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163 results on '"Hong, Weiqi"'

2. Intranasal delivery of a subunit protein vaccine provides protective immunity against JN.1 and XBB-lineage variants

Author

Lei, Hong, Hong, Weiqi, Yang, Jingyun, He, Cai, Zhou, Yanan, Zhang, Yu, Alu, Aqu, Shi, Jie, Liu, Jian, qin, Furong, Ao, Danyi, Huang, Xiya, Chen, Zimin, Yang, Hao, Yang, Yun, Yu, Wenhai, Tang, Cong, Wang, Junbin, Li, Bai, Huang, Qing, Hu, Hongbo, Cheng, Wei, Dong, Haohao, Lei, Jian, Chen, Lu, Zhou, Xikun, Li, Jiong, Yang, Li, Wang, Zhenling, Wang, Wei, Shen, Guobo, Yang, Jinliang, Zhao, Zhiwei, Song, Xiangrong, Lu, Guangwen, Sun, Qiangming, Wang, Youchun, Lu, Shuaiyao, and Wei, Xiawei

Published
2024
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3. SARS-CoV-2 Delta and Omicron variants resist spike cleavage by human airway trypsin-like protease

Author

Ren, Wenyan, Hong, Weiqi, Yang, Jingyun, Zou, Jun, Chen, Li, Zhou, Yanan, Lei, Hong, Alu, Aqu, Que, Haiying, Gong, Yanqiu, Bi, Zhenfei, He, Cai, Fu, Minyang, Peng, Dandan, Yang, Yun, Yu, Wenhai, Tang, Cong, Huang, Qing, Yang, Mengli, Li, Bai, Li, Jingmei, Wang, Junbin, Ma, Xuelei, Hu, Hongbo, Cheng, Wei, Dong, Haohao, Lei, Jian, Chen, Lu, Zhou, Xikun, Li, Jiong, Wang, Wei, Lu, Guangwen, Shen, Guobo, Yang, Li, Yang, Jinliang, Wang, Zhenling, Jia, Guowen, Su, Zhaoming, Shao, Bin, Miao, Hanpei, Lau, Johnson Yiu-Nam, Wei, Yuquan, Zhang, Kang, Dai, Lunzhi, Lu, Shuaiyao, and Wei, Xiawei

Subjects
Medical research, Medicine, Experimental, Proteases -- Health aspects, Viral proteins -- Physiological aspects, Airway (Medicine) -- Health aspects
Abstract

Soluble host factors in the upper respiratory tract can serve as the first line of defense against SARS-CoV-2 infection. In this study, we described the identification and function of a human airway trypsin-like protease (HAT), capable of reducing the infectivity of ancestral SARS-CoV-2. Further, in mouse models, HAT analogue expression was upregulated by SARS- CoV-2 infection. The antiviral activity of HAT functioned through the cleavage of the SARS-CoV-2 spike glycoprotein at R682. This cleavage resulted in inhibition of the attachment of ancestral spike proteins to host cells, which inhibited the cell-cell membrane fusion process. Importantly, exogenous addition of HAT notably reduced the infectivity of ancestral SARS- CoV-2 in vivo. However, HAT was ineffective against the Delta variant and most circulating Omicron variants, including the BQ.1.1 and XBB.1.5 subvariants. We demonstrate that the P681R mutation in Delta and P681H mutation in the Omicron variants, adjacent to the R682 cleavage site, contributed to HAT resistance. Our study reports what we believe to be a novel soluble defense factor against SARS-CoV-2 and resistance of its actions in the Delta and Omicron variants., Introduction The causative agent for COVID-19, SARS-CoV-2, is a single-stranded, positive-sense RNA virus that replicates through the viral RNA-dependent RNA polymerase (RdRp) and the exoribonuclease (ExoN). The combination of RdRp [...]

