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Background: Children and young people affected by kidney failure experience complexities in their care. Little is known about the unique needs of this young patient population group living with a long‐term condition. Objective: A meta‐aggregation of all qualitative studies was conducted to identify experiences of supportive care among children and young people living with kidney failure. Methods: A systematic review of qualitative studies was conducted following the Joanna Briggs Institute meta‐aggregation method. This review has been reported according to the PRISMA statement guidelines. Six electronic databases (CINAHL, Cochrane Library, MEDLINE, Proquest, PsycINFO, and Scopus) were comprehensively searched by an expert systematic review librarian using keywords and subject headings, from inception to September 2022. All studies were accessed using a predetermined inclusion and exclusion criteria. Methodological quality assessment and data extraction performed. Qualitative findings accompanied by illustrative quotes from included studies were extracted and grouped into categories which created the overall synthesised findings. Results: A total of 34 studies were included in this review representing a total of 613 children and young people affected by kidney failure. There was a total of 190 findings which created 13 categories representing experiences of supportive care. The meta‐aggregation developed five synthesised findings namely: 'physical needs', 'information and technology', 'treatment and healthcare', 'social needs' and 'psychological impacts'. Conclusion: This systematic review identified that children and young people affected by kidney failure can experience a range of unmet supportive care needs in routine clinical services. Kidney failure impacted children and young people's self‐identify, social and peer networks, introduced daily practical needs because of inherent physical and psychological burden due to the failure and associated treatments. Despite improvements in the medical management of kidney failure in children and young people, further attention is needed to optimise supported self‐management in this young patient group. [ABSTRACT FROM AUTHOR]

Background: Eating disorders (ED) are serious psychiatric disorders, taking a life every 52 minutes, with high relapse. There are currently no support or effective intervention therapeutics for individuals with an ED in their everyday life. The aim of this study is to build idiographic machine learning (ML) models to evaluate the performance of physiological recordings to detect individual ED behaviors in naturalistic settings. Methods: From an ongoing study (Final N = 120), we piloted the ability for ML to detect an individual's ED behavioral episodes (e.g. purging) from physiological data in six individuals diagnosed with an ED, all of whom endorsed purging. Participants wore an ambulatory monitor for 30 days and tapped a button to denote ED behavioral episodes. We built idiographic (N = 1) logistic regression classifiers (LRC) ML trained models to identify onset of episodes (~600 windows) v. baseline (~571 windows) physiology (Heart Rate, Electrodermal Activity, and Temperature). Results: Using physiological data, ML LRC accurately classified on average 91% of cases, with 92% specificity and 90% sensitivity. Conclusions: This evidence suggests the ability to build idiographic ML models that detect ED behaviors from physiological indices within everyday life with a high level of accuracy. The novel use of ML with wearable sensors to detect physiological patterns of ED behavior pre-onset can lead to just-in-time clinical interventions to disrupt problematic behaviors and promote ED recovery. [ABSTRACT FROM AUTHOR]

This essay examines the relationship between patriarchal culture and Black separatist politics in Toni Morrison's Paradise. While these two themes are obviously central to the text, they are generally treated as merely contiguous elements of life in Ruby, Morrison's fictional all-Black town. A close examination of classic Black nationalist discourse, however, reveals that the politics of Black separatism has, from the time of its origin, stemmed from efforts to establish a Black patriarchal order that could stand in opposition to racist institutions and practices that strip the Black man of the patriarchal status enjoyed by white men. I argue that Morrison's novel exposes this causal relationship between patriarchal culture and Black separatism and the way that it generates within Black nationalist ideology a tendency to hijack, obscure, or even eliminate racial solidarity efforts that are more intersectional, inclusive, and democratic. [ABSTRACT FROM AUTHOR]

BACKGROUND: Glucosamine and chondroitin sulfate are used to treat osteoarthritis. The multicenter, double-blind, placebo- and celecoxib-controlled Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) evaluated their efficacy and safety as a treatment for knee pain from osteoarthritis. METHODS: We randomly assigned 1583 patients with symptomatic knee osteoarthritis to receive 1500 mg of glucosamine daily, 1200 mg of chondroitin sulfate daily, both glucosamine and chondroitin sulfate, 200 mg of celecoxib daily, or placebo for 24 weeks. Up to 4000 mg of acetaminophen daily was allowed as rescue analgesia. Assignment was stratified according to the severity of knee pain (mild [N=1229] vs. moderate to severe [N=354]). The primary outcome measure was a 20 percent decrease in knee pain from baseline to week 24. RESULTS: The mean age of the patients was 59 years, and 64 percent were women. Overall, glucosamine and chondroitin sulfate were not significantly better than placebo in reducing knee pain by 20 percent. As compared with the rate of response to placebo (60.1 percent), the rate of response to glucosamine was 3.9 percentage points higher (P=0.30), the rate of response to chondroitin sulfate was 5.3 percentage points higher (P=0.17), and the rate of response to combined treatment was 6.5 percentage points higher (P=0.09). The rate of response in the celecoxib control group was 10.0 percentage points higher than that in the placebo control group (P=0.008). For patients with moderate-to-severe pain at baseline, the rate of response was significantly higher with combined therapy than with placebo (79.2 percent vs. 54.3 percent, P=0.002). Adverse events were mild, infrequent, and evenly distributed among the groups. CONCLUSIONS: Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Exploratory analyses suggest that the combination of glucosamine and chondroitin sulfate may be effective in the subgroup of patients with moderate-to-severe knee pain.

Results from one long-term study and one summer-time field campaign in which the sulfur dioxide (SO2) mixing ratio was determined in mid-to-high latitude marine air at Cape Grim, Tasmania, are presented and analysed to provide a perspective on the potential role of SO2 in the production of aerosol sulfate at this site. Sulfur dioxide at Cape Grim has a distinct seasonal cycle, with a maximum mixing ratio in summer and minimum in winter, consistent with a similar cycle observed previously at Cape Grim for dimethyl sulfide (CH3SCH3; DMS) and its other oxidation products. Concentrations of SO2 in the summer were typically 10 ppt (pmole mole-1), which is considerably lower than those found at other sites subject to marine air more equatorial in origin. A modelling study suggests that differences between equatorial and mid-to-high latitude marine SO2 concentrations result from lower levels of the DMS precursor at mid latitudes and a lower rate of SO2 production at lower temperatures. The analysis also suggests the existence of an additional non-DMS source of boundary layer sulfur, relatively more important in winter when DMS levels are low. Entrainment from the lower free troposphere appears to be one likely source.