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6. Heat-denatured human immunodeficiency virus type 1 protein 24 antigen: prognostic value in adults with early-stage disease

Author

Sterling, T R., Hoover, D R., Astemborski, J., Vlahov, D., Bartlett, J G., Schüpbach, J., Sterling, T R., Hoover, D R., Astemborski, J., Vlahov, D., Bartlett, J G., and Schüpbach, J.

Abstract

CD4(+) lymphocyte count and human immunodeficiency virus (HIV) type 1 RNA level are useful for determining when to initiate antiretroviral therapy but are not used widely in developing countries due to the high cost. Heat-denatured protein 24 (p24) antigen is an inexpensive assay that predicts disease progression among persons with advanced disease but has not been assessed among persons with early-stage disease. Plasma levels of heat-denatured p24 antigen were quantified in baseline study-visit specimens obtained from injection drug users enrolled in a longitudinal cohort study of HIV-1 infection. Of the 494 study participants (median initial CD4(+) lymphocyte count, 518 lymphocytes/mm(3)), 90 (18%) progressed to acquired immunodeficiency syndrome within 5 years. p24 antigen level correlated with both CD4(+) lymphocyte count (r=-0.34; P<.0001) and HIV-1 RNA level (r=0.55; P<.0001). p24 antigen level >5 pg/mL predicted disease progression, comparable with that of cutoff CD4(+) lymphocyte count <350 lymphocytes/mm(3) and HIV-1 RNA level >30,000 copies/mL. Heat-denatured p24 antigen level predicted subsequent clinical disease progression in early-stage HIV-1 infection and correlated with both CD4(+) lymphocyte count and HIV-1 RNA level

Published
2017

9. Heat-denatured human immunodeficiency virus type 1 protein 24 antigen: prognostic value in adults with early-stage disease

Author

Sterling, T R, Hoover, D R, Astemborski, J, Vlahov, D, Bartlett, J G, Schüpbach, J, and University of Zurich

Subjects
10028 Institute of Medical Virology, 2723 Immunology and Allergy, virus diseases, 570 Life sciences, biology, 610 Medicine & health, 2725 Infectious Diseases
Abstract

CD4(+) lymphocyte count and human immunodeficiency virus (HIV) type 1 RNA level are useful for determining when to initiate antiretroviral therapy but are not used widely in developing countries due to the high cost. Heat-denatured protein 24 (p24) antigen is an inexpensive assay that predicts disease progression among persons with advanced disease but has not been assessed among persons with early-stage disease. Plasma levels of heat-denatured p24 antigen were quantified in baseline study-visit specimens obtained from injection drug users enrolled in a longitudinal cohort study of HIV-1 infection. Of the 494 study participants (median initial CD4(+) lymphocyte count, 518 lymphocytes/mm(3)), 90 (18%) progressed to acquired immunodeficiency syndrome within 5 years. p24 antigen level correlated with both CD4(+) lymphocyte count (r=-0.34; P5 pg/mL predicted disease progression, comparable with that of cutoff CD4(+) lymphocyte count 30,000 copies/mL. Heat-denatured p24 antigen level predicted subsequent clinical disease progression in early-stage HIV-1 infection and correlated with both CD4(+) lymphocyte count and HIV-1 RNA level

Published
2002

11. Risk factors for non-Hodgkin's lymphomas in acquired immunodeficiency syndrome (AIDS)

Author

Armenian, H. K., Hoover, D. R., Rubb, S., Metz, S., Martinez-Maza, O., Chmiel, J., Lawrence Kingsley, and Saah, A.

Subjects
Adult, Male, Epidemiology, Lymphoma, Non-Hodgkin, Urban Health, Environmental Exposure, United States, Risk Factors, Case-Control Studies, Population Surveillance, Bisexuality, Humans, Prospective Studies, Homosexuality, Male, Lymphoma, AIDS-Related
Abstract