Published
2024
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12. JMJD family proteins in cancer and inflammation

Author

Wang Manni, Xue Jianxin, Hong Weiqi, Chen Siyuan, and Shi Huashan

Subjects
Medicine, Biology (General), QH301-705.5
Abstract

Abstract The occurrence of cancer entails a series of genetic mutations that favor uncontrollable tumor growth. It is believed that various factors collectively contribute to cancer, and there is no one single explanation for tumorigenesis. Epigenetic changes such as the dysregulation of enzymes modifying DNA or histones are actively involved in oncogenesis and inflammatory response. The methylation of lysine residues on histone proteins represents a class of post-translational modifications. The human Jumonji C domain-containing (JMJD) protein family consists of more than 30 members. The JMJD proteins have long been identified with histone lysine demethylases (KDM) and histone arginine demethylases activities and thus could function as epigenetic modulators in physiological processes and diseases. Importantly, growing evidence has demonstrated the aberrant expression of JMJD proteins in cancer and inflammatory diseases, which might serve as an underlying mechanism for the initiation and progression of such diseases. Here, we discuss the role of key JMJD proteins in cancer and inflammation, including the intensively studied histone lysine demethylases, as well as the understudied group of JMJD members. In particular, we focused on epigenetic changes induced by each JMJD member and summarized recent research progress evaluating their therapeutic potential for the treatment of cancer and inflammatory diseases.

Published
2022
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13. Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Author

Hong, Weiqi, Yang, Jingyun, Zou, Jun, Bi, Zhenfei, He, Cai, Lei, Hong, He, Xuemei, Li, Xue, Alu, Aqu, Ren, Wenyan, Wang, Zeng, Jiang, Xiaohua, Zhong, Kunhong, Jia, Guowen, Yang, Yun, Yu, Wenhai, Huang, Qing, Yang, Mengli, Zhou, Yanan, Zhao, Yuan, Kuang, Dexuan, Wang, Junbin, Wang, Haixuan, Chen, Siyuan, Luo, Min, Zhang, Ziqi, Lu, Tianqi, Chen, Li, Que, Haiying, He, Zhiyao, Sun, Qiu, Wang, Wei, Shen, Guobo, Lu, Guangwen, Zhao, Zhiwei, Yang, Li, Yang, Jinliang, Wang, Zhenling, Li, Jiong, Song, Xiangrong, Dai, Lunzhi, Chen, Chong, Geng, Jia, Gou, Maling, Chen, Lu, Dong, Haohao, Peng, Yong, Huang, Canhua, Qian, Zhiyong, Cheng, Wei, Fan, Changfa, Wei, Yuquan, Su, Zhaoming, Tong, Aiping, Lu, Shuaiyao, Peng, Xiaozhong, and Wei, Xiawei

Published
2022
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14. A self-assembled trimeric protein vaccine induces protective immunity against Omicron variant

Author

He, Cai, Yang, Jingyun, Hong, Weiqi, Chen, Zimin, Peng, Dandan, Lei, Hong, Alu, Aqu, He, Xuemei, Bi, Zhenfei, Jiang, Xiaohua, Jia, Guowen, Yang, Yun, Zhou, Yanan, Yu, Wenhai, Tang, Cong, Huang, Qing, Yang, Mengli, Li, Bai, Li, Jingmei, Wang, Junbin, Que, Haiying, Chen, Li, Ren, Wenyan, Wan, Dandan, Li, Jiong, Wang, Wei, Shen, Guobo, Zhao, Zhiwei, Yang, Li, Yang, Jinliang, Wang, Zhenling, Su, Zhaoming, Wei, Yuquan, Cen, Xiaobo, Tanaka, Yoshimasa, Song, Xiangrong, Lu, Shuaiyao, Peng, Xiaozhong, Lu, Guangwen, and Wei, Xiawei

Published
2022
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19. A chimeric adenovirus‐vectored vaccine based on Beta spike and Delta RBD confers a broad‐spectrum neutralization against Omicron‐included SARS‐CoV‐2 variants

