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262 results on '"Hong, Ki Bae"'

14. Flavor and Taste of Red Beet (Beta vulgaris L.) Harvested in Jeju Island Using the Electronic Nose, Electronic Tongue, and GC-MS

Author

Yoon, Sojeong, primary, Hong, Ki-Bae, additional, Jeong, Hyangyeon, additional, Hong, Seong Jun, additional, Jo, Seong Min, additional, Park, Hyeonjin, additional, Ban, Younglan, additional, Youn, Moon Yeon, additional, Cheon, Ga Yeong, additional, Kim, Jeong Seon, additional, Lee, Youngseung, additional, Park, Sung-Soo, additional, and Shin, Eui-Cheol, additional

Published
2023
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19. Combined Effects of Ziziphus jujuba , Dimocarpus longan , and Lactuca sativa on Sleep-Related Behaviors through GABAergic Signaling.

Author

Bae, Gi Yeon, Ko, Kayoung, Yang, Eunseon, Park, Sung-Soo, Suh, Hyung Joo, and Hong, Ki-Bae

Subjects
GABA receptors, LONGAN, JUJUBE (Plant), SLEEP duration, NEUROTRANSMITTER receptors, LABORATORY mice
Abstract

We aimed to analyze the increase in the sleep-promoting effects based on the mixed ratio of botanical extracts, Ziziphus jujuba seeds, Dimocarpus longan fruits, and Lactuca sativa leaves, using animal models. Behavioral analyses, including an analysis of the total sleep time of Drosophila melanogaster, were conducted to select the optimal mixed ratio of the three botanical extracts. The effects were verified in a caffeine-induced sleepless model, specific neurotransmitter receptor antagonists, and ICR mice. In D. melanogaster exposed to 2.0% of each extract, group behavior was significantly reduced, and the mixed extracts of Z. jujuba, D. longan, and L. sativa (4:1:1 and 1:4:1) significantly increased the total sleep time with individual fruit flies. In the caffeine-induced insomnia model, mixed extracts (4:1:1 and 1:4:1) led to the highest increase in total sleep time. An analysis of locomotor ability revealed a significant reduction in the mobility percentage in the mixed extract groups (0:0:1, 1:0:1, 1:1:1, 4:1:1, and 1:4:1). The administration of Z. jujuba extract and mixed extracts (4:1:1) significantly increased the expression of GABAA-R, whereas the administration of the mixed extracts (4:1:1) and (1:4:1) significantly increased the expression of GABAB-R1 and GABAB-R2, respectively. D. longan extract and the mixed ratio (1:4:1) reduced the subjective nighttime movement and increased the total sleep time in the presence of flumazenil. An analysis of ICR mice indicated that the administration of mixed extracts (4:1:1) significantly increased sleep duration in a dose-dependent manner. These results indicated that the mixed ratio of Z. jujuba, D. longan, and L. sativa extracts, particularly the mixed ratio of 4:1:1, may have sleep-enhancing effects in fruit flies and mice. The study also identified changes in gene expression related to GABA receptors, indicating the potential mechanism for the observed sleep-promoting effects. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Macrolide resistance of Mycoplasma pneumoniae, South Korea, 2000-2011

Author

Hong, Ki Bae, Choi, Eun Hwa, Lee, Hoan Jong, Lee, Seong Yeon, Cho, Eun Young, Choi, Jae Hong, Kang, Hyun Mi, Lee, Jina, Ahn, Young Min, Kang, Yeon-Ho, and Lee, Joon-Ho

Subjects
Epidemics -- Drug therapy -- Health aspects, Bacterial pneumonia -- Drug therapy -- Health aspects, Drug resistance in microorganisms -- Drug therapy -- Health aspects, Pneumonia -- Drug therapy -- Health aspects, Antibacterial agents -- Health aspects, Children -- Health aspects, RNA -- Health aspects, Health
Abstract

Mycoplasma pneumoniae is 1 of the most common IVI causes of community-acquired pneumonia in children and young adults (1). Epidemics of mycoplasma pneumonia typically occur every 4-7 years; however, epidemics [...]

Published
2013
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42. Preparation of chitosan oligosaccharides from chitosan of tenebrio molitorand its prebiotic activity

Author

Kim, Hyemi, Cheon, Ga Yeong, Kim, Jae Hee, Choi, Ra-Yeong, Kim, In-Woo, Suh, Hyung Joo, Hong, Ki-Bae, and Han, Sung Hee

Abstract

This study aimed to establish the optimal production conditions for mealworm chitosan oligosaccharides (MCOS) using the response surface methodology and measure the prebiotic effect of MCOS prepared on cecal microbiota through in vitro anaerobic fermentation. The optimal conditions for MCOS production using chitosanase were 2.5% substrate, 30 mg/g enzyme, and 6 h reaction time. Matrix-assisted laser desorption ionization-time of flight mass spectrometry, Fourier transform infrared spectroscopy, and in vitro assays to confirm that the chemical structure and physicochemical properties of MCOS are similar to those of commercially available chitosan oligosaccharides. The growth of Lactobacillus acidophilus, Lacticaseibacillus casei, and Bifidobacterium bifidumwas increased by MOCS and confirmed that the prebiotic effect of MCOS was significant in a concentration-dependent manner. The addition of 1% and 2% MCOS to in vitro anaerobic fermentation resulted in changes in the content of short-chain fatty acids (SCFAs) and an increase in Verrucomicrobiotaabundance compared with the control. In the case of Romboutsia,Turicibacter, and Akkermansia, a significant increase was confirmed in the MCOS-containing groups compared to that in the control group. Compared to 2% MCOS, 1% MCOS more significantly affected Lactobacilluslevels. MCOS produced by chitosanase under optimal conditions contains oligosaccharides with 2–6 degree of polymerization and exerts a prebiotic effect that affects changes in the SCFA content and microbiota composition in the cecum.

Published
2024
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