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4. A critical role of Ca2+/calmodulin‐dependent protein kinase II in coupling between evening and morning circadian oscillators in the suprachiasmatic nucleus.

Author

Yoshikawa, Tomoko, Honma, Ken‐ichi, Shigeyoshi, Yasufumi, Yamagata, Yoko, and Honma, Sato

Subjects
SUPRACHIASMATIC nucleus, PROTEIN kinases, MOLECULAR clock, CALMODULIN, MORNING
Abstract

Ca2+/calmodulin‐dependent protein kinase IIα (CaMKIIα) is widely expressed in the brain and is involved in various functions, including memory formation, mood and sleep. We previously reported that CaMKIIα is involved in the circadian molecular clock. Mice lacking functional CaMKIIα (K42R mice) exhibited a gradual increase in activity time (α decompression) of running‐wheel (RW) activity due to a lengthened circadian period (τ) of activity offset under constant darkness (DD). In the present study, to investigate the functional roles of CaMKIIα in behavioural rhythms, we measured RW and general movements simultaneously under prolonged DD. Tau became longer as the relative intensity of behaviour activity within an activity time shifted from activity onset towards activity offset. In some K42R mice, α was gradually expanded with a marked reduction of RW activity, while general movements persisted without noticeable decline, which was followed by an abrupt shortening of α (α compression) with differential phase shifts of the activity onset and offset and recovery of RW activity. These results suggest that an internal coupling between the oscillators controlling activity onset and offset is bidirectional but with different strengths. The α compression occurred recurrently in 38% of K42R mice examined with an average interval of 37 days in association with attenuation of RW activity but never in the wild‐type (WT) mice. Consistent with behavioural rhythms, the circadian period of the PER2::LUC rhythm in the cultured suprachiasmatic nucleus (SCN) slice was significantly longer in K42R than in WT. These findings are best interpreted by assuming that a loss of functional CaMKIIα attenuates the coupling between the onset and offset oscillators. [ABSTRACT FROM AUTHOR]

Published
2024
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8. The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.

Author

Ono, Daisuke, Weaver, David R., Hastings, Michael H., Honma, Ken-Ichi, Honma, Sato, and Silver, Rae

Abstract

It has been 50 years since the suprachiasmatic nucleus (SCN) was first identified as the central circadian clock and 25 years since the last overview of developments in the field was published in the Journal of Biological Rhythms. Here, we explore new mechanisms and concepts that have emerged in the subsequent 25 years. Since 1997, methodological developments, such as luminescent and fluorescent reporter techniques, have revealed intricate relationships between cellular and network-level mechanisms. In particular, specific neuropeptides such as arginine vasopressin, vasoactive intestinal peptide, and gastrin-releasing peptide have been identified as key players in the synchronization of cellular circadian rhythms within the SCN. The discovery of multiple oscillators governing behavioral and physiological rhythms has significantly advanced our understanding of the circadian clock. The interaction between neurons and glial cells has been found to play a crucial role in regulating these circadian rhythms within the SCN. Furthermore, the properties of the SCN network vary across ontogenetic stages. The application of cell type–specific genetic manipulations has revealed components of the functional input-output system of the SCN and their correlation with physiological functions. This review concludes with the high-risk effort of identifying open questions and challenges that lie ahead. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ

Author

Lee, Jae Wook, Hirota, Tsuyoshi, Ono, Daisuke, Honma, Sato, Honma, Ken-ichi, Park, Keunwan, and Kay, Steve A.

Abstract

Circadian rhythms are controlled by transcriptional feedback loops of clock genes and proteins. The stability of clock proteins is regulated by post-translational modification, such as phosphorylation by kinases. In particular, casein kinase I (CKI) phosphorylates the PER protein to regulate proteasomal degradation and nuclear localization. Therefore, CKI inhibition can modulate mammalian circadian rhythms. In the present study, we have developed novel CKIα and CKIδ dual inhibitors by extensive structural modification of N9 and C2 position of longdaysin. We identified NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cell-based circadian assay. The following in vitro kinase assay showed that NCC007 inhibited CKIα and CKIδ with an IC50 of 1.8 and 3.6 μM. We further demonstrated that NCC007 lengthened the period of mouse behavioral rhythms in vivo. Thus, NCC007 is a valuable tool compound to control circadian rhythms through CKI inhibition., ファイル公開：2020-02-28

