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Inspired by the structure of nacre, bionic laminar composites composed of 85.6 wt% Cu, 11.9 wt% Al, and 2.5 wt% Mn were prepared using highly flexible Cu-coated graphene films as fillers. The effects of surface modification and graphene films content on the properties were investigated. Results indicated that the loss factor of composites with 0.1 wt% Cu-coated graphene films is improved by approximately 28% and reaches 0.044 compared to uncoated samples. The density and tensile strength are increased by up to 98% and 362 MPa, respectively. This enhancement is attributed to the improved bonding at the graphene films/matrix interface due to the Cu coating, which allows for efficient load transfer. Concurrently, the activation of interlayer sliding in the graphene films dissipates substantial energy. However, an excessive addition of graphene films leads to decreased density and increased internal defects in the composites, resulting in deteriorated properties. This study provides a reference for the preparation of CuAlMn matrix composites with enhanced mechanical and damping properties.

Abstract This paper proposed the additional fractional gradient descent identification algorithm based on the multi-innovation principle for autoregressive exogenous models. This algorithm incorporates an additional fractional order gradient to the integer order gradient. The two gradients are synchronously used to identify model parameters, thereby accelerating the convergence of the algorithm. Furthermore, to address the limitation of conventional gradient descent algorithms, which only use the information of the current moment to estimate the parameters of the next moment, resulting in low information utilisation, the multi-innovation principle is applied. Specifically, the integer-order gradient and additional fractional-order gradient are expanded into multi-innovation forms, and the parameters of the next moment are simultaneously estimated using multi-innovation matrices, thereby further enhancing the parameter estimation speed and identification accuracy. The convergence of the algorithm is demonstrated, and its effectiveness is verified through simulations and experiments involving the identification of a 3-DOF gyroscope system.

With the increasing energy consumption in buildings, the proportion of energy consumption in public buildings continues to grow. As an essential component of public buildings, sports buildings are receiving more attention regarding energy-saving technologies. This paper aims to study the passive energy-saving design methods of small-and medium-sized sports halls in hot summer and cold winter regions, exploring how to reduce building energy consumption by improving the spatial design and thermal performance of the enclosure structures of sports halls. Taking the Wuhu County Sports Center as an example, this study uses computer simulation software to analyze the building’s wind environment and the thermal performance of its external walls and roof. The results show that the large volume of the sports hall significantly impacts the distribution of wind speed and pressure around it, and this impact decreases with height. The thermal simulation of the enclosure structures demonstrates that adding insulation layers to the interior and exterior of the walls and roof of the sports hall is an effective way to reduce energy consumption in both winter and summer. Additionally, wind environment simulations of different roof shapes reveal that flat roofs have the most significant blocking effect on wind and are prone to inducing strong vortices on the leeward side; concave arch roofs have the least blocking effect on airflow, and arch and wave-shaped roofs maintain lower vortex intensity on the leeward side. Hopefully, this study can provide significant references for the energy-saving design of future small- and medium-sized sports buildings.

With the rapid development of mobile devices, aggregation security and efficiency topics are more important than past in crowd sensing. When collecting large-scale vehicle-provided data, the data transmitted via autonomous networks are publicly accessible to all attackers, which increases the risk of vehicle exposure. So we need to ensure data aggregation security. In addition, low aggregation efficiency will lead to insufficient sensing data, making the data unable to provide data mining services. Aiming at the problem of aggregation security and efficiency in large-scale data collection, this article proposes a data collection mechanism (VDCM) for crowd sensing in vehicular ad hoc networks (VANETs). The mechanism includes two mechanism assumptions and selects appropriate methods to reduce consumption. It selects sub mechanism 1 when there exist very few vehicles or the coalition cannot be formed, otherwise selects sub mechanism 2. Single aggregation is used to collect data in sub mechanism 1. In sub mechanism 2, cooperative vehicles are selected by using coalition formation strategy and auction cooperation agreement, and multi aggregation is used to collect data. Two sub mechanisms use Paillier homomorphic encryption technology to ensure the security of data aggregation. In addition, mechanism supplements the data update and scoring steps to increase the amount of available data. The performance analysis shows that the mechanism proposed in this paper can safely aggregate data and reduce consumption. The simulation results indicate that the proposed mechanism reduces time consumption and increases the amount of available data compared with existing mechanisms.

Systemic air embolism is a fatal complication of computed tomography-guided percutaneous lung biopsy. Here, we report a case of acute coronary artery air embolism following computed tomography (CT) guided percutaneous lung biopsy. The patient exhibited cardiac symptoms, and CT showed air density in left ventricle and aorta, indicating air embolism. Trendelenburg positioning and coronary angiography were performed during the treatment, and the patient was discharged without obvious complications.

Inspired by the design principle of pearl structure, a bottom-up flake powder self-assembly arrangement strategy, flake powder metallurgy, is used to prepare graphene films (GFs) reinforced CoCrFeNiMn high-entropy alloy (HEA) matrix composites with a pearl laminated structure. Flaky HEA powder was prepared by ball milling method and homogeneously mixed with Ni plated GFs. Vacuum hot-press sintering (VHPS) technique was carried out to solidify the mixed powders to obtain composites with uniform distribution of GFs(Ni) and flaky HEA. The results show that the bottom-up preparation strategy can effectively fabricate bionic laminated HEA matrix composites, and the composites have a distinct pearly laminated structure. The tensile strength of the composites with 5 vol% GFs(Ni) content reached 834.04 MPa, and the elongation reached 26.58 %. The compressive strength in parallel and perpendicular laminar directions reached 2069.66 MPa and 2418.45 MPa at 50 % strain, respectively. The laminated GFs(Ni)/HEA matrix composites possessed excellent strength and maintained good plasticity. In this study, the strengthening and toughening mechanism of the laminated GFs(Ni)/HEA matrix composites is discussed in detail, and the results show that the laminated structure and GFs(Ni) are favorable for the hardening and strengthening of the HEA matrix.

To integrate the sponge city concept into urban development, we propose an analytical approach for runoff volume control, considering urban expansion. Using Changchun City as a case study and historical land-use data, we simulated the prediction of Changchun City’s land-use structure for 2035 change with the GeoSOS-FLUS platform. We calculated storage volumes for Low Impact Development (LID) designs using 2019 and 2035 land surface data. The objective is an 80% runoff volume control rate by 2035. Through Monte Carlo simulation and sensitivity analysis, we assessed the impact of various land-use types on LID storage volume calculations. Findings show that industrial land significantly influences LID storage volumes. This highlights the need for precise surveys of industrial land properties and surface composition in sponge city planning for more accurate runoff volume control analysis in Changchun City. The results indicate that LID storage volumes based on current data may not meet long-term sponge city goals due to increased impervious surfaces and runoff coefficients during urbanization.

