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1. Fast quantitative MRI as a nonlinear tomography problem

Author

Sbrizzi, Alessandro, van der Heide, Oscar, Cloos, Martijn, van der Toorn, Annette, Hoogduin, Hans, Luijten, Peter R., and Berg, Cornelis A. T. van den

Subjects
Physics - Applied Physics, Physics - Medical Physics
Abstract

Quantitative Magnetic Resonance Imaging (MRI) is based on a two-steps approach: estimation of the magnetic moments distribution inside the body, followed by a voxel-by-voxel quantification of the human tissue properties. This splitting simplifies the computations but poses several constraints on the measurement process, limiting its efficiency. Here, we perform quantitative MRI as a one step process; signal localization and parameter quantification are simultaneously obtained by the solution of a large scale nonlinear inversion problem based on first-principles. As a consequence, the constraints on the measurement process can be relaxed and acquisition schemes that are time efficient and widely available in clinical MRI scanners can be employed. We show that the nonlinear tomography approach is applicable to MRI and returns human tissue maps from very short experiments. Keywords: MR-STAT, quantitative MRI, nonlinear tomography, MR Fingerprinting, large scale inversion.

Published
2017
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4. Amide proton transfer weighted imaging in pediatric neuro-oncology: initial experience

Author

Center for Image Sciences, Highfield Research Group, Cancer, Precision Imaging Group, Brain, PMC Medisch specialisten, Circulatory Health, Regenerative Medicine and Stem Cells, Child Health, Infection & Immunity, MS Radiologie, Obdeijn, Iris V., Wiegers, Evita C., Alic, Lejla, Plasschaert, Sabine L.A., Kranendonk, Mariëtte E.G., Hoogduin, Hans M., Klomp, Dennis W.J., Wijnen, Jannie P., Lequin, Maarten H., Center for Image Sciences, Highfield Research Group, Cancer, Precision Imaging Group, Brain, PMC Medisch specialisten, Circulatory Health, Regenerative Medicine and Stem Cells, Child Health, Infection & Immunity, MS Radiologie, Obdeijn, Iris V., Wiegers, Evita C., Alic, Lejla, Plasschaert, Sabine L.A., Kranendonk, Mariëtte E.G., Hoogduin, Hans M., Klomp, Dennis W.J., Wijnen, Jannie P., and Lequin, Maarten H.

Published
2024

5. Design of a Cryogenic RF Coil Prototype for a Full Body 1.5T MRI Receive Array

Author

Zhurbenko, Vitaliy, Gosselink, Mark, Voogt, Ingmar, Alborahal, Cezar, Hoogduin, Hans, Jepsen, Rasmus Alexander, Sanchez Heredia, Juan Diego, Klomp, Dennis, Zhurbenko, Vitaliy, Gosselink, Mark, Voogt, Ingmar, Alborahal, Cezar, Hoogduin, Hans, Jepsen, Rasmus Alexander, Sanchez Heredia, Juan Diego, and Klomp, Dennis

Abstract

An RF coil is the first component in the MRI scanner receiver chain. This component therefore defines signal-to-noise ratio (SNR) and influences image quality. The ultimate goal of MRI development has always been to increase SNR. As the name indicates, SNR increase can be achieved by increasing the signal level and by decreasing the noise. The majority of efforts in the history of MRI development have been focused on increasing the signal. This is the reason typical MRI scans often rely on close-fitting coils. From a usability perspective and for the comfort of the patient it is beneficial to eliminate close-fitting RF coils1 and make them virtually invisible by integrating them into the scanner bore. In this work, this approach is studied, and a prototype of an integrated coil is developed.

Published
2024

11. Neural Correlates of Dutch Verb Second in Speech Production

Author

den Ouden, Dirk-Bart, Hoogduin, Hans, and Stowe, Laurie A.

Abstract

Dutch speakers with agrammatic Broca's aphasia are known to have problems with the production of finite verbs in main clauses. This performance pattern has been accounted for in terms of the specific syntactic complexity of the Dutch main clause structure, which requires an extra syntactic operation (Verb Second), relative to the basic Subject-Object-Verb order surfacing in Dutch subordinate clauses. We report an fMRI study into the question whether this syntactic complexity is reflected in increased brain activation correlated with the production of Dutch main clause word order, in speakers without language impairment. Nineteen healthy subjects performed a covert sentence completion task, during which main and subordinate clauses were alternately elicited in a block design. Results show a left middle to superior frontal cluster of activation correlated to production of Verb-Second over Verb-Final clauses, with no activation in the opposite contrast. This activation pattern is counter to what might be expected from the frequency distribution of main and subordinate clauses. We conclude that the Verb-Second deviation from the basic Dutch SOV word order costs extra neural resources and that this also underlies the agrammatic problems with the production of finite verbs in Dutch main clauses.