Published
2019

41. sj-pdf-1-jbr-10.1177_07487304211047937 – Supplemental material for The Food-entrainable Oscillator Is a Complex of Non-SCN Activity Bout Oscillators Uncoupled From the SCN Circadian Pacemaker

Author

Nishide, Shinya, Suzuki, Yohko, Ono, Daisuke, Honma, Sato, and Honma, Ken-ichi

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 110306 Endocrinology, 69999 Biological Sciences not elsewhere classified, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jbr-10.1177_07487304211047937 for The Food-entrainable Oscillator Is a Complex of Non-SCN Activity Bout Oscillators Uncoupled From the SCN Circadian Pacemaker by Shinya Nishide, Yohko Suzuki, Daisuke Ono, Sato Honma and Ken-ichi Honma in Journal of Biological Rhythms

Published
2021
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43. Physical exercise accelerates reentrainment of human sleep-wake cycle but not of plasma melatonin rhythm to 8-h phase-advanced sleep schedule

Author

Yamanaka, Yujiro, Hashimoto, Satoko, Tanahashi, Yusuke, Nishide, Shin-ya, Honma, Sato, and Honma, Ken-ichi

Subjects
Melatonin -- Physiological aspects, Melatonin -- Research, Circadian rhythms -- Physiological aspects, Circadian rhythms -- Research, Sleep -- Physiological aspects, Exercise -- Research, Exercise -- Physiological aspects, Biological sciences
Abstract

Effects of timed physical exercise were examined on the reentrainment of sleep-wake cycle and circadian rhythms to an 8-h phase-advanced sleep schedule. Seventeen male adults spent 12 days in a temporal isolation facility with dim light conditions (< 10 lux). The sleep schedule was phase-advanced by 8 h from their habitual sleep times for 4 days, which was followed by a free-run session for 6 days, during which the subjects were deprived of time cues. During the shift schedule, the exercise group (n = 9) performed physical exercise with a bicycle ergometer in the early and middle waking period for 2 h each. The control group (n = 8) sat on a chair at those times. Their sleep-wake cycles were monitored every day by polysomnography and/or weight sensor equipped with a bed. The circadian rhythm in plasma melatonin was measured on the baseline day before phase shift: on the 4th day of shift schedule and the 5th day of free-run. As a result, the sleep-onset on the first day of free-run in the exercise group was significantly phase-advanced from that in the control and from the baseline. On the other hand, the circadian melatonin rhythm was significantly phase-delayed in the both groups, showing internal desynchronization of the circadian rhythms. The sleep-wake cycle resynchronized to the melatonin rhythm by either phase-advance or phase-delay shifts in the free-run session. These findings indicate that the reentrainment of the sleep-wake cycle to a phase-advanced schedule occurs independent of the circadian pacemaker and is accelerated by timed physical exercise. humans; isolation facility; dim light; shift schedule; nonphotic entrainment doi:10.1152/ajpregu.00345.2009

