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BACKGROUND Poor bowel preparation is commonly observed in inpatients undergoing colonoscopy, particularly those with higher risks for inadequate bowel preparation. AIMS The objective of this study was to determine whether personalized bowel preparation regimens combined with face-to-face instruction (FFI) could improve the quality of bowel preparation for inpatient. METHODS In this endoscopist-blinded, randomized controlled trial, 320 inpatients were enrolled and randomly allocated (1:1) to the control and intervention groups. The intervention group received FFI and personalized bowel preparation regimens, while the control group received the routine bowel preparation regimen and education. The primary outcome was adequate bowel preparation rate. Secondary outcomes included rates of procedure-related adverse events, incorrect diet restriction and laxative intake, etc. RESULTS: The adequate bowel preparation rate in the intervention group was significantly higher compared to control group [intention-to-treat (ITT) analysis: 70.0% vs 51.3%, P

Circular RNA (circRNA) is a kind of endogenous non-coding RNAs and has shown diagnostic values in various cancers. This study aimed to explore whether hsa_circ_0001789 could be a novel biomarker for gastric cancer (GC).Quantitative reverse transcriptase PCR was used to detect the expression of hsa_circ_0001789 in 108 paired GC and paracancerous tissues as well as in 24 paired plasma specimens. Possible associations between hsa_circ_0001789 expression and clinicopathologic factors of GC patients were examined using one-way ANOVA. A receiver operating characteristic (ROC) curve was established to investigate the diagnostic value of hsa_circ_0001789 in GC.GC tissues and plasma samples showed down-regulated hsa_circ_0001789 levels than their counterparts, which were closely correlated with the malignant characteristics of GC. The area under the ROC curve (AUC) of hsa_circ_0001789 in GC tissues was 0.82, while the cut-off value was 9.5, indicating a favorable diagnostic value. Compared with the traditional tumor biomarkers, hsa_circ_0001789 had preferred AUCs that reached 0.786 for predicting the stage of invasion, 0.603 for predicting the stage of lymphatic metastasis, 0.722 for predicting the stage of distant metastasis, and 0.786 for predicting TNM stage.Hsa_circ_0001789 may be a novel biomarker for the diagnosis of gastric carcinoma.

Stellar flares are characterized by sudden enhancement of electromagnetic radiation from the atmospheres of stars. Compared to their solar counterparts, our knowledge on the coronal plasma dynamics of stellar flares and their connection to coronal mass ejections (CMEs) remains very limited. With time-resolved high-resolution spectroscopic observations from the \textit{Chandra} X-ray observatory, we detected noticeable coronal plasma flows during several stellar flares on a nearby dMe star EV Lac. In the observed spectra of O~{\sc{viii}} (3 MK), Fe~{\sc{xvii}} (6 MK), Mg~{\sc{xii}} (10 MK), and Si~{\sc{xiv}} (16 MK) lines, these flare-induced upflows/downflows appear as significant Doppler shifts of several tens to \speed{130}, and the upflow velocity generally increases with temperature. Variable line ratios of the Si~{\sc{xiii}} triplet reveal that these plasma flows in most flares are accompanied by an increase of the coronal plasma density and temperature. We interpret these results as X-ray evidences for chromospheric evaporation on EV Lac. In two successive flares, the plasma flow pattern and a sharp increase of the measured coronal density are highly suggestive of explosive evaporation. The transition from redshifts to blueshifts in such an explosive evaporation occurs at a temperature of at least 10 MK, much higher than that observed in solar flares ($\sim$1 MK). However, in one flare the cool and warm upflows appear to be accompanied by a decreasing plasma density, which might be explained by a stellar filament/prominence eruption coupled to this flare. These results provide important clues to understand the coronal plasma dynamics during flares on M dwarfs., accepted by ApJ

