Search

Your search keyword '"Honge, J. L."' showing total 10 results
Start Over Author "Honge, J. L."
10 results on '"Honge, J. L."'

3. Influence of acute glycaemic level on measures of myocardial infarction in non-diabetic pigs

Author

Diemar, S. S., Sejling, A. S., Iversen, K. K., Engstrøm, T., Honge, J. L., Tønder, N., Vejlstrup, N., Idorn, M., Ekström, K., Pedersen-Bjergaard, U., Thorsteinsson, B., and Dalsgaard, M.

Subjects
Myocardium/pathology, Hyperglycemia/blood, Time Factors, Blood Glucose/metabolism, Ventricular Fibrillation/blood, Swine, Coronary Artery Disease, Cardiovascular disease, Myocardial Reperfusion Injury/blood, Myocardial infarction, Disease Models, Animal, Risk Factors, Diabetes Mellitus, cardiovascular system, Animals, Hypoglycemia/blood, Female, cardiovascular diseases, Hypoglycaemia, Myocardial Infarction/blood, Biomarkers/blood
Abstract

Objective. Patients with diabetes are at increased risk of experiencing myocardial infarction. The influence of the prevailing plasma glucose level on infarction and mortality after acute ischaemia is however unknown. The aim was to study the effect of the acute plasma glucose level on the myocardial infarction size in a closed-chest pig model. Design. 38 non-diabetic pigs were randomised to hypoglycaemic (1.8-2.2 mmol/l; n = 15), normoglycaemic (5-7 mmol/l; n = 12) or hyperglycaemic glucose clamping (22-23 mmol/l; n = 11). After 30 min within glucose target myocardial infarction was induced for 30 min followed by reperfusion for 120 min. Hereafter the heart was double-stained to delineate infarction from viable tissue within the area at risk. Results. Mean infarction size was 201 ± 35 mm 2 (mean ± SEM) in the hypoglycaemic group, 154 ± 40 mm 2 in the normoglycaemic group and 134 ± 40 mm 2 in the hyperglycaemic group, with no differences in infarction size, infarct/area at risk ratio or troponin T levels between the groups. There was no difference in incidence of ventricular fibrillation or mortality between the groups. Conclusion. No statistically significant associations were observed between the acute glycaemic level and measures of myocardial infarction, rates of ventricular fibrillation and subsequent premature death in the setting of acute ischaemia and reperfusion.

Published
2015

5. Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation

Author

Cremer, Signe Emilie, Zois, Nora Elisabeth, Moesgaard, S. G., Ravn, Nathja, Cirera Salicio, Susanna, Honge, J. L., Smerup, Morten Holdgaard, Hasenkam, J. Michael, Sloth, E., Leifsson, Páll S., Falk, Bo Torkel, Oyama, M. A., Orton, C., Martinussen, Torben, Olsen, Lisbeth Høier, Cremer, Signe Emilie, Zois, Nora Elisabeth, Moesgaard, S. G., Ravn, Nathja, Cirera Salicio, Susanna, Honge, J. L., Smerup, Morten Holdgaard, Hasenkam, J. Michael, Sloth, E., Leifsson, Páll S., Falk, Bo Torkel, Oyama, M. A., Orton, C., Martinussen, Torben, and Olsen, Lisbeth Høier

Published
2015

7. Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation

Author

Cremer, Signe Emilie, Zois, Nora Elisabeth, Moesgaard, S. G., Ravn, Nathja, Cirera Salicio, Susanna, Honge, J. L., Smerup, Morten Holdgaard, Hasenkam, J. Michael, Sloth, E., Leifsson, Páll S., Falk, Bo Torkel, Oyama, M. A., Orton, C., Martinussen, Torben, Olsen, Lisbeth Høier, Cremer, Signe Emilie, Zois, Nora Elisabeth, Moesgaard, S. G., Ravn, Nathja, Cirera Salicio, Susanna, Honge, J. L., Smerup, Morten Holdgaard, Hasenkam, J. Michael, Sloth, E., Leifsson, Páll S., Falk, Bo Torkel, Oyama, M. A., Orton, C., Martinussen, Torben, and Olsen, Lisbeth Høier