Published
2008
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12. The use of variable delay multipulse chemical exchange saturation transfer for separately assessing different CEST pools in the human brain at 7T

Author

Highfield Research Group, Infection & Immunity, Cancer, Brain, Schmitz-Abecassis, Bárbara, Vinogradov, Elena, Wijnen, Jannie P, van Harten, Thijs, Wiegers, Evita C, Hoogduin, Hans, van Osch, Matthias J P, Ercan, Ece, Highfield Research Group, Infection & Immunity, Cancer, Brain, Schmitz-Abecassis, Bárbara, Vinogradov, Elena, Wijnen, Jannie P, van Harten, Thijs, Wiegers, Evita C, Hoogduin, Hans, van Osch, Matthias J P, and Ercan, Ece

Published
2022

22. No need to detune transmitters in 32-channel receiver arrays at 7 T

Author

Highfield Research Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Gosselink, Mark, Hoogduin, Hans, Froeling, Martijn, Klomp, Dennis W J, Highfield Research Group, Brain, Cancer, Circulatory Health, Regenerative Medicine and Stem Cells, Gosselink, Mark, Hoogduin, Hans, Froeling, Martijn, and Klomp, Dennis W J

Published
2021

23. Validation of multiparametric MRI by histopathology after nephrectomy: a case study

Author

Researchgr. Cardiovasculaire Radiologie, Cancer, Nefro Vasculaire Geneeskunde, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, MS Nefrologie, Highfield Research Group, Pathologie afdeling Cytologie, Pathologie Pathologen staf, Regenerative Medicine and Stem Cells, Zorgeenheid Vaatchirurgie Medisch, Other research (not in main researchprogram), de Boer, Anneloes, Pieters, Tobias T, Harteveld, Anita A, Blankestijn, Peter J, Bos, Clemens, Froeling, Martijn, Goldschmeding, Roel, Hoogduin, Hans J M, Joles, Jaap A, Petri, Bart-Jeroen, Verhaar, Marianne C, Leiner, Tim, Nguyen, Tri Q, van Zuilen, Arjan D, Researchgr. Cardiovasculaire Radiologie, Cancer, Nefro Vasculaire Geneeskunde, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, MS Nefrologie, Highfield Research Group, Pathologie afdeling Cytologie, Pathologie Pathologen staf, Regenerative Medicine and Stem Cells, Zorgeenheid Vaatchirurgie Medisch, Other research (not in main researchprogram), de Boer, Anneloes, Pieters, Tobias T, Harteveld, Anita A, Blankestijn, Peter J, Bos, Clemens, Froeling, Martijn, Goldschmeding, Roel, Hoogduin, Hans J M, Joles, Jaap A, Petri, Bart-Jeroen, Verhaar, Marianne C, Leiner, Tim, Nguyen, Tri Q, and van Zuilen, Arjan D

Published
2021

24. Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study

Author

Cancer, Researchgr. Cardiovasculaire Radiologie, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, Computational Imaging, Fysica Radiotherapie Research, MS Nefrologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Nefro Vasculaire Geneeskunde, de Boer, Anneloes, Harteveld, Anita A., Stemkens, Bjorn, Blankestijn, Peter J., Bos, Clemens, Franklin, Suzanne L., Froeling, Martijn, Joles, Jaap A., Verhaar, Marianne C., van den Berg, Nico, Hoogduin, Hans, Leiner, Tim, Cancer, Researchgr. Cardiovasculaire Radiologie, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, Computational Imaging, Fysica Radiotherapie Research, MS Nefrologie, Highfield Research Group, Regenerative Medicine and Stem Cells, Nefro Vasculaire Geneeskunde, de Boer, Anneloes, Harteveld, Anita A., Stemkens, Bjorn, Blankestijn, Peter J., Bos, Clemens, Franklin, Suzanne L., Froeling, Martijn, Joles, Jaap A., Verhaar, Marianne C., van den Berg, Nico, Hoogduin, Hans, and Leiner, Tim