Author

Hong, Weiqi, primary, Lei, Hong, additional, Peng, Dandan, additional, Huang, Yuhe, additional, He, Cai, additional, Yang, Jingyun, additional, Zhou, Yanan, additional, Liu, Jian, additional, Pan, Xiangyu, additional, Que, Haiying, additional, Alu, Aqu, additional, Chen, Li, additional, Ai, Jiayuan, additional, Qin, Furong, additional, Wang, Binhan, additional, Ao, Danyi, additional, Zeng, Zhen, additional, Hao, Ying, additional, Zhang, Yu, additional, Huang, Xiya, additional, Ye, Chunjun, additional, Fu, MinYang, additional, He, Xuemei, additional, Bi, Zhenfei, additional, Han, Xuejiao, additional, Luo, Min, additional, Hu, Hongbo, additional, Cheng, Wei, additional, Dong, Haohao, additional, Lei, Jian, additional, Chen, Lu, additional, Zhou, Xikun, additional, Wang, Wei, additional, Lu, Guangwen, additional, Shen, Guobo, additional, Yang, Li, additional, Yang, Jinliang, additional, Li, Jiong, additional, Wang, Zhenling, additional, Song, Xiangrong, additional, Sun, Qiangming, additional, Lu, Shuaiyao, additional, Wang, Youchun, additional, Cheng, Ping, additional, and Wei, Xiawei, additional

Published
2024
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20. Nanoplatform Based Intranasal Vaccines: Current Progress and Clinical Challenges

Author

Bai, Ziyi, Wan, Dandan, Lan, Tianxia, Hong, Weiqi, Dong, Haohao, Wei, Yuquan, and Wei, Xiawei

Abstract

Multiple vaccine platforms have been employed to develop the nasal SARS-CoV-2 vaccines in preclinical studies, and the dominating pipelines are viral vectored as protein-based vaccines. Among them, several viral vectored-based vaccines have entered clinical development. Nevertheless, some unsatisfactory results were reported in these clinical studies. In the face of such urgent situations, it is imperative to rapidly develop the next-generation intranasal COVID-19 vaccine utilizing other technologies. Nanobased intranasal vaccines have emerged as an approach against respiratory infectious diseases. Harnessing the power of nanotechnology, these vaccines offer a noninvasive yet potent defense against pathogens, including the threat of COVID-19. The improvements made in vaccine mucosal delivery technologies based on nanoparticles, such as lipid nanoparticles, polymeric nanoparticles, inorganic nanoparticles etc., not only provide stability and controlled release but also enhance mucosal adhesion, effectively overcoming the limitations of conventional vaccines. Hence, in this review, we overview the evaluation of intranasal vaccine and highlight the current barriers. Next, the modern delivery systems based on nanoplatforms are summarized. The challenges in clinical application of nanoplatform based intranasal vaccine are finally discussed.

Published
2024
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22. Cholesterolized TLR7 agonist liposomes combined with radiotherapy elicit antitumor immunity through oxidized mitochondrial DNA- driven inflammasome pathway

Author

Han, Xuejiao, primary, Cheng, Yuan, additional, Wan, Dandan, additional, Alu, Aqu, additional, Zhang, Ziqi, additional, Bi, Zhenfei, additional, Wang, Manni, additional, Hong, Weiqi, additional, Chen, Siyuan, additional, Chen, Li, additional, Wei, Yuquan, additional, and Wei, Xiawei, additional

Published
2023
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28. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Author

