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187 results on '"Hopenhayn, Claudia"'

13. Human papillomavirus prevalence in oropharyngeal cancer before vaccine introduction, United States

Author

Steinau, Martin, Saraiya, Mona, Goodman, Marc T., Peters, Edward S., Watson, Meg, Cleveland, Jennifer L., Lynch, Charles F., Wilkinson, Edward J., Hernandez, Brenda Y., Copeland, Glen, Saber, Maria S., Hopenhayn, Claudia, Huang, Youjie, Cozen, Wendy, Lyu, Christopher, and Unger, Elizabeth R.

Subjects
Throat cancer -- Diagnosis -- Demographic aspects -- Prevention, Papillomavirus infections -- Research -- Demographic aspects -- Health aspects, Health
Abstract

Oropharyngeal cancers include malignancies that occur where the oral cavity and pharynx merge, including in the palatine and lingual tonsils, the posterior 1/3 (base) of the tongue, the soft palate, [...]

Published
2014
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14. Arsenic and Drinking Water

Author

Weinberg, Clarice, Hopenhayn, Claudia, Hertz-Picciotto, Irva, Browning, Steven R., and Huang, Bin

Published
2004

19. An in-depth and updated perspective on determinants of cervical cancer screening among central Appalachian women

Author

Schoenberg, Nancy E., Hopenhayn, Claudia, Christian, Amy, Knight, Evelyn A., and Rubio, Angel

Subjects
Rural women -- Health aspects, Cancer -- Diagnosis, Cancer -- Research, Health, Women's issues/gender studies
Abstract

Although cervical cancer rates in the U.S. have declined sharply, certain groups remain at elevated risk, including Appalachian women. To establish culturally-relevant cervical cancer prevention programs requires a comprehensive, current understanding of the factors which influence women's decisions to undergo Pap tests. Since most studies that found low rates of Pap test use in Appalachia were carried out decades ago, an in-depth update is warranted. Local, trained interviewers conducted interviews with rarely or never screened Appala chian women from Kentucky and West Virginia. Sessions were tape recorded, transcribed, and content analyzed. Participants (N = 25) suggested the following positive influences on obtaining screening: having an orientation toward the use of preventive health services; having health insurance and access to a good medical environment; and mainraining a flexible enough schedule to keep appointments. Screening barriers included: fear of subjecting oneself to medical scrutiny because of obesity or being a smoker: inadequate health care access such as clinician shortages, scarcity of specialty providers, long travel time to services, and clinic schedules that do not accommodate working women; and lack of providers' recommendations. Rarely mentioned were some previously reported factors including male relatives' refusal to permit Pap tests, concern over privacy, and lack of belief in Pap tests. KEYWORDS. Appalachia, rural women, attitudes/perceptions, cervical cancer, screening

Published
2005

27. Patterns of colorectal cancer incidence, risk factors, and screening in Kentucky

Author

Hopenhayn, Claudia, Moore, Derek B., Huang, Bin, Redmond, Jennifer, Tucker, Thomas C., Kryscio, Richard J., and Boissonneault, Gilbert A.

Subjects
Colorectal cancer -- Research -- Statistics, Health, American Cancer Society -- Statistics
Abstract

Background: Colorectal cancer incidence rates are higher in Kentucky than in the United States in general, and there are regional variations within the state. Methods: This study investigates these variations [...]

Published
2004

28. Prevalence of human papillomavirus types in invasive cervical cancers from seven US cancer registries prior to vaccine introduction

Author

Hopenhayn, Claudia, Christian, Amy, Christian, W. Jay, Watson, Meg, Unger, Elizabeth R., Lynch, Charles F., Peters, Edward S., Wilkinson, Edward J., Huang, Youjie, Copeland, Glenn, Cozen, Wendy, Saber, Maria Sibug, Goodman, Marc T., Hernandez, Brenda Y., Steinau, Martin, Lyu, Christopher, Tucker, Thomas T., and Saraiya, Mona

Subjects
Adult, Aged, 80 and over, Molecular Epidemiology, Adolescent, Genotype, Genotyping Techniques, Uterine Cervical Neoplasms, Middle Aged, Article, United States, Young Adult, Prevalence, Humans, Female, Registries, Papillomaviridae, Aged
Abstract

