasibility and Safety of Hydrogen Gas Inhalation for Post-Cardiac Arrest Syndrome – First-in-Human Pilot Study –

Author

Tamura, Tomoyoshi, primary, Hayashida, Kei, additional, Sano, Motoaki, additional, Suzuki, Masaru, additional, Shibusawa, Takayuki, additional, Yoshizawa, Joe, additional, Kobayashi, Yosuke, additional, Suzuki, Takeshi, additional, Ohta, Shigeo, additional, Morisaki, Hiroshi, additional, Fukuda, Keiichi, additional, and Hori, Shingo, additional

Published
2016
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49. 新規水素吸入療法による院外心停止患者の予後改善を目指した臨床研究

Author

慶應義塾大学・医学部・教授, 慶應義塾大学・医学部・准教授, 慶應義塾大学・医学部・講師, 日本医科大学・大学院医学研究科・教授, 慶應義塾大学・医学部・助教, ホリ, シンゴ, サノ, モトアキ, スズキ, マサル, オオタ, シゲオ, ハヤシダ, ケイ, Hori, Shingo, Sano, Motoaki, Suzuki, Masaru, Ota, Shigeo, Hayashida, Kei, 堀, 進悟, 佐野, 元昭, 鈴木, 昌, 太田, 成男, 林田, 敬, 慶應義塾大学・医学部・教授, 慶應義塾大学・医学部・准教授, 慶應義塾大学・医学部・講師, 日本医科大学・大学院医学研究科・教授, 慶應義塾大学・医学部・助教, ホリ, シンゴ, サノ, モトアキ, スズキ, マサル, オオタ, シゲオ, ハヤシダ, ケイ, Hori, Shingo, Sano, Motoaki, Suzuki, Masaru, Ota, Shigeo, Hayashida, Kei, 堀, 進悟, 佐野, 元昭, 鈴木, 昌, 太田, 成男, and 林田, 敬

Abstract

Research team head, Research team member, Publisher, 本研究は, 水素吸入療法の院外心停止蘇生後患者に臨床応用を目指したトランスレーショナルリサーチである。まず, ラット心停止蘇生後モデルを用い水素吸入の有用性の検証した。水素吸入群では, 脳機能スコアおよび生存率が対照群と比較して改善した。水素吸入と低体温療法を併用することにより最も改善効果を認めた。さらに, 蘇生後患者に対し水素吸入の安全性と有効性の評価を行った。事前に設定した予測しうる心停止発症後7日間以内の臨床的異常変動を観察し, 副作用および臨床上の不利益をみとめなかった。対象全5例中4例が独歩退院した。今後, 多施設無作為化試験により心停止後症候群患者に対する水素吸入の効果を検証する予定である。 本研究は, 水素吸入療法の院外心停止蘇生後患者に臨床応用を目指したトランスレーショナルリサーチである。まず, ラット心停止蘇生後モデルを用い水素吸入の有用性の検証した。水素吸入群では, 脳機能スコアおよび生存率が対照群と比較して改善した。水素吸入と低体温療法を併用することにより最も改善効果を認めた。さらに, 蘇生後患者に対し水素吸入の安全性と有効性の評価を行った。事前に設定した予測しうる心停止発症後7日間以内の臨床的異常変動を観察し, 副作用および臨床上の不利益をみとめなかった。対象全5例中4例が独歩退院した。今後, 多施設無作為化試験により心停止後症候群患者に対する水素吸入の効果を検証する予定である。 This study is a translational research aimed at clinical application of hydrogen inhalation therapy (HIT) in out-of-hospital cardiac arrest (CA) patient. First, we verified the usefulness of hydrogen inhalation using a rat CA model. Brain function scores and survival rates in the HIT group were improved compared to the control group. It showed the most improvement effect by the combined use of HIT and therapeutic hypothermia. In addition, we evaluated the safety and efficacy of HIT for patients successfully resuscitated after CA. There were no side effects and clinical disadvantages. Four patients of all 5 eligible patients discharged from hospital with alert consciousness. We are planning to verify the efficacy of HIT for post-CA patients by multicenter randomized trial., 研究種目 : 基盤研究(B) 研究期間 : 2012～2014 課題番号 : 24390405 研究分野 : 救急医療

Published
2015

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