We performed photometric and spectroscopic studies on four W Ursae Majoris eclipsing binaries (V384 Ser, AQ Psc, V480 Gem and 2MASS J07095549+3643564). The binaries were observed from 2015 to 2018. The orbital period of V384 Ser showed an interesting cyclic variation overlaying a decreasing period, which may be caused by the light-time effect (LITE) of approximately 2.84 ± 0.01 yr or the magnetic activity cycle of 2.83 ± 0.01 yr. For AQ Psc, we found cyclic variations in its period caused by the LITE either as a result of a tertiary companion or because of a magnetic activity cycle. We derived the cycle of the tertiary component of AQ Psc as 23.87 (±0.14) yr or a magnetic cycle of 44.08 (±1.15) yr. We revised the linear ephemeris of eclipsing binaries V480 Gem and 2MASS J07095549+3643564. We also determined their orbital parameters and star-spot parameters by fitting the light curves. In addition, we found weak excess emissions in the LAMOST spectra of V384 Ser, AQ Psc, V480 Gem and 2MASS J07095549+3643564 in the Hα line, which indicates weak chromospheric activities.

Objectives: Colorectal cancer in the right side of the colon is supposed to harder to detect by colonoscopy. The aim of this study was to evaluate whether a second forward-view examination of the right side of the colon could increase adenoma detection rate (ADR) and polyp detection rate (PDR).Methods: This was a single-centre randomized controlled trial. Patients undergoing colonoscopy were recruited and randomly assigned to the second forward-view examination (SFE) group, in which the right side of the colon was examined twice and a traditional colonoscopy (TC) group in which the colonoscopy was performed in a standard manner. The primary outcomes were the proximal PDR and ADR. The overall PDR and ADR, and advanced lesion detection rate were also recorded and compared..Results: A total of 392 patients were included in the study (SFE group 197 vs. TC group 195). The proximal PDR and ADR in the SFE group were significantly higher than those in the TC group (PDR 17.8% vs. 9.7%, P =0.021; ADR 14.2% vs.7.2%, P =0.024). No significant difference was found for overall PDR/ADR, or advanced lesion detection rate between the two groups. Conclusions: This prospective study revealed that a second forward-view examination of the right side of the colon could result in a modest improvement in proximal ADR and PDR. This simple and time-effective technique might be recommended for routine colonoscopy. Trial registration: Clinical Trials.gov, NCT03619122. Registered on 7/8/2018.

Additional file 1: Table S5. Operators’ ADR.

Background We performed this systematic review and pooled analysis to assess the effectiveness and safety of different endoscopic resection methods for 10- to 20-mm non-pedunculated colorectal polyps. Methods Articles in PubMed, EMBASE, and the Cochrane Library related to the common endoscopic treatment of 10- to 20-mm non-pedunculated polyps published as of April 2020 were searched. Primary outcomes were the complete resection rate (CRR) and the en bloc resection rate (EBRR). Secondary outcomes were safety and the recurrence rate. Meta-regression and subgroup analysis were also performed. Results A total of 36 studies, including 3212 polyps were included in the final analysis. Overall, the efficacy of resection methods with a submucosal uplifting effect, including endoscopic mucosal resection (EMR), cold EMR and underwater EMR, was better than that of non-submucosal uplifting methods [CRR 90% (95% CI 0.81–0.94, I2=84%) vs 82% (95% CI 0.78–0.85, I2=0%); EBRR 85% (95% CI 0.79–0.91, I2=83%) vs 74% (95% CI 0.47–0.94, I2=94%)] (figure 1). In terms of safety, the pooled data showed that hot resection (hot snare polypectomy and EMR) had a higher risk of early bleeding compared to cold resection [3% (95% CI 0.01–0.05, I2=68%) vs 0% (95% CI 0–0.01, I2=0%)], while the incidence of perforation and polypectomy were both low. Critical heterogeneity was observed in the main outcomes. Conclusions Methods with submucosal uplifting effects for 10- to 20-mm non-pedunculated colorectal polyps are more effective, and cold resection may be safer. Additional research is needed to prove the advantages of these methods, especially cold EMR, in this area.

