1. Dysfunction of γδ T cells in pediatric chronic active Epstein-Barr virus infection
- Author
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Junhong Ai, Haijuan Xiao, Linlin Zhang, Honghao Ma, Dong Wang, Dilara Dilmurat, Ran Wang, and Zhengde Xie
- Subjects
Epstein-Barr virus ,Chronic active Epstein-Barr virus infection ,γδ T cells ,Pediatric ,Dysfunction ,Pediatrics ,RJ1-570 - Abstract
Abstract Chronic active Epstein-Barr virus infection (CAEBV) is a progressive and life-threatening disease characterized by persistent or recurrent EBV activation. It has been reported that, γδ T cells, a type of cytotoxic lymphocyte, play a critical role in restricting EBV. However, the functional status of γδ T cells in pediatric CAEBV patients has not yet been described. In this study, flow cytometry analysis was conducted to explore the cytokine production capacity of γδ T cells in CAEBV patients. A diminished frequency of γδ T cells and decreased expression of cytolytic molecule granzyme B were found in CAEBV patients, suggesting a dysfunction in the immune regulatory function of γδ T cells in this disease.
- Published
- 2024
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