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Objectives 1) To explore the pattern of CD147 expression and its applicability in the prognosis of liver hepatocellular carcinoma (LIHC). 2) To establish hazard ratio and probability points for predicting the prognosis of HCC by correlating CD147 expression with clinical characteristics. 3) To determine if CD147 can be a reliable biomarker in LIHC prognosis. Methods CD147 expression profile in LIHC and corresponding clinical data were obtained from The Cancer Genome Atlas (TCGA) database. The expression patterns of CD147 were then validated by analyzing data from the Gene Expression Omnibus (GEO) database. In addition, CD147 Immunohistochemistry (IHC) in LIHC was obtained from the Human Protein Atlas (HPA). CD147 expression patterns and clinical characteristics in the prognosis of HCC were analyzed by accessing the UALCAN web resource. Accuracy, sensitivity, and specificity of the CD147 expression profile in predictive prognosis were determined by the Time-dependent Receiver Operating Characteristic (ROC) curves. Kaplan-Meier curves were plotted to estimate the hazard ratio (HR) of survival in LIHC. Univariate and multivariate Cox regression proportional hazards analyses of CD147 expression levels and clinical characteristics as prognostic factors of LIHC were performed. Nomograms were used to establish probability points and predict prognosis. Results Data from TCGA and GEO databases revealed that CD147 was significantly overexpressed in LIHC (p = 1.624e-12 and p = 1.2e-05), respectively. The expression of CD147 and prognosis of LIHC were significantly correlated with the clinical characteristicsof LIHC as per the data from the UALCAN web resource (p < 0.05). Kaplan-Meier analysis of CD147 expression in LIHC revealed that the high expression groups showed poor prognosis and an HR of survival > 1 [(Log-rank test, p = 0.000542, HR (in high expression groups) = 1.856, 95% CI (1.308, 2.636)]. ROC curves were plotted to analyze the 1-year, 3-year, and 5-year survival rates, the Area under the ROC curve (AUC) values were 0.675, 95% CI (0.611–0.74); 0.623, 95% CI (0.555–0.692); and 0.664, 95% CI (0.582–9.745) respectively. Univariate Cox analysis of CD147 expression and clinical characteristics of LIHC, and multivariate Cox analysis of CD147 patterns and pTNM-stage showed significant differences [(Uni-Cox, p = 0.00013, HR = 1.42437, 95% CI (1.8838, 1.70723) and p = 0.00066, HR = 1.37612, 95% CI (1.14521, 1.65359); Multi-Cox, p = 0.00578, HR = 1.50746, 95% CI (1.12637, 2.0175) and p= 0.00336, HR = 1.44319, 95% CI (1.12941, 1.84415)]. Nomograms were plotted to establish the probability points and predict prognosis, the total points ranged from 0 to 180, and the C-index value was 0.673, 95% CI (0.6–1.0), p < 0.01. Conclusions Overexpression of CD147 was correlated with poor prognosis in LHIC. CD147 expression profile combined with clinical characteristics can reliably predict the prognosis of HCC. CD147 can serve as a biomarker to predict the prognosis of HCC.

An effective method combined with finite element method (FEM) and boundary integral method (BIM) is presented in this paper to study the composite electromagnetic scattering from a 2-D coated objec...

Objective: This study aimed to detect the association between P-selectin autoantibody positive and response to steroid treatment in newly diagnosed immune thrombocytopenia (ITP) patients. Methods: The data from 105 newly diagnosed adult ITP patients administered with first-line of steroid treatment from October 2016 to May 2021 were retrospectively analyzed. Treatment responses were evaluated within 3 months after the onset of treatment. Results: Among the 105 patients, 80.00% (84/105) of patients presented with platelet glycoprotein-specific antibody positive; 44.76% (47/105) patients were anti-P-selectin positive, while 35.24% (37/105) were anti-P-selectin negative. No significant difference in overall response was observed between patients who were anti-P-selectin positive and those who were anti-P-selectin negative (74.47% vs. 89.19, χ2 = 2.910, p = 0.088). But patients who were anti-P-selectin negative had significantly higher complete response rate, compared to those who were anti-P-selectin positive (72.97% vs. 48.94%, χ2 = 4,965, p = 0.026). Logistic regression analysis revealed that anti-GP IIb/IIIa positive (OR = 3.114, p = 0.010, 95% CI: 1.313–7.388) and anti-P-selectin positive (OR = 0.309, p = 0.036, 95% CI: 0.127–0.753) were two factors that could affect patients’ response. Conclusions: Our study found that ITP patients with anti-GP IIb/IIIa may have a higher response to steroid treatment, but anti-P-selectin-mediated-ITP might be less responsive to steroid treatment. In adults with ITP, the presence of anti-P-selectin autoantibodies is a predictive factor for poor response to steroid treatment.

Background An interesting clinical phenomenon occures frequently in our work, which indicates that blood pressure could return to normal in some hypertension patients with cervical & upper thoracic esophageal cancer undergoing radiotherapy. We speculated that this may be related to thyroid gland damage by radiotherapy.Methods We retrospectively analyzed pre- and post-radiotherapy (RT, 1.5months, 4.5months and 7.5months) systolic blood pressure (SBP) and diastolic blood pressure (DBP) for a cohort of esophageal cancer patients. At 7.5 months post-RT, serum free triiodothyronine (FT3), free tetraiodothyronine (FT4) and thyroid-stimulating hormone (TSH) concentrations were also measured to evaluate the changes of thyroid hormones (THs) and its correaltion with changes of blood pressure. To confirm the influence of radiation on thyroid, patients were divided into cervical & upper thoracic group (C&U, n=55) and middle & lower thoracic group (M&L, n=57). Results In the C&U group, the decreases (±SD) in SBP and DBP, respectively, were 5.51 mmHg (±1.83, P=0.003) and 3.62 mmHg (±1.38, P=0.002) at 1.5 months post-RT, 6.73 mmHg (±2.24, P=0.001) and 6.15 mmHg (±1.57, P=0.012) at 4.5 months post-RT, and 8.02 mmHg (±2.73, PPPPP =0.001; r=0.667, P P =0.005; r = 0.469, P < 0.001 respectively). Conclusion The present study suggests that radiotherapy in patients with cervical and upper thoracic esophageal cancer might result in lowering BP, which might be related to thyroid gland damage by radiotherapy.