Yang, Jingyun, Wang, Wei, Chen, Zimin, Lu, Shuaiyao, Yang, Fanli, Bi, Zhenfei, Bao, Linlin, Mo, Fei, Li, Xue, Huang, Yong, Hong, Weiqi, Yang, Yun, Zhao, Yuan, Ye, Fei, Lin, Sheng, Deng, Wei, Chen, Hua, Lei, Hong, Zhang, Ziqi, Luo, Min, Gao, Hong, Zheng, Yue, Gong, Yanqiu, Jiang, Xiaohua, Xu, Yanfeng, Lv, Qi, Li, Dan, Wang, Manni, Li, Fengdi, Wang, Shunyi, Wang, Guanpeng, Yu, Pin, Qu, Yajin, Yang, Li, Deng, Hongxin, Tong, Aiping, Li, Jiong, Wang, Zhenling, Yang, Jinliang, Shen, Guobo, Zhao, Zhiwei, Li, Yuhua, Luo, Jingwen, Liu, Hongqi, Yu, Wenhai, Yang, Mengli, Xu, Jingwen, Wang, Junbin, Li, Haiyan, Wang, Haixuan, Kuang, Dexuan, Lin, Panpan, Hu, Zhengtao, Guo, Wei, Cheng, Wei, He, Yanlin, Song, Xiangrong, Chen, Chong, Xue, Zhihong, Yao, Shaohua, Chen, Lu, Ma, Xuelei, Chen, Siyuan, Gou, Maling, Huang, Weijin, Wang, Youchun, Fan, Changfa, Tian, Zhixin, Shi, Ming, Wang, Fu-Sheng, Dai, Lunzhi, Wu, Min, Li, Gen, Wang, Guangyu, Peng, Yong, Qian, Zhiyong, Huang, Canhua, Lau, Johnson Yiu-Nam, Yang, Zhenglin, Wei, Yuquan, Cen, Xiaobo, Peng, Xiaozhong, Qin, Chuan, Zhang, Kang, Lu, Guangwen, and Wei, Xiawei

Published
2020
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29. Cisplatin‐induced oxPAPC release enhances MDSCs infiltration into LL2 tumour tissues through MCP‐1/CCL2 and LTB4/LTB4R pathways.

Author

Nie, Ji, Ai, Jiayuan, Hong, Weiqi, Bai, Ziyi, Wang, Binhan, Yang, Jingyun, Zhang, Ziqi, Mo, Fei, Yang, Jing, Sun, Qiu, and Wei, Xiawei

Subjects
MYELOID-derived suppressor cells, CHEMOTAXIS, NEUTROPHILS, LOW density lipoproteins
Abstract

Lung cancer is the leading global cause of cancer‐related death, however, resistance to chemotherapy drugs remains a huge barrier to effective treatment. The elevated recruitment of myeloid derived suppressor cells (MDSCs) to tumour after chemotherapy has been linked to resistance of chemotherapy drugs. Nevertheless, the specific mechanism remains unclear. oxPAPC is a bioactive principal component of minimally modified low‐density lipoproteins and regulates inflammatory response. In this work, we found that cisplatin, oxaliplatin and ADM all increased oxPAPC release in tumour. Treating macrophages with oxPAPC in vitro stimulated the secretion of MCP‐1 and LTB4, which strongly induced monocytes and neutrophils chemotaxis, respectively. Injection of oxPAPC in vivo significantly upregulated the percentage of MDSCs in tumour microenvironment (TME) of wild‐type LL2 tumour‐bearing mice, but not CCL2−/− mice and LTB4R−/− mice. Critically, oxPAPC acted as a pro‐tumor factor in LL2 tumour model. Indeed, cisplatin increased oxPAPC level in tumour tissues of WT mice, CCL2−/− and LTB4R−/− mice, but caused increased infiltration of Ly6Chigh monocytes and neutrophils only in WT LL2‐bearing mice. Collectively, our work demonstrates cisplatin treatment induces an overproduction of oxPAPC and thus recruits MDSCs infiltration to promote the tumour growth through the MCP‐1/CCL2 and LTB4/LTB4R pathways, which may restrict the effect of multiple chemotherapy. This provides evidence for a potential strategy to enhance the efficacy of multiple chemotherapeutic drugs in the treatment of lung cancer by targeting oxPAPC. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Intranasal boosting with RBD-HR protein vaccine elicits robust mucosal and systemic immune responses

Author

Chen, Li, primary, Ren, Wenyan, additional, Lei, Hong, additional, Wang, Jiayu, additional, Que, Haiying, additional, Wan, Dandan, additional, Alu, Aqu, additional, Peng, Dandan, additional, Fu, Minyang, additional, Hong, Weiqi, additional, Huang, Yuhe, additional, Song, Xiangrong, additional, Lu, Guangwen, additional, and Wei, Xiawei, additional