The possibility that an agent in addition to the human immunodeficiency virus (HIV) may contribute to the etiology of non-Hodgkin's lymphoma in persons with acquired immunodeficiency syndrome (AIDS) was studied using participants from the Multicenter AIDS Cohort Study (MACS) of homosexual and bisexual men enrolled in 1984-1985 and also in 1987-1991. A nested case-control analysis was conducted. The primary source of information on potential exposures and characteristics of the participants was the baseline study entry interview that was conducted prior to the development of AIDS. A total of 84 cases of non-Hodgkin's lymphoma were identified and compared with 527 participants who developed AIDS but had no evidence of cancer. The groups were similar for most sociodemographic characteristics as well as sexual activity and past history of antecedent illnesses. Although the non-Hodgkin's lymphoma cases reported less frequent use of recreational drugs and cigarettes compared with other persons with AIDS, these differences were not significant. Non-Hodgkin's lymphoma cases reported more frequent intake of aspirin during the week before the interview. However, there were no differences between the comparison groups for long-term aspirin intake or intake of other analgesics. The absence of any specific and strong association between non-Hodgkin's lymphoma and the various behavior-related activities and exposures considered in this analysis suggests that these factors are not related to a second agent in the etiology of HIV-induced non-Hodgkin's lymphoma. The possibility that a very common agent in this study population or that differences in the nature of the immune dysfunction resulting from HIV infection could act as a cofactor for HIV-induced non-Hodgkin's lymphoma cannot be excluded.

Published
1996

15. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women

Author

Gunter, M. J., primary, Hoover, D. R., additional, Yu, H., additional, Wassertheil-Smoller, S., additional, Rohan, T. E., additional, Manson, J. E., additional, Li, J., additional, Ho, G. Y. F., additional, Xue, X., additional, Anderson, G. L., additional, Kaplan, R. C., additional, Harris, T. G., additional, Howard, B. V., additional, Wylie-Rosett, J., additional, Burk, R. D., additional, and Strickler, H. D., additional

Published
2008
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22. Essential oils as spatial repellents for the brown marmorated stink bug, Halyomorpha halys ( Stål) ( Hemiptera: Pentatomidae).

Author

Zhang, Q.‐H., Schneidmiller, R. G., Hoover, D. R., Zhou, G., Margaryan, A., and Bryant, P.

Subjects
ESSENTIAL oils, REPELLENTS, STINKBUGS, HEMIPTERA, LEMONGRASS oil, SPEARMINT oil, METHYL benzoate
Abstract

The brown marmorated stink bug ( BMSB), Halyomorpha halys ( Stål), native to Northeastern Asia, is a serious invasive pest in the United States, Canada, Switzerland, Germany and France. Several common essential oils and their compositions were tested against BMSBs as potential repellents. All the tested individual essential oils and a ternary oil blend showed significant repellency to both BMSB nymphs and adults. Clove oil, lemongrass oil, spearmint oil, ylang-ylang oil, and the ternary oil mixture (clove, lemongrass and spearmint) almost completely blocked attraction of BMSBs to the stink bug attractant-baited traps; whereas wintergreen oil, geranium oil, pennyroyal oil and rosemary oil resulted in 60-85% trap catch reductions. Over 20 BMSB antennally active compounds were identified from SPME headspace samples of the eight repellent essential oils using GC- EAD and GC- MS techniques. Among the synthetic EAD-active compounds tested in the field, eugenol, l-carvone, p/l-menthone, pulegone, methyl salicylate, trans/ cis-citral, methyl benzoate and β-caryophyllene significantly reduced trap catches of BMSBs by 72-99%; these compounds are likely responsible for the repellency of their corresponding essential oils. Surprisingly, a synthetic mixture of the predacious spined soldier bug ( SSB) [ Podisus maculiventris (Say)] aggregation pheromone ( trans-2-hexenal, α-terpineol and benzyl alcohol) also showed a significant inhibition of BMSB response to its attractants. These repellent essential oils and their active compounds, as well as the synthetic SSB pheromone, are potentially useful as part of an efficient, environmentally sound semiochemical-based IPM programme to combat this serious invasive stink bug. [ABSTRACT FROM AUTHOR]

Published
2014
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23. SOME AUTHORS REPLY

Author

Armenian, H. K., primary, Hoover, D. R., additional, Rubb, S., additional, Metz, S., additional, Saah, A., additional, and Chmiel, J., additional

Published
1997
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24. HIV-Related Depression

Author

Lyketsos, C. G., primary, Hoover, D. R., additional, Guccione, M., additional, Dew, M. A., additional, Wesch, J. E., additional, and Bing, E. G., additional

Published
1997
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40. Dementia in AIDS patients

Author

McArthur, J. C., primary, Hoover, D. R., additional, Bacellar, H., additional, Miller, E. N., additional, Cohen, B. A., additional, Becker, J. T., additional, Graham, N.M.H., additional, McArthur, J. H., additional, Selnes, O. A., additional, Jacobson, L. P., additional, Visscher, B. R., additional, Concha, M., additional, and Saah, A., additional

Published
1993
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45. Depression in the first year of stay for elderly long-term nursing home residents in the USA.