Published
2010

44. Abstracts for the 6th Congress of Asian Sleep Research Society

Author

Kim, Seog Ju, Lyoo, In Kyoon, Lee, Yu-Jin, Jeong, Do-Un, Kanai, Hirohiko, Ookubo, Masanori, Yoshimura, Atsushi, Okawa, Masako, Yamada, Noto, Munezawa, Takeshi, Kaneita, Yoshitaka, Osaki, Yoneatsu, Kanda, Hideyuki, Ohtsu, Tadahiro, Minowa, Masumi, Suzuki, Kenji, Hijuchi, Susumu, Suzuki, Hiroyuki, Ohida, Takashi, Abe, Takashi, Komada, Yoko, Asaoka, Shoichi, Inoue, Yuichi, Lee, Jin-Seong, Cho, Sang-Yong, Kumar, Deependra, Mallick, Hruda N., Kumar, Velayudhan M., Kaushik, Mahesh K., Karashima, Akihiro, Katayama, Noiihiro, Nakao, Mitsuyuki, Nagendra, Ravindra P., Sulekha, Sathiamma, Narasappa, Sathyaprabha T., Nityanadan, Pradhan, Kutty, Bindu M., Nirmala, M., Ravindra, P. N., Tubaki, Basavaraj Ramappa, Sathyaprabha, T. N., Sudhakar, D., Lavekar, G. S., Chandrashekar, C. R., Kitaoka, Kazuyoshi, Shimizu, Mika, Chikahisa, Sachiko, Yoshizaki, Kazuo, Sei, Hiroyoshi, Kim, Jong-Won, Takegami, Misa, Yamazaki, Shin, Hayashino, Yasuaki, Ono, Rei, Otani, Koji, Sekiguchi, Miho, Konno, Shinichi, Fukuhara, Shunichi, Jakobson, Antonia J., Fitzgerald, Paul, Conduit, Russell, Li, Xin Shirley, Lam, Siu Ping Joyce, Yu, Wai Man Mandy, Wing, Yun Kwok, Okamoto-Mizuno, Kazue, Mizuno, Koh, Yamamoto, Mituaki, Shirakawa, Shuichiro, Doi, Hirokazu, Kato, Mikako, Shinohara, Kazuyuki, Tamaki, Masako, Matsuda, Shiori, Yamazaki, Katsuo, Hori, Tadao, Ogawa, Keiko, Takahashi, Kazumi, Kitahama, Kunio, Yamazaki, Katuo, Koyama, Yoshimasa, Shioda, Kohei, Ueda, Yugo, Nakamura, Yukiko, Inoue, Clara, Goto, Kazushige, Uchida, Sunao, Morita, Yuko, Honda, Yoshiko, Kodama, Tohru, Hagihara, Mari, Nakajima, Toru, Saito, Masato, Koga, Yoshihiko, Tanaka, Shinichiro, Yamadera, Hiroshi, Takahara, Madoka, Suwa, Sachiko, Onozuka, Minoru, Sato, Sadao, Togo, Fumiharu, Komatsu, Taiki, Mitani, Takeshi, Choi, Jongbae, Zhang, Bin, Sasai, Taeko, Mitsubayashi, Hiromi, Ohtsu, Mitsuhiro, Hasegawa, Isao, Ishii, Tatsuya, Komori, Akira, Suzuki, Asami, Nakahara, Yue, Hiroki, Mitsuyasu, Nakauma, Mariko, Someya, Nobuo, Ochiai, Tomomasa, Komori, Shouhei, Chiang, Rayleigh Ping-Ying, Yeh, Zai-Ting, Kim, Seong T., Yoon, Seung H., Kwon, Jeong S., Choi, Jong H., Ahn, Hyung J., Kim, Youngsoo, Yunren, Bolortuya, Chen, Lichao, Basheer, Radhika, Mccarley, Robert W., Strecker, Robert E., Honda, Makoto, Arai, Tetsuaki, Fukazawa, Miyuki, Honda, Yutaka, Tsuchiya, Kuniaki, Akiyama, Haruhiko, Mignot, Emmanuel, Jung, Ki-Young, Ko, Deokwon, Koo, Yong-Seo, Zhang, Jihui, Ping Lam, Siu, Hong, Seung Chul, Chung, Kyoo In, Lee, Sung Pil, Lee, Chung Tai, Seo, Ho Jun, Jeong, Jong Hyeon, Lim, Hyeon Kuk, Shin, Yoon Kyung, You, Ji Hee, Suzuki, Jun-Ichi, Ogawa, Masahito, Liu, Xianchen, Ye, Wenyu, Watson, Peter, Dube, Sanjay, Wohlreich, Madelaine, Kwan, Benjamin C. H., Joseph, Francoise, Mckenzie, David M., Lee, Bonne, Lee, Sang-Ahm, Lee, Eun-Mi, Kim, Cheon-Sik, Nishijima, Tsuguo, Sakurai, Shigeru, Tokunaga, Jun, Takahashi, Susumu, Kanbayashi, Takashi, Hitomi, Jirou, Shimizu, Tetsuo, Murashima, Koji, Ozaki, Masayuki, Hang, Liang-Wen, Lin, Chen-Liang, Huang, Cheng-Ning, Huang, Wen-Yen, Choi, Ji