Background and objective Low-density computed tomography (LDCT) improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data. Hence, accurate diagnosis of early-stage lung cancer remains challenging. The purpose of the study was to assess the feasibility of using circulating tumour cells (CTCs) to differentiate malignant from benign pulmonary nodules. Materials and methods 122 patients with suspected malignant pulmonary nodules detected on chest CT in preparation for surgery were prospectively recruited. Peripheral blood samples were collected before surgery, and CTCs were identified upon isolation by size of epithelial tumour cells and morphological analysis. Laser capture microdissection, MALBAC amplification, and whole-exome sequencing were performed on 8 samples. The diagnostic efficacy of CTCs counting, and the genomic variation profile of benign and malignant CTCs samples were analysed. Results Using 2.5 cells/5 mL as the cut-off value, the area under the receiver operating characteristic curve was of 0.651 (95% confidence interval: 0.538-0.764), with a sensitivity and specificity of 0.526 and 0.800, respectively, and positive and negative predictive values of 91.1% and 30.3%, respectively. Distinct sequence variations differences in DNA damage repair-related and driver genes were observed in benign and malignant samples. TP53 mutations were identified in CTCs of four malignant cases; in particular, g.7578115T>C, g.7578645C>T, and g.7579472G>C were exclusively detected in all four malignant samples. Conclusion CTCs play an ancillary role in the diagnosis of pulmonary nodules. TP53 mutations in CTCs might be used to identify benign and malignant pulmonary nodules.

Abstract. Background:. LY01005 (Goserelin acetate sustained-release microsphere injection) is a modified gonadotropin-releasing hormone (GnRH) agonist injected monthly. This phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate cancer. Methods:. We conducted a randomized controlled, open-label, non-inferiority trial across 49 sites in China. This study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three injections. The primary efficacy endpoints were the percentage of patients with testosterone suppression ≤50 ng/dL at day 29 and the cumulative probability of testosterone ≤50 ng/dL from day 29 to 85. Non-inferiority was prespecified at a margin of -10%. Secondary endpoints included significant castration (≤20 ng/dL), testosterone surge within 72 h following repeated dosing, and changes in luteinizing hormone, follicle-stimulating hormone, and prostate specific antigen levels. Results:. On day 29, in the LY01005 and goserelin implant groups, testosterone concentrations fell below medical-castration levels in 99.3% (142/143) and 100% (140/140) of patients, respectively, with a difference of -0.7% (95% confidence interval [CI], -3.9% to 2.0%) between the two groups. The cumulative probabilities of maintaining castration from days 29 to 85 were 99.3% and 97.8%, respectively, with a between-group difference of 1.5% (95% CI, -1.3% to 4.4%). Both results met the criterion for non-inferiority. Secondary endpoints were similar between groups. Both treatments were well-tolerated. LY01005 was associated with fewer injection-site reactions than the goserelin implant (0% vs. 1.4% [2/145]). Conclusion:. LY01005 is as effective as goserelin implants in reducing testosterone to castration levels, with a similar safety profile. Trial registration:. ClinicalTrials.gov, NCT04563936.

Abstract Background Diagnosing persistent pulmonary consolidation still faces challenges. The purpose of this study is to compare the diagnostic yield and the complication rate between percutaneous transthoracic CT-guided coaxial needle biopsy (PTCNB) and transbronchial lung biopsy (TBLB) of persistent pulmonary consolidation. Materials From January 1, 2016, to December 31, 2020, we have retrospectively enrolled a total of 155 consecutive patients (95 males, 60 females) with persistent pulmonary consolidation who underwent both TBLB and PTCNB. According to the standard reference, the diagnostic yield, accuracy, sensitivity and specificity of PTCNB and TBLB were assessed and compared. Results According to the standard reference, the final biopsy diagnoses of 11 cases were confirmed true malignant based on the surgical resections, the remaining were confirmed by clinical and imaging follow-up for at least 12 months. The overall diagnostic accuracy, sensitivity and specificity of PTCNB for malignant diagnosis were 91.61%, 72.34% and 100%, whereas of TBLB were 87.74%, 59.57% and 100%. The diagnostic yield of PTCNB and TBLB were 50.32% and 25.16%, respectively. For the TBLB-based negative cases, PTCNB provided a definite diagnostic yield of 37.93%. There were 45 (29.03%), 22 (14.19%) and 13 (8.39%) patients who experienced pneumothorax, intrapulmonary hemorrhage and hemoptysis, respectively, in PTCNB, while there were only 5 (3.22%) cases of mild intraprocedural bleeding occurring in TBLB. Conclusions CT-guided co-axial needle biopsy is an effective and safe modality, associated with higher diagnostic yield and better diagnostic accuracy compared to transbronchial lung biopsy for malignancy presenting as persistent consolidation, especially as the complementary method for TBLB-based negative lung lesions. Key Points Both PTCNB and TBLB showed high diagnostic accuracy for malignancy. PTCNB had a higher diagnostic yield than TBLB for persistent pulmonary consolidation. PTCNB could provide a complementary diagnosis for TBLB-based negative lung consolidation.

PurposeThis study aimed to evaluate the diagnostic performance of perfusion-weighted phase-resolved functional lung (PW-PREFUL) magnetic resonance imaging (MRI) in patients with chronic pulmonary embolism (CPE).Materials and methodsThis study included 86 patients with suspected chronic thromboembolic pulmonary hypertension (CTEPH), who underwent PREFUL MRI and ventilation/perfusion (V/Q) single-photon emission computed tomography/computed tomography (SPECT/CT). PREFUL MRI was performed at 1.5 T using a balanced steady-state free precession sequence during free breathing. Color-coded PW images and quantitative parameters were obtained by postprocessing. Meanwhile, V/Q SPECT/CT imaging was performed as a reference standard. Hypoperfused areas in the lungs were scored for each lobe and segment using V/Q SPECT/CT images and PW-PREFUL MR images, respectively. Normalized perfusion (QN) and perfusion defect percentage (QDP) were calculated for all slices. For intra- and interobserver variability, the MRI images were analyzed 2 months after the first analysis by the same radiologist and another radiologist (11 years of lung MRI experience) blinded to the results of the first reader.ResultsOf the 86 enrolled patients, 77 met the inclusion criteria (36 diagnosed with CPE using V/Q SPECT/CT and 41 diagnosed with non-CPE etiology). For the PW-PREFUL MRI, the sensitivity, specificity, accuracy, and positive and negative predictive values for the diagnosis of CPE were 97, 95, 96, 95, and 98% at the patient level; 91, 94, 93, 91, and 94% at the lobe level, and 85, 94, 92, 88, and 94% at the segment level, respectively. The detection of segmental and subsegmental hypoperfusion using PW-PREFUL MRI revealed a moderate agreement with V/Q SPECT/CT (κ = 0.65; 95% confidence interval: 0.61–0.68). The quantitative results indicated that the QN was lower in the CPE group than in the non-CPE group [median score (interquartile range, IQR) 6.3 (2.8–9.2) vs. 13.0 (8.8–16.7), p

Visible light communication (VLC)/radio frequency (RF) hybrid networks exhibit large system capacity, high reliability, and low access latency. To simplify the resource allocation process of such hybrid networks, we devise a random compensation algorithm based on supermartingale theory. Firstly, a network queuing model with random arrival traffic and random compensation service mechanism are established. Then, the delay performance is evaluated based on supermartingale theory, and a tighter delay violation probability bound is derived. A search algorithm is designed to obtain the compensation bandwidth and compensation probability based on the RF. Finally, the devised algorithm is compared with that based on large deviation theory. The results of simulations demonstrate that the proposed algorithm is authentic and could save bandwidth.