Published
2021

31. The YOUth cohort study: MRI protocol and test-retest reliability in adults

Author

Onderzoeksgroep 1, Brain, Strategische Impuls RvB ISI, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Circulatory Health, Beeldverwerking ISI, Divisie Beeld, Fysica Radiologie, Projectafdeling functional imaging, Onderzoek, Onderzoeksgroep 8, Buimer, Elizabeth E.L., Pas, Pascal, Brouwer, Rachel M., Froeling, Martijn, Hoogduin, Hans, Leemans, Alexander, Luijten, Peter, van Nierop, Bastiaan J., Raemaekers, Mathijs, Schnack, Hugo G., Teeuw, Jalmar, Vink, Matthijs, Visser, Fredy, Hulshoff Pol, Hilleke E., Mandl, René C.W., Onderzoeksgroep 1, Brain, Strategische Impuls RvB ISI, Highfield Research Group, Regenerative Medicine and Stem Cells, Cancer, Circulatory Health, Beeldverwerking ISI, Divisie Beeld, Fysica Radiologie, Projectafdeling functional imaging, Onderzoek, Onderzoeksgroep 8, Buimer, Elizabeth E.L., Pas, Pascal, Brouwer, Rachel M., Froeling, Martijn, Hoogduin, Hans, Leemans, Alexander, Luijten, Peter, van Nierop, Bastiaan J., Raemaekers, Mathijs, Schnack, Hugo G., Teeuw, Jalmar, Vink, Matthijs, Visser, Fredy, Hulshoff Pol, Hilleke E., and Mandl, René C.W.

Published
2020

32. Decreased native renal T1 up to one week after gadobutrol administration in healthy volunteers

Author

Researchgr. Cardiovasculaire Radiologie, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Cancer, Highfield Research Group, Regenerative Medicine and Stem Cells, de Boer, Anneloes, Harteveld, Anita A., Pieters, Tobias T., Blankestijn, Peter J., Bos, Clemens, Froeling, Martijn, Joles, Jaap A., Verhaar, Marianne C., Leiner, Tim, Hoogduin, Hans, Researchgr. Cardiovasculaire Radiologie, Researchgr. Beeldg. Moleculaire Interv., Brain, Circulatory Health, Nefro Vasculaire Geneeskunde, MS Nefrologie, Cancer, Highfield Research Group, Regenerative Medicine and Stem Cells, de Boer, Anneloes, Harteveld, Anita A., Pieters, Tobias T., Blankestijn, Peter J., Bos, Clemens, Froeling, Martijn, Joles, Jaap A., Verhaar, Marianne C., Leiner, Tim, and Hoogduin, Hans

Published
2020

33. Whole‐brain 3D FLAIR at 7T using direct signal control

Author

Beqiri, Arian, Hoogduin, Hans, Sbrizzi, Alessandro, Hajnal, Joseph V., and Malik, Shaihan J.

Subjects
ultrahigh field, Imaging, Three-Dimensional, Full Paper, parallel transmission, Full Papers—Imaging Methodology, FLAIR, RF shimming, Brain, Humans, Signal Processing, Computer-Assisted, Direct signal control, dynamic RF shimming, Magnetic Resonance Imaging
Abstract

Purpose Image quality obtained for brain imaging at 7T can be hampered by inhomogeneities in the static magnetic field, B0, and the RF electromagnetic field, B1. In imaging sequences such as fluid‐attenuated inversion recovery (FLAIR), which is used to assess neurological disorders, these inhomogeneities cause spatial variations in signal that can reduce clinical efficacy. In this work, we aim to correct for signal inhomogeneities to ensure whole‐brain coverage with 3D FLAIR at 7T. Methods The direct signal control (DSC) framework was used to optimize channel weightings applied to the 8 transmit channels used in this work on a pulse‐by‐pulse basis through the echo train in the FLAIR sequences. 3D FLAIR brain images were acquired on 5 different subjects and compared with imaging using a quadrature‐like mode of the transmit array. Precomputed “universal” DSC solutions calculated from a separate set of 5 subjects were also explored. Results DSC consistently enabled improved imaging across all subjects, with no dropouts in signal seen over the entire brain volume, which contrasted with imaging in quadrature mode. Further, the universal DSC solutions also consistently improved imaging despite not being optimized specifically for the subject being imaged. Conclusion 3D FLAIR brain imaging at 7T is substantially improved using DSC and is able to recover regions of low signal without increasing imaging time or interecho spacing.

