337 results on '"Honkakoski, Paavo"'
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2. Filling the Blank Space: Branched 4-Nonylphenol Isomers Are Responsible for Robust Constitutive Androstane Receptor (CAR) Activation by Nonylphenol
3. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
4. A novel differentiated HuH-7 cell model to examine bile acid metabolism, transport and cholestatic hepatotoxicity
5. Alterations in zonal distribution and plasma membrane localization of hepatocyte bile acid transporters in patients with NAFLD
6. Ocular drug-metabolizing enzymes: focus on esterases.
7. Mass spectrometry in ocular drug research
8. Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle
9. A Reverse Transfection Method for Screening of Nuclear Receptor Activators
10. Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
11. Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity
12. Improved assays for xenosensor activation based on reverse transfection
13. Single nucleotide polymorphisms in pigmentation‐related dopachrome tautomerase and melanocortin‐1 receptor genes are associated with wet age‐related macular degeneration in a Finnish cohort
14. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates
15. Activity and Expression of Carboxylesterases and Arylacetamide Deacetylase in Human Ocular Tissues
16. A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine
17. Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system
18. Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates.
19. Regulation of gene expression by CAR: an update
20. Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system
21. Characterization of human cytochrome P450 induction by pesticides
22. Searching for Constitutive Androstane Receptor Modulators
23. Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
24. Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
25. Novel Bile Acid-Dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors
26. Identification of Key Amino Acids that Impact Organic Solute Transporter Alpha/Beta (OSTα/β)
27. Effluxing ABC transporters in human corneal epithelium
28. Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor α and β agonists
29. Up-regulation of CYP expression in hepatoma cells stably transfected by chimeric nuclear receptors
30. Monocarboxylate transport in human corneal epithelium and cell lines
31. Mechanism‐Based Experimental Models for the Evaluation of BSEP Inhibition and DILI
32. Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
33. Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy
34. Carboxylesterase Activities and Protein Expression in Rabbit and Pig Ocular Tissues
35. Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors
36. Comparison of homology models and X-ray structures of the nuclear receptor CAR: Assessing the structural basis of constitutive activity
37. Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity
38. Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR
39. A Novel Drug-Regulated Gene Expression System Based on the Nuclear Receptor Constitutive Androstane Receptor (CAR)
40. Chapter 13. Receptor-Mediated Regulation of Cytochromes P450
41. Use of comprehensive screening methods to detect selective human CAR activators
42. The EDCMET Project: Metabolic Effects of Endocrine Disruptors
43. The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression
44. Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor
45. Inhibition and induction of human cytochrome P450 enzymes: current status
46. Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells
47. Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines
48. Substrates and inhibitors of efflux proteins interfere with the MTT assay in cells and may lead to underestimation of drug toxicity
49. Effects of triaryl phosphates on mouse and human nuclear receptors
50. Extracellular and intracellular barriers in non-viral gene delivery
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