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BackgroundLumbar disc herniation (LDH) has become a serious public health and socioeconomic problem. Tuina is a Chinese medicine treatment method based on meridian acupuncture theory and modern anatomy. Tuina can relieve pain and muscle tension and improve functional disorders; this massage is performed by pressing, kneading, pushing, pulling, and shaking the skin, muscles, and bones. However, the mechanism of action and the effect of Tuina as an external treatment on the activities of the central nervous system to relieve LDH pain is unclear. Therefore, we performed functional magnetic resonance imaging (fMRI), which is widely used in pain-related research, as it can detect the effects of different types of pain on brain activity. ObjectiveOur randomized controlled parallel-group trial aims to compare the effects of Tuina with those of transcutaneous electrical nerve stimulation (TENS) with traction in patients with LDH. MethodsThis trial will be conducted between May 2024 and April 2025 in the Rehabilitation Hospital affiliated to Fujian University of Traditional Chinese Medicine. Seventy-six participants with LDH will be enrolled for this trial and randomly assigned to 2 groups: Tuina intervention group and TENS with traction intervention group. Participants in both groups will receive treatment for 14 days. fMRI will be performed for the main pain measurements by assessing the effect of the intervention on brain activity before and after the end of the intervention. Short-Form McGill Pain Questionnaire, pressure pain thresholds, and the Oswestry disability index will be used to reflect the degree of pain and lumbar dysfunction, and the results will be used as secondary outcome measurements. ResultsThe study protocol has been approved by the ethics review committee of The Rehabilitation Hospital affiliated to Fujian University of Traditional Chinese Medicine. This study was registered on May 1, 2024, with the Chinese Clinical Trial Registry. Data collection began on May 2024 and is expected to end on April 2025. Currently, data from this trial are in the collection phase, and no data analysis has been performed. As of July 1, 2024, we have collected data from 21 patients. The results of this trial are expected to be submitted for publication in September 2025. ConclusionsThis clinical trial will compare the effectiveness of Tuina with that of TENS with traction in the treatment of patients with LDH and will show the cerebral mechanism of Tuina in LDH treatment by using fMRI. The results of our trial will be helpful in clarifying the cerebral mechanism of Tuina in the treatment of LDH and provide a solid foundation for Tuina therapy research. Trial RegistrationChinese Clinical Trial Registry ChiCTR2400083784; https://www.chictr.org.cn/showproj.html?proj=225157 International Registered Report Identifier (IRRID)DERR1-10.2196/63852

The effects of short movies on social media platforms are gaining worldwide popularity and are now attracting global academic attention. Employing self-perception theory and qualitative research methodology, the study examines the influence of short video applications (TikTok) on app-user engagement and evaluates the self-perceived cognitive psychological understanding of Chinese university students. The findings show that identity, attitude change, emotional perception, and civic engagement are the most influential aspects of Chinese youths’ self-perceptions. Furthermore, the positive and negative correlated components influence the distribution of short video values. Such tactical use of personality construction contributes to the present psychological research of Chinese university students.

IntroductionNeuropathic Pain (NP) is often accompanied by mood disorders, which seriously affect the quality of life of patients. This study aimed to analyze the hotspots and trends in NP-related mood disorder research using bibliometric methods and to provide valuable predictions for future research in this field.MethodsArticles and review articles on NP-related mood disorders published from January 2003 to May 2023 were retrieved from the Web of Science Core Collection. We used CiteSpace to analyze publications, countries, institutions, authors, cited authors, journals, cited journals, references, cited references, and keywords. We also analyzed collaborative network maps and co-occurrence network maps.ResultsA total of 4,540 studies were collected for analysis. The number of publications concerning NP-related mood disorders every year shows an upward trend. The United States was a major contributor in this field. The University of Toronto was the most productive core institution. C GHELARDINI was the most prolific author, and RH DWORKIN was the most frequently cited author. PAIN was identified as the journal with the highest productivity and citation rate. The current research hotspots mainly included quality of life, efficacy, double-blind methodology, gabapentin, pregabalin, postherpetic neuralgia, and central sensitization. The frontiers in research mainly focused on the mechanisms associated with microglia activation, oxidative stress, neuroinflammation, and NP-related mood disorders.DiscussionIn conclusion, the present study provided insight into the current state and trends in NP-related mood disorder research over the past 20 years. Consequently, researchers will be able to identify new perspectives on potential collaborators and cooperative institutions, hot topics, and research frontiers in this field.

Bimetallic nanozymes have been emerging as essential catalysts due to their unique physicochemical properties from the monometallics. However, the access to optimize catalytic performance is often limited by the thermodynamic immiscibility and also heterogeneity. Thus, we present a one-step coreduction strategy to prepare the miscible Cu–Pd bimetallic nanozymes with controllable shape and homogeneously alloyed structure. The homogeneity is systematically explored and luckily, the homogeneous introduction of Cu successfully endows Cu–Pd bimetallic nanozymes with enhanced Fenton-like efficiency. Density functional theory (DFT) theoretical calculation reveals that Cu–Pd bimetallic nanozymes exhibit smaller d-band center compared with Pd nanozymes. Easier adsorption of H2O2 molecular contributed by the electronic structure of Cu significantly accelerate the catalytic process together with the strong repulsive interaction between H atom and Pd atom. In vitro cytotoxicity and intracellular ROS generation performance reveal the potential for in vivo biocatalysis. The strategy to construct kinetically miscible Cu–Pd bimetallic nanozymes will guide the development of bimetallic catalysts with excellent Fenton-like efficiency for biocatalytic nanomedicine.