Published
2023
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37. Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vaccine

Author

Peng, Dandan, primary, Zhao, Tingmei, additional, Hong, Weiqi, additional, Fu, Minyang, additional, He, Cai, additional, Chen, Li, additional, Ren, Wenyan, additional, Lei, Hong, additional, Yang, Jingyun, additional, Alu, Aqu, additional, Ni, Yanghong, additional, Liu, Jian, additional, Li, Jiong, additional, Wang, Wei, additional, Shen, Guobo, additional, Zhao, Zhiwei, additional, Yang, Li, additional, Yang, Jinliang, additional, Wang, Zhenling, additional, Tanaka, Yoshimasa, additional, Lu, Guangwen, additional, Song, Xiangrong, additional, and Wei, Xiawei, additional

Published
2023
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38. TFAM deficiency in dendritic cells leads to mitochondrial dysfunction and enhanced antitumor immunity through cGAS-STING pathway

Author

Lu, Tianqi, primary, Zhang, Ziqi, additional, Bi, Zhenfei, additional, Lan, Tianxia, additional, Zeng, Hao, additional, Liu, Yu, additional, Mo, Fei, additional, Yang, Jingyun, additional, Chen, Siyuan, additional, He, Xuemei, additional, Hong, Weiqi, additional, Zhang, Zhe, additional, Pi, Ruyu, additional, Ren, Wenyan, additional, Tian, Xiaohe, additional, Wei, Yuquan, additional, Luo, Min, additional, and Wei, Xiawei, additional

Published
2023
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39. Publisher Correction: A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity

Author

Yang, Jingyun, Wang, Wei, Chen, Zimin, Lu, Shuaiyao, Yang, Fanli, Bi, Zhenfei, Bao, Linlin, Mo, Fei, Li, Xue, Huang, Yong, Hong, Weiqi, Yang, Yun, Zhao, Yuan, Ye, Fei, Lin, Sheng, Deng, Wei, Chen, Hua, Lei, Hong, Zhang, Ziqi, Luo, Min, Gao, Hong, Zheng, Yue, Gong, Yanqiu, Jiang, Xiaohua, Xu, Yanfeng, Lv, Qi, Li, Dan, Wang, Manni, Li, Fengdi, Wang, Shunyi, Wang, Guanpeng, Yu, Pin, Qu, Yajin, Yang, Li, Deng, Hongxin, Tong, Aiping, Li, Jiong, Wang, Zhenling, Yang, Jinliang, Shen, Guobo, Zhao, Zhiwei, Li, Yuhua, Luo, Jingwen, Liu, Hongqi, Yu, Wenhai, Yang, Mengli, Xu, Jingwen, Wang, Junbin, Li, Haiyan, Wang, Haixuan, Kuang, Dexuan, Lin, Panpan, Hu, Zhengtao, Guo, Wei, Cheng, Wei, He, Yanlin, Song, Xiangrong, Chen, Chong, Xue, Zhihong, Yao, Shaohua, Chen, Lu, Ma, Xuelei, Chen, Siyuan, Gou, Maling, Huang, Weijin, Wang, Youchun, Fan, Changfa, Tian, Zhixin, Shi, Ming, Wang, Fu-Sheng, Dai, Lunzhi, Wu, Min, Li, Gen, Wang, Guangyu, Peng, Yong, Qian, Zhiyong, Huang, Canhua, Lau, Johnson Yiu-Nam, Yang, Zhenglin, Wei, Yuquan, Cen, Xiaobo, Peng, Xiaozhong, Qin, Chuan, Zhang, Kang, Lu, Guangwen, and Wei, Xiawei

Published
2021
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43. Secular Difference in Body Mass Index From 2014 to 2020 in Chinese Older Adults : A Time-Series Cross-Sectional Study

