Search

Your search keyword '"Hood, Gillian A."' showing total 33 results
Start Over Author "Hood, Gillian A."
33 results on '"Hood, Gillian A."'

2. The generation of senescent-like CD4+ EMRA T cells in T2D and their contribution to poor COVID-19 vaccine responses

Author

Garrod-Ketchley, Conor, primary, d’Algue, Laure Mourgue, additional, Littlewood, Katie, additional, Hood, Gillian, additional, Worthington, Anne, additional, Pattrick, Melanie, additional, Sutcliffe, Caroline, additional, Valla, Zoi, additional, Joti, Noorshad, additional, Zalak, Udeshi, additional, Edwards, Amy, additional, Finer, Sarah, additional, and Henson, Sian M, additional

Published
2023
Full Text
View/download PDF

3. Clinical efficacy and safety of a light mask for prevention of dark adaptation in treating and preventing progression of early diabetic macular oedema at 24 months (CLEOPATRA): a multicentre, phase 3, randomised controlled trial

Author

Ahfat, Frank, Bhatnagar, Ajay, Narendran, Nirodhini, Chavan, Randhir, Cole, Abosede, Crosby-Nwaobi, Roxanne, Patrao, Namritha, Menon, Deepthy, Hogg, Chris, Rubin, Gary, Leitch-Devlin, Lauren, Egan, Catherine, Shah, Nisha, Mansour, Tatiana, Peto, Tunde, Eleftheriadis, Haralabos, Gibson, Joanathan, Ghulakhszian, Arevik, Vafidis, Gilli, Hughes, Edward, Jafree, Afsar, Menon, Geeta, Prakash, Priya, Sandinha, Maria, Smith, Richard, Scanlon, Peter, Chave, Steve, Aldington, Steve, Dale, Angela, Hood, Gillian, Hitman, Graham A, Crabb, David, Denniston, Alaistair, Lewin, Douglas, Grierson, Ian, Walker, Sarah, Sturt, Jackie, Sahu, Debendra, Sivaprasad, Sobha, Vasconcelos, Joana C, Prevost, A Toby, Holmes, Helen, Hykin, Philip, George, Sheena, Murphy, Caroline, Kelly, Joanna, and Arden, Geoffrey B

Published
2018
Full Text
View/download PDF

5. Toll-like receptor 5 signalling mediates pro-inflammatory and fibrogenic responses in non-alcoholic steatohepatitis (NASH)

Author

Li, Wenhao, primary, Garrido, Patricia, additional, Mir, Iris Gines, additional, Waller, Kathryn, additional, Jong, Anja Versteeg-de, additional, Brindley, James Hallimond, additional, Khan, Waleed, additional, Hood, Gillian, additional, Boot, James, additional, Mein, Chaz, additional, Devalia, Kalpana, additional, Loy, John, additional, and Alazawi, William, additional

Published
2023
Full Text
View/download PDF

8. Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

Author

Bhatnagar, A, Burton, B, Chakravarthy, U, Eleftheriadis, H, Empeslidis, T, Gale, R, George, S, Habib, M, Kelly, S, Lotery, A, McKibbin, M, Membrey, L, Menon, G, Mushtaq, B, Nicholson, L, Ramu, J, Osoba, O, Patel, J, Prakash, P, Purbrick, R, Ross, A, Stylianides, A, Talks, J, Harding, S, Peto, T, Yeo, S T, Laidlaw, Alistair, Amoaku, Winfried, Hood, Gillian, Hitman, Graham A, Preece, Daniel, Burns, Paul, Walker, Sarah, Mensah, Evelyn, Karia, Niral, Sivaprasad, Sobha, Prevost, A Toby, Vasconcelos, Joana C, Riddell, Amy, Murphy, Caroline, Kelly, Joanna, Bainbridge, James, Tudor-Edwards, Rhiannon, Hopkins, David, and Hykin, Philip

Published
2017
Full Text
View/download PDF

9. The contribution of daytime sleepiness to impaired quality of life in NAFLD in an ethnically diverse population

Author

Fisiología, Fisiologia, Li, Wenhao, Kadler, Benjamin Karl, Brindley, James Hallimond, Hood, Gillian, Devalia, Kalpana, Loy, John, Syn, Wing-Kin, Alazawi, William, Fisiología, Fisiologia, Li, Wenhao, Kadler, Benjamin Karl, Brindley, James Hallimond, Hood, Gillian, Devalia, Kalpana, Loy, John, Syn, Wing-Kin, and Alazawi, William

Abstract

Health-related quality of life (HRQoL) is lower in people with NAFLD compared to the general population. Sleep disturbance resulting in daytime sleepiness is common in patients with NAFLD, but the effect of daytime sleepiness on HRQoL in NAFLD is unclear. The prevalence and natural history of NAFLD vary in different ethnic groups, but there has been limited ethnic diversity in HrQoL studies to date. We aimed to assess whether daytime sleepiness is independently associated with reduced HRQoL in an ethnically diverse UK population. We conducted HRQoL assessments using SF-36 version 2 and Epworth Sleepiness Scale (ESS) questionnaires in 192 people with NAFLD. Multivariate linear regression was used to identify factors independently affecting HRQoL scales. People with NAFLD reported significantly reduced physical health-related SF-36 scores compared to the general UK population. South Asian NAFLD patients reported impairment in physical health, but not mental health, approximately a decade before White NAFLD patients. In multivariate linear regression, daytime sleepiness (ESS score > 10), was the most significant independent predictor of reduced physical health. Age, BMI and liver stiffness score were also significantly associated. HRQoL is impaired earlier in patients of South Asian ethnicity. ESS score > 10, indicative of excessive daytime sleepiness, is an independent predictor of reduced HRQoL in people with NAFLD regardless of ethnicity. Daytime sleepiness should be considered as a contributing factor to reduced HRQoL in clinical practice and when evaluating patient-related outcomes in clinical trials.

Published
2022

10. Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8+ EMRA T Cells During Type 2 Diabetes

Author

Callender, Lauren A., primary, Carroll, Elizabeth C., additional, Garrod-Ketchley, Conor, additional, Schroth, Johannes, additional, Bystrom, Jonas, additional, Berryman, Victoria, additional, Pattrick, Melanie, additional, Campbell-Richards, Desiree, additional, Hood, Gillian A., additional, Hitman, Graham A., additional, Finer, Sarah, additional, and Henson, Sian M., additional

Published
2021
Full Text
View/download PDF

16. A perspective from one clinical research center in the United Kingdom

Author

Hood, Gillian A.

Subjects
European Union, General interest, Health
Abstract

Trepidation and concern have been central to many U.K.-based discussions on the impact of the EU Directive on Good Clinical Practice in Clinical Trials. (1) Some have suggested that the [...]

Published
2004

18. Clinical efficacy and safety of a light mask for prevention of dark adaptation in treating and preventing progression of early diabetic macular oedema at 24 months (CLEOPATRA): a multicentre, phase 3, randomised controlled trial

Author

Sivaprasad, Sobha, primary, Vasconcelos, Joana C, additional, Prevost, A Toby, additional, Holmes, Helen, additional, Hykin, Philip, additional, George, Sheena, additional, Murphy, Caroline, additional, Kelly, Joanna, additional, Arden, Geoffrey B, additional, Ahfat, Frank, additional, Bhatnagar, Ajay, additional, Narendran, Nirodhini, additional, Chavan, Randhir, additional, Cole, Abosede, additional, Crosby-Nwaobi, Roxanne, additional, Patrao, Namritha, additional, Menon, Deepthy, additional, Hogg, Chris, additional, Rubin, Gary, additional, Leitch-Devlin, Lauren, additional, Egan, Catherine, additional, Shah, Nisha, additional, Mansour, Tatiana, additional, Peto, Tunde, additional, Eleftheriadis, Haralabos, additional, Gibson, Joanathan, additional, Ghulakhszian, Arevik, additional, Vafidis, Gilli, additional, Hughes, Edward, additional, Jafree, Afsar, additional, Menon, Geeta, additional, Prakash, Priya, additional, Sandinha, Maria, additional, Smith, Richard, additional, Scanlon, Peter, additional, Chave, Steve, additional, Aldington, Steve, additional, Dale, Angela, additional, Hood, Gillian, additional, Hitman, Graham A, additional, Crabb, David, additional, Denniston, Alaistair, additional, Lewin, Douglas, additional, Grierson, Ian, additional, Walker, Sarah, additional, Sturt, Jackie, additional, and Sahu, Debendra, additional

Published
2018
Full Text
View/download PDF

19. Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial

Author

Sivaprasad, Sobha, primary, Prevost, A Toby, additional, Vasconcelos, Joana C, additional, Riddell, Amy, additional, Murphy, Caroline, additional, Kelly, Joanna, additional, Bainbridge, James, additional, Tudor-Edwards, Rhiannon, additional, Hopkins, David, additional, Hykin, Philip, additional, Bhatnagar, A, additional, Burton, B, additional, Chakravarthy, U, additional, Eleftheriadis, H, additional, Empeslidis, T, additional, Gale, R, additional, George, S, additional, Habib, M, additional, Kelly, S, additional, Lotery, A, additional, McKibbin, M, additional, Membrey, L, additional, Menon, G, additional, Mushtaq, B, additional, Nicholson, L, additional, Ramu, J, additional, Osoba, O, additional, Patel, J, additional, Prakash, P, additional, Purbrick, R, additional, Ross, A, additional, Stylianides, A, additional, Talks, J, additional, Harding, S, additional, Peto, T, additional, Yeo, S T, additional, Laidlaw, Alistair, additional, Amoaku, Winfried, additional, Hood, Gillian, additional, Hitman, Graham A, additional, Preece, Daniel, additional, Burns, Paul, additional, Walker, Sarah, additional, Mensah, Evelyn, additional, and Karia, Niral, additional

Published
2017
Full Text
View/download PDF

31. The Mela Study: exploring barriers to diabetes research in black and minority ethnic groups.

Author

Hood, Gillian A., Chowdhury, Tahseen A., Griffiths, Christopher J., Hood, Rosie K.E., Mathews, Christopher, and Hitman, Graham A.

Subjects
*BLACK people, *DIABETES, *DISEASE susceptibility, *DRUG side effects, *ETHNIC groups, *FEAR, *MINORITIES, *PATIENT advocacy, *PROBABILITY theory, *QUESTIONNAIRES, *STATISTICAL sampling, *SEX distribution, *TIME, *TRUST, *CITY dwellers, *SOCIAL attitudes, *COMMUNICATION barriers, *HUMAN research subjects, *CROSS-sectional method, *PATIENT selection, *HEALTH literacy, *DESCRIPTIVE statistics
Abstract

BackgroundBlack and minority ethnic (BME) groups are particularly susceptible to diabetes and its vascular complications in the United Kingdom and most western societies. To understand potential predisposition and tailor treatments accordingly, there is a real need to engage these groups in diabetes research. Despite this, BME participation in research studies continues to remain low in most countries and this may be a contributory factor to reduced health outcomes and poorer quality of life in these groups. This study explores the barriers BME groups may have towards participation in diabetes research in one area of East London, and includes local recommendations on how to improve this for the future.MethodsA questionnaire designed from previously reported exploratory work and piloted in several BME localities was distributed at the East London Bangladeshi Mela and similar cultural and religious events in London, UK. People were asked opportunistically to complete the survey themselves if they understood English, or discuss their responses with an advocate. The purpose of the questionnaire was to understand current local awareness with regards to diabetes, identify specific BME barriers and attitudes towards diabetes research by ethnicity, gender and age, and gain insight into how these barriers may be addressed.ResultsOf 1682 people surveyed (16–90 years; median age 40 years), 36.4% were South Asian, 25.9% White, and 11.1% Black and other ethnicities; 26.6% withheld their ethnicity. Over half cited language problems generally (54%) and lack of research awareness (56%) as main barriers to engaging in research. South Asian groups were more likely to cite research as too time consuming (42%) whereas Black groups were more concerned with potential drug side effects in research (39%). Participants expressed a general mistrust of research, and the need for researchers to be honest in their approach. Recommendations for increased participation in South Asian groups centred round both helping the community (61%) and improving health (55%). With regards to gender influences, females (34.6%) were significantly more likely to fear drug side effects than males (23.8%), P<0.001. Females were also significantly more likely not to participate in research due to fear of experimentation (25.8%) compared with males (18.9%) P=<0.001.ConclusionInitial findings from the study demonstrate that in East London research barriers are focused on time, drug side effects, lack of awareness and language. There is a perception that research is time consuming even though the majority of those surveyed had not taken part in a research study. Further potential solutions from the survey have suggested that researchers also need to involve BME community leaders in their study strategy and indicate any individual health benefits to participation in research. Accessible studies with regards to time and advocacy provision need to be included in the design. [ABSTRACT FROM PUBLISHER]

Published
2015
Full Text
View/download PDF

33. Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8 + EMRA T Cells During Type 2 Diabetes.

Author

Callender LA, Carroll EC, Garrod-Ketchley C, Schroth J, Bystrom J, Berryman V, Pattrick M, Campbell-Richards D, Hood GA, Hitman GA, Finer S, and Henson SM

Abstract

Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8 + EMRA T cells exhibit mitochondrial dysfunction and alterations to oxidative phosphorylation, however, the metabolic properties of senescent CD8 + T cells from people living with type 2 diabetes (T2D) are not known. We show here that mitochondria from T2D CD8 + T cells had a higher oxidative capacity together with increased levels of mitochondrial reactive oxgen species (mtROS), compared to age-matched control cells. While fatty acid uptake was increased, fatty acid oxidation was impaired in T2D CD8 + EMRA T cells, which also showed an accumulation of lipid droplets and decreased AMPK activity. Increasing glucose and fatty acids in healthy CD8 + T cells resulted in increased p-p53 expression and a fragmented mitochondrial morphology, similar to that observed in T2D CD8 + EMRA T cells. The resulting mitochondrial changes are likely to have a profound effect on T cell function. Consequently, a better understanding of these metabolic abnormalities is crucial as metabolic manipulation of these cells may restore correct T cell function and help reduce the impact of T cell dysfunction in T2D., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Callender, Carroll, Garrod-Ketchley, Schroth, Bystrom, Berryman, Pattrick, Campbell-Richards, Hood, Hitman, Finer and Henson.)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results