Ho, Kim, Eun Joong, Kim, Tae Hoon, Lee, Sang Hag, Shin, Chol, Lee, Seung Hoon, Chen, Chia Chi, Lo, Men-Tzung, Lin, Chen, Lee, Min-Ying, Lin, Chia-Mo, Tsuiki, Satoru, Kobayashi, Mina, Takashima, Akiyo, Maeda, Keiko, Matsuura, Masato, Furukawa, Tomokazu, Nakano, Hiroshi, Hirayama, Kenji, Tanahashi, Tokusei, Yoshihara, Kazufumi, Kubo, Chiharu, Sudo, Nobuyuki, Kim, Eui-Joong, Ahn, Young Min, Shin, Hong-Beom, Kim, Jong Won, Matsuo, Akira, Nakai, Takayuki, Tsuiki, Storu, Chiba, Higoshige, Sawada, Koki, Chiba, Shintaro, Endo, Makoto, Moriwaki, Hiroto, Uchida, Ryo, Kim, Sung Wan, Chung, Dae Han, Shin, Seung Youp, Lee, Kun Hee, Cho, Joong Saeng, Tazoe, Mari, Ayuse, Takao, Yamamura, Satoshi, Kirkness, Jason P., Oi, Kumiko, Ishida, Katsunori, Kato, Masahiko, Kato, Yosuke, Yanagihara, Kiyotaka, Kinugasa, Yoshiharu, Sugihara, Shinobu, Hirai, Masayuki, Hamada, Toshihiro, Igawa, Osamu, Hisatome, Ichiro, Shigemasa, Chiaki, Shimizu, Noriyuki, Oura, Masahiro, Usui, Akira, Okajima, Isa, Matsuura, Noriko, Hiroki, Ikeda, Mitsuo, Hayashi, Choi, Jiae, Yoon, Inyoung, Furutani, Maki, Takase, M., Nakayama, K., Kita, Y., Sakohara, T., Yoshimura, H., Satoki, Y., Sakai, Y., Murakami, A., Kouno, K., Ikeda, R., Tanaka, H., Tanaka, Hideki, Yamano, Emi, Fukuda, Sanae, Joudoi, Takako, Mizuno, Kei, Tanaka, Masaaki, Kawatani, Junko, Takano, Miyuki, Tomoda, Akemi, Imai-Matsumura, Kyoko, Miike, Teruhisa, Watanabe, Yasuyoshi, Furihata, Ryuji, Uchiyama, Makoto, Takahashi, Sakae, Suzuki, Masahiro, Konno, Chisato, Ohsaki, Kouichi, Chiang, Hsin Ju, Tsai, Ling Ling, Weng, Chia Ying, Kawauchi, Tomomi, Tanaka, Yuu, Ohira, Hideki, Na, Hae-Ran, Kang, Eun-Ho, Sim, Hyun-Bo, Woo, Jong-Min, Yu, Bum-Hee, Ahmed, Wael, Kitanaka, Takahiro, Nishimura, Yoichi, Ando, Kayoko, Kurahashi, Hiroki, Abe, Akiko, Yamamoto, Ryuichiro, Matsuda, Michikazu, Ogawa, Toru, Ito, Toshimi, Suzuki, Tasuku, Sasaki, Keiichi, Shinno, Hideto, Otsuki, Manabu, Tsuchiya, Satoshi, Oka, Yasunori, Kawada, Seiichi, Innami, Toshihiko, Horikoshi, Tatsuru, Sasaki, Akira, Hineno, Takashi, Sakamoto, Tetsuro, Inami, Yasushi, Yamashita, Hidehisa, Mizuno, Soichi, Nakamura, Yu, Horiguchi, Jun, Iwanaga, Koichi, Kanemura, Takashi, Ohno, Mikako, Kato, Yuichi, Miyazaki, Soichiro, Maritani, Shinji, Ito, Yukihiko, Shen, Manzhen, Takahashi, Satomi, Kajiwara, Nobuko, Satoh, Makoto, Kinouchi, Kaori, Tokuyama, Kana, Akai, Yukiko, Fukuyama, Tomoko, Takahashi, Hiroe, Tanbara, Tadashi, Nishihara, Kyoko, Ozawa, Nobuyuki, Shin, Duk, Sakai, Hiroyuki, Uchiyama, Yuji, Wakita, Toshihiro, Sugi, Takenao, Yoshiyama, Hiroaki, Matsuoka, Genya, Sakai, Kazuhiro, Nakamura, Masatoshi, Cho, Yong Won, Lee, Joo Hwa, Jung, Sang Hun, Cho, Hwa Ra, Yi, Sang Doe, Kobayashi, Masato, Moromugi, Shunji, Sakamoto, Taichi, Ishimatsu, Takakazu, Lee, Jeong Su, Chung, Gih Sung, Park, Kwang Suk, Shin, Won Chul, Yoon, Jung Eun, Jang, Eun Joo, Sung, Min Jee, Cha, Hyun