The three-stage isothermal solidification process of TLP bonded Mar-M247 nickel-based superalloy was studied. The transient liquid phase bonding of Mar-M247 superalloys was conducted at 1150 °C for 1, 60, 120 and 240 min. Dendritic formation and solute partitioning governed the microstructure development. Ni-rich solid solution, Ni-rich boride W-rich boride and other carboborides were formed in the joint area. The maximum tensile strength of 443 MPa was obtained when TLP bonding at 1150 °C for 240 min. It had completed isothermal solidification. After isothermal solidification, the distribution of microhardness across the joints was more homogeneous. Enrichment of refractory elements in the Ni-Cr-Co-W-Ta-B interlayer was detrimental to the process of isothermal solidification. The presence of hard and brittle borides reduced the hardness and tensile strength of the bonded area. Post-bonding heat treatments are suggested to improve mechanical properties in future studies.

A multihybrid method combining numerical vector finite-element method/boundary integral method (FEM/BIM) and analytic Kirchhoff approximation (KA) is developed to study electromagnetic scattering from a 3-D coated target above 2-D conductive randomly rough surface. The hybrid vector FEM/BIM is applied to model scattering from the coated target, while the scattering from the rough surface is studied by KA, which can greatly reduce the computation time and memory requirement. An iterative approach is adopted to take into account the interaction between the target and underlying rough surface. The electric fields integral equations of the induced difference current on the rough surface and the induced electric and magnetic currents on the surface of the target are derived based on green’s function and the boundary conditions. Our numerical code is validated by the commercial software. The convergence and the iteration error of the multihybrid method are discussed. Using the Monte Carlo method to generate 2-D Gaussian rough surface, bistatic difference field radar cross section of a 3-D coated sphere above a 2-D conductive rough surface is numerically simulated.

A hybrid approach combining the edge-based vector finite-element method (FEM) and the method of moments (MoM) is first extended to study 3-D scattering from a dielectric object above a conductive rough surface. The hybrid FEM/MoM technique is based on the electric field vector Helmholtz's equation. To reduce the calculational domain, the solution region is divided into the FEM region containing the object and the MoM region containing the rough surface. In our hybrid method, tetrahedral elements are applied to handle the object region based on vector basis functions, whereas triangular elements are used to deal with the rough surface based on Rao–Wilton–Glisson basis functions. The electromagnetic coupling between the object and the rough surface is considered by the surface integral equation with the Green's function. The hybrid technique presented here combines advantages between FEM and MoM, which is highly efficient in terms of computing memory, time consumed, and versatility.

The two-dimensional electromagnetic scattering properties from multilayer rough surfaces with an object buried were studied in this article by the finite element method (FEM). When FEM is applied to analyze an open-space scattering problem and an artificial boundary needs to be built to truncate the computational domain. The perfectly matched layer (PML) has been proved to be an accurate boundary condition in the electromagnetic scattering problems. It is widely used in the electromagnetic simulations for limited objects. However, there are few articles provided to deal with the scattering problem of the multilayer rough surfaces. In this letter, the modeling of multilayer rough surfaces with an object buried is presented, and the application of FEM and PML is provided in detail. The method is validated by the method of moments (MoM), and some numerical results are provided to discuss the scattering properties. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:429–433, 2016

An efficient iterative analytical-numerical method is proposed for three-dimensional (3D) electromagnetic scattering from an inhomogeneous object buried beneath a two-dimensional (2D) randomly dielectric rough surface. In the hybrid method, the electric and magnetic currents on the dielectric rough surface are obtained by current-based Kirchhoff approximation (KA), while the scattering from the inhomogeneous object is rigorously studied by finite element method (FEM) combined with the boundary integral method (BIM). The multiple interactions between the buried object and rough surface are taken into account by updating the electric and magnetic current densities on them. Several numerical simulations are considered to demonstrate the algorithm’s ability to deal with the scattering from the inhomogeneous target buried beneath a dielectric rough surface, and the effectiveness of our proposed method is also illustrated.

A practical, rapid, and efficient reaction using microreactors for the direct N-alkylation from aniline derivatives and alkyl dihalides has been achieved in the presence of aqueous potassium carbonate at an elevated temperature. This improved synthetic methodology provides a straightforward microfluid approach to the synthesis of a variety of N-aryl azacycloalkanes.

Raney Ni‐Al alloy in a dilute alkaline aqueous solution has been shown to be a powerful reducing agent, which is highly effective in the reduction of benzophenones to the corresponding hydrocarbon derivatives, in the absence of any organic solvents.

For the first time, N-aryl azacycloalkanes (III) are prepared in a continuous-flow laboratory-scale microreactor.

Raney Ni‐Al alloy in a dilute alkaline aqueous solution has been shown to be a powerful reducing agent, which is highly effective in the reduction of benzophenones to the corresponding hydrocarbon derivatives, in the absence of any organic solvents.