371 results on '"Honkakoski, Paavo"'
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2. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
3. A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity
4. Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
5. Ocular drug-metabolizing enzymes: focus on esterases.
6. Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
7. Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells
8. Mass spectrometry in ocular drug research
9. Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells
10. A Reverse Transfection Method for Screening of Nuclear Receptor Activators
11. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity
12. Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle
13. Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
14. Improved assays for xenosensor activation based on reverse transfection
15. Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
16. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine
17. Single nucleotide polymorphisms in pigmentation‐related dopachrome tautomerase and melanocortin‐1 receptor genes are associated with wet age‐related macular degeneration in a Finnish cohort
18. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
19. Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues
20. Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator
21. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
22. Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
23. Regulation of gene expression by CAR: an update
24. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system
25. Characterization of human cytochrome P450 induction by pesticides
26. Use of comprehensive screening methods to detect selective human CAR activators
27. Searching for Constitutive Androstane Receptor Modulators
28. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
29. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates.
30. Effluxing ABC transporters in human corneal epithelium
31. Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists
32. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors
33. Monocarboxylate transport in human corneal epithelium and cell lines
34. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
35. Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
36. Identification of Key Amino Acids that Impact Organic Solute Transporter Alpha/Beta (OSTα/β)
37. Mechanism‐Based Experimental Models for the Evaluation of BSEP Inhibition and DILI
38. Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy
39. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor
40. Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors
41. Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity
42. Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity
43. Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues
44. A Novel Drug-Regulated Gene Expression System Based on the Nuclear Receptor Constitutive Androstane Receptor (CAR)
45. Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells
46. Chapter 13. Receptor-Mediated Regulation of Cytochromes P450
47. Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
48. The EDCMET Project: Metabolic Effects of Endocrine Disruptors
49. Amino Acids Important for Ligand Specificity of the Human Constitutive Androstane Receptor
50. Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines
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