Clostridium perfringens type A infections are economically devastating to dairy farms. In spite of low morbidity, mortality is close to 100%. Although this disease has frequently been reported in calves, it is rarely seen in adult cattle, especially postpartum dairy cows. Sudden onset of symptoms, rapidly followed by death, was successively recorded in 14 postpartum dairy cows. Veterinary treatment was ineffective. The 14 cows fell ill after parturition, either within 24 h (fast invasion) or within 2–3 days (slow invasion). All the cows died shortly after symptom onset. Comprehensive analysis of epidemiology, clinical manifestation, autopsy results, and laboratory tests confirmed the 14 cases as most acute and acute C. perfringens type A infections. After the enactment of appropriate preventive and treatment measures, in conjunction with improved feeding management, no further symptoms of infection were observed in the postpartum cows. Our results demonstrated that autopsies and laboratory tests are required for the definitive diagnosis of this disease and highlighted importance of feeding management during the early perinatal period to prevent postpartum diseases in cows. This work also provides a reference for clinical veterinary diagnosis and the treatment of this disease, so as to reduce the economic losses of dairy farms.

Cermets with Cu and Fe as matrix and zirconia toughened alumina (ZTA) as reinforcement phase were prepared by vacuum hot pressing sintering. Electroless Ni plating was carried out on ZTA particles to improve the interfacial bonding ability between ZTA and metal matrix. Cu-xFe-ZTA cermets (x = 20, 50, 80) were prepared by using different proportions of Cu powders and Fe powders as the binder in order to investigate the influence of binder types on the grinding performance of cermets. The phase composition, microstructure, mechanical properties and grinding properties of Cu–Fe-ZTA cermets were systematically studied. It revealed that the difference of cermet grinding performance lay in the bonding force between metal matrix and abrasive. The coating ability of abrasive is stronger with the increase of Cu content in the matrix. Because the matrix is soft and easy to grind, the cermet grinding wheel material has strong self-sharpening, and Cu–20Fe-ZTA grinding effect is the best. The friction coefficient of Cu–20Fe-ZTA cermets was 0.405, the grinding surface roughness was 7.972 μm, and the residual stress σx and σy were 180.5 and 89.6 MPa, respectively. As the Fe content decreased, the grinding mechanism changed from ploughing and cutting to friction.

Objective: This study was designed to compare the effects of hamstring muscle injection of botulinum toxin type A (BoNT/A) combined with periarticular injection to those of simple periarticular injection alone, in terms of early pain reduction and functional recovery following total knee arthroplasty (TKA). Methods: This study included 40 patients who underwent elective unilateral TKA at our hospital from February 2021 to December 2021. The patients were randomly assigned to either the experimental group (BoNT/A injection into the hamstring muscle + periarticular injection, n = 20 cases) or the control group (0.9% normal saline injection into the hamstring muscle + periarticular injection, n = 20 cases). The preoperative and postoperative 3-day HSS scores were compared between the two groups. Postoperative visual analog scale (VAS) pain scores were observed and compared between the two groups. The Lovett grading method was used to evaluate the postoperative muscle strength of both groups. Additionally, postoperative knee joint pain scores, maximum active flexion angle, and any postoperative adverse reactions were observed and compared between the two groups. Results: The experimental group showed significantly lower VAS pain scores than the control group at 24 h, 48 h, and 72 h after the operation, with a statistically significant difference (P < 0.05). Furthermore, compared to the control group, the patients in the experimental group exhibited larger knee joint active flexion angles at 1 day, 3 days, and 5 days post-operation, also demonstrating a statistically significant difference (P < 0.05). These findings hold scientific significance (P < 0.05). Additionally, the combined administration of BoNT/A hamstring muscle injection with periarticular injection exhibited a low incidence of adverse reactions during the perioperative period and had no significant effect on quadriceps muscle strength. Conclusion: The combination of BoNT/A hamstring muscle injection with periarticular injection effectively alleviates early postoperative pain following TKA and promotes early functional recovery of the knee joint.

In recent years, numerous viruses have been identified from ticks, and some have been linked to clinical cases of emerging tick-borne diseases. Chinese northeast frontier is tick infested. However, there is a notable lack of systematic monitoring efforts to assess the viral composition in the area, leaving the ecological landscape of viruses carried by ticks not clear enough. Between April and June 2017, 7101 ticks were collected to perform virus surveillance on the China–North Korea border, specifically in Tonghua, Baishan, and Yanbian. A total of 2127 Ixodes persulcatus were identified. Further investigation revealed the diversity of tick-borne viruses by transcriptome sequencing of Ixodes persulcatus. All ticks tested negative for tick-borne encephalitis virus. Transcriptome sequencing expanded 121 genomic sequence data of 12 different virus species from Ixodes persulcatus. Notably, a new segmented flavivirus, named Baishan Forest Tick Virus, were identified, closely related to Alongshan virus and Harz mountain virus. Therefore, this new virus may pose a potential threat to humans. Furthermore, the study revealed the existence of seven emerging tick-borne viruses dating back to 2017. These previously identified viruses included Mudanjiang phlebovirus, Onega tick phlebovirus, Sara tick phlebovirus, Yichun mivirus, and three unnamed viruses (one belonging to the Peribunyaviridae family and the other two belonging to the Phenuiviridae family). The existence of these emerging tick-borne viruses in tick samples collected in 2017 suggests that their history may extend further than previously recognized. This study provides invaluable insights into the virome of Ixodes persulcatus in the China–North Korea border region, enhancing our ongoing efforts to manage the risks associated with tick-borne viruses.

Abstract Objective The purpose of this study was to evaluate the usefulness of intraprocedural CT and prior PET/CT fusion imaging in improving the diagnostic yield of CT-guided transthoracic core-needle biopsy (CNB) in lung masses. Methods In total, 145 subjects with lung masses suspicious for malignancy underwent image-guided transthoracic CNB. According to imaging modality the subjects were divided into two groups. PET/CT images obtained no more than 14 days before the biopsy were integrated with intraprocedural CT images. The integrated or fused images were then used to plan the puncture sites. The clinical characteristics, diagnostic yield of CNB, diagnostic accuracy rate, procedure-related complications and procedure duration were recorded and compared between the two groups. Final clinical diagnosis was determined by surgical pathology or at least 6-months follow-up. The diagnostic accuracy of CNB was obtained by comparing with final clinical diagnosis. Results 145 subjects underwent CNB with adequate samples, including 76 in fusion imaging group and 69 in routine group. The overall diagnostic yield and diagnostic accuracy rate were 80.3% (53/66), 82.9% (63/76) for fusion imaging group, 70.7% (41/58), 75.4% (52/69) for routine group, respectively. In addition, the diagnostic yield for malignancy in fusion imaging group (98.1%, 52/53) was higher than that in routine group (81.3%, 39/48). No serious procedure-related complications occurred in both two groups. Conclusion CNB with prior PET/CT fusion imaging is particularly helpful in improving diagnostic yield and accurate rate of biopsy in lung masses, especially in heterogeneous ones, thus providing greater potential benefit for patients.