AimsTemperature screening is important in the population during the outbreak of 2019 Novel Coronavirus (COVID-19). This study aimed to compare the accuracy and precision of wrist and forehead temperature with tympanic temperature under different circumstances.MethodsWe performed a prospective observational study in a real-life population. We consecutively collected wrist and forehead temperatures in Celsius (°C) using a non-contact infrared thermometer (NCIT). We also measured the tympanic temperature using a tympanic thermometers (IRTT) and defined fever as a tympanic temperature ≥37.3°C.ResultsWe enrolled a total of 528 participants including 261 indoor and 267 outdoor participants. We divided outdoor participants into four types according to their means of transportation to the hospital as walk, bicycle, electric vehicle, car, and inside the car. Under different circumstance, the mean difference ranged from −1.72 to −0.56°C in different groups for the forehead measurements, and −0.96 to −0.61°C for the wrist measurements. Both measurements had high fever screening abilities in inpatients (wrist: AUC 0.790; 95% CI: 0.725-0.854, P P ConclusionsWrist measurement is more stable than forehead measurement under different circumstance. Both measurements have great fever screening abilities for indoor patients. The cut-off value of both measurements was 36.2°C. (ClinicalTrials.gov number: NCT04274621)

Background We performed a systematic review and pooled analysis to assess the effectiveness and safety of different endoscopic resection methods for 10- to 20-mm nonpedunculated colorectal polyps. Methods Articles in PubMed, EMBASE, and the Cochrane Library related to the common endoscopic treatment of 10- to 20-mm nonpedunculated polyps published as of April 2020 were searched. Primary outcomes were the R0 resection rate and en bloc resection rate. Secondary outcomes were safety and the recurrence rate. Meta-regression and subgroup analysis were also performed. Results A total of 36 studies involving 3212 polyps were included in the final analysis. Overall, the effectiveness of resection methods with a submucosal uplifting effect, including endoscopic mucosal resection (EMR), cold EMR and underwater EMR (UEMR), was better than that of methods without a nonsubmucosal uplifting effect [R0 resection rate, 90% (95% confidence interval (CI) 0.81-0.94, I2 = 84%) vs 82% (95% CI 0.78-0.85, I2 = 0%); en bloc resection rate 85% (95% CI 0.79-0.91, I2 = 83%) vs 74% (95% CI 0.47-0.94, I2 = 94%)]. Regarding safety, the pooled data showed that hot resection [hot snare polypectomy, UEMR and EMR] had a higher risk of intraprocedural bleeding than cold resection [3% (95% CI 0.01-0.05, I2 = 68%) vs 0% (95% CI 0-0.01, I2 = 0%)], while the incidences of delayed bleeding, perforation and post-polypectomy syndrome were all low. Conclusions Methods with submucosal uplifting effects are more effective than those without for resecting 10- to 20-mm nonpedunculated colorectal polyps, and cold EMR is associated with a lower risk of intraprocedural bleeding than other methods. Additional research is needed to verify the advantages of these methods, especially cold EMR.

The Mujicun Cu (Mo) ore deposit at Laiyuan, Hebei Province, is a currently proven large-sized Cu (Mo) polymetallic ore deposit and it is located in the second-ordered fault depression basin of the ditachment belt on the hanging-wall on the western side at the juncture of the Laiyuan dumbell-shaped complex in the northern part of the Fuping mantle-branch structure. Metallogenesis is controlled by diorite porphyrite in intrusive relation with the fault depression basin and other relevant fault structure systems and intenstive wall-rock alteration zones. This study, in conjunction with the most recent exploration data, analyzed the geological background of metallogenesis of this deposit, summaried the geological characteristics of typical ore deposits, determined the alteration zonation of the deposit, investigated regional metallogenesis and the genesis of typical ore deposits, discussed the regional ore-forming and ore-controlling structures, and generalized the regional ore-controlling model and metallogenic model of the deposit. It is considered that the Mujicun porphry Cu (Mo) deposit, the Tieling, Futuyu, Xiaoligou and other skarn-type Fe-Cu deposits and the He’ergou hydrothermal-type Pb-Zn-Ag deposit jointly constitute a three-in-one polymetallic orefield, with the characteristics of typical metallogenic series.

In order to solve the optimization problems with constraint, a constrained differential evolutionary (CDE) algorithm is presented in this paper. By introducing constraint handling based upon the differential evolutionary (DE) algorithm, the CDE algorithm can find the optimal solution within a fairly short period of time. Empirical results show that the CDE algorithm is an effective, general and robust method.