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Annexin A2 (ANXA2) encodes an oncoprotein whose expression has been found to correlate with poorer overall survival (OS) of pancreatic adenocarcinoma (PAAD) patients. Although peptides are available for targeting ANXA2, none of these were initially selected to target this protein specifically. Here, we took ANXA2 as a molecular target for PAAD and employed the phage display technique to screen for a new ANXA2‐targeted peptide. The resultant heptapeptide, YW7, was firstly labeled with fluorescein isothiocyanate (FITC) to evaluate its selectivity in cellular uptake, and further with the near‐infrared fluorescent (NIRF) dye Cy7 to assess in vivo distribution in a mouse model bearing PANC‐1 human pancreatic cancer xenografic tumors. We found that both FITC‐YW7 and Cy7‐YW7 probes showed significantly higher uptake in PANC‐1 cells compared to the HPDE6‐C7 pancreatic epithelium cells. Mice intravenously injected with Cy7‐YW7 showed higher tumor‐to‐background ratios (TBRs) (~ 2.7‐fold) in tumor tissues compared to those injected with Cy7 alone. Our study suggested that YW7 is a novel peptide targeting ANXA2 and Cy7‐YW7 is an NIRF probe potentially useful for the early detection of PAAD. [ABSTRACT FROM AUTHOR]

Metasurfaces, employed to simultaneously generate nanoprinting and holographic images, have been extensively explored recently. Among them, multi-wavelength multiplexing in a single metasurface is often accompanied by dispersion and crosstalk, which hinder the display of multicolor patterns. Here, we propose an efficient phase method to decouple the wavelength and realize a three-channel display operating at different wavelengths. Holographic images appear in the far field with the illumination of two different circularly polarized lights while a nanoprinting image is reconstructed by inserting an orthogonal optical path with the illumination of linear polarization light. The proposed metasurface is only composed of four types of unit cells, which significantly decreases the complexity of fabrication and improves the information capacity. Benefiting from its different decoding strategies and capability of multi-wavelength control, this approach may develop broad applications in information encryption, security, and color display. [ABSTRACT FROM AUTHOR]