This study aimed to report on a method for injecting botulinum toxin type A into the hamstring muscles combined with periarticular injection in total knee arthroplasty (TKA) patients. We enrolled patients who underwent elective unilateral TKA at our hospital from February 2021 to December 2021 and administered botulinum toxin type A hamstring muscle injection combined with periarticular injection. We established and reported a detailed method for this combined approach, which could provide an alternative analgesic regimen after TKA in clinical practice.

Abstract Background Endoscopic combined intrarenal surgery (ECIRS) is well established as a minimally invasive procedure for the treatment of multiple urolithiasis. The position is the key to the perfect combination of percutaneous nephrolithotomy (PCNL) and retrograde intrarenal surgery (RIRS). Galdakao-modified supine Valdivia (GMSV) and prone split-leg positions are widely used. However, both positions have their own advantages and disadvantages. This study aimed to evaluate the effect of ECIRS in the treatment of multiple urolithiasis in the modified prone split-leg position. Patients and methods A total of 96 patients with multiple urolithiasis underwent ECIRS in modified prone split-leg position from September 2017 to January 2021. Relevant demographic and clinical data were analysed retrospectively. Clinical outcomes, such as the stone free rate, complications and postoperative hospital stay were evaluated. The chi-square test was used to compare categorical variables and Student’s t test was applied for continuous variables of the treatment groups. Results The mean renal stone size was 32.5 ± 10.7 mm and renal stone surface area was 712.2 ± 264.8 mm2. The mean ureteral stones size was 24.8 ± 12.3 mm. The mean surgical time was 82.2 ± 38.3 min. The incidence of complications was 16.7%, and they were mainly grade 1 and grade 2. No complications occurred above grade 3. The stone was completely removed in 75 (78.1%) patients in a single operation. The risk factors affecting the stone-free rate of ECIRS were analysed, and only the number of involved calyces by stone was found to be significant (p = 0.01). Conclusion ECIRS is safe and effective in the treatment of multiple renal calculi or multiple renal calculi with ipsilateral ureteral calculi in the modified prone split-leg position. The modification of the prone split-leg position makes the retrograde operation more convenient, which is conducive to the combination of RIRS and PCNL.

Cu–Al–Mn–Ti–xTa alloys (x = 0, 1, 2, 3, wt.%) prepared by spark plasma sintering were investigated for the effect of Ta content on the microstructure, mechanical and damping properties. The microstructure and phase composition indicate that the alloy is mainly composed of β′1 martensite, γ′1 martensite, Ti-rich and Ta-rich phase. As the Ta content increases, the grain size of the alloy first decreases and then increases. The reverse trend was observed for hardness, tensile and compressive strength. The hardness, tensile strength and compressive strength increased by 18.2%, 44.9% and 28%, respectively, when the Ta content was 1 wt.% compared to the alloy without Ta element. The presence of martensite provides the alloy with promising damping properties. Meanwhile, the formation of the second phase has a two-sided effect on the damping characteristics. That is, the increase in grain boundaries provides more interfaces for energy dissipation, but the increased compressive stress between the interfaces also hinders the movement of the interfaces. Excellent damping performance is demonstrated with the addition of 1 wt.% of Ta element. The peak values of damping capacity at room temperature and at about 580 °C reached 0.026 and 0.19, respectively. The results confirm that the addition of Ta elements is achievable to obtain Cu–Al–Mn–Ti alloys with both high mechanical and damping properties.

The ADAM (a disintegrin and metalloprotease) gene-related family including ADAM, ADAMTS, and ADAM-like decysin-1 has been reported to play an important role in the pathogenesis of multiple diseases, including cancers (lung cancer, gliomas, colorectal cancer, and gastrointestinal cancer). However, its biological role in gliomas remains largely unknown. Here, we aimed to investigate the biological functions and potential mechanism of ADAMDEC1 in gliomas. The mRNA and protein expression levels of ADAMDEC1 were upregulated in glioma tissues and cell lines. ADAMDEC1 showed a phenomenon of “abundance and disappear” expression in gliomas and normal tissues in that the higher the expression of ADAMDEC1 presented, the higher the malignancy of gliomas and the worse the prognosis. High expression of ADAMDEC1 was associated with immune response. Knockdown of ADAMDEC1 could decrease the proliferation and colony-forming ability of LN229 cells, whereas ADAMDEC1 overexpression has opposite effects in LN229 cells in vitro. Furthermore, we identified that ADAMDEC1 accelerates GBM progression via the activation of the MMP2 pathway. In the present study, we found that the expression levels of ADAMDEC1 were significantly elevated compared with other ADAMs by analyzing the expression levels of ADAM family proteins in gliomas. This suggests that ADAMDEC1 has potential as a glioma clinical marker and immunotherapy target.

Primary neuroendocrine carcinoma of the breast (NECB) is a rare tumour with an incident rate of 0.3–0.5%. The most common metastatic sites of NECB are liver, bones, lung, pancreas, soft tissues and brain, while leptomeninges metastasis (LM) is reported rarely. This current case report describes a 50-year-old female patient with NECB and LM whose overall survival was 2 months. The report also presents the current literature regarding the knowledge of this unusual tumour and metastatic type. The current patient was diagnosed with NECB with right cerebellar metastasis, followed by LM. She underwent modified radical mastectomy of the left breast, left whole breast radiation therapy and incomplete adjuvant chemotherapy until the metastasis occurred. Whole-brain radiation therapy and a first-line salvage regimen of etoposide and cis-platinum were then undertaken. The patient died 2 months after their LM diagnosis. Primary NECB with LM is sporadic, devoid of effective treatment and associated with a poor prognosis. Consequently, it is vitally important to identify LM in order to achieve longer patient survival.

Many real-world systems can be expressed in temporal networks with nodes playing different roles in structure and function, and edges representing the relationships between nodes. Identifying critical nodes can help us control the spread of public opinions or epidemics, predict leading figures in academia, conduct advertisements for various commodities and so on. However, it is rather difficult to identify critical nodes, because the network structure changes over time in temporal networks. In this paper, considering the sequence topological information of temporal networks, a novel and effective learning framework based on the combination of special graph convolutional and long short-term memory network (LSTM) is proposed to identify nodes with the best spreading ability. The special graph convolutional network can embed nodes in each sequential weighted snapshot and LSTM is used to predict the future importance of timing-embedded features. The effectiveness of the approach is evaluated by a weighted Susceptible-Infected-Recovered model. Experimental results on four real-world temporal networks demonstrate that the proposed method outperforms both traditional and deep learning benchmark methods in terms of the Kendall τ coefficient and top k hit rate.