Keuk, Taguchi, T., Nakamori, M., Taneike, R., Hayashi, A., Sugimori, S., Kamiyama, J., Hamada, T., Itoi, H., Koyama, Emi, Kubo, Tomohide, Takahashi, Masaya, Sato, Tomoaki, Sasaki, Takeshi, Oka, Tatsuo, Iwasaki, Kenji, Son, Mia, Yeom, Myeonggul, Harma, Mikko, Wakamura, Tomoko, Tojo, Chiaki, Horita, Sachiko, Takahashi, Ken-Ichi, Sumi, Kensuke, Nakayama-Ashida, Yukiyo, Nakamura, Takaya, Minami, Itunari, Oka, Yasunari, Chin, Kazuo, Kadotani, Hiroshi, Hayashi, Etsuko, Kato, Rumiko, Tanaka, Yu, Yamamoto, Takuro, Yamashita, Shiko, Matsumoto, Masahiro, Nakashima, Yusaku, Soma, Haruhiko, Yasuda, Akio, Kuriki, Ayano, Hayashi, Mituo, MurakI, Takeya, Yamashiro, Keitaro, Aritomi, Ryoji, Sakurai, Shihomi, Kishi, Akifumi, Natelson, Benjamin H., Struzik, Zbigniew R., Yamamoto, Yoshiharu, Terashima, Ryuta, Nakade, Miyo, Murata, Chiyoe, Hirai, Hiroshi, Kondo, Katsunori, Tsutsui, Hideyo, Tsuboi, Hirohito, Ojima, Toshiyuki, Fu, Ying-Hui, He, Ying, Jones, Christopher, Fujiki, Nobuhiro, Nishino, Seiji, Ito, Asao, Fredholm, Bertil B., Hillman, David R., Hayashi, Mitsuo, Kennaway, David J., Mallick, H. N., Hui, David S., Chee, Michael W. L., Takahashi, Toshiharu, Sasaki, Mitsuo, Gedal, Lalaine, Honma, Sato, Yoshikawa, Tomoko, Hashimoto, Satoko, Honma, Ken-Ichi, Lee, Li-Ang, Li, Hsueh-Yu, Tsai, Ling-Ling, Hsieh, Shulan, Zucconi, Marco, Yang, Chien-Ming, Lo, Hsiao-Sui, Wu, Chia-Suo, Huang, Yen-Ling, Tsai, Ming-Chieh, Han, Fang, Yoshida, Kazuya, Mcardle, Nigel, Jung, Chul Ho, Choi, Ji Hye, Soon, Park Chan, Sarte, Michael Alexius A., Wai, Talen, Sasao, Yasuhiro, Liu, Lianqi, Owens, Judith, Shrivastava, Deepak, Kanabayashi, Takashi, Hishikawa, Yasuo, Naughton, Matthew T., Miyamoto, Masayuki, Lam, Jamie C., Dworak, Markus, Kalinchuk, Anna, Kim, Tae, Brown, Ritchie, Strecker, Robert, Huang, Yu-Shu, Tsou, Meng-Chen, Hsu, Shih-Pin, Vachiramon, Amornpong, Nakata, Seiichi, Luppi, Pierre-Herve, Chen, Ning-Hung, Mallick, Birendra N., Hong, Seung Bong, Ho, Crover K., Goh, Yau Hong, Mark, Ignatius, Opp, Mark R., Sullivan, Colin E., Kim, Kwang-Jin, Preutthipan, Aroonwan, Strohl, Kingman P., Fuller, Patrick, Wang, Yang, Bhatia, Manvir, Lee, Chul Hee, and Bassetti, Claudio L.

Published
2009
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48. Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine

Author

Honma, Sato, Yasuda, Tsubura, Yasui, Akira, van der Horst, Gijsbertus T. J., and Honma, Ken-ichi

Subjects
Animal behavior -- Physiological aspects -- Research, Gene expression -- Physiological aspects -- Research, Methamphetamine -- Dosage and administration -- Physiological aspects -- Research, Circadian rhythms -- Physiological aspects -- Research, Cytochromes -- Physiological aspects -- Research, Biological sciences, Physiological aspects, Research, Dosage and administration
Abstract

Byline: Sato Honma (Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, sathonma@med.hokudai.ac.jp); Tsubura Yasuda (Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan); Akira Yasui [...]

Published
2008
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