Author

Jiang, Ying, Zhang, Xiaomin, Xu, Tianwei, Hong, Weiqi, Chen, Zhiqi, Gao, Xiang, Xu, Renying, Jiang, Ying, Zhang, Xiaomin, Xu, Tianwei, Hong, Weiqi, Chen, Zhiqi, Gao, Xiang, and Xu, Renying

Abstract

Background: Body mass index (BMI) is the most widely used parameter to assess the body weight status. Both the increase of BMI (overweight and obesity) and decrease of BMI (underweight) has been associated with high risk of adverse outcome, such as stroke, disability, and even death. However, recent data on secular differences in BMI in the Chinese aged population are limited. The present study provides robust new evidence about the evolving epidemic of obesity among aged adults in China. Objective: Evaluating secular difference in BMI in a group of Chinese older adults. Materials and Methods: We analyzed 7 continuous survey years (2014–2020), including 50,192 Chinese aged participants (25,505 men and 24,687 women, aged 71.9 ± 6.1 years, age range: 65–99 years). Information on sex, age, height, and body weight, was collected based on medical history. Participants were classified into four groups: underweight (BMI < 18.5 kg/m2), normal weight (18.5 kg/m2 ≤ BMI < 25 kg/m2), overweight (25 kg/m2 ≤ BMI < 30 kg/m2), and obesity (BMI ≥ 30 kg/m2). Linear regressions were used to assess the secular difference in BMI. Sex and age differences were also evaluated by stratified analyses. Results: From 2014 to 2020, age-adjusted mean BMI increased by 0.3 kg/m2 (95% CI: 0.1, 0.5 kg/m2) in men, and 0.5 kg/m2 (95% CI: 0.2, 0.7 kg/m2) in women. Age-standardized prevalence of underweight decreased from 3.0 to 2.3% in men, and from 3.0 to 2.1% in women. Age-standardized prevalence of overweight increased in both men (from 40.1 to 41.7%) and women (from 37.8 to 39.8%), and so as obesity (men: from 4.1 to 6.1%; women: from 5.8 to 8.7%). Conclusion: Our results confirmed that BMI gradually increased from 2014 to 2020. The age-adjusted mean BMI increased by 0.3 kg/m2 in older men, and 0.5 kg/m2 in older women. The age- and sex-standardized prevalence of overweight and obesity significantly increased, especially in 70–79-year age group, while the prevalence of underweight decrease

Published
2022
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44. The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB.1.5 and BQ.1.1 subvariants.

Author

Ao, Danyi, He, Xuemei, Hong, Weiqi, and Wei, Xiawei

Subjects
SARS-CoV-2 Omicron variant, IMMUNE response, MONOCLONAL antibodies, PUBLIC health, EPIDEMIOLOGY
Abstract

As the fifth variant of concern of the SARS‐CoV‐2 virus, the Omicron variant (B.1.1.529) has quickly become the dominant type among the previous circulating variants worldwide. During the Omicron wave, several subvariants have emerged, with some exhibiting greater infectivity and immune evasion, accounting for their fast spread across many countries. Recently, two Omicron subvariants, BQ.1 and XBB lineages, including BQ.1.1, XBB.1, and XBB.1.5, have become a global public health issue given their ability to escape from therapeutic monoclonal antibodies and herd immunity induced by prior coronavirus disease 2019 (COVID‐19) vaccines, boosters, and infection. In this respect, XBB.1.5, which has been established to harbor a rare mutation F486P, demonstrates superior transmissibility and immune escape ability compared to other subvariants and has emerged as the dominant strain in several countries. This review provides a comprehensive overview of the epidemiological features, spike mutations, and immune evasion of BQ.1 and XBB lineages. We expounded on the mechanisms underlying mutations and immune escape from neutralizing antibodies from vaccinated or convalescent COVID‐19 individuals and therapeutic monoclonal antibodies (mAbs) and proposed strategies for prevention against BQ.1 and XBB sublineages. [ABSTRACT FROM AUTHOR]

Published
2023
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