Abstract Background To evaluate the feasibility and safety of microcoil in simultaneous localization for multiple pulmonary nodules before video-assisted thoracic surgery (VATS). Methods Twenty-eight consecutive patients (26 two-nodule, 2 three-nodule; 58 nodules in total; Group A) underwent simultaneous CT-guided localization of multiple pulmonary nodules before VATS using microcoil. Successful targeting, localization, and VATS were defined as implantation of microcoil at the target site on CT image which was obtained immediately after the marking procedure, visualization of nodule location, and complete resection of the target nodule with adequate margin, respectively. Meanwhile, the clinical characteristics, localization procedure-related variables of the nodules and procedure-related complications in group A were also assessed and compared with those in a control group (221 single-localization procedures in 221 patients; Group B). Results Similar rates of successful targeting, localization and VATS were observed in group A and B (96.6% vs. 98.2%; 91.4% vs. 91.0%; 100% vs. 99.1%). Although the rate of overall complications (including localized pneumothorax and intrapulmonary hemorrhage) was a bit higher in group A than that in group B (32.8% vs. 30.8%, p = 0.771), only minor complications were observed in the subjects of the two groups with no need for further treatment. In addition, the duration of simultaneous localization procedures was significantly longer than that of single localization (24 ± 7.5 vs.13 ± 6 min, p

In this study, B4C-Al2O3 multiphase ceramic composites were prepared by spark plasma sintering (SPS) and Y2O3 was used as a sintering aid. Results show that in the range of 1350–1500°C, nearly full dense B4C-Al2O3 multiphase ceramic composites with a high densification rate (4×10−3/s) can be fabricated. Addition of Y2O3 can lead to reduce activation energy of densification and plastic flow mechanism during sintering of the ceramic composites. At the same time, Y2O3 can react with Al2O3 to form liquid Y3Al5O12, which can effectively reduce the densification temperature of the ceramic composites. With the increase of Y2O3 content, the temperature was lowered from 1500 °C to 1350 °C. When the Y2O3 content was 1.0 vol.%, relative density, hardness, fracture toughness, and flexural strength of the ceramic composites were 98.60%, 23.75 GPa, 4.89 MPa•m1/2, and 464.96 MPa, respectively. The toughening mechanism of the ceramic composites followed particle toughening and micro-crack toughening. The internal grains of the composites were tightly bonded, they were mainly fractured in the transgranular form and the cross section was relatively rough with a high bending strength of 450 MPa.

Objectives: To preliminarily evaluate the clinical effectiveness and safety of computed tomography (CT) image-guided irreversible electroporation (IRE) for the treatment of recurrent hepatocellular carcinoma (HCC) after surgical resection. Methods: From January 2016 to February 2018, 18 patients diagnosed with recurrent HCC after surgical resection received IRE under CT image guidance for 22 tumors. Patients were enrolled for IRE when ineligible for thermal ablation due to tumor location. Clinical records and imaging data were reviewed to assess complete ablation rate, local tumor progression free rate (LTPFR), local tumor progression free survival (LTPFS) and complications after a median follow-up time of 14 months. Results: Successful complete ablations were achieved in 20/22 (90.1%) tumors. Mean LTPFS was 10.5 ​± ​9.4 months. Overall 3-, 6- and 12-months LTPFR in 22 tumors following IRE were 68.2% (95% confidence interval [CI]: 45%–83%), 59.1% (95% CI: 33%–76%) and 36.4% (95% CI: 17%–56%), respectively. Complications included pneumothorax (2/18, 11.1%), localized pain (3/18, 16.7%), bile duct dilation (1/18, 5.6%) and transient hypertension (1/18, 5.6%). No major complications or treatment-related deaths were observed. The alpha-fetoprotein levels of two patients decreased to the normal range at 3 and 4 months, respectively. Conclusions: This study showed that percutaneous CT image-guided IRE can serve as a safe and effective treatment for recurrent HCC not suitable for thermal ablation.

Abstract Background The most serious complication of ureter stent is long-term retention of ureteral stent and stone formation around the stent. Case presentation A 51-year old female patient with left ureteral stent placed 2 years before developed both pyelic and vesical stones on the two ends of the double J was admitted to our hospital. Intravesical lithotripsy, retrograde ureteroscopy, and percutaneous nephrolithotripsy were performed with the patient in the prone split-leg position. All the stones and the ureteral stent were successfully removed in a single session. Conclusions Combined endoscopic techniques in the prone split-leg position can effectively and safely manage severely encrusted stents.

Abstract Background The importance of mRNA methylation erased by ALKBH5 in mRNA biogenesis, decay, and translation control is an emerging research focus. Ectopically activated YAP is associated with the development of many human cancers. However, the mechanism whereby ALKBH5 regulates YAP expression and activity to inhibit NSCLC tumor growth and metastasis is not clear. Methods Protein and transcript interactions were analyzed in normal lung cell and NSCLC cells. Gene expression was evaluated by qPCR and reporter assays. Protein levels were determined by immunochemical approaches. Nucleic acid interactions and status were analyzed by immunoprecipitation. Cell behavior was analyzed by standard biochemical tests. The m6A modification was analyzed by MeRIP. Results Our results show that YAP expression is negatively correlated with ALKBH5 expression and plays an opposite role in the regulation of cellular proliferation, invasion, migration, and EMT of NSCLC cells. ALKBH5 reduced m6A modification of YAP. YTHDF3 combined YAP pre-mRNA depending on m6A modification. YTHDF1 and YTHDF2 competitively interacted with YTHDF3 in an m6A-independent manner to regulate YAP expression. YTHDF2 facilitated YAP mRNA decay via the AGO2 system, whereas YTHDF1 promoted YAP mRNA translation by interacting with eIF3a; both these activities are regulated by m6A modification. Furthermore, ALKBH5 decreased YAP activity by regulating miR-107/LATS2 axis in an HuR-dependent manner. Further, ALKBH5 inhibited tumor growth and metastasis in vivo by reducing the expression and activity of YAP. Conclusions The presented findings suggest m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC. Moreover, effective inhibition of m6A modification of ALKBH5 might constitute a potential treatment strategy for lung cancer.

For the communication scenarios of heterogeneous arrivals in the fifth generation cellular networks, slicing is believed to be an effective way to provide quality-of-service (QoS) provisioning. However, the reports on an effective segmentation of resources for random and bursty arrival are rare. Relying on the bandwidth estimation and service design, we give a simple but effective scheme for the slicing of bandwidths named two-hole leaky bucket random service mechanism. The service in our scheme comprises two parts, the specific basic service and shared random compensation service. Accordingly, the mechanism of resource allocation is just like leaky bucket with two holes, one of which has a random leak rate. To guarantee the statistical QoS of heterogeneous traffic flows, effective bandwidth/capacity theory is introduced into the slicing scheme. By establishing function equations, we deduce the compensation probability of each slice, which is taken as the slicing adjustment factor. Simulation results prove that the random compensation scheme can satisfy the statistical QoS requirements of heterogeneous traffic flows. Although the scheme is proved to be effective against two slices, the proposed model is applicable to general multiple heterogeneous arrivals.