We conducted a baseline study of human papillomavirus (HPV) type prevalence in invasive cervical cancers (ICCs) using data from 7 cancer registries (CRs) in the United States. Cases were diagnosed between 1994 and 2005 before the implementation of the HPV vaccines.Cancer registries from Florida, Kentucky, Louisiana, Michigan, Hawaii, Iowa, and Los Angeles, California identified eligible ICC cases and obtained sections from representative blocks of archived tumor specimens for DNA extraction. All extracts were assayed by linear array and, if inadequate or HPV negative, retested with INNO-LiPA Genotype test. Clinical and demographic factors were obtained from the CRs and merged with the HPV typing data to analyze factors associated with different types and with HPV negativity.A total of 777 ICCs were included in this analysis, with broad geographic, age, and race distribution. Overall, HPV was detected in 91% of cases, including 51% HPV-16, 16% HPV-18 (HPV-16-negative), and 24% other oncogenic and rare types. After HPV-16 and -18, the most common types were 45, 33, 31, 35, and 52. Older age and nonsquamous histology were associated with HPV-negative typing.This study provides baseline prevaccine HPV types for postvaccine ICC surveillance in the future. HPV-16 and/or -18 were found in 67% of ICCs, indicating the potential for vaccines to prevent a significant number of cervical cancers.

Published
2014

29. Prevalence of Human Papillomavirus (HPV) Types in Invasive Vulvar Cancers and VIN3 in the United States Before Vaccine Introduction

Author

Gargano, Julia W., Wilkinson, Edward J., Unger, Elizabeth R., Steinau, Martin, Watson, Meg, Huang, Youjie, Copeland, Glenn, Cozen, Wendy, Goodman, Marc T., Hopenhayn, Claudia, Lynch, Charles F., Hernandez, Brenda Y., Peters, Edward S., Saber, Maria Sibug, Lyu, Christopher W., Sands, Lauren A., and Saraiya, Mona

Subjects
Adult, Aged, 80 and over, Viral Structural Proteins, Microscopy, Genotype, Vulvar Neoplasms, Histocytochemistry, Papillomavirus Infections, Middle Aged, Polymerase Chain Reaction, Article, United States, DNA, Viral, Prevalence, Humans, Female, Papillomaviridae, Carcinoma in Situ, Aged
Abstract

The study aimed to determine the baseline prevalence of human papillomavirus (HPV) types in invasive vulvar cancer (IVC) and vulvar intraepithelial neoplasia 3 (VIN 3) cases using data from 7 US cancer registries.Registries identified eligible cases diagnosed in 1994 to 2005 and requested pathology laboratories to prepare 1 representative block for HPV testing on those selected. Hematoxylin-eosin-stained sections preceding and following those used for extraction were reviewed to confirm representation. Human papillomavirus was detected using L1 consensus polymerase chain reaction (PCR) with PGMY9/11 primers and type-specific hybridization, with retesting of samples with negative and inadequate results with SPF10 primers. For IVC, the confirmatory hematoxylin-eosin slides were re-evaluated to determine histological type. Descriptive analyses were performed to examine distributions of HPV by histology and other factors.Human papillomavirus was detected in 121/176 (68.8%) cases of IVC and 66/68 (97.1%) cases of VIN 3 (p.0001). Patients with IVC and VIN 3 differed by median age (70 vs 55 y, p = .003). Human papillomavirus 16 was present in 48.6% of IVC cases and 80.9% of VIN 3 cases; other high-risk HPV was present in 19.2% of IVC cases and 13.2% of VIN 3 cases. Prevalence of HPV differed by squamous cell carcinoma histological subtype (p.0001) as follows: keratinizing, 49.1% (n = 55); nonkeratinizing, 85.7% (n = 14), basaloid, 92.3% (n = 14), warty 78.2% (n = 55), and mixed warty/basaloid, 100% (n = 7).Nearly all cases of VIN 3 and two thirds of IVC cases were positive for high-risk HPV. Prevalence of HPV ranged from 49.1% to 100% across squamous cell carcinoma histological subtypes. Given the high prevalence of HPV in IVC and VIN 3 cases, prophylactic vaccines have the potential to decrease the incidence of vulvar neoplasia.

Published
2012

31. Prevalence of Human Papillomavirus Types in Invasive Cervical Cancers From 7 US Cancer Registries Before Vaccine Introduction

Author

Hopenhayn, Claudia, primary, Christian, Amy, additional, Christian, Warren Jay, additional, Watson, Meg, additional, Unger, Elizabeth R., additional, Lynch, Charles F., additional, Peters, Edward S., additional, Wilkinson, Edward J., additional, Huang, Youjie, additional, Copeland, Glenn, additional, Cozen, Wendy, additional, Saber, Maria Sibug, additional, Goodman, Marc T., additional, Hernandez, Brenda Y., additional, Steinau, Martin, additional, Lyu, Christopher, additional, Tucker, Thomas T., additional, and Saraiya, Mona, additional

Published
2014
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32. Human Papillomavirus Prevalence in Invasive Anal Cancers in the United States Before Vaccine Introduction