Author

Hoover DR, Siegel M, Lucas J, Kalay E, Gaboda D, Devanand DP, Crystal S, Hoover, D R, Siegel, M, Lucas, J, Kalay, E, Gaboda, D, Devanand, D P, and Crystal, S

Abstract

Background: Understanding the prevalence, incidence and cofactors of depression among long-term elderly nursing home (LTNH) residents domiciled for eight months or more may help optimize depression treatment in this vulnerable group. We quantified first year depression in American LTNH residents and the associations between depression and resident/facility characteristics.Methods: Data were obtained from the Minimum Data Set and Online Survey Certification and Reporting for 634,060 LTNH residents admitted from 1999 to 2005 in 4,216 facilities. Depression first diagnosed at admission and at subsequent quarterly intervals through the first year of stay was examined. Logistic regressions modeled correlates of newly identified depression in each time-period.Results: Recorded depression at admission and during the first year increased from 1999 to 2005. By 2005, 54.4% of LTNH residents had depression diagnosed over the first year; 32.8% at admission and a further 21.6% later during the first year. Antidepressant use was reported prior to depression diagnosis for 48% of those first identified depressed after admission. Men, non-Hispanic blacks, never married, and severely-cognitively impaired LTNH residents were less often identified with depression, particularly at admission. Pain and physical comorbidity were positively associated with depression identified throughout the first year. Prior institutionalization was associated with depression at admission, but not new depression after admission. Facility characteristics had weaker associations with depression.Conclusions: High depression rates at admission and during the first year indicate a need to monitor and treat large numbers of American LTNH residents for depression. Reduced associations between demographics and depression as stays progress suggest other factors have increased roles in depression etiology. [ABSTRACT FROM AUTHOR]

Published
2010
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48. Children of injection drug users: impact of parental HIV status, AIDS, and depression.

Author

Pilowsky, Daniel, Knowlton, Amy, Latkin, Carl, Hoover, Donald, Chung, Shang-en, Celentano, David, Pilowsky, D J, Knowlton, A R, Latkin, C A, Hoover, D R, Chung, S E, and Celentano, D D

Abstract

We investigated the association between parental factors (including infection with human immunodeficiency virus [HIV], acquired immunodeficiency syndrome [AIDS] diagnosis, parental medical illness, and depression) and children's behavioral and emotional problems among children of injection drug users (IDUs). IDUs were recruited through community outreach. The sample included 73 parents of 73 children, aged 4 to 12 years. Parental depression (odds ratio [OR] = 4.61) and medical illness (OR = 4.70) were found to be significantly associated with internalizing (depressive and anxiety-related symptoms), but not with externalizing (aggressive and disruptive behaviors) symptoms in the children of IDUs. The clinical implications are that children of IDUs are known to be at high risk for psychiatric symptoms and disorders; these data suggest that children of depressed and/or medically ill IDU parents may be at even higher risk of internalizing symptoms (depression and anxiety symptoms) than children of IDUs who do not suffer from these conditions. [ABSTRACT FROM AUTHOR]

Published
2001
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50. Association of HIV-1 load and CD4 lymphocyte count with mortality among untreated African children over one year of age.

Author

Taha, Taha E., Kumwenda, Newton I., Hoover, Donald R., Biggar, Robert J., Broadhead, Robin L., Cassol, Sharon, van der Hoven, Len, Markakis, Diane, Liomba, George N., Chiphangwi, John D., Miotti, Paolo G., Taha, T E, Kumwenda, N I, Hoover, D R, Biggar, R J, Broadhead, R L, Cassol, S, van der Hoven, L, Markakis, D, and Liomba, G N

Published
2000
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