Published
2018

35. The use of variable delay multipulse chemical exchange saturation transfer for separately assessing different CEST pools in the human brain at 7T.

Author

Schmitz‐Abecassis, Bárbara, Vinogradov, Elena, Wijnen, Jannie P., van Harten, Thijs, Wiegers, Evita C., Hoogduin, Hans, van Osch, Matthias J. P., and Ercan, Ece

Subjects
MAGNETIZATION transfer, OVERHAUSER effect (Nuclear physics), FOREIGN exchange rates, SERUM albumin
Abstract

Purpose: Current challenges of in vivo CEST imaging include overlapping signals from different pools. The overlap arises from closely resonating pools and/or the broad magnetization transfer contrast (MTC) from macromolecules. This study aimed to evaluate the feasibility of variable delay multipulse (VDMP) CEST to separately assess solute pools with different chemical exchange rates in the human brain in vivo, while mitigating the MTC. Methods: VDMP saturation buildup curves were simulated for amines, amides, and relayed nuclear Overhauser effect. VDMP data were acquired from glutamate and bovine serum albumin phantoms, and from six healthy volunteers at 7T. For the in vivo data, MTC removal was performed via a three‐pool Lorentzian fitting. Different B1 amplitudes and mixing times were used to evaluate CEST pools with different exchange rates. Results: The results show the importance of removing MTC when applying VDMP in vivo and the influence of B1 for distinguishing different pools. Finally, the optimal B1 and mixing times to effectively saturate slow‐ and fast‐exchanging components are also reported. Slow‐exchanging amides and rNOE components could be distinguished when using B1 = 1 μT and tmix = 10 ms and 40 ms, respectively. Fast‐exchanging components reached the highest saturation when using a B1 = 2.8 μT and tmix = 0 ms. Conclusion: VDMP is a powerful CEST‐editing tool, exploiting chemical exchange‐rate differences. After MTC removal, it allows separate assessment of slow‐ and fast‐exchanging solute pools in in vivo human brain. [ABSTRACT FROM AUTHOR]

Published
2022
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41. The YOUth cohort study: MRI protocol and test-retest reliability in adults

Author

Buimer, Elizabeth E.L., primary, Pas, Pascal, additional, Brouwer, Rachel M., additional, Froeling, Martijn, additional, Hoogduin, Hans, additional, Leemans, Alexander, additional, Luijten, Peter, additional, van Nierop, Bastiaan J., additional, Raemaekers, Mathijs, additional, Schnack, Hugo G., additional, Teeuw, Jalmar, additional, Vink, Matthijs, additional, Visser, Fredy, additional, Hulshoff Pol, Hilleke E., additional, and Mandl, René C.W., additional

Published
2020
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42. Validation of multiparametric MRI by histopathology after nephrectomy: a case study

Author

de Boer, Anneloes, primary, Pieters, Tobias T., additional, Harteveld, Anita A., additional, Blankestijn, Peter J., additional, Bos, Clemens, additional, Froeling, Martijn, additional, Goldschmeding, Roel, additional, Hoogduin, Hans J. M., additional, Joles, Jaap A., additional, Petri, Bart-Jeroen, additional, Verhaar, Marianne C., additional, Leiner, Tim, additional, Nguyen, Tri Q., additional, and van Zuilen, Arjan D., additional

Published
2020
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43. Multiparametric Renal MRI: An Intrasubject Test–Retest Repeatability Study

Author

Boer, Anneloes, primary, Harteveld, Anita A., additional, Stemkens, Bjorn, additional, Blankestijn, Peter J., additional, Bos, Clemens, additional, Franklin, Suzanne L., additional, Froeling, Martijn, additional, Joles, Jaap A., additional, Verhaar, Marianne C., additional, Berg, Nico, additional, Hoogduin, Hans, additional, and Leiner, Tim, additional

Published
2020
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47. Implications of Extracranial Distortion in Ultra-High-Field Magnetic Resonance Imaging for Image-Guided Cranial Neurosurgery