Published
2014

8. Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation

Author

Cremer, S E, Zois, N E, Moesgaard, S G, Ravn, N, Cirera Salicio, Susanna, Honge, J L, Smerup, M H, Hasenkam, J M, Sloth, E, Leifsson, P S, Falk, Bo Torkel, Oyama, M A, Orton, C, Martinussen, T, Olsen, Lisbeth Høier, Cremer, S E, Zois, N E, Moesgaard, S G, Ravn, N, Cirera Salicio, Susanna, Honge, J L, Smerup, M H, Hasenkam, J M, Sloth, E, Leifsson, P S, Falk, Bo Torkel, Oyama, M A, Orton, C, Martinussen, T, and Olsen, Lisbeth Høier

Published
2014

9. Serotonin markers show altered transcription levels in an experimental pig model of mitral regurgitation.

Author

Cremer, S. E., Zois, N. E., Moesgaard, S. G., Ravn, N., Cirera, S., Honge, J. L., Smerup, M. H., Hasenkam, J. M., Sloth, E., Leifsson, P. S., Falk, T., Oyama, M. A., Orton, C., Martinussen, T., and Olsen, L. H.

Subjects
*SEROTONIN, *LABORATORY swine, *MITRAL valve insufficiency, *MITRAL valve diseases, *MYOCARDIUM
Abstract

Serotonin (5-hydroxytryptamine, 5-HT) signalling is implicated in the pathogenesis of myxomatous mitral valve disease (MMVD) through 5-HT1B receptor (R), 5-HT2AR and 5-HT2AR-induced myxomatous pathology. Based on increased tryptophan hydroxylase-1 (TPH-1) and decreased serotonin re-uptake transporter (SERT) in MMVD-affected valves, increased valvular 5-HT synthesis and decreased clearance have been suggested. It remains unknown how haemodynamic changes associated with mitral regurgitation (MR) affect 5-HT markers in the mitral valve, myocardium and circulation. Twenty-eight pigs underwent surgically induced MR or sham-operation, resulting in three MR groups: control (CON, n = 12), mild MR (mMR, n = 10) and severe MR (sMR, n = 6). The gene expression levels of 5-HT1BR, 5-HT2AR, 5-HT2BR, SERT and TPH-1 were analysed using quantitative PCR (qPCR) in the mitral valve (MV), anterior papillary muscle (AP) and left ventricle (LV). MV 5-HT2BR was also analysed with immunohistochemistry (1HC) in relation to histological lesions and valvular myofibroblasts. All 5-HTR mRNAs were up-regulated in MV compared to AP and LV (P< 0.01). In contrast, SERT and TPH-1 were up-regulated in AP and LV compared to MV (P< 0.05). In MV, mRNA levels were increased for 5-HT2BR (P=0.02) and decreased for SERT (P= 0.03) in sMR vs. CON. There were no group differences in 5-HT2BR staining (IHC) but co-localisation was found with α-SMA- positive cells in 91% of all valves and with 33% of histological lesions. In LV, 5-HT1BR mRNA levels were increased in sMR vs. CON (P = 0.01). In conclusion, these data suggest that MR may affect mRNA expression of valvular 5-HT2BR and SERT, and left ventricular 5-HT1BR in some pigs. [ABSTRACT FROM AUTHOR]

Published
2015
Full Text
View/download PDF

10. Strong association between activated valvular interstitial cells and histopathological lesions in porcine model of induced mitral regurgitation.

Author

Cremer SE, Zois NE, Moesgaard SG, Ravn N, Cirera S, Honge JL, Smerup MH, Hasenkam JM, Sloth E, Leifsson PS, Falk T, Oyama MA, Orton C, Martinussen T, and Olsen LH

Subjects
Actins biosynthesis, Animals, Cell Differentiation, Disease Models, Animal, Male, Mitral Valve metabolism, Swine, Mitral Valve cytology, Mitral Valve Insufficiency pathology
Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results