In order to solve the problem the permeability coefficient and strength of pervious concrete pavement are difficult to coordinate. In this paper, the basalt fiber was incorporated into pervious concrete, and the single factor control variable method was used to carry out the test of basalt fiber modified pervious concrete, and combined with the microstructure image, the influence law of different diameters, lengths, and dosages of basalt fibers on mechanical properties and pervious properties of pervious concrete were studied. The optimal incorporation index of basalt fiber was determined by a new analysis method—the entropy method. Finally, it is concluded that basalt fiber can improve the mechanical and pervious properties of pervious concrete by changing the internal structure of pervious concrete. In addition, when the diameter of basalt fiber increases from 14 μm to 20 μm, the compressive strength of pervious concrete decreases by 17.79%. The splitting tensile strength showed a trend of increasing to decreasing. The porosity and water permeability increased by 2.55% and 48.66%, respectively. When the basalt fiber length increases from 12 mm to 24 mm, the compressive strength of pervious concrete increases by 20.54%, and the splitting tensile strength increases first and then decreases. The porosity and water permeability increased by 6.40% and 57.68%, respectively. When the content of basalt fiber increases from 2 kg/m3 to 6 kg/m3, the compressive strength of pervious concrete decreases by 16.25%. The splitting tensile strength increases by 23.72%. The porosity and permeability decreased by 7.75% and 39.36%, respectively. Finally, the entropy method is used to comprehensively analyze the optimum incorporation indexes of basalt fiber, which can achieve the optimal mechanical properties and water permeability at the same time with, 20 μm in diameter, 24 mm in length, and 2 kg/m3 in dosage, and it provides a reference value for the popularization and application of basalt fiber pervious concrete in practical engineering.

Immune-related adverse events (irAEs) following treatment with immune checkpoint inhibitors (ICIs) can affect almost any organ systems. Multiple-organs irAEs are a rare occurrence which makes its management and treatment very challenging. This is a case report of a 71-year-old man with advanced non-small cell lung cancer (NSCLC) who developed multiple-organs irAEs (lung, muscle, myocardium, liver, and pituitary) after a single cycle (21 days) of the BGB-A317 (Tislelizumab). After more than two months of immunosuppression treatment with glucocorticoids, the tumor and inflammatory lesions in the lung were reduced. The levels of serum creatase, cardiac troponin T (TNT), and hepatic transaminase were also reduced. Four months after the termination of ICI therapy, the lung tumor reappeared in the previous site. This rare case report supplies several experiences in the management of multiple-organs irAEs, including full-scale monitoring of immunological indicators, early differential diagnosis, and prompt glucocorticoid therapy. This patient was not a candidate for the ICI re-challenge therapy due to the number and seriousness of irAEs. Multiple-organs irAEs add complexity to the management, and additional research is needed to develop optimal therapeutic guidelines.

The application of the low impact development (LID) in a cold climate such as northeastern China is constrained by two unresolved research questions with regards to its infiltration potential through the winter and its varied runoff regimes between winters and summers. This study picked a typical residential district under construction in Changchun, China, and modeled the storm drainage system with and without LID facilities based on the Storm Water Management Model. The hydrological performance of LID was evaluated through various design storms and historic rain events in dry, average, and wet years. The influence of the Horton and the Green–Ampt infiltration methods on the seasonal water budgets was particularly compared since the former is universally adopted in China while the latter is more widely used in the U.S. and other countries. The results indicate that the Horton method tended to generate a higher infiltration volume than the Green–Ampt method. Consequently, when driven by the 100-year design storm, the Horton method led to a 17.4% higher outflow than the Green–Ampt method; when driven by the measured 3-year precipitation in the study area, the yearly runoff coefficients, with regards to the Horton method, were at least 1.3 times higher than those modeled by the Green–Ampt method. This finding challenged the interchangeable use of the Horton and Green–Ampt methods without tests. Furthermore, the formation of snow covers in winter also reduced the permeability of LID and its capacity of managing runoff compared to summer. However, LID still exhibited a decent potential of regulating the winter runoff in the cold region compared to the baseline, possibly owing to the presence of frequent freezing-thawing cycles.

The presence of gastric cancer stem cells (GCSCs) marks the onset of gastric carcinoma. The sonic hedgehog (SHH) pathway plays a vital role in the maintenance of GCSC characteristics. Apatinib has been approved in China for advanced gastric cancer (GC) treatment. However, whether apatinib can target GCSCs and affect the SHH pathway remains unclear. The present study aimed to investigate the underlying mechanism of apatinib’s antitumor effects on GC. The expression levels of GCSC markers and number of CD133+ cells were significantly elevated in the sphere-forming cells. Apatinib effectively suppressed GCSC traits by inhibiting tumorsphere formation and cell proliferation, suppressing GCSC markers expression and CD133+ cell number, and inducing apoptosis. Apatinib downregulated the activation of the SHH pathway; while upregulation of the SHH pathway attenuated the inhibitory effects of apatinib on GCSCs. Moreover, apatinib treatment significantly delayed tumor growth and inhibited GCSC characteristics in the xenograft model. Our data suggested that apatinib exhibited inhibitory effects on GCSCs by suppressing SHH pathway both in vitro and in vivo, thus providing new insights into the therapeutic application of apatinib in GCSC suppression and advanced gastric cancer treatment.

Abstract Background To investigate whether MRI findings, including texture analysis, can differentiate KRAS mutation status in rectal cancer. Methods Totally, 158 patients with pathologically proved rectal cancers and preoperative pelvic MRI examinations were enrolled. Patients were stratified into two groups: KRAS wild-type group (KRASwt group) and KRAS mutation group (KRASmt group) according to genomic DNA extraction analysis. MRI findings of rectal cancers (including texture features) and relevant clinical characteristics were statistically evaluated to identify the differences between the two groups. The independent samples t test or Mann-Whitney U test were used for continuous variables. The differences of the remaining categorical polytomous variables were analyzed using the Chi-square test or Fisher exact test. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory power of MRI features. The area under the ROC curve (AUC) and the optimal cut-off values were calculated using histopathology diagnosis as a reference; meanwhile, sensitivity and specificity were determined. Results Mean values of six texture parameters (Mean, Variance, Skewness, Entropy, gray-level nonuniformity, run-length nonuniformity) were significantly higher in KRASmt group compared to KRASwt group (p

The photochemical-reduction methods exhibit many interesting applications in metal and metal oxide nanoparticles with promising properties such as easy-to-handle, easy-to-inkjet and cost-effective. Using the soluble graphene oxide (GO) as a precursor, graphene production can be achieved via photochemical reduction, paving the way for manufacturing graphene products in controllable microscopic patterns. In this work, I used a photochemical method to obtain reduced graphene oxide (rGO), assisted by strong reducing $\alpha $ -aminoalkyl ( $\alpha $ -A*) radicals generated by photoinitiator Irgacure-907. The extent of oxygen reduction can be continually controlled by manipulating light dosage and characterized by quantitative measurements of structure, morphology, chemical composition and electrical conductivity. The high quality of obtained rGO makes this photochemical-reduction based technology ideal for inkjet printing microstructures of graphene, thus achieving desirable conductivity, other physical and chemical properties associated.