Author

Steinau, Martin, primary, Unger, Elizabeth R., additional, Hernandez, Brenda Y., additional, Goodman, Marc T., additional, Copeland, Glenn, additional, Hopenhayn, Claudia, additional, Cozen, Wendy, additional, Saber, Maria S., additional, Huang, Youjie, additional, Peters, Edward S., additional, Lynch, Charles F., additional, Wilkinson, Edward J., additional, Rajeevan, Mangalathu S., additional, Lyu, Christopher, additional, and Saraiya, Mona, additional

Published
2013
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33. Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic

Author

Streinmaus, Craig, Moore, Lee E., Shipp, Miriam, Kalman, Dave, Rey, Omar A., Biggs, Mary Lou, Hopenhayn, Claudia, Bates, Michael N., Zheng, Schichun, Wiencke, John, Smith, Allan H., Streinmaus, Craig, Moore, Lee E., Shipp, Miriam, Kalman, Dave, Rey, Omar A., Biggs, Mary Lou, Hopenhayn, Claudia, Bates, Michael N., Zheng, Schichun, Wiencke, John, and Smith, Allan H.

Abstract

Methylation is the primary route of metabolism of inorganic arsenic in humans, and previous studies showed that interindividual differences in arsenic methylation may have important impacts on susceptibility to arsenic-induced cancer. To date, the factors that regulate arsenic methylation in humans are mostly unknown. Urinary arsenic methylation patterns and genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) were investigated in 170 subjects from an arsenic-exposed region in Argentina. Previous studies showed that subjects with the TT/AA polymorphisms at MTHFR 677 and 1298 have lower MTHFR activity than others. In this study, it was found that subjects with the TT/AA variant of MTHFR 677/1298 excreted a significantly higher proportion of ingested arsenic as inorganic arsenic and a lower proportion as dimethylarsinic acid. Women with the null genotype of GSTM1 excreted a significantly higher proportion of arsenic as monomethylarsonate than women with the active genotype. No associations were seen between polymorphisms in GSTT1 and arsenic methylation. This is the first study to report (1) associations between MTHFR and arsenic metabolism in humans, and (2) gender differences between genetic polymorphisms and urinary arsenic methylation patterns. Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer., Fil: Streinmaus, Craig. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States, Fil: Moore, Lee E. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States, Fil: Shipp, Miriam. Occupational and Environmental Medicine, University of California, San Francisco, CA, United States, Fil: Kalman, Dave. School of Public Health and Community Medicine, University of Washington, Seattle, WA, United States, Fil: Rey, Omar A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina, Fil: Biggs, Mary Lou. Fred Hutchinson Cancer Research Center, Seattle, WA, United States, Fil: Hopenhayn, Claudia. College of Public Health, University of Kentucky, Lexington, KY, United States, Fil: Bates, Michael N. School of Public Health, University of California, Berkeley, CA, United States, Fil: Zheng, Schichun. Department of Neurological Surgery, University of California, San Francisco, CA, United States, Fil: Wiencke, John. Department of Neurological Surgery, University of California, San Francisco, CA, United States, Fil: Smith, Allan H. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States

Published
2007

35. Prevalence of Human Papillomavirus Types in Invasive Vulvar Cancers and Vulvar Intraepithelial Neoplasia 3 in the United States Before Vaccine Introduction

Author

Gargano, Julia W., primary, Wilkinson, Edward J., additional, Unger, Elizabeth R., additional, Steinau, Martin, additional, Watson, Meg, additional, Huang, Youjie, additional, Copeland, Glenn, additional, Cozen, Wendy, additional, Goodman, Marc T., additional, Hopenhayn, Claudia, additional, Lynch, Charles F., additional, Hernandez, Brenda Y., additional, Peters, Edward S., additional, Saber, Maria Sibug, additional, Lyu, Christopher W., additional, Sands, Lauren A., additional, and Saraiya, Mona, additional

Published
2012
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36. P-196

Author

Arnold, Susanne, primary, Hopenhayn, Claudia, additional, Christian, Warren, additional, Sanderson, Wayne, additional, Huang, Bin, additional, Unrine, Jason, additional, Johnson, Nancy, additional, Shelton, Brent, additional, and Tucker, Thomas, additional

Published
2012
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39. Abstract 1871: Ecological association of trace element exposure and lung and colorectal cancer incidence in Southeastern Kentucky

Author

Shelton, Brent J., primary, Johnson, Nancy, additional, Tucker, Thomas, additional, Li, Li, additional, Unrine, Jason, additional, Christian, Jay, additional, Huang, Bin, additional, Arnold, Susanne, additional, Hopenhayn, Claudia, additional, Chen, Li, additional, Sanderson, Wayne, additional, and Shi, Xianglin, additional

Published
2011
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