1. Triazole resistance in Aspergillus fumigatus exposed to new chiral fungicide mefentrifluconazole
- Author
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Shiji Xu, Jiatao Shen, Hongbin Lang, Luqing Zhang, Hua Fang, and Yunlong Yu
- Subjects
Insect Science ,General Medicine ,Agronomy and Crop Science - Abstract
Triazole resistance in the human fungal pathogen Aspergillus fumigatus has been a growing challenge in clinic treatment with triazole drugs such as itraconazole. The fast evolvement of triazole resistance in A. fumigatus in the ecosystem has drawn great attention, and there has been a possible link between the application of triazole fungicides in agriculture and triazole resistance in A. fumigatus. The change in susceptibility of A. fumigatus exposed to the new chiral triazole fungicide mefentrifluconazole was investigated in this study.The results indicated that triazole resistance in A. fumigatus was acquired with exposure to mefentrifluconazole at a level of greater than or equal to 2 mg LThe results suggest that triazole resistance in A. fumigatus could be resulted from the selection of mefentrifluconazole at concentrations larger than 2 mg L
- Published
- 2022
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