Author

Voormolen, Eduard H, Diederen, Sander J H, Woerdeman, Peter, van der Sprenkel, Jan Willem Berkelbach, Noordmans, Herke Jan, Visser, Fredy, Viergever, Max A, Luijten, Peter, Hoogduin, Hans, Robe, Pierre A, Voormolen, Eduard H, Diederen, Sander J H, Woerdeman, Peter, van der Sprenkel, Jan Willem Berkelbach, Noordmans, Herke Jan, Visser, Fredy, Viergever, Max A, Luijten, Peter, Hoogduin, Hans, and Robe, Pierre A

Published
2019

48. Implications of Extracranial Distortion in Ultra-High-Field Magnetic Resonance Imaging for Image-Guided Cranial Neurosurgery

Author

ZL Algemene en Acute Nec Medisch, Brain, Opleiding Neurochirurgie, ZL Kinder Ner en Nec Medisch, Team Innovatie Research MTKF, Other research (not in main researchprogram), Cancer, Regenerative Medicine and Stem Cells, Circulatory Health, Highfield Research Group, Beeldverwerking ISI, Neurochirurgie, Voormolen, Eduard H, Diederen, Sander J H, Woerdeman, Peter, van der Sprenkel, Jan Willem Berkelbach, Noordmans, Herke Jan, Visser, Fredy, Viergever, Max A, Luijten, Peter, Hoogduin, Hans, Robe, Pierre A, ZL Algemene en Acute Nec Medisch, Brain, Opleiding Neurochirurgie, ZL Kinder Ner en Nec Medisch, Team Innovatie Research MTKF, Other research (not in main researchprogram), Cancer, Regenerative Medicine and Stem Cells, Circulatory Health, Highfield Research Group, Beeldverwerking ISI, Neurochirurgie, Voormolen, Eduard H, Diederen, Sander J H, Woerdeman, Peter, van der Sprenkel, Jan Willem Berkelbach, Noordmans, Herke Jan, Visser, Fredy, Viergever, Max A, Luijten, Peter, Hoogduin, Hans, and Robe, Pierre A

Published
2019

49. Analysis of chemical exchange saturation transfer contributions from brain metabolites to the Z-spectra at various field strengths and pH

Author

Brain, Highfield Research Group, Cancer, Regenerative Medicine and Stem Cells, Circulatory Health, Khlebnikov, Vitaliy, van der Kemp, Wybe J. M., Hoogduin, Hans, Klomp, Dennis W. J., Prompers, Jeanine J., Brain, Highfield Research Group, Cancer, Regenerative Medicine and Stem Cells, Circulatory Health, Khlebnikov, Vitaliy, van der Kemp, Wybe J. M., Hoogduin, Hans, Klomp, Dennis W. J., and Prompers, Jeanine J.

Published
2019

50. Establishing upper limits on neuronal activity-evoked pH changes with APT-CEST MRI at 7 T

Author

Khlebnikov, Vitaly, Siero, JCW, Bhogal, Alex A, Luijten, Peter R, Klomp, DWJ, Hoogduin, Hans, and Spinoza Centre for Neuroimaging

Subjects
Journal Article
Abstract

PURPOSE: To detect neuronal activity-evoked pH changes by amide proton transfer-chemical exchange saturation transfer (APT-CEST) MRI at 7 T. METHODS: Three healthy subjects participated in the study. A low-power 3-dimensional APT-CEST sequence was optimized through the Bloch-McConnell equations. pH sensitivity of the sequence was estimated both in phantoms and in vivo. The feasibility of pH-functional MRI was tested in Bloch-McConnell-simulated data using the optimized sequence. In healthy subjects, the visual stimuli were used to evoke transient pH changes in the visual cortex, and a 3-dimensional APT-CEST volume was acquired at the pH-sensitive frequency offset of 3.5 ppm every 12.6 s. RESULTS: In theory, a three-component general linear model was capable of separating the effects of blood oxygenation level-dependent contrast and pH. The Bloch-McConnell equations indicated that a change in pH of 0.03 should be measurable at the experimentally determined temporal signal-to-noise ratio of 108. However, only a blood oxygenation level-dependent effect in the visual cortex could be discerned during the visual stimuli experiments performed in the healthy subjects. CONCLUSIONS: The results of this study suggest that if indeed there are any transient brain pH changes in response to visual stimuli, those are under 0.03 units pH change, which is extremely difficult to detect using the existent techniques. Magn Reson Med, 2017. © 2017 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Published
2018

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