Phthalic acid esters (PAEs) are environmental organic pollutants that are ubiquitous in the ocean, and di-(2-ethylhexyl) phthalate (DEHP) is the most widely used PAE. The environmental concentration of DEHP was reported to be up to 42.52 μg/L in seawater in the estuaries located in Jiaozhou Bay along the Yellow Sea. DEHP has been investigated with respect to its toxicity in marine organisms. However, evidence on the dose-dependent effects of DEHP remains contradictory and limited. We used marine mussel Mytilus galloprovincialis as the experimental animal to study the dose-dependent effects of various levels of exposure to DEHP (concentrations of 4, 12, 36, 108, and 324 μg/L). These effects and the underlying mechanisms were elucidated by the levels of antioxidant enzyme activity, gene expression, and metabolite. The results indicated that, at environmentally relevant concentrations (12 and 36 μg/L), DEHP induced significant hormetic effects. This was indicated by the U-shaped or inverted U-shaped responses of the gene expression levels related to stress response (CAT, GST, and MgGLYZ) and antioxidant enzyme activities (SOD and CAT). The metabolic profiles revealed that DEHP generally caused monophasic response in osmotic regulation (homarine) and biphasic response (hormesis) in energy metabolism (glucose, glycogen, and amino acids), respectively. These findings can aid in ecological risk assessment with respect to DEHP and the determination of hormetic dose responses.

ABSTRACT: Purpose: The objective of our study was to compare the effectiveness of the combination of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with that of surgical resection (SR) in Barcelona-Clinic Liver Cancer (BCLC) A hepatocellular carcinoma.Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for comparisons of the two therapies from January 2006 to December 2017. Overall survival rate (OS), recurrence-free survival rate (RFS), complications, and the average length of hospital stay were compared and analyzed. Review Manager v. 5.2 from the Cochrane Collaboration was used for statistical analyses.Results: Seven case-control studies and one randomized controlled trial were identified, of which 717 were treated with a combination of TACE and RFA and 785 were treated with SR. Meta-analysis data revealed that TACE plus RFA had significantly better effectiveness on 1.0-y OS (OR = 0.50, p = .009). The major complications (ORcomplications = 1.88, p = .02) after the combined therapy were significantly lower than those after SR. There were three studies that reported the average length of hospital stay. The hospital stay for the SR group vs the combined therapy group was 19.8 ± 8.4 d vs 7.4 ± 2.2 d, respectively (p < .0001); 18.7 ± 4.9 d vs 11.5 ± 6.9 d, respectively (p < .0001); and 16.6 ± 6.7 d vs 8.5 ± 4.1 d, respectively (p < .0001). There was no significant difference in 3.0- or 5.0-y OS and 1.0-, 3.0-, or 5.0-y RFS.Conclusion: The combination of TACE and RFA has advantages in improving 1.0-y OS, reducing complications, and shortening the length of hospital stay over that of SR in the treatment of patients with BCLC A HCC. Keywords:: radiofrequency ablation, transarterial chemoembolization, surgical resection, hepatocellular carcinoma, meta-analysis

To understand the hydraulic vibration characteristics in a traditional hydropower system and identify possible exciting sources that may induce serious hydraulic vibrations in the flow passage, experimental tests and numerical calculations were conducted for different operating conditions. The experimental results show that the pressure fluctuations are mainly related to the vortex rope phenomena in the draft tube, and the dominant frequency of pressure fluctuation is 0.2~0.4 times the runner rotational frequency (fn). The numerical results show all the attenuating factors are negative, which indicates the system itself is stable on the condition that all the hydraulic elements have steady operating performance. The free vibration analyses confirm that the frequency range of the vortex rope in the draft tube partly overlaps the natural frequencies of the hydropower system. Apart from the vortex rope, the runner rotational frequency is another common frequency that is approximately equal to the frequency of the 10th vibration mode. From the vibration mode shapes, it is inferred that a small disturbance in its frequency close or equal to a specific natural frequency of the vibration mode could induce large pressure oscillations in the tail tunnel. In light of the system’s response to different forcing frequencies, the vortex rope formed under off-design conditions and runner rotational frequency is verified to be the potential exciting source of a traditional hydropower system, and the frequency 0.2 fn is much more dangerous than other disturbances to the system.

Detailed investigations on the microstructure and mechanical properties of the surface of the praying mantis’ foreleg were carried out in this work since the microstructure and mechanical properties of insect organisms surface are well adjusted to their functions. Scanning electron microscopy revealed the surface microstructures of the tibia and femur were composed of squamous fibre and the spine surfaces on these two parts are arris. A nanoindenter was used to investigate the mechanical properties of the praying mantis's foreleg, including the mean Young's modulus and hardness of the femur cuticle, tibia cuticle and the apical claw. The test results on these parts were E = 5.533 GPa, H = 0.239 GPa, E = 3.471 GPa, H = 0.186 GPa, E = 2.232 GPa, H = 0.449 GPa, respectively. The variation of mechanical properties agreed with the analysis of microstructure.

The hot-rolled alloy Ti-45Al-8.5Nb-0.2W-0.2B-0.02Y was exposed to 700 °C air for up to 10,000 h. The changes in microstructure were observed using scanning and transmission electron microscopies. It was found that the α2 laths, α2 + γ lamellae, and B2(ω) structure of the alloy showed thermodynamic instability. There were three types of phase transformation in the alloy during long-term thermal exposure. The first was α2 → γ, which occurs in the interior and boundary of the α2 + γ lamellae. The second was α2 + γ → B2(ω), which occurs on the α2 + γ boundary. In addition, B2(ω) also precipitates on the γ/γ interfaces. The third was B2(ω) → γ, which describes the precipitation of micron-scale γ phases in the B2(ω) area after thermal exposure of 5000 h. The volume fraction and size of the B2(ω) area and equiaxed γ grains continued to increase throughout the exposure process. Large-sized γ grains and a B2 area of tens of microns appeared in the microstructure after long-term thermal exposure. The volume fractions of the B2 area and the equiaxed γ grains after thermal exposure of 10,000 h reached 16.8% and 63.2%, respectively.

In this paper, the surface of 7N01 aluminum alloy profile is sandblasted or electropolished. The influence of different surface conditions on its conditional fatigue strength and fatigue mechanism under the alternating load after prefabricated short crack are studied. Results show that the 7N01 aluminum alloy with sandblasting treatment has formed a work hardened layer and its fatigue strength is increased by 42.9% comparing with the original surface specimens. The fatigue strength of the 7N01 aluminum alloy after electropolishing is almost unchanged compared with the original specimen. The fatigue behavior of the 7N01 aluminum alloy after prefabricated side straight through the notch deviated from the theoretical smooth specimen law and long crack propagation law in which is a ‘shortage effect’. When the notch size is smaller than the transition crack size a _0 , the fatigue limit of the notched specimen is lower than the fatigue limit of the smooth specimen. When the notch size is larger than the transition crack size, the fatigue limit of the long-notched specimen is still lower than that predicted by linear elastic fracture mechanics. Due to the ‘short notch effect’, the effective notch propagation threshold ΔK _eff.th of the long crack is 0.39 Mpa m ^1/2 based on the effective notch propagation size a _0 eff of the alloy.

The cermet based on metallic iron with zirconia toughened alumina (ZTA) as the reinforcing phase was prepared by vacuum hot-pressed sintering. The ZTA particles were subjected to electroless nickel plating to improve the interfacial bonding ability of ZTA and Fe matrix. In this paper, after electroless nickel plating, the effects of different particle sizes and different contents of ZTA particles on the grinding properties of Fe-based ZTA (Fe-ZTA) cermets were investigated. The results show that the ZTA particles are tightly bound to the Fe matrix. An interface layer is formed between the ZTA particles and the Fe matrix and it can improve the grinding ability of the Fe-ZTA cermet. By reducing the particle size and the content of ZTA particles, the friction coefficient between Fe-based ZTA cermet and the machined surface can be increased, and the surface roughness of the machined surface will reduce. When the ZTA particle size is F14 and the iron binder content is 40%, the friction coefficient between the Fe-ZTA cermet and the steel bar is 0.4981, the surface roughness of steel bar is 40.164 μ m, the grinding ratio is 685.952.

The corrosion behavior of copper matrix composites with different Al _2 O _3 whisker content in NaCl solution (3.6 wt%) at different temperatures was studied by electrochemical test and electron microscope. The results showed that with the increase of Al _2 O _3 whisker content, the corrosion tendency of the composites first increases and then decreases. The charge-transfer resistance (Rct) value and corrosion current density tend to decrease first and then rise slowly. The whiskers can cause huge differences in performance in different directions so that it is easy to agglomerate and entangle in the matrix, which can increase the heterogeneity of materials in copper matrix alloys, hence, the addition of whiskers will cause the increase of corrosion phenomenon. As the whisker content continues to increase, a large number of reinforcing phases will form a natural protective layer when exposed on the metal surface, which will slow down the corrosion situation. As the temperature increases, the corrosion resistance decreases first and then increases. When the temperature increases from 25 °C to 50 °C, the electrochemical reaction is accelerated, the free electrons between the metal atoms obtain external energy, the ion migration rate is accelerated, and the corrosion reaction is more likely to occur. When the temperature increases from 50 °C to 75 °C, the corrosion reaction rate is mainly controlled by the diffusion of oxygen. As the temperature increases, the solubility of oxygen decreases and the cathode reaction requires oxygen to participate, consequently, the corrosion rate decreases. For the microstructure of the corrosion specimen, corrosion mainly occurred at or around the reinforcement phase/matrix interface. Intermetallic compound particles often appear near corrosion initiation points along the reinforcement phase/matrix interface, and the corrosion behavior of composites is mainly determined by copper. Copper is used as the anode of the battery, and the corrosion products are mainly copper chloride salts.

A large amount of electric vehicles (EVs) charging load will bring significant impact to the power system. An appropriate resource allocation strategy is required for securing the power system safety and satisfying EVs charging demand. This paper proposed a power coordination allocation strategy of EVs’ in distribution systems. The strategy divides the allocation into two stages. The first stage is based on scores assigned to EVs through an entropy method, whereas the second stage allocates energy according to EV’s state of charge. The charging power is delivered in order to maximize EV users’ satisfaction and fairness without violation of grid constraints. Simulation on a typical power-limited residential distribution network proves the effectiveness of the strategy. The analysis re- sults indicate that compared with traditional methods, EVs, which have higher charging requirement and shorter available time will get more energy delivered than others. The root- mean-square-error (RMSE) and standard-deviation (SD) results prove the effectiveness of the methodology for improving the balance of power delivery.

Multistage fractured horizontal wells (MFHWs) have become the main technology for shale gas exploration. However, the existing models have neglected the percolation mechanism in nanopores of organic matter and failed to consider the differences among the reservoir properties in different areas. On that account, in this study, a modified apparent permeability model was proposed describing gas flow in shale gas reservoirs by integrating bulk gas flow in nanopores and gas desorption from nanopores. The apparent permeability was introduced into the macroseepage model to establish a dynamic pressure analysis model for MFHWs dual-porosity formations. The Laplace transformation and the regular perturbation method were used to obtain an analytical solution. The influences of fracture half-length, fracture permeability, Langmuir volume, matrix radius, matrix permeability, and induced fracture permeability on pressure and production were discussed. Results show that fracture half-length, fracture permeability, and induced fracture permeability exert a significant influence on production. A larger Langmuir volume results in a smaller pressure and pressure derivative. An increase in matrix permeability increases the production rate. Besides, this model fits the actual field data relatively well. It has a reliable theoretical foundation and can preferably describe the dynamic changes of pressure in the exploration process.

ITO ceramics with full densities are difficult to achieve using conventional heating because of the volatilization property of both indium oxide (In2O3) and tin oxide (SnO2) at high temperatures. In our present study, we proposed to use a ZnO-doped and microwave hybrid-sintering approach to prepare for ITO ceramics with full densities under normal atmospheric condition. The investigation on the effect of the content of ZnO on the densification and resistivity of the ITO ceramics showed that as the ZnO content increased, the relative density of the ceramics increased while the weight loss and grain size decreased. The resistivity of the ceramics initially decreased by increasing the ZnO content but increased when the content of ZnO was more than 9.09 wt.%. Employing this logic, a relative density approaching 99% of the theoretical density was obtained and the sintering time required was just 25 min. The obtained ITO ceramics were pure ITO phase and had the lowest resistivity and the relative density of 98.1% when the content of ZnO was 9.09 wt.%. This hybrid sintering approach might open a new avenue in the fabrication of ITO ceramics with high densities.

Currently, the optical components of a camera embedded in the device constrain its overall thickness. Moreover, if the camera is strongly shaken, the lens and sensor may be misaligned, resulting in a defocusing effect. In this paper, we propose a novel lensless-camera communication model, which removes the lens of camera, therefore decreasing the overall thickness of the device without affecting communications. To decode the images captured by the lensless camera, a decoding algorithm aided by back propagation (BP) neural network was designed, which recognizes the blurred image patterns efficiently. To adapt to time-varying environments, an adaptive training sequence adjustment mechanism was designed. Simulation results show that the proposed image decoding algorithm presents a good bit-error-rate (BER) performance. The proposed system has robust movements and provides resilience to interference, benefiting from the neural network and the designed algorithm.