The Xiangyangping uranium deposit is a newly discovered granite-type uranium deposit, which is one of the representative granite-hosted uranium deposits in the Miaoershan uranium ore field.The Xiangyangping uranium deposit has developed a large number of primary pitchblende veins, but the chronology characteristics of uranium minerals are obscure, especially the application of in-situ analysis technique is lacking.In order to further clarify the uranium mineralization age of the uranium deposits, in-situ U-Pb isotopic dating of pitchblende veins exposed in the borehole was studied by using LA-ICP-MS.The U-Pb age dating of the pitchblende obtained ages of 51.59 Ma and 41.10 Ma, suggesting that there are two phases of uranium mineralization in the Xiangyangping area, which are consistent with the main mineralization periods of 65-50 Ma and 45-40 Ma for the Shazijiang uranium deposit.The former is the main metallogenic age of Xiangyangping uranium ore deposit, while the latter is the thermal event time of late fluid activity leading to pitchblende alteration, indicating that there is a major uranium metallogenic event of about 52 Ma in the Miaoershan uranium ore field.The chondrite-normalized patterns of rare earth elements are rich in light-REE, with obvious negative Eu anomalies.The distribution curve of rare earth elements in pitchblende is characterized by in seagull pattern, which is similar to low-high grade uranium ore, and different from the "right-dipping type" of fresh granite and altered granitic cataclastic rock.The migration of REE and pitchblende was synchronous, which is the product of crystallization and precipitation at a low-temperature hydrothermal environment.

Abstract As a noninvasive therapeutic technique, photodynamic therapy (PDT) has attracted numerous research interests for cancer therapy. Nevertheless, the residual photosensitizers (PSs) still produce reactive oxygen species (ROS) and damage normal cells under sunlight after PDT, which limits their practical application in clinic. Herein, the authors propose a self‐degradable type‐I PS based on conjugated polymer, which is composed of aggregation‐induced emission (AIE) and imidazole units. Due to the effective conjugated skeleton and unique AIE properties, thus‐obtained polymers can effectively generate superoxide radical (O2−•) through the type‐I process under light irradiation, which is ideal for hypoxic tumors treatment. Intriguingly, under light irradiation, O2−• produced by the conjugated polymers can further lead to the self‐degradation of the polymer to form nontoxic micro‐molecules. It not only helps to resolve the potential phototoxicity problems of residual PSs, but also can accelerate the metabolism of the conjugated polymers to avoid the potential biotoxicity of drug accumulation. This work develops a self‐degradable type‐I PS, which can turn off the generation of ROS in time after PDT, providing a novel strategy to balance the PDT effect and postoperative safety.

Fluorescent sensor has demonstrated to be a facile and effective method to detect heavy metal ions owing to its unique characteristics such as simplicity, ease of operation and cost-effectiveness. In this work, a novel fluorescent probe with aggregation-induced emission (AIE) feature that contains an amide ligand base on the tetraphenylethylene (TPE) dye was designed and successfully synthesized. The utilization of the AIE-active fluorescent probe (named as FDPA) for detection of Cu2+ in aqueous solution has also been examined. We demonstrated that the resultant AIE-active molecule displays amphiphilic property and can self-assemble in aqueous solution with remarkable enhancement of fluorescent intensity owing to its AIE feature. The detection limit of probe for Cu2+ determination is 6.11 × 10−9 M and shows excellent selectivity in the presence of competitive ions. This work provides a useful route to overcome the fluorescence quenching of conventional fluorescent probes in aqueous solution and an elegant way to prepare fluorescent probes with better fluorescence properties.

In this study, an innovation was made by adding helical fins on the vortex finder of a cylindrical gas-solid cyclone separator, and the effect of this structural improvement on the separation performance was analyzed based on the flow field characteristics. The results show that both cyclones with and without helical fins exhibit a separation efficiency of almost 100% for particles larger than 5 µm. As the inlet velocity increases, the effect of adding helical fins on the overall separation efficiency decreases, with a relative deviation of only 0.16% at an inlet velocity of 27 m/s, while it becomes increasingly effective in reducing energy consumption, with a pressure drop of 25.33%. The mechanism of the overall performance improvement lies in the fact that the helical fins change the flow field distribution in the cyclone, where the turbulence intensity in the vortex finder is significantly reduced, the tangential velocity of the external vortex is decreased, and the pressure gradient is reduced. The purpose of this paper is to provide new ideas for the optimal design of the internal components of the cyclone separator. [ABSTRACT FROM AUTHOR]