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33 results on '"Honma Tadashi"'

1. Therapeutic Effect of an Immunomodulator on Pancreatic Endocrine Secretion Disorder and Insulitis in an Animal Model of Autoimmune Pancreatitis

Author

Yamamiya Akira, Mitsui Yuta:筆頭著者, Tanaka Shigeki, Yukawa Akihiro, Yamazaki Takahisa, Ishii Yu, Imamura Tsunao, Nomoto Tomohiro, Kitamura Katsuya, Honma Tadashi, Sato Yoshiki, Ikegami Akitoshi, and Yoshida Hitoshi:責任著者

Subjects
Animal model, business.industry, Immunology, Therapeutic effect, medicine, Pancreatic Endocrine Secretion, medicine.disease, business, Insulitis, Autoimmune pancreatitis
Published
2018

2. Usefulness of Continuous Regional Arterial Infusion with Doripenem and Protease Inhibitors for Severe Acute Pancreatitis

Author

YAMAMIYA, Akira, KITAMURA, Katsuya, ISHII, Yu, SATO, Yoshiki, IWATA, Tomoyuki, NOMOTO, Tomohiro, HONMA, Tadashi, and YOSHIDA, Hitoshi

Abstract

Doripenem (DRPM) is a relatively new drug belonging to the carbapenem antibiotic group. We hypothesized that the pharmacological characteristics of DRPM could make it useful in the treatment of severe acute pancreatitis (SAP). We investigated the usefulness of continuous regional arterial infusion (CRAI) with DRPM and protease inhibitors for SAP. Two hundred and forty-two patients with SAP were admitted to Showa University Hospital between November 2002 and June 2013. Of these, 53 patients were treated with CRAI with carbapenem antibiotics and nafamostat mesilate (NM), a serine protease inhibitor, via the celiac and superior mesenteric arteries. Clinical outcomes were evaluated retrospectively in 34 patients treated with DRPM and 19 patients undergoing non-DRPM therapy (meropenem n=11, imipenem n=6; biapenem n=2). The median time to commencement of oral intake was significantly shorter in the DRPM than non-DRPM group (9 vs 14 hospital days, respectively; P

Published
2015

3. Therapeutic Effect of an Immunomodulator on Pancreatic Endocrine Secretion Disorder and Insulitis in an Animal Model of Autoimmune Pancreatitis

Author

MITSUI, Yuta, primary, HONMA, Tadashi, additional, SATO, Yoshiki, additional, YAMAMIYA, Akira, additional, ISHII, Yu, additional, NOMOTO, Tomohiro, additional, YAMAZAKI, Takahisa, additional, YUKAWA, Akihiro, additional, KITAMURA, Katsuya, additional, IMAMURA, Tsunao, additional, IKEGAMI, Akitoshi, additional, TANAKA, Shigeki, additional, and YOSHIDA, Hitoshi, additional

Published
2018
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4. Features of and Mechanisms Underlying Insulitis In aly/aly Male Mice as an Animal Model of Autoimmune Pancreatitis: Activation of CD11c+, CD4+, and Th2 Cells and Predominant Destruction of β-cells

Author

SATO, Yoshiki, YOSHIDA, Hitoshi, TANAKA, Shigeki, NOMOTO, Tomohiro, HONMA, Tadashi, IWATA, Tomoyuki, YAMAZAKI, Takahisa, YUKAWA, Akihiro, KITAMURA, Katsuya, IMAMURA, Tsunao, IKEGAMI, Akitoshi, and IMAWARI, Michio

Abstract

Diabetes mellitus (DM) is observed in patients with autoimmune pancreatitis (AIP). The development of DM in AIP is believed to be due to blood flow obstruction of the endocrine gland that accompanies pancreatitis, as well as injury to the islets caused by inflammation. The latter is called insulitis and the detailed mechanisms underlying its development are not yet clear. The aim of the present study was to elucidate the mechanisms involved in the development of insulitis in AIP using aly mice as an animal model of AIP: results in aly/aly male mice, as the AIP group, were compared with those inaly/+ male mice as a control group. Mice in both groups were killed between 16 and 48 weeks of age, and pancreatitis and insulitis were evaluated histologically. Inflammatory and endocrine cells were evaluated by immunofluorescence staining with anti-CD4, anti-CD8, anti-CD11b, and anti-CD11c antibodies, as well as immunohistochemical analyses using insulin and glucagon antibodies. Plasma levels and the pancreatic content of interferon (IFN)-γ (as a Th1-secreted cytokine) and interleukin (IL)-4 (as a Th2-secreted cytokine) were determined. Pancreatitis was seen in aly/aly mice from 16 weeks of age and it developed gradually thereafter. Insulitis also developed gradually and was seen in mice after 24 weeks of age in association with a decrease in the number of islets. CD11c+ cells and CD4+ T cells were seen to infiltrate into the islets. Although the number of β-cells decreased with time, the number of α-cells was maintained until mice were 48 weeks of age. IFN-γ content peaked in mice at 16 weeks of age and declined rapidly from 20 weeks. There were two peaks in IL-4 content, one at 16 weeks and the other at 32 weeks, suggesting an association between IL-4 content and advanced insulitis after 32 weeks. In conclusion, the results suggest that insulitis in AIP is induced predominantly by the infiltration of CD11c+ cells and CD4+ T cells into the islets, and progression is facilitated by the imbalance of the activation of Th2 rather than Th1. Furthermore, insulitis in AIP predominantly involves β-cells rather than α-cells.

Published
2012

16. Prognosis of severe acute pancreatitis for body mass index

Author

KITAMURA, Katsuya, primary, YOSHIDA, Hitoshi, additional, SATO, Yoshiki, additional, IWATA, Tomoyuki, additional, NOMOTO, Tomohiro, additional, YUKAWA, Akihiro, additional, YAMASAKI, Takahisa, additional, HONMA, Tadashi, additional, IKEGAMI, Akitoshi, additional, and IMAWARI, Michio, additional

Published
2012
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17. Features of and Mechanisms Underlying Insulitis In aly/aly MaleMice as an Animal Model of Autoimmune Pancreatitis: Activation of CD11c+, CD4+, and Th2 Cells and Predominant Destruction of β-cells

Author

SATO, Yoshiki, primary, YOSHIDA, Hitoshi, additional, TANAKA, Shigeki, additional, NOMOTO, Tomohiro, additional, HONMA, Tadashi, additional, IWATA, Tomoyuki, additional, YAMAZAKI, Takahisa, additional, YUKAWA, Akihiro, additional, KITAMURA, Katsuya, additional, IMAMURA, Tsunao, additional, IKEGAMI, Akitoshi, additional, and IMAWARI, Michio, additional

Published
2012
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18. Insulitis Behind Pancreatitis May Be Evoked by Infiltration of CD11c-Positive Cells and CD4-Posotive T Cells, and Deteriorated by TH2 Activation in Autoimmune Pancreatitis (AIP)

Author

Sato, Yoshiki, primary, Yoshida, Hitoshi, additional, Tanaka, Shigeki, additional, Iwata, Tomoyuki, additional, Yamazaki, Takahisa, additional, Yukawa, Akihiro, additional, Nomoto, Tomohiro, additional, Honma, Tadashi, additional, Kitamura, Katsuya, additional, Imamura, Tsunao, additional, Ikegami, Akitoshi, additional, and Imawari, Michio, additional

Published
2011
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19. Relationship between juxtapapillary duodenal diverticula and endoscopic retrograde cholangiopancreatography (ERCP) including treatments by using ERCP

Author

Iwata, Tomoyuki, primary, Yoshida, Hitoshi, additional, Sato, Yoshiki, additional, Nomoto, Tomohiro, additional, Yamazaki, Takahisa, additional, Yukawa, Akihiro, additional, Honma, Tadashi, additional, Kitamura, Katsuya, additional, Ikegami, Akitoshi, additional, and Imawari, Michio, additional

Published
2010
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21. Regeneration after Two Types of Rat Acute Pancreatitis Compared with Human Autoimmune Pancreatitis

Author

YAMAZAKI, Takahisa, primary, YOSHIDA, Hitoshi, additional, HONMA, Tadashi, additional, IKEGAMI, Akitoshi, additional, NIIKAWA, Junichi, additional, TANAKA, Shigeki, additional, AWAI, Toshinari, additional, YUKAWA, Akihiro, additional, KITAMURA, Katsuya, additional, HANAWA, Katsuhiro, additional, IMAMURA, Tsunao, additional, and IMAWARI, Michio, additional

Published
2008
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22. A case of remnant gastric cancer, diagnosed by autopsy, with metastatic bone and skin tumors and pleuritis carcinomatosa

Author

Hiraide, Ayako, primary, Arai, Katsuhito, additional, Honma, Tadashi, additional, Kitamura, Katsuya, additional, Kurahashi, Toshinori, additional, Baba, Toshiyuki, additional, Nozu, Fumihiko, additional, Yoshikawa, Nozomi, additional, Imawari, Michio, additional, Takanashi, Shuichiro, additional, Hirayama, Yuichi, additional, and Ota, Shuichi, additional

Published
2006
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32. Electrocautery vs non-electrocautery dilation catheters in endoscopic ultrasonography-guided pancreatic fluid collection drainage.

Author

Kitamura K, Yamamiya A, Ishii Y, Nomoto T, Honma T, and Yoshida H

Abstract

Aim: To investigate the safety and utility of an electrocautery dilation catheter for endoscopic ultrasonography (EUS)-guided pancreatic fluid collection drainage., Methods: A single-center, exploratory, retrospective study was conducted between August 2010 and August 2014. This study was approved by the Medical Ethics Committee of our institution. Informed, written consent was obtained from each patient prior to the procedure. The subjects included 28 consecutive patients who underwent EUS-guided transmural drainage (EUS-TD) for symptomatic pancreatic and peripancreatic fluid collections (PFCs) by fine needle aspiration using a 19-gauge needle. These patients were retrospectively divided into two groups based on the use of an electrocautery dilation catheter as a fistula dilation device; 15 patients were treated with an electrocautery dilation catheter (electrocautery group), and 13 patients were treated with a non-electrocautery dilation catheter (non-electrocautery group). We evaluated the technical and clinical successes and the adverse events associated with EUS-TD for the treatment of PFCs between the two groups., Results: There were no significant differences in age, sex, type, location and diameter of PFCs between the groups. Thirteen patients (87%) in the electrocautery group and 10 patients (77%) in the non-electrocautery group presented with infected PFCs. The technical success rates of EUS-TD for the treatment of PFCs were 100% (15/15) and 100% (13/13) for the electrocautery and the non-electrocautery groups, respectively. The clinical success rates of EUS-TD for the treatment of PFCs were 67% (10/15) and 69% (9/13) for the electrocautery and the non-electrocautery groups, respectively (P = 0.794). The procedure time of EUS-TD for the treatment of PFCs in the electrocautery group was significantly shorter than that of the non-electrocautery group (mean ± SD: 30 ± 12 min vs 52 ± 20 min, P < 0.001). Adverse events associated with EUS-TD for the treatment of PFCs occurred in 0 patients and 1 patient for the electrocautery and the non-electrocautery groups, respectively (P = 0.942)., Conclusion: EUS-TD using an electrocautery dilation catheter as a fistula dilation device for the treatment of symptomatic PFCs appears safe and contributes to a shorter procedure time.

Published
2016
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33. [Two cases of gastric cancer expressing Glypican 3, but producing AFP with different lectin affinity].

Author

Oishi C, Baba T, Kubota Y, Shimotsuma Y, Kitamura K, Honma T, Ikegami A, Inokuchi M, Umeda T, Yoshida H, and Imawari M

Subjects
Aged, 80 and over, Humans, Immunohistochemistry, Male, Adenocarcinoma metabolism, Biomarkers, Tumor analysis, Glypicans analysis, Stomach Neoplasms metabolism, alpha-Fetoproteins biosynthesis
Abstract

We encountered 2 cases of AFP-producing gastric cancer. In the first patient, an 82-year-old man was found to have advanced type II advanced carcinoma in the stomach with a massive tumor embolus in the portal vein. In the second case, an 80-year-old man was given a diagnosis of multiple liver metastases of gastric cancer with portal vein thrombosis. Our diagnosis of gastric cancer in both cases was AFP-producing. It was supposed that the elevation of serum level of AFP might be caused by enteroblastic differentiation in the first case and hepatoid differentiation in the second case. Although, in both cases, the biopsy specimens of the gastric neoplasm proved moderately to poorly differentiated adenocarcinoma without hepatoid differentiation, the localization of Glypican 3 in gastric cancer cells was observed using immunostaining with a monoclonal antibody. In both cases, Glypican 3 was a sensitive and useful marker for AFP-producing gastric cancer with or without hepatoid